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Network neighborhood for query Sequence : NAL10_HUMAN

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NAL10_HUMAN
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NAL10_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	55
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	0 (rank : 2)	NC score	0.988227 (rank : 2)
Query Neighborhood Hits	55	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CIAS1_HUMAN
θ value	6.27148e-94 (rank : 3)	NC score	0.921601 (rank : 5)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NAL12_HUMAN
θ value	1.70789e-91 (rank : 4)	NC score	0.912633 (rank : 7)
Query Neighborhood Hits	55	Target Neighborhood Hits	96	Shared Neighborhood Hits	33
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_MOUSE
θ value	3.93732e-88 (rank : 5)	NC score	0.917871 (rank : 6)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NALP1_HUMAN
θ value	5.17823e-64 (rank : 6)	NC score	0.880529 (rank : 12)
Query Neighborhood Hits	55	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP6_HUMAN
θ value	1.66577e-62 (rank : 7)	NC score	0.934738 (rank : 3)
Query Neighborhood Hits	55	Target Neighborhood Hits	52	Shared Neighborhood Hits	33
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NAL14_HUMAN
θ value	2.84138e-62 (rank : 8)	NC score	0.890562 (rank : 11)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP6_MOUSE
θ value	2.48917e-58 (rank : 9)	NC score	0.929837 (rank : 4)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP4_HUMAN
θ value	6.77864e-56 (rank : 10)	NC score	0.898128 (rank : 9)
Query Neighborhood Hits	55	Target Neighborhood Hits	81	Shared Neighborhood Hits	32
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP7_HUMAN
θ value	6.34462e-54 (rank : 11)	NC score	0.903836 (rank : 8)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP2_HUMAN
θ value	5.93839e-52 (rank : 12)	NC score	0.891652 (rank : 10)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL13_HUMAN
θ value	1.32601e-43 (rank : 13)	NC score	0.876589 (rank : 13)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP5_HUMAN
θ value	3.26607e-42 (rank : 14)	NC score	0.857869 (rank : 14)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP5_MOUSE
θ value	1.62093e-41 (rank : 15)	NC score	0.799676 (rank : 16)
Query Neighborhood Hits	55	Target Neighborhood Hits	560	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NAL11_HUMAN
θ value	2.19584e-30 (rank : 16)	NC score	0.848394 (rank : 15)
Query Neighborhood Hits	55	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

CAR15_MOUSE
θ value	7.0802e-21 (rank : 17)	NC score	0.709627 (rank : 17)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
θ value	2.69047e-20 (rank : 18)	NC score	0.690103 (rank : 18)
Query Neighborhood Hits	55	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

C2TA_HUMAN
θ value	4.91457e-14 (rank : 19)	NC score	0.619116 (rank : 24)
Query Neighborhood Hits	55	Target Neighborhood Hits	190	Shared Neighborhood Hits	25
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_MOUSE
θ value	8.38298e-14 (rank : 20)	NC score	0.645095 (rank : 21)
Query Neighborhood Hits	55	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CARD4_HUMAN
θ value	1.74796e-11 (rank : 21)	NC score	0.633771 (rank : 23)
Query Neighborhood Hits	55	Target Neighborhood Hits	102	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
θ value	4.76016e-09 (rank : 22)	NC score	0.637299 (rank : 22)
Query Neighborhood Hits	55	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

MEFV_HUMAN
θ value	3.08544e-08 (rank : 23)	NC score	0.123837 (rank : 42)
Query Neighborhood Hits	55	Target Neighborhood Hits	431	Shared Neighborhood Hits	19
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MEFV_MOUSE
θ value	3.08544e-08 (rank : 24)	NC score	0.226271 (rank : 40)
Query Neighborhood Hits	55	Target Neighborhood Hits	236	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

ASC_MOUSE
θ value	6.43352e-06 (rank : 25)	NC score	0.395278 (rank : 25)
Query Neighborhood Hits	55	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

BIR1A_MOUSE
θ value	2.44474e-05 (rank : 26)	NC score	0.269998 (rank : 33)
Query Neighborhood Hits	55	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1B_MOUSE
θ value	3.19293e-05 (rank : 27)	NC score	0.250395 (rank : 37)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

ASC_HUMAN
θ value	9.29e-05 (rank : 28)	NC score	0.338784 (rank : 31)
Query Neighborhood Hits	55	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

