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Network neighborhood for query Sequence : CFLAR_MOUSE

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CFLAR_MOUSE
 
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
Rank Plots


Hits sorted by θ


CFLAR_MOUSE
 
θ value 0 (rank : 1) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 32 Target Neighborhood Hits 32 Shared Neighborhood Hits 32
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CFLAR_HUMAN
 
θ value 1.36511e-173 (rank : 2) NC score 0.976500 (rank : 2)
Query Neighborhood Hits 32 Target Neighborhood Hits 47 Shared Neighborhood Hits 21
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CASP8_MOUSE
 
θ value 2.27234e-27 (rank : 3) NC score 0.750578 (rank : 3)
Query Neighborhood Hits 32 Target Neighborhood Hits 57 Shared Neighborhood Hits 21
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP8_HUMAN
 
θ value 2.77775e-25 (rank : 4) NC score 0.750082 (rank : 4)
Query Neighborhood Hits 32 Target Neighborhood Hits 62 Shared Neighborhood Hits 21
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASPA_HUMAN
 
θ value 1.16975e-15 (rank : 5) NC score 0.706891 (rank : 5)
Query Neighborhood Hits 32 Target Neighborhood Hits 53 Shared Neighborhood Hits 21
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASP3_HUMAN
 
θ value 2.98157e-11 (rank : 6) NC score 0.626163 (rank : 6)
Query Neighborhood Hits 32 Target Neighborhood Hits 27 Shared Neighborhood Hits 19
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP3_MOUSE
 
θ value 5.62301e-10 (rank : 7) NC score 0.622803 (rank : 7)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 19
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP7_MOUSE
 
θ value 1.63604e-09 (rank : 8) NC score 0.620913 (rank : 8)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP7_HUMAN
 
θ value 4.76016e-09 (rank : 9) NC score 0.620502 (rank : 9)
Query Neighborhood Hits 32 Target Neighborhood Hits 26 Shared Neighborhood Hits 19
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP2_MOUSE
 
θ value 1.06045e-08 (rank : 10) NC score 0.579116 (rank : 14)
Query Neighborhood Hits 32 Target Neighborhood Hits 34 Shared Neighborhood Hits 19
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP2_HUMAN
 
θ value 1.80886e-08 (rank : 11) NC score 0.581874 (rank : 13)
Query Neighborhood Hits 32 Target Neighborhood Hits 31 Shared Neighborhood Hits 19
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP6_HUMAN
 
θ value 1.17247e-07 (rank : 12) NC score 0.610740 (rank : 10)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP6_MOUSE
 
θ value 1.29631e-06 (rank : 13) NC score 0.602524 (rank : 11)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP9_HUMAN
 
θ value 4.92598e-06 (rank : 14) NC score 0.585697 (rank : 12)
Query Neighborhood Hits 32 Target Neighborhood Hits 33 Shared Neighborhood Hits 19
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CASP1_HUMAN
 
θ value 0.000121331 (rank : 15) NC score 0.405615 (rank : 17)
Query Neighborhood Hits 32 Target Neighborhood Hits 41 Shared Neighborhood Hits 19
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASPC_MOUSE
 
θ value 0.00298849 (rank : 16) NC score 0.378977 (rank : 20)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
CASP1_MOUSE
 
θ value 0.00665767 (rank : 17) NC score 0.404021 (rank : 18)
Query Neighborhood Hits 32 Target Neighborhood Hits 38 Shared Neighborhood Hits 19
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP4_MOUSE
 
θ value 0.0148317 (rank : 18) NC score 0.393357 (rank : 19)
Query Neighborhood Hits 32 Target Neighborhood Hits 28 Shared Neighborhood Hits 19
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
ASZ1_HUMAN
 
θ value 0.21417 (rank : 19) NC score 0.020523 (rank : 30)
Query Neighborhood Hits 32 Target Neighborhood Hits 341 Shared Neighborhood Hits 2
SwissProt Accessions Q8WWH4 Gene names ASZ1, GASZ
Domain
Architecture
Description Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).
PRS6B_MOUSE
 
