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Network neighborhood for query Sequence : SPG3A_HUMAN

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SPG3A_HUMAN
SwissProt Accessions	Q8WXF7, O95890, Q96FK0	Gene names	SPG3A, GBP3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3) (Brain-specific GTP-binding protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPG3A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXF7, O95890, Q96FK0	Gene names	SPG3A, GBP3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3) (Brain-specific GTP-binding protein).

SPG3A_MOUSE
θ value	0 (rank : 2)	NC score	0.999237 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BH66, Q8BJH5	Gene names	Spg3a, Gbp3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3).

ZN179_HUMAN
θ value	2.27762e-19 (rank : 3)	NC score	0.421625 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	178	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

GBP1_MOUSE
θ value	5.8054e-15 (rank : 4)	NC score	0.534550 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	302	Shared Neighborhood Hits	10
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

GBP2_HUMAN
θ value	2.88119e-14 (rank : 5)	NC score	0.515751 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	349	Shared Neighborhood Hits	10
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

GBP4_HUMAN
θ value	6.41864e-14 (rank : 6)	NC score	0.498249 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	484	Shared Neighborhood Hits	10
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

GBP2_MOUSE
θ value	1.42992e-13 (rank : 7)	NC score	0.520735 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	323	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0E6, Q8CIC6, Q921N2, Q9R1I0	Gene names	Gbp2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (mGBP2) (mGBP-2).

GBP5_MOUSE
θ value	4.59992e-12 (rank : 8)	NC score	0.533395 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	254	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CFB4, Q8CFA4	Gene names	Gbp5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (MuGBP-5).

GBP1_HUMAN
θ value	8.67504e-11 (rank : 9)	NC score	0.499502 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	339	Shared Neighborhood Hits	10
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

GBP5_HUMAN
θ value	4.30538e-10 (rank : 10)	NC score	0.518954 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q96PP8	Gene names	GBP5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (GBP-TA antigen).

TMC1_HUMAN
θ value	0.21417 (rank : 11)	NC score	0.055363 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

I23O_HUMAN
θ value	0.813845 (rank : 12)	NC score	0.059711 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P14902	Gene names	INDO, IDO
Domain Architecture
Description	Indoleamine 2,3-dioxygenase (EC 1.13.11.52) (IDO) (Indoleamine-pyrrole 2,3-dioxygenase).

SPB10_MOUSE
θ value	1.06291 (rank : 13)	NC score	0.014094 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K1K6	Gene names	Serpinb10
Domain Architecture	No domain graphic available
Description	Serpin B10.

P85A_HUMAN
θ value	1.81305 (rank : 14)	NC score	0.026684 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	479	Shared Neighborhood Hits	4
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MRP7_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.007539 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48	Gene names	ABCC10, MRP7, SIMRP7
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 7 (ATP-binding cassette sub- family C member 10).

TMC1_MOUSE
θ value	6.88961 (rank : 16)	NC score	0.029120 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4P5, Q9D435	Gene names	Tmc1, Bth, dn
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1 (Beethoven protein) (Deafness protein).

Hits sorted by NC score

SPG3A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXF7, O95890, Q96FK0	Gene names	SPG3A, GBP3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3) (Brain-specific GTP-binding protein).

SPG3A_MOUSE
NC score	0.999237 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BH66, Q8BJH5	Gene names	Spg3a, Gbp3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3).

GBP1_MOUSE
NC score	0.534550 (rank : 3)	θ value	5.8054e-15 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	302	Shared Neighborhood Hits	10
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

GBP5_MOUSE
NC score	0.533395 (rank : 4)	θ value	4.59992e-12 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	254	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CFB4, Q8CFA4	Gene names	Gbp5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (MuGBP-5).

GBP2_MOUSE
NC score	0.520735 (rank : 5)	θ value	1.42992e-13 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	323	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0E6, Q8CIC6, Q921N2, Q9R1I0	Gene names	Gbp2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (mGBP2) (mGBP-2).

GBP5_HUMAN
NC score	0.518954 (rank : 6)	θ value	4.30538e-10 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q96PP8	Gene names	GBP5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (GBP-TA antigen).

GBP2_HUMAN
NC score	0.515751 (rank : 7)	θ value	2.88119e-14 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	349	Shared Neighborhood Hits	10
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

GBP1_HUMAN
NC score	0.499502 (rank : 8)	θ value	8.67504e-11 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	339	Shared Neighborhood Hits	10
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

GBP4_HUMAN
NC score	0.498249 (rank : 9)	θ value	6.41864e-14 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	484	Shared Neighborhood Hits	10
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

ZN179_HUMAN
NC score	0.421625 (rank : 10)	θ value	2.27762e-19 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	178	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

I23O_HUMAN
NC score	0.059711 (rank : 11)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P14902	Gene names	INDO, IDO
Domain Architecture
Description	Indoleamine 2,3-dioxygenase (EC 1.13.11.52) (IDO) (Indoleamine-pyrrole 2,3-dioxygenase).

TMC1_HUMAN
NC score	0.055363 (rank : 12)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

TMC1_MOUSE
NC score	0.029120 (rank : 13)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4P5, Q9D435	Gene names	Tmc1, Bth, dn
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1 (Beethoven protein) (Deafness protein).

P85A_HUMAN
NC score	0.026684 (rank : 14)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	479	Shared Neighborhood Hits	4
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SPB10_MOUSE
NC score	0.014094 (rank : 15)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K1K6	Gene names	Serpinb10
Domain Architecture	No domain graphic available
Description	Serpin B10.

MRP7_HUMAN
NC score	0.007539 (rank : 16)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48	Gene names	ABCC10, MRP7, SIMRP7
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 7 (ATP-binding cassette sub- family C member 10).