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Network neighborhood for query Sequence : SIRT7_MOUSE

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SIRT7_MOUSE
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIRT7_HUMAN
θ value	0 (rank : 1)	NC score	0.988439 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT6_HUMAN
θ value	4.122e-45 (rank : 3)	NC score	0.883877 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_MOUSE
θ value	2.26182e-43 (rank : 4)	NC score	0.883581 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT4_HUMAN
θ value	2.7842e-17 (rank : 5)	NC score	0.723901 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT4_MOUSE
θ value	3.63628e-17 (rank : 6)	NC score	0.720318 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT2_MOUSE
θ value	6.00763e-12 (rank : 7)	NC score	0.615570 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT3_HUMAN
θ value	1.74796e-11 (rank : 8)	NC score	0.632776 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT2_HUMAN
θ value	1.133e-10 (rank : 9)	NC score	0.598410 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT3_MOUSE
θ value	3.29651e-10 (rank : 10)	NC score	0.634053 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT5_MOUSE
θ value	2.79066e-09 (rank : 11)	NC score	0.613530 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT5_HUMAN
θ value	4.76016e-09 (rank : 12)	NC score	0.599308 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT1_HUMAN
θ value	1.43324e-05 (rank : 13)	NC score	0.512778 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

SIRT1_MOUSE
θ value	1.43324e-05 (rank : 14)	NC score	0.516524 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

NEMO_HUMAN
θ value	0.0563607 (rank : 15)	NC score	0.047259 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	820	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

MYH8_HUMAN
θ value	0.0736092 (rank : 16)	NC score	0.058286 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	1610	Shared Neighborhood Hits	29
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH3_HUMAN
θ value	0.0961366 (rank : 17)	NC score	0.057045 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	1660	Shared Neighborhood Hits	29
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH8_MOUSE
θ value	0.0961366 (rank : 18)	NC score	0.057968 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	1600	Shared Neighborhood Hits	29
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH1_HUMAN
θ value	0.279714 (rank : 19)	NC score	0.058259 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	1478	Shared Neighborhood Hits	29
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH4_MOUSE
θ value	0.279714 (rank : 20)	NC score	0.058923 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	1476	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH1_MOUSE
θ value	0.365318 (rank : 21)	NC score	0.058539 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	1461	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

CTRO_MOUSE
θ value	0.47712 (rank : 22)	NC score	0.018082 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	2344	Shared Neighborhood Hits	28
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MYH2_HUMAN
θ value	0.47712 (rank : 23)	NC score	0.057469 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	1491	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH4_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.058830 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	1377	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

BRE1B_HUMAN
θ value	0.813845 (rank : 25)	NC score	0.050056 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	1040	Shared Neighborhood Hits	27
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	0.813845 (rank : 26)	NC score	0.051748 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	970	Shared Neighborhood Hits	27
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

CROCC_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.041570 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	1409	Shared Neighborhood Hits	29
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

ZFY19_HUMAN
θ value	0.813845 (rank : 28)	NC score	0.052181 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

GRAP1_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.045192 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	1234	Shared Neighborhood Hits	29
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

EEA1_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.040158 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	1637	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

ZFY19_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.037823 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

AZI1_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.037290 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	990	Shared Neighborhood Hits	27
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BRAP_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.036772 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	560	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

CCD21_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.035873 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	1228	Shared Neighborhood Hits	27
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

IFT81_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.044544 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	893	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IFT81_MOUSE
θ value	4.03905 (rank : 36)	NC score	0.041388 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	959	Shared Neighborhood Hits	27
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

SDCG8_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.043555 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	886	Shared Neighborhood Hits	29
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

CARD9_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.041338 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	602	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

MYH13_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.055274 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	1504	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

UACA_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.033853 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	1622	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

CCD21_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.035002 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	1135	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

USF2_MOUSE
θ value	6.88961 (rank : 42)	NC score	0.012122 (rank : 47)
Query Neighborhood Hits	44	Target Neighborhood Hits	173	Shared Neighborhood Hits	6
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

AR13B_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.016685 (rank : 46)
Query Neighborhood Hits	44	Target Neighborhood Hits	528	Shared Neighborhood Hits	16
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

RAD50_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.035311 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	1366	Shared Neighborhood Hits	27
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

MYH6_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.053611 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	1426	Shared Neighborhood Hits	27
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.053697 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	1501	Shared Neighborhood Hits	27
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.053349 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	1559	Shared Neighborhood Hits	27
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