θ value 0.365318 (rank : 20) NC score 0.024490 (rank : 28)
Query Neighborhood Hits 32 Target Neighborhood Hits 89 Shared Neighborhood Hits 4
SwissProt Accessions P54775 Gene names Psmc4, Tbp7
Domain
Architecture
Description 26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).
FADD_MOUSE
 
θ value 0.47712 (rank : 21) NC score 0.187579 (rank : 24)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 7
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
FADD_HUMAN
 
θ value 0.62314 (rank : 22) NC score 0.234749 (rank : 23)
Query Neighborhood Hits 32 Target Neighborhood Hits 20 Shared Neighborhood Hits 7
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
BPAEA_MOUSE
 
θ value 1.06291 (rank : 23) NC score 0.008055 (rank : 35)
Query Neighborhood Hits 32 Target Neighborhood Hits 1480 Shared Neighborhood Hits 5
SwissProt Accessions Q91ZU8, Q8K5D4 Gene names Dst, Bpag1
Domain
Architecture
Description Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).
PRS6B_HUMAN
 
θ value 1.06291 (rank : 24) NC score 0.022001 (rank : 29)
Query Neighborhood Hits 32 Target Neighborhood Hits 85 Shared Neighborhood Hits 3
SwissProt Accessions P43686, Q96FV5, Q9UBM3, Q9UEX3 Gene names PSMC4, TBP7
Domain
Architecture
Description 26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).
CASPE_MOUSE
 
θ value 1.81305 (rank : 25) NC score 0.442494 (rank : 15)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 19
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
SPA11_HUMAN
 
θ value 2.36792 (rank : 26) NC score 0.007099 (rank : 37)
Query Neighborhood Hits 32 Target Neighborhood Hits 83 Shared Neighborhood Hits 2
SwissProt Accessions Q86U17 Gene names SERPINA11
Domain
Architecture

No domain graphic available

Description Serpin A11 precursor.
IFT74_HUMAN
 
θ value 3.0926 (rank : 27) NC score 0.007806 (rank : 36)
Query Neighborhood Hits 32 Target Neighborhood Hits 949 Shared Neighborhood Hits 4
SwissProt Accessions Q96LB3, Q6PGQ8, Q9H643, Q9H8G7 Gene names IFT74, CCDC2, CMG1
Domain
Architecture

No domain graphic available

Description Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).
CPNS1_MOUSE
 
θ value 4.03905 (rank : 28) NC score 0.011060 (rank : 33)
Query Neighborhood Hits 32 Target Neighborhood Hits 60 Shared Neighborhood Hits 2
SwissProt Accessions O88456, Q3V0X5, Q5BKQ2, Q8CEI2, Q8VEK4, Q9R1C5 Gene names Capns1, Capn4
Domain
Architecture
Description Calpain small subunit 1 (CSS1) (Calcium-dependent protease small subunit 1) (Calcium-dependent protease small subunit) (CDPS) (Calpain regulatory subunit) (Calcium-activated neutral proteinase small subunit) (CANP small subunit).
K0317_MOUSE
 
θ value 5.27518 (rank : 29) NC score 0.012926 (rank : 31)
Query Neighborhood Hits 32 Target Neighborhood Hits 43 Shared Neighborhood Hits 3
SwissProt Accessions Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5 Gene names Kiaa0317
Domain
Architecture

No domain graphic available

Description Protein KIAA0317.
RAD50_HUMAN
 
θ value 6.88961 (rank : 30) NC score 0.003688 (rank : 38)
Query Neighborhood Hits 32 Target Neighborhood Hits 1317 Shared Neighborhood Hits 4
SwissProt Accessions Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86 Gene names RAD50
Domain
Architecture

No domain graphic available

Description DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).
RPGF5_MOUSE
 
θ value 6.88961 (rank : 31) NC score 0.009391 (rank : 34)
Query Neighborhood Hits 32 Target Neighborhood Hits 85 Shared Neighborhood Hits 2
SwissProt Accessions Q8C0Q9, Q8BJJ9, Q8C0R5 Gene names Rapgef5, Gfr, Kiaa0277, Mrgef
Domain
Architecture
Description Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).
K0317_HUMAN
 