BIR1F_MOUSE
θ value	0.000121331 (rank : 29)	NC score	0.262720 (rank : 34)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIRC1_HUMAN
θ value	0.000121331 (rank : 30)	NC score	0.286000 (rank : 32)
Query Neighborhood Hits	55	Target Neighborhood Hits	61	Shared Neighborhood Hits	28
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

CAR12_HUMAN
θ value	0.000121331 (rank : 31)	NC score	0.346102 (rank : 29)
Query Neighborhood Hits	55	Target Neighborhood Hits	132	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

BIR1G_MOUSE
θ value	0.00020696 (rank : 32)	NC score	0.255063 (rank : 36)
Query Neighborhood Hits	55	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1E_MOUSE
θ value	0.00175202 (rank : 33)	NC score	0.259407 (rank : 35)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

CF182_HUMAN
θ value	0.0113563 (rank : 34)	NC score	0.030818 (rank : 55)
Query Neighborhood Hits	55	Target Neighborhood Hits	474	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

PTH2_HUMAN
θ value	0.163984 (rank : 35)	NC score	0.048432 (rank : 54)
Query Neighborhood Hits	55	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3E5, Q9NTE5	Gene names	PTRH2, BIT1, PTH2
Domain Architecture
Description	Peptidyl-tRNA hydrolase 2, mitochondrial precursor (EC 3.1.1.29) (PTH 2) (Bcl-2 inhibitor of transcription 1).

DYNA_HUMAN
θ value	0.365318 (rank : 36)	NC score	0.013965 (rank : 61)
Query Neighborhood Hits	55	Target Neighborhood Hits	1194	Shared Neighborhood Hits	11
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	0.365318 (rank : 37)	NC score	0.014060 (rank : 60)
Query Neighborhood Hits	55	Target Neighborhood Hits	1084	Shared Neighborhood Hits	11
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

DYH9_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.014731 (rank : 59)
Query Neighborhood Hits	55	Target Neighborhood Hits	291	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

GP107_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.013704 (rank : 62)
Query Neighborhood Hits	55	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BUV8, Q6ZPL4, Q8BM58, Q8BMN6, Q8BTW1	Gene names	Gpr107, Kiaa1624
Domain Architecture	No domain graphic available
Description	Protein GPR107 precursor.

ZN318_HUMAN
θ value	3.0926 (rank : 40)	NC score	0.016033 (rank : 57)
Query Neighborhood Hits	55	Target Neighborhood Hits	497	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

CENPE_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.001414 (rank : 73)
Query Neighborhood Hits	55	Target Neighborhood Hits	2060	Shared Neighborhood Hits	17
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

INVO_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.004831 (rank : 71)
Query Neighborhood Hits	55	Target Neighborhood Hits	636	Shared Neighborhood Hits	11
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

CF152_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.005192 (rank : 70)
Query Neighborhood Hits	55	Target Neighborhood Hits	597	Shared Neighborhood Hits	8
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CSKI2_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.000533 (rank : 75)
Query Neighborhood Hits	55	Target Neighborhood Hits	812	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DNL1_MOUSE
θ value	6.88961 (rank : 45)	NC score	0.007336 (rank : 67)
Query Neighborhood Hits	55	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

GP73_HUMAN
θ value	6.88961 (rank : 46)	NC score	0.008238 (rank : 66)
Query Neighborhood Hits	55	Target Neighborhood Hits	309	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

LYAR_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.009795 (rank : 65)
Query Neighborhood Hits	55	Target Neighborhood Hits	153	Shared Neighborhood Hits	3
SwissProt Accessions	Q08288, Q9D9X2	Gene names	Lyar
Domain Architecture	No domain graphic available
Description	Cell growth-regulating nucleolar protein.

NEB2_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.006553 (rank : 68)
Query Neighborhood Hits	55	Target Neighborhood Hits	889	Shared Neighborhood Hits	9
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PTH2_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.028802 (rank : 56)
Query Neighborhood Hits	55	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R2Y8, Q8BI01, Q8BI31	Gene names	Ptrh2, Pth2
Domain Architecture
Description	Peptidyl-tRNA hydrolase 2, mitochondrial precursor (EC 3.1.1.29) (PTH 2).

FRM4A_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.002979 (rank : 72)
Query Neighborhood Hits	55	Target Neighborhood Hits	108	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

GOGB1_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.000589 (rank : 74)
Query Neighborhood Hits	55	Target Neighborhood Hits	2297	Shared Neighborhood Hits	16
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GSLG1_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.011161 (rank : 63)
Query Neighborhood Hits	55	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q92896, Q13221	Gene names	GLG1, CFR1, ESL1, MG160
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Cysteine-rich fibroblast growth factor receptor) (CFR-1).