Hits sorted by NC score

SIRT7_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_HUMAN
NC score	0.988439 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT6_HUMAN
NC score	0.883877 (rank : 3)	θ value	4.122e-45 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_MOUSE
NC score	0.883581 (rank : 4)	θ value	2.26182e-43 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT4_HUMAN
NC score	0.723901 (rank : 5)	θ value	2.7842e-17 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT4_MOUSE
NC score	0.720318 (rank : 6)	θ value	3.63628e-17 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT3_MOUSE
NC score	0.634053 (rank : 7)	θ value	3.29651e-10 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT3_HUMAN
NC score	0.632776 (rank : 8)	θ value	1.74796e-11 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT2_MOUSE
NC score	0.615570 (rank : 9)	θ value	6.00763e-12 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT5_MOUSE
NC score	0.613530 (rank : 10)	θ value	2.79066e-09 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT5_HUMAN
NC score	0.599308 (rank : 11)	θ value	4.76016e-09 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT2_HUMAN
NC score	0.598410 (rank : 12)	θ value	1.133e-10 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT1_MOUSE
NC score	0.516524 (rank : 13)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SIRT1_HUMAN
NC score	0.512778 (rank : 14)	θ value	1.43324e-05 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

MYH4_MOUSE
NC score	0.058923 (rank : 15)	θ value	0.279714 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	1476	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH4_HUMAN
NC score	0.058830 (rank : 16)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	1377	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH1_MOUSE
NC score	0.058539 (rank : 17)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	1461	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH8_HUMAN
NC score	0.058286 (rank : 18)	θ value	0.0736092 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	1610	Shared Neighborhood Hits	29
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH1_HUMAN
NC score	0.058259 (rank : 19)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	1478	Shared Neighborhood Hits	29
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH8_MOUSE
NC score	0.057968 (rank : 20)	θ value	0.0961366 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	1600	Shared Neighborhood Hits	29
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH2_HUMAN
NC score	0.057469 (rank : 21)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	1491	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH3_HUMAN
NC score	0.057045 (rank : 22)	θ value	0.0961366 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	1660	Shared Neighborhood Hits	29
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH13_HUMAN
NC score	0.055274 (rank : 23)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	1504	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH6_MOUSE
NC score	0.053697 (rank : 24)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	44	Target Neighborhood Hits	1501	Shared Neighborhood Hits	27
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_HUMAN
NC score	0.053611 (rank : 25)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	1426	Shared Neighborhood Hits	27
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
NC score	0.053349 (rank : 26)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	44	Target Neighborhood Hits	1559	Shared Neighborhood Hits	27
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

ZFY19_HUMAN
NC score	0.052181 (rank : 27)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

BRE1B_MOUSE
NC score	0.051748 (rank : 28)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	970	Shared Neighborhood Hits	27
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

BRE1B_HUMAN
NC score	0.050056 (rank : 29)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	1040	Shared Neighborhood Hits	27
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

NEMO_HUMAN
NC score	0.047259 (rank : 30)	θ value	0.0563607 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	820	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

GRAP1_MOUSE
NC score	0.045192 (rank : 31)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	1234	Shared Neighborhood Hits	29
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

IFT81_HUMAN
NC score	0.044544 (rank : 32)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	893	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

SDCG8_MOUSE
NC score	0.043555 (rank : 33)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	886	Shared Neighborhood Hits	29
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

CROCC_HUMAN
NC score	0.041570 (rank : 34)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	1409	Shared Neighborhood Hits	29
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

IFT81_MOUSE
NC score	0.041388 (rank : 35)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	959	Shared Neighborhood Hits	27
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CARD9_HUMAN
NC score	0.041338 (rank : 36)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	602	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

EEA1_MOUSE
NC score	0.040158 (rank : 37)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	1637	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

ZFY19_MOUSE
NC score	0.037823 (rank : 38)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

AZI1_MOUSE
NC score	0.037290 (rank : 39)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	990	Shared Neighborhood Hits	27
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BRAP_HUMAN
NC score	0.036772 (rank : 40)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	560	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

CCD21_HUMAN
NC score	0.035873 (rank : 41)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	1228	Shared Neighborhood Hits	27
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

RAD50_MOUSE
NC score	0.035311 (rank : 42)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	1366	Shared Neighborhood Hits	27
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

CCD21_MOUSE
NC score	0.035002 (rank : 43)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	1135	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

UACA_HUMAN
NC score	0.033853 (rank : 44)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	1622	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

CTRO_MOUSE
NC score	0.018082 (rank : 45)	θ value	0.47712 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	2344	Shared Neighborhood Hits	28
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

AR13B_HUMAN
NC score	0.016685 (rank : 46)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	528	Shared Neighborhood Hits	16
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

USF2_MOUSE
NC score	0.012122 (rank : 47)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	173	Shared Neighborhood Hits	6
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).