θ value 8.99809 (rank : 32) NC score 0.011445 (rank : 32)
Query Neighborhood Hits 32 Target Neighborhood Hits 46 Shared Neighborhood Hits 3
SwissProt Accessions O15033, Q7LDY1, Q8IYY9 Gene names KIAA0317
Domain
Architecture

No domain graphic available

Description Protein KIAA0317.
CASP4_HUMAN
 
θ value θ > 10 (rank : 33) NC score 0.340664 (rank : 22)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 18
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
CASP5_HUMAN
 
θ value θ > 10 (rank : 34) NC score 0.362798 (rank : 21)
Query Neighborhood Hits 32 Target Neighborhood Hits 28 Shared Neighborhood Hits 18
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASPE_HUMAN
 
θ value θ > 10 (rank : 35) NC score 0.427755 (rank : 16)
Query Neighborhood Hits 32 Target Neighborhood Hits 26 Shared Neighborhood Hits 18
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
ICBR_HUMAN
 
θ value θ > 10 (rank : 36) NC score 0.068380 (rank : 27)
Query Neighborhood Hits 32 Target Neighborhood Hits 11 Shared Neighborhood Hits 2
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.
PEA15_HUMAN
 
θ value θ > 10 (rank : 37) NC score 0.077796 (rank : 26)
Query Neighborhood Hits 32 Target Neighborhood Hits 10 Shared Neighborhood Hits 4
SwissProt Accessions Q15121, O00511 Gene names PEA15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).
PEA15_MOUSE
 
θ value θ > 10 (rank : 38) NC score 0.078463 (rank : 25)
Query Neighborhood Hits 32 Target Neighborhood Hits 7 Shared Neighborhood Hits 4
SwissProt Accessions Q62048, Q3U5N7 Gene names Pea15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15.

Hits sorted by NC score


CFLAR_MOUSE
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 1)
Query Neighborhood Hits 32 Target Neighborhood Hits 32 Shared Neighborhood Hits 32
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CFLAR_HUMAN
 
NC score 0.976500 (rank : 2) θ value 1.36511e-173 (rank : 2)
Query Neighborhood Hits 32 Target Neighborhood Hits 47 Shared Neighborhood Hits 21
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CASP8_MOUSE
 
NC score 0.750578 (rank : 3) θ value 2.27234e-27 (rank : 3)
Query Neighborhood Hits 32 Target Neighborhood Hits 57 Shared Neighborhood Hits 21
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP8_HUMAN
 
NC score 0.750082 (rank : 4) θ value 2.77775e-25 (rank : 4)
Query Neighborhood Hits 32 Target Neighborhood Hits 62 Shared Neighborhood Hits 21
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASPA_HUMAN
 
NC score 0.706891 (rank : 5) θ value 1.16975e-15 (rank : 5)
Query Neighborhood Hits 32 Target Neighborhood Hits 53 Shared Neighborhood Hits 21
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASP3_HUMAN
 
NC score 0.626163 (rank : 6) θ value 2.98157e-11 (rank : 6)
Query Neighborhood Hits 32 Target Neighborhood Hits 27 Shared Neighborhood Hits 19
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP3_MOUSE
 
NC score 0.622803 (rank : 7) θ value 5.62301e-10 (rank : 7)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 19
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP7_MOUSE
 
NC score 0.620913 (rank : 8) θ value 1.63604e-09 (rank : 8)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP7_HUMAN
 
NC score 0.620502 (rank : 9) θ value 4.76016e-09 (rank : 9)
Query Neighborhood Hits 32 Target Neighborhood Hits 26 Shared Neighborhood Hits 19
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP6_HUMAN
 
NC score 0.610740 (rank : 10) θ value 1.17247e-07 (rank : 12)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP6_MOUSE
 
NC score 0.602524 (rank : 11) θ value 1.29631e-06 (rank : 13)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP9_HUMAN
 