GSLG1_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.011070 (rank : 64)
Query Neighborhood Hits	55	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q61543, Q9QZ40	Gene names	Glg1, Esl1, Mg160, Selel
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Selel).

SEMG2_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.006391 (rank : 69)
Query Neighborhood Hits	55	Target Neighborhood Hits	251	Shared Neighborhood Hits	5
SwissProt Accessions	Q02383, Q6X2M6	Gene names	SEMG2
Domain Architecture
Description	Semenogelin-2 precursor (Semenogelin II) (SGII).

ZCH10_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.015042 (rank : 58)
Query Neighborhood Hits	55	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

BIRC2_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.058542 (rank : 47)
Query Neighborhood Hits	55	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.059772 (rank : 46)
Query Neighborhood Hits	55	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.053780 (rank : 50)
Query Neighborhood Hits	55	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.052598 (rank : 52)
Query Neighborhood Hits	55	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC4_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.054950 (rank : 49)
Query Neighborhood Hits	55	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.056075 (rank : 48)
Query Neighborhood Hits	55	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC5_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.052991 (rank : 51)
Query Neighborhood Hits	55	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.052052 (rank : 53)
Query Neighborhood Hits	55	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

CARD8_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.131657 (rank : 41)
Query Neighborhood Hits	55	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

CF154_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.340382 (rank : 30)
Query Neighborhood Hits	55	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC14_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.062280 (rank : 45)
Query Neighborhood Hits	55	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

LRC31_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.359318 (rank : 27)
Query Neighborhood Hits	55	Target Neighborhood Hits	139	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.390464 (rank : 26)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC34_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.350133 (rank : 28)
Query Neighborhood Hits	55	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC45_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.114225 (rank : 44)
Query Neighborhood Hits	55	Target Neighborhood Hits	933	Shared Neighborhood Hits	29
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.120949 (rank : 43)
Query Neighborhood Hits	55	Target Neighborhood Hits	959	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

RGP1_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.237737 (rank : 38)
Query Neighborhood Hits	55	Target Neighborhood Hits	124	Shared Neighborhood Hits	16
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.227101 (rank : 39)
Query Neighborhood Hits	55	Target Neighborhood Hits	105	Shared Neighborhood Hits	16
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RINI_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.657515 (rank : 19)
Query Neighborhood Hits	55	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.651755 (rank : 20)
Query Neighborhood Hits	55	Target Neighborhood Hits	87	Shared Neighborhood Hits	21
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

Hits sorted by NC score

NAL10_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	55
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
NC score	0.988227 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	55	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NALP6_HUMAN
NC score	0.934738 (rank : 3)	θ value	1.66577e-62 (rank : 7)
Query Neighborhood Hits	55	Target Neighborhood Hits	52	Shared Neighborhood Hits	33
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
NC score	0.929837 (rank : 4)	θ value	2.48917e-58 (rank : 9)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

CIAS1_HUMAN
NC score	0.921601 (rank : 5)	θ value	6.27148e-94 (rank : 3)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
NC score	0.917871 (rank : 6)	θ value	3.93732e-88 (rank : 5)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL12_HUMAN
NC score	0.912633 (rank : 7)	θ value	1.70789e-91 (rank : 4)
Query Neighborhood Hits	55	Target Neighborhood Hits	96	Shared Neighborhood Hits	33
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NALP7_HUMAN
NC score	0.903836 (rank : 8)	θ value	6.34462e-54 (rank : 11)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP4_HUMAN
NC score	0.898128 (rank : 9)	θ value	6.77864e-56 (rank : 10)
Query Neighborhood Hits	55	Target Neighborhood Hits	81	Shared Neighborhood Hits	32
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
NC score	0.891652 (rank : 10)	θ value	5.93839e-52 (rank : 12)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL14_HUMAN
NC score	0.890562 (rank : 11)	θ value	2.84138e-62 (rank : 8)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP1_HUMAN
NC score	0.880529 (rank : 12)	θ value	5.17823e-64 (rank : 6)
Query Neighborhood Hits	55	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NAL13_HUMAN
NC score	0.876589 (rank : 13)	θ value	1.32601e-43 (rank : 13)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP5_HUMAN
NC score	0.857869 (rank : 14)	θ value	3.26607e-42 (rank : 14)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL11_HUMAN
NC score	0.848394 (rank : 15)	θ value	2.19584e-30 (rank : 16)
Query Neighborhood Hits	55	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP5_MOUSE
NC score	0.799676 (rank : 16)	θ value	1.62093e-41 (rank : 15)
Query Neighborhood Hits	55	Target Neighborhood Hits	560	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

