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Network neighborhood for query Sequence : SIRT1_HUMAN

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SIRT1_HUMAN
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIRT1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

SIRT1_MOUSE
θ value	0 (rank : 2)	NC score	0.991419 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	50	Shared Neighborhood Hits	20
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SIRT2_MOUSE
θ value	8.85319e-56 (rank : 3)	NC score	0.903041 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT2_HUMAN
θ value	2.41096e-53 (rank : 4)	NC score	0.900389 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT3_HUMAN
θ value	1.61718e-49 (rank : 5)	NC score	0.900204 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT3_MOUSE
θ value	1.32601e-43 (rank : 6)	NC score	0.899119 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT5_HUMAN
θ value	5.07402e-19 (rank : 7)	NC score	0.721066 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT4_MOUSE
θ value	8.10077e-17 (rank : 8)	NC score	0.696102 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT5_MOUSE
θ value	6.85773e-16 (rank : 9)	NC score	0.711548 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT4_HUMAN
θ value	4.44505e-15 (rank : 10)	NC score	0.693561 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT6_HUMAN
θ value	7.84624e-12 (rank : 11)	NC score	0.616372 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_MOUSE
θ value	9.59137e-10 (rank : 12)	NC score	0.599351 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT7_MOUSE
θ value	1.43324e-05 (rank : 13)	NC score	0.512778 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_HUMAN
θ value	0.000121331 (rank : 14)	NC score	0.502165 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

OGFR_HUMAN
θ value	0.125558 (rank : 15)	NC score	0.023109 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	1582	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PHLB2_HUMAN
θ value	0.125558 (rank : 16)	NC score	0.035649 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	964	Shared Neighborhood Hits	11
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

MS3L1_HUMAN
θ value	0.163984 (rank : 17)	NC score	0.044805 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5Y2, Q9UG70, Q9Y5Z8	Gene names	MSL3L1
Domain Architecture
Description	Male-specific lethal 3-like 1 (MSL3-like 1) (Male-specific lethal-3 homolog 1).

FOG1_MOUSE
θ value	0.47712 (rank : 18)	NC score	0.009210 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	1237	Shared Neighborhood Hits	11
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

IF4G3_HUMAN
θ value	0.47712 (rank : 19)	NC score	0.027256 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	247	Shared Neighborhood Hits	5
SwissProt Accessions	O43432, Q15597, Q8NEN1	Gene names	EIF4G3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

MAP1B_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.022801 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	977	Shared Neighborhood Hits	14
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

PHLB2_MOUSE
θ value	0.47712 (rank : 21)	NC score	0.026970 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	1016	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

HSP74_MOUSE
θ value	0.62314 (rank : 22)	NC score	0.014142 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	257	Shared Neighborhood Hits	3
SwissProt Accessions	Q61316	Gene names	Hspa4, Hsp110
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2).

ANR12_HUMAN
θ value	1.06291 (rank : 23)	NC score	0.014748 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	1081	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

IQEC3_MOUSE
θ value	1.81305 (rank : 24)	NC score	0.014025 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PCLO_MOUSE
θ value	1.81305 (rank : 25)	NC score	0.011054 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	2275	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PHF12_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.019104 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

ZSCA1_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.002601 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	724	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.

GON4L_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.018488 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	555	Shared Neighborhood Hits	9
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

NCOA3_MOUSE
θ value	3.0926 (rank : 29)	NC score	0.018806 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	203	Shared Neighborhood Hits	4
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

RIMB1_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.013708 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	1479	Shared Neighborhood Hits	16
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MEFV_HUMAN
θ value	4.03905 (rank : 31)	NC score	0.005461 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	431	Shared Neighborhood Hits	4
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MLL3_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.008616 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	1399	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

LIPA1_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.005571 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	1294	Shared Neighborhood Hits	13
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

NET2_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.005786 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	O00634	Gene names	NTN2L
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor.

POT15_HUMAN
θ value	5.27518 (rank : 35)	NC score	0.007062 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	893	Shared Neighborhood Hits	12
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

ZDHC9_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.007623 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y397, Q59EK4, Q5JSW5, Q8WWS7, Q9BPY4, Q9NSP0, Q9NVL0, Q9NVR6	Gene names	ZDHHC9, ZNF379
Domain Architecture
Description	Palmitoyltransferase ZDHHC9 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379).

CUTL1_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.005733 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	1574	Shared Neighborhood Hits	17
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

DEK_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.015600 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	199	Shared Neighborhood Hits	7
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

TEX14_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.006164 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	1103	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

AGRIN_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.002812 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	582	Shared Neighborhood Hits	5
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ANR21_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.005936 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	864	Shared Neighborhood Hits	12
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

BAG3_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.010866 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	314	Shared Neighborhood Hits	8
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

PITM2_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.005790 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZPQ6, Q9R1P5	Gene names	Pitpnm2, Kiaa1457, Nir3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) (Drosophila retinal degeneration B homolog 2) (RdgB2).