NC score 0.585697 (rank : 12) θ value 4.92598e-06 (rank : 14)
Query Neighborhood Hits 32 Target Neighborhood Hits 33 Shared Neighborhood Hits 19
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CASP2_HUMAN
 
NC score 0.581874 (rank : 13) θ value 1.80886e-08 (rank : 11)
Query Neighborhood Hits 32 Target Neighborhood Hits 31 Shared Neighborhood Hits 19
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP2_MOUSE
 
NC score 0.579116 (rank : 14) θ value 1.06045e-08 (rank : 10)
Query Neighborhood Hits 32 Target Neighborhood Hits 34 Shared Neighborhood Hits 19
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASPE_MOUSE
 
NC score 0.442494 (rank : 15) θ value 1.81305 (rank : 25)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 19
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASPE_HUMAN
 
NC score 0.427755 (rank : 16) θ value θ > 10 (rank : 35)
Query Neighborhood Hits 32 Target Neighborhood Hits 26 Shared Neighborhood Hits 18
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP1_HUMAN
 
NC score 0.405615 (rank : 17) θ value 0.000121331 (rank : 15)
Query Neighborhood Hits 32 Target Neighborhood Hits 41 Shared Neighborhood Hits 19
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP1_MOUSE
 
NC score 0.404021 (rank : 18) θ value 0.00665767 (rank : 17)
Query Neighborhood Hits 32 Target Neighborhood Hits 38 Shared Neighborhood Hits 19
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP4_MOUSE
 
NC score 0.393357 (rank : 19) θ value 0.0148317 (rank : 18)
Query Neighborhood Hits 32 Target Neighborhood Hits 28 Shared Neighborhood Hits 19
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
CASPC_MOUSE
 
NC score 0.378977 (rank : 20) θ value 0.00298849 (rank : 16)
Query Neighborhood Hits 32 Target Neighborhood Hits 24 Shared Neighborhood Hits 19
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
CASP5_HUMAN
 
NC score 0.362798 (rank : 21) θ value θ > 10 (rank : 34)
Query Neighborhood Hits 32 Target Neighborhood Hits 28 Shared Neighborhood Hits 18
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASP4_HUMAN
 
NC score 0.340664 (rank : 22) θ value θ > 10 (rank : 33)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 18
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
FADD_HUMAN
 
NC score 0.234749 (rank : 23) θ value 0.62314 (rank : 22)
Query Neighborhood Hits 32 Target Neighborhood Hits 20 Shared Neighborhood Hits 7
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
FADD_MOUSE
 
NC score 0.187579 (rank : 24) θ value 0.47712 (rank : 21)
Query Neighborhood Hits 32 Target Neighborhood Hits 23 Shared Neighborhood Hits 7
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
PEA15_MOUSE
 
NC score 0.078463 (rank : 25) θ value θ > 10 (rank : 38)
Query Neighborhood Hits 32 Target Neighborhood Hits 7 Shared Neighborhood Hits 4
SwissProt Accessions Q62048, Q3U5N7 Gene names Pea15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15.
PEA15_HUMAN
 
NC score 0.077796 (rank : 26) θ value θ > 10 (rank : 37)
Query Neighborhood Hits 32 Target Neighborhood Hits 10 Shared Neighborhood Hits 4
SwissProt Accessions Q15121, O00511 Gene names PEA15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).
ICBR_HUMAN
 
NC score 0.068380 (rank : 27) θ value θ > 10 (rank : 36)
Query Neighborhood Hits 32 Target Neighborhood Hits 11 Shared Neighborhood Hits 2
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.
PRS6B_MOUSE
 
NC score 0.024490 (rank : 28) θ value 0.365318 (rank : 20)
Query Neighborhood Hits 32 Target Neighborhood Hits 89 Shared Neighborhood Hits 4
SwissProt Accessions P54775 Gene names Psmc4, Tbp7
Domain
Architecture
Description 26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).
PRS6B_HUMAN
 