CAR15_MOUSE
NC score	0.709627 (rank : 17)	θ value	7.0802e-21 (rank : 17)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.690103 (rank : 18)	θ value	2.69047e-20 (rank : 18)
Query Neighborhood Hits	55	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

RINI_HUMAN
NC score	0.657515 (rank : 19)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	55	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
NC score	0.651755 (rank : 20)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	55	Target Neighborhood Hits	87	Shared Neighborhood Hits	21
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

C2TA_MOUSE
NC score	0.645095 (rank : 21)	θ value	8.38298e-14 (rank : 20)
Query Neighborhood Hits	55	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CARD4_MOUSE
NC score	0.637299 (rank : 22)	θ value	4.76016e-09 (rank : 22)
Query Neighborhood Hits	55	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CARD4_HUMAN
NC score	0.633771 (rank : 23)	θ value	1.74796e-11 (rank : 21)
Query Neighborhood Hits	55	Target Neighborhood Hits	102	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

C2TA_HUMAN
NC score	0.619116 (rank : 24)	θ value	4.91457e-14 (rank : 19)
Query Neighborhood Hits	55	Target Neighborhood Hits	190	Shared Neighborhood Hits	25
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

ASC_MOUSE
NC score	0.395278 (rank : 25)	θ value	6.43352e-06 (rank : 25)
Query Neighborhood Hits	55	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

LRC34_HUMAN
NC score	0.390464 (rank : 26)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC31_HUMAN
NC score	0.359318 (rank : 27)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	55	Target Neighborhood Hits	139	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_MOUSE
NC score	0.350133 (rank : 28)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	55	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CAR12_HUMAN
NC score	0.346102 (rank : 29)	θ value	0.000121331 (rank : 31)
Query Neighborhood Hits	55	Target Neighborhood Hits	132	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CF154_HUMAN
NC score	0.340382 (rank : 30)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	55	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

ASC_HUMAN
NC score	0.338784 (rank : 31)	θ value	9.29e-05 (rank : 28)
Query Neighborhood Hits	55	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

BIRC1_HUMAN
NC score	0.286000 (rank : 32)	θ value	0.000121331 (rank : 30)
Query Neighborhood Hits	55	Target Neighborhood Hits	61	Shared Neighborhood Hits	28
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
NC score	0.269998 (rank : 33)	θ value	2.44474e-05 (rank : 26)
Query Neighborhood Hits	55	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1F_MOUSE
NC score	0.262720 (rank : 34)	θ value	0.000121331 (rank : 29)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.259407 (rank : 35)	θ value	0.00175202 (rank : 33)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.255063 (rank : 36)	θ value	0.00020696 (rank : 32)
Query Neighborhood Hits	55	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.250395 (rank : 37)	θ value	3.19293e-05 (rank : 27)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

RGP1_HUMAN
NC score	0.237737 (rank : 38)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	55	Target Neighborhood Hits	124	Shared Neighborhood Hits	16
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.227101 (rank : 39)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	55	Target Neighborhood Hits	105	Shared Neighborhood Hits	16
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

MEFV_MOUSE
NC score	0.226271 (rank : 40)	θ value	3.08544e-08 (rank : 24)
Query Neighborhood Hits	55	Target Neighborhood Hits	236	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

CARD8_HUMAN
NC score	0.131657 (rank : 41)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	55	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

MEFV_HUMAN
NC score	0.123837 (rank : 42)	θ value	3.08544e-08 (rank : 23)
Query Neighborhood Hits	55	Target Neighborhood Hits	431	Shared Neighborhood Hits	19
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LRC45_MOUSE
NC score	0.120949 (rank : 43)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	55	Target Neighborhood Hits	959	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
NC score	0.114225 (rank : 44)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	55	Target Neighborhood Hits	933	Shared Neighborhood Hits	29
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC14_HUMAN
NC score	0.062280 (rank : 45)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	55	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

BIRC2_MOUSE
NC score	0.059772 (rank : 46)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	55	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC2_HUMAN
NC score	0.058542 (rank : 47)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	55	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC4_MOUSE
NC score	0.056075 (rank : 48)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	55	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC4_HUMAN
NC score	0.054950 (rank : 49)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	55	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC3_HUMAN
NC score	0.053780 (rank : 50)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	55	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC5_HUMAN
NC score	0.052991 (rank : 51)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	55	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC3_MOUSE
NC score	0.052598 (rank : 52)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	55	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC5_MOUSE
NC score	0.052052 (rank : 53)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	55	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

PTH2_HUMAN
NC score	0.048432 (rank : 54)	θ value	0.163984 (rank : 35)
Query Neighborhood Hits	55	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3E5, Q9NTE5	Gene names	PTRH2, BIT1, PTH2
Domain Architecture
Description	Peptidyl-tRNA hydrolase 2, mitochondrial precursor (EC 3.1.1.29) (PTH 2) (Bcl-2 inhibitor of transcription 1).

