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Network neighborhood for query Sequence : ASC_HUMAN

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ASC_HUMAN
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ASC_HUMAN
θ value	1.35324e-88 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

ASC_MOUSE
θ value	1.11475e-66 (rank : 2)	NC score	0.979142 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

NALP1_HUMAN
θ value	7.0802e-21 (rank : 3)	NC score	0.409423 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	138	Shared Neighborhood Hits	13
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

MEFV_MOUSE
θ value	1.80886e-08 (rank : 4)	NC score	0.297944 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

NALP6_MOUSE
θ value	4.45536e-07 (rank : 5)	NC score	0.328139 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

MEFV_HUMAN
θ value	2.21117e-06 (rank : 6)	NC score	0.145707 (rank : 21)
Query Neighborhood Hits	18	Target Neighborhood Hits	431	Shared Neighborhood Hits	11
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

NAL10_HUMAN
θ value	9.29e-05 (rank : 7)	NC score	0.338784 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

CARD8_HUMAN
θ value	0.0330416 (rank : 8)	NC score	0.295040 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

CIAS1_MOUSE
θ value	0.0330416 (rank : 9)	NC score	0.265575 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	67	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NALP6_HUMAN
θ value	0.0961366 (rank : 10)	NC score	0.307914 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

CIAS1_HUMAN
θ value	0.163984 (rank : 11)	NC score	0.264723 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NAL10_MOUSE
θ value	0.62314 (rank : 12)	NC score	0.281614 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

RIPK2_MOUSE
θ value	0.813845 (rank : 13)	NC score	0.013615 (rank : 36)
Query Neighborhood Hits	18	Target Neighborhood Hits	776	Shared Neighborhood Hits	4
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

NAL12_HUMAN
θ value	1.06291 (rank : 14)	NC score	0.248113 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	96	Shared Neighborhood Hits	14
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CARD4_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.138268 (rank : 25)
Query Neighborhood Hits	18	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CAF1B_HUMAN
θ value	2.36792 (rank : 16)	NC score	0.016733 (rank : 35)
Query Neighborhood Hits	18	Target Neighborhood Hits	345	Shared Neighborhood Hits	2
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

NALP7_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.224778 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

RIPK2_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.012005 (rank : 37)
Query Neighborhood Hits	18	Target Neighborhood Hits	774	Shared Neighborhood Hits	4
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

C2TA_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.125207 (rank : 29)
Query Neighborhood Hits	18	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.134131 (rank : 27)
Query Neighborhood Hits	18	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CAR12_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.053805 (rank : 34)
Query Neighborhood Hits	18	Target Neighborhood Hits	132	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CAR15_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.139611 (rank : 23)
Query Neighborhood Hits	18	Target Neighborhood Hits	77	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.138336 (rank : 24)
Query Neighborhood Hits	18	Target Neighborhood Hits	93	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CARD4_MOUSE
θ value	θ > 10 (rank : 24)	NC score	0.125777 (rank : 28)
Query Neighborhood Hits	18	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CF154_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.080063 (rank : 30)
Query Neighborhood Hits	18	Target Neighborhood Hits	36	Shared Neighborhood Hits	8
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC31_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.068121 (rank : 31)
Query Neighborhood Hits	18	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.064612 (rank : 32)
Query Neighborhood Hits	18	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC34_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.062271 (rank : 33)
Query Neighborhood Hits	18	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

NAL11_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.183589 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NAL13_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.190837 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NAL14_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.203734 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP2_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.211445 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP4_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.219026 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	81	Shared Neighborhood Hits	13
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP5_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.196834 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP5_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.171595 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	560	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RINI_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.141958 (rank : 22)
Query Neighborhood Hits	18	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.137506 (rank : 26)
Query Neighborhood Hits	18	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

Hits sorted by NC score

ASC_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.35324e-88 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

ASC_MOUSE
NC score	0.979142 (rank : 2)	θ value	1.11475e-66 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

NALP1_HUMAN
NC score	0.409423 (rank : 3)	θ value	7.0802e-21 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	138	Shared Neighborhood Hits	13
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NAL10_HUMAN
NC score	0.338784 (rank : 4)	θ value	9.29e-05 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NALP6_MOUSE
NC score	0.328139 (rank : 5)	θ value	4.45536e-07 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP6_HUMAN
NC score	0.307914 (rank : 6)	θ value	0.0961366 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

MEFV_MOUSE
NC score	0.297944 (rank : 7)	θ value	1.80886e-08 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

CARD8_HUMAN
NC score	0.295040 (rank : 8)	θ value	0.0330416 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

NAL10_MOUSE
NC score	0.281614 (rank : 9)	θ value	0.62314 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CIAS1_MOUSE
NC score	0.265575 (rank : 10)	θ value	0.0330416 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	67	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

CIAS1_HUMAN
NC score	0.264723 (rank : 11)	θ value	0.163984 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NAL12_HUMAN
NC score	0.248113 (rank : 12)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	96	Shared Neighborhood Hits	14
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NALP7_HUMAN
NC score	0.224778 (rank : 13)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP4_HUMAN
NC score	0.219026 (rank : 14)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	18	Target Neighborhood Hits	81	Shared Neighborhood Hits	13
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
NC score	0.211445 (rank : 15)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	18	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL14_HUMAN
NC score	0.203734 (rank : 16)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	18	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP5_HUMAN
NC score	0.196834 (rank : 17)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	18	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL13_HUMAN
NC score	0.190837 (rank : 18)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	18	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NAL11_HUMAN
NC score	0.183589 (rank : 19)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	18	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP5_MOUSE
NC score	0.171595 (rank : 20)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	18	Target Neighborhood Hits	560	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

MEFV_HUMAN
NC score	0.145707 (rank : 21)	θ value	2.21117e-06 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	431	Shared Neighborhood Hits	11
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

RINI_HUMAN
NC score	0.141958 (rank : 22)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	18	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

CAR15_HUMAN
NC score	0.139611 (rank : 23)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	18	Target Neighborhood Hits	77	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
NC score	0.138336 (rank : 24)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	18	Target Neighborhood Hits	93	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CARD4_HUMAN
NC score	0.138268 (rank : 25)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

RINI_MOUSE
NC score	0.137506 (rank : 26)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	18	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

C2TA_MOUSE
NC score	0.134131 (rank : 27)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CARD4_MOUSE
NC score	0.125777 (rank : 28)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	18	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_HUMAN
NC score	0.125207 (rank : 29)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

CF154_HUMAN
NC score	0.080063 (rank : 30)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	18	Target Neighborhood Hits	36	Shared Neighborhood Hits	8
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC31_HUMAN
NC score	0.068121 (rank : 31)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	18	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_HUMAN
NC score	0.064612 (rank : 32)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	18	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC34_MOUSE
NC score	0.062271 (rank : 33)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	18	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CAR12_HUMAN
NC score	0.053805 (rank : 34)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	18	Target Neighborhood Hits	132	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CAF1B_HUMAN
NC score	0.016733 (rank : 35)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	345	Shared Neighborhood Hits	2
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

RIPK2_MOUSE
NC score	0.013615 (rank : 36)	θ value	0.813845 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	776	Shared Neighborhood Hits	4
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK2_HUMAN
NC score	0.012005 (rank : 37)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	774	Shared Neighborhood Hits	4
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).