NC score 0.022001 (rank : 29) θ value 1.06291 (rank : 24)
Query Neighborhood Hits 32 Target Neighborhood Hits 85 Shared Neighborhood Hits 3
SwissProt Accessions P43686, Q96FV5, Q9UBM3, Q9UEX3 Gene names PSMC4, TBP7
Domain
Architecture
Description 26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).
ASZ1_HUMAN
 
NC score 0.020523 (rank : 30) θ value 0.21417 (rank : 19)
Query Neighborhood Hits 32 Target Neighborhood Hits 341 Shared Neighborhood Hits 2
SwissProt Accessions Q8WWH4 Gene names ASZ1, GASZ
Domain
Architecture
Description Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).
K0317_MOUSE
 
NC score 0.012926 (rank : 31) θ value 5.27518 (rank : 29)
Query Neighborhood Hits 32 Target Neighborhood Hits 43 Shared Neighborhood Hits 3
SwissProt Accessions Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5 Gene names Kiaa0317
Domain
Architecture

No domain graphic available

Description Protein KIAA0317.
K0317_HUMAN
 
NC score 0.011445 (rank : 32) θ value 8.99809 (rank : 32)
Query Neighborhood Hits 32 Target Neighborhood Hits 46 Shared Neighborhood Hits 3
SwissProt Accessions O15033, Q7LDY1, Q8IYY9 Gene names KIAA0317
Domain
Architecture

No domain graphic available

Description Protein KIAA0317.
CPNS1_MOUSE
 
NC score 0.011060 (rank : 33) θ value 4.03905 (rank : 28)
Query Neighborhood Hits 32 Target Neighborhood Hits 60 Shared Neighborhood Hits 2
SwissProt Accessions O88456, Q3V0X5, Q5BKQ2, Q8CEI2, Q8VEK4, Q9R1C5 Gene names Capns1, Capn4
Domain
Architecture
Description Calpain small subunit 1 (CSS1) (Calcium-dependent protease small subunit 1) (Calcium-dependent protease small subunit) (CDPS) (Calpain regulatory subunit) (Calcium-activated neutral proteinase small subunit) (CANP small subunit).
RPGF5_MOUSE
 
NC score 0.009391 (rank : 34) θ value 6.88961 (rank : 31)
Query Neighborhood Hits 32 Target Neighborhood Hits 85 Shared Neighborhood Hits 2
SwissProt Accessions Q8C0Q9, Q8BJJ9, Q8C0R5 Gene names Rapgef5, Gfr, Kiaa0277, Mrgef
Domain
Architecture
Description Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).
BPAEA_MOUSE
 
NC score 0.008055 (rank : 35) θ value 1.06291 (rank : 23)
Query Neighborhood Hits 32 Target Neighborhood Hits 1480 Shared Neighborhood Hits 5
SwissProt Accessions Q91ZU8, Q8K5D4 Gene names Dst, Bpag1
Domain
Architecture
Description Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).
IFT74_HUMAN
 
NC score 0.007806 (rank : 36) θ value 3.0926 (rank : 27)
Query Neighborhood Hits 32 Target Neighborhood Hits 949 Shared Neighborhood Hits 4
SwissProt Accessions Q96LB3, Q6PGQ8, Q9H643, Q9H8G7 Gene names IFT74, CCDC2, CMG1
Domain
Architecture

No domain graphic available

Description Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).
SPA11_HUMAN
 
NC score 0.007099 (rank : 37) θ value 2.36792 (rank : 26)
Query Neighborhood Hits 32 Target Neighborhood Hits 83 Shared Neighborhood Hits 2
SwissProt Accessions Q86U17 Gene names SERPINA11
Domain
Architecture

No domain graphic available

Description Serpin A11 precursor.
RAD50_HUMAN
 
NC score 0.003688 (rank : 38) θ value 6.88961 (rank : 30)
Query Neighborhood Hits 32 Target Neighborhood Hits 1317 Shared Neighborhood Hits 4
SwissProt Accessions Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86 Gene names RAD50
Domain
Architecture

No domain graphic available

Description DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).