CF182_HUMAN
NC score	0.030818 (rank : 55)	θ value	0.0113563 (rank : 34)
Query Neighborhood Hits	55	Target Neighborhood Hits	474	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

PTH2_MOUSE
NC score	0.028802 (rank : 56)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	55	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R2Y8, Q8BI01, Q8BI31	Gene names	Ptrh2, Pth2
Domain Architecture
Description	Peptidyl-tRNA hydrolase 2, mitochondrial precursor (EC 3.1.1.29) (PTH 2).

ZN318_HUMAN
NC score	0.016033 (rank : 57)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	55	Target Neighborhood Hits	497	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

ZCH10_MOUSE
NC score	0.015042 (rank : 58)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	55	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

DYH9_HUMAN
NC score	0.014731 (rank : 59)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	55	Target Neighborhood Hits	291	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

DYNA_MOUSE
NC score	0.014060 (rank : 60)	θ value	0.365318 (rank : 37)
Query Neighborhood Hits	55	Target Neighborhood Hits	1084	Shared Neighborhood Hits	11
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

DYNA_HUMAN
NC score	0.013965 (rank : 61)	θ value	0.365318 (rank : 36)
Query Neighborhood Hits	55	Target Neighborhood Hits	1194	Shared Neighborhood Hits	11
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

GP107_MOUSE
NC score	0.013704 (rank : 62)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	55	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BUV8, Q6ZPL4, Q8BM58, Q8BMN6, Q8BTW1	Gene names	Gpr107, Kiaa1624
Domain Architecture	No domain graphic available
Description	Protein GPR107 precursor.

GSLG1_HUMAN
NC score	0.011161 (rank : 63)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	55	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q92896, Q13221	Gene names	GLG1, CFR1, ESL1, MG160
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Cysteine-rich fibroblast growth factor receptor) (CFR-1).

GSLG1_MOUSE
NC score	0.011070 (rank : 64)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	55	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q61543, Q9QZ40	Gene names	Glg1, Esl1, Mg160, Selel
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Selel).

LYAR_MOUSE
NC score	0.009795 (rank : 65)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	55	Target Neighborhood Hits	153	Shared Neighborhood Hits	3
SwissProt Accessions	Q08288, Q9D9X2	Gene names	Lyar
Domain Architecture	No domain graphic available
Description	Cell growth-regulating nucleolar protein.

GP73_HUMAN
NC score	0.008238 (rank : 66)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	55	Target Neighborhood Hits	309	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

DNL1_MOUSE
NC score	0.007336 (rank : 67)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	55	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

NEB2_MOUSE
NC score	0.006553 (rank : 68)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	55	Target Neighborhood Hits	889	Shared Neighborhood Hits	9
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SEMG2_HUMAN
NC score	0.006391 (rank : 69)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	55	Target Neighborhood Hits	251	Shared Neighborhood Hits	5
SwissProt Accessions	Q02383, Q6X2M6	Gene names	SEMG2
Domain Architecture
Description	Semenogelin-2 precursor (Semenogelin II) (SGII).

CF152_MOUSE
NC score	0.005192 (rank : 70)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	55	Target Neighborhood Hits	597	Shared Neighborhood Hits	8
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

INVO_HUMAN
NC score	0.004831 (rank : 71)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	55	Target Neighborhood Hits	636	Shared Neighborhood Hits	11
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

FRM4A_MOUSE
NC score	0.002979 (rank : 72)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	55	Target Neighborhood Hits	108	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

CENPE_HUMAN
NC score	0.001414 (rank : 73)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	55	Target Neighborhood Hits	2060	Shared Neighborhood Hits	17
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

GOGB1_HUMAN
NC score	0.000589 (rank : 74)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	55	Target Neighborhood Hits	2297	Shared Neighborhood Hits	16
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

CSKI2_MOUSE
NC score	0.000533 (rank : 75)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	55	Target Neighborhood Hits	812	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.