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Network neighborhood for query Sequence : CASPE_HUMAN

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CASPE_HUMAN
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CASPE_HUMAN
θ value	1.47893e-127 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASPE_MOUSE
θ value	8.19079e-94 (rank : 2)	NC score	0.996523 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASP2_MOUSE
θ value	5.23862e-24 (rank : 3)	NC score	0.873007 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_HUMAN
θ value	2.59989e-23 (rank : 4)	NC score	0.872304 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP7_MOUSE
θ value	1.6852e-22 (rank : 5)	NC score	0.870291 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP3_MOUSE
θ value	3.75424e-22 (rank : 6)	NC score	0.877309 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_HUMAN
θ value	1.09232e-21 (rank : 7)	NC score	0.875864 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP7_HUMAN
θ value	7.0802e-21 (rank : 8)	NC score	0.864579 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP8_HUMAN
θ value	5.07402e-19 (rank : 9)	NC score	0.800064 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP8_MOUSE
θ value	5.60996e-18 (rank : 10)	NC score	0.809825 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP6_MOUSE
θ value	9.56915e-18 (rank : 11)	NC score	0.847560 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP9_HUMAN
θ value	1.38178e-16 (rank : 12)	NC score	0.873384 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CASPA_HUMAN
θ value	1.38178e-16 (rank : 13)	NC score	0.818249 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

CASP6_HUMAN
θ value	1.16975e-15 (rank : 14)	NC score	0.843663 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP4_MOUSE
θ value	3.40345e-15 (rank : 15)	NC score	0.768248 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP5_HUMAN
θ value	3.40345e-15 (rank : 16)	NC score	0.768865 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASP1_HUMAN
θ value	7.58209e-15 (rank : 17)	NC score	0.760042 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP1_MOUSE
θ value	3.76295e-14 (rank : 18)	NC score	0.770180 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASPC_MOUSE
θ value	1.58096e-12 (rank : 19)	NC score	0.746465 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

CASP4_HUMAN
θ value	2.0648e-12 (rank : 20)	NC score	0.748314 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

SNX23_HUMAN
θ value	1.81305 (rank : 21)	NC score	0.004619 (rank : 31)
Query Neighborhood Hits	26	Target Neighborhood Hits	944	Shared Neighborhood Hits	3
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

CFLAR_HUMAN
θ value	4.03905 (rank : 22)	NC score	0.475932 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CP250_HUMAN
θ value	6.88961 (rank : 23)	NC score	-0.000431 (rank : 32)
Query Neighborhood Hits	26	Target Neighborhood Hits	1805	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

GPI8_HUMAN
θ value	8.99809 (rank : 25)	NC score	0.016599 (rank : 28)
Query Neighborhood Hits	26	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q92643, O14822, Q5TG77	Gene names	PIGK, GPI8
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) (hGPI8).

GPI8_MOUSE
θ value	8.99809 (rank : 26)	NC score	0.016586 (rank : 29)
Query Neighborhood Hits	26	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CXY9, Q8BH63	Gene names	Pigk
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K).

CFLAR_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.427755 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

FADD_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.092452 (rank : 24)
Query Neighborhood Hits	26	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FADD_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.079707 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

ICBR_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.158967 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

PEA15_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.058500 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

PEA15_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.059099 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

Hits sorted by NC score

CASPE_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.47893e-127 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASPE_MOUSE
NC score	0.996523 (rank : 2)	θ value	8.19079e-94 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASP3_MOUSE
NC score	0.877309 (rank : 3)	θ value	3.75424e-22 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_HUMAN
NC score	0.875864 (rank : 4)	θ value	1.09232e-21 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP9_HUMAN
NC score	0.873384 (rank : 5)	θ value	1.38178e-16 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CASP2_MOUSE
NC score	0.873007 (rank : 6)	θ value	5.23862e-24 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_HUMAN
NC score	0.872304 (rank : 7)	θ value	2.59989e-23 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP7_MOUSE
NC score	0.870291 (rank : 8)	θ value	1.6852e-22 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP7_HUMAN
NC score	0.864579 (rank : 9)	θ value	7.0802e-21 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP6_MOUSE
NC score	0.847560 (rank : 10)	θ value	9.56915e-18 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP6_HUMAN
NC score	0.843663 (rank : 11)	θ value	1.16975e-15 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASPA_HUMAN
NC score	0.818249 (rank : 12)	θ value	1.38178e-16 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

CASP8_MOUSE
NC score	0.809825 (rank : 13)	θ value	5.60996e-18 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP8_HUMAN
NC score	0.800064 (rank : 14)	θ value	5.07402e-19 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP1_MOUSE
NC score	0.770180 (rank : 15)	θ value	3.76295e-14 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP5_HUMAN
NC score	0.768865 (rank : 16)	θ value	3.40345e-15 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASP4_MOUSE
NC score	0.768248 (rank : 17)	θ value	3.40345e-15 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP1_HUMAN
NC score	0.760042 (rank : 18)	θ value	7.58209e-15 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP4_HUMAN
NC score	0.748314 (rank : 19)	θ value	2.0648e-12 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

CASPC_MOUSE
NC score	0.746465 (rank : 20)	θ value	1.58096e-12 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

CFLAR_HUMAN
NC score	0.475932 (rank : 21)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CFLAR_MOUSE
NC score	0.427755 (rank : 22)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

ICBR_HUMAN
NC score	0.158967 (rank : 23)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	26	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

FADD_HUMAN
NC score	0.092452 (rank : 24)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	26	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FADD_MOUSE
NC score	0.079707 (rank : 25)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

PEA15_MOUSE
NC score	0.059099 (rank : 26)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	26	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

PEA15_HUMAN
NC score	0.058500 (rank : 27)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	26	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

GPI8_HUMAN
NC score	0.016599 (rank : 28)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q92643, O14822, Q5TG77	Gene names	PIGK, GPI8
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) (hGPI8).

GPI8_MOUSE
NC score	0.016586 (rank : 29)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CXY9, Q8BH63	Gene names	Pigk
Domain Architecture
Description	GPI-anchor transamidase precursor (EC 3.-.-.-) (GPI transamidase) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K).

SNX23_HUMAN
NC score	0.004619 (rank : 31)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	944	Shared Neighborhood Hits	3
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

CP250_HUMAN
NC score	-0.000431 (rank : 32)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	1805	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).