SCN2A_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.004601 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

Hits sorted by NC score

SIRT1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

SIRT1_MOUSE
NC score	0.991419 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	50	Shared Neighborhood Hits	20
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SIRT2_MOUSE
NC score	0.903041 (rank : 3)	θ value	8.85319e-56 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT2_HUMAN
NC score	0.900389 (rank : 4)	θ value	2.41096e-53 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT3_HUMAN
NC score	0.900204 (rank : 5)	θ value	1.61718e-49 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT3_MOUSE
NC score	0.899119 (rank : 6)	θ value	1.32601e-43 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT5_HUMAN
NC score	0.721066 (rank : 7)	θ value	5.07402e-19 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT5_MOUSE
NC score	0.711548 (rank : 8)	θ value	6.85773e-16 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT4_MOUSE
NC score	0.696102 (rank : 9)	θ value	8.10077e-17 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT4_HUMAN
NC score	0.693561 (rank : 10)	θ value	4.44505e-15 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT6_HUMAN
NC score	0.616372 (rank : 11)	θ value	7.84624e-12 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_MOUSE
NC score	0.599351 (rank : 12)	θ value	9.59137e-10 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT7_MOUSE
NC score	0.512778 (rank : 13)	θ value	1.43324e-05 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_HUMAN
NC score	0.502165 (rank : 14)	θ value	0.000121331 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

MS3L1_HUMAN
NC score	0.044805 (rank : 15)	θ value	0.163984 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5Y2, Q9UG70, Q9Y5Z8	Gene names	MSL3L1
Domain Architecture
Description	Male-specific lethal 3-like 1 (MSL3-like 1) (Male-specific lethal-3 homolog 1).

PHLB2_HUMAN
NC score	0.035649 (rank : 16)	θ value	0.125558 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	964	Shared Neighborhood Hits	11
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

IF4G3_HUMAN
NC score	0.027256 (rank : 17)	θ value	0.47712 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	247	Shared Neighborhood Hits	5
SwissProt Accessions	O43432, Q15597, Q8NEN1	Gene names	EIF4G3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

PHLB2_MOUSE
NC score	0.026970 (rank : 18)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	1016	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

OGFR_HUMAN
NC score	0.023109 (rank : 19)	θ value	0.125558 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	1582	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

MAP1B_MOUSE
NC score	0.022801 (rank : 20)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	977	Shared Neighborhood Hits	14
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

PHF12_HUMAN
NC score	0.019104 (rank : 21)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

NCOA3_MOUSE
NC score	0.018806 (rank : 22)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	203	Shared Neighborhood Hits	4
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

GON4L_HUMAN
NC score	0.018488 (rank : 23)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	555	Shared Neighborhood Hits	9
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

DEK_HUMAN
NC score	0.015600 (rank : 24)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	199	Shared Neighborhood Hits	7
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

ANR12_HUMAN
NC score	0.014748 (rank : 25)	θ value	1.06291 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	1081	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

HSP74_MOUSE
NC score	0.014142 (rank : 26)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	257	Shared Neighborhood Hits	3
SwissProt Accessions	Q61316	Gene names	Hspa4, Hsp110
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2).

IQEC3_MOUSE
NC score	0.014025 (rank : 27)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

RIMB1_HUMAN
NC score	0.013708 (rank : 28)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	1479	Shared Neighborhood Hits	16
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PCLO_MOUSE
NC score	0.011054 (rank : 29)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	2275	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

BAG3_HUMAN
NC score	0.010866 (rank : 30)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	314	Shared Neighborhood Hits	8
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

FOG1_MOUSE
NC score	0.009210 (rank : 31)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	1237	Shared Neighborhood Hits	11
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

MLL3_MOUSE
NC score	0.008616 (rank : 32)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	1399	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

ZDHC9_HUMAN
NC score	0.007623 (rank : 33)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y397, Q59EK4, Q5JSW5, Q8WWS7, Q9BPY4, Q9NSP0, Q9NVL0, Q9NVR6	Gene names	ZDHHC9, ZNF379
Domain Architecture
Description	Palmitoyltransferase ZDHHC9 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379).

POT15_HUMAN
NC score	0.007062 (rank : 34)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	893	Shared Neighborhood Hits	12
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

TEX14_HUMAN
NC score	0.006164 (rank : 35)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	1103	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ANR21_HUMAN
NC score	0.005936 (rank : 36)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	864	Shared Neighborhood Hits	12
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

PITM2_MOUSE
NC score	0.005790 (rank : 37)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZPQ6, Q9R1P5	Gene names	Pitpnm2, Kiaa1457, Nir3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) (Drosophila retinal degeneration B homolog 2) (RdgB2).

NET2_HUMAN
NC score	0.005786 (rank : 38)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	O00634	Gene names	NTN2L
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor.

CUTL1_HUMAN
NC score	0.005733 (rank : 39)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	1574	Shared Neighborhood Hits	17
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

LIPA1_HUMAN
NC score	0.005571 (rank : 40)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	1294	Shared Neighborhood Hits	13
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

MEFV_HUMAN
NC score	0.005461 (rank : 41)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	431	Shared Neighborhood Hits	4
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

SCN2A_HUMAN
NC score	0.004601 (rank : 42)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

AGRIN_HUMAN
NC score	0.002812 (rank : 43)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	582	Shared Neighborhood Hits	5
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ZSCA1_HUMAN
NC score	0.002601 (rank : 44)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	724	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.