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Network neighborhood for query Sequence : CFLAR_HUMAN

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CFLAR_HUMAN
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CFLAR_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CFLAR_MOUSE
θ value	1.36511e-173 (rank : 2)	NC score	0.976500 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CASP8_MOUSE
θ value	6.17384e-33 (rank : 3)	NC score	0.786718 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	57	Shared Neighborhood Hits	24
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP8_HUMAN
θ value	1.0531e-32 (rank : 4)	NC score	0.784602 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASPA_HUMAN
θ value	1.99067e-23 (rank : 5)	NC score	0.752506 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

CASP3_HUMAN
θ value	1.133e-10 (rank : 6)	NC score	0.658315 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_MOUSE
θ value	1.133e-10 (rank : 7)	NC score	0.655983 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP2_HUMAN
θ value	1.47974e-10 (rank : 8)	NC score	0.625213 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP6_HUMAN
θ value	2.52405e-10 (rank : 9)	NC score	0.649141 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP2_MOUSE
θ value	3.29651e-10 (rank : 10)	NC score	0.622614 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP7_HUMAN
θ value	2.79066e-09 (rank : 11)	NC score	0.651113 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP6_MOUSE
θ value	3.64472e-09 (rank : 12)	NC score	0.640952 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP7_MOUSE
θ value	1.38499e-08 (rank : 13)	NC score	0.651680 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP9_HUMAN
θ value	8.40245e-06 (rank : 14)	NC score	0.620466 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	33	Shared Neighborhood Hits	22
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CASP5_HUMAN
θ value	9.29e-05 (rank : 15)	NC score	0.441687 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASP4_MOUSE
θ value	0.00020696 (rank : 16)	NC score	0.462670 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP1_HUMAN
θ value	0.00035302 (rank : 17)	NC score	0.463917 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASPC_MOUSE
θ value	0.000786445 (rank : 18)	NC score	0.440316 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

CASP1_MOUSE
θ value	0.00228821 (rank : 19)	NC score	0.464905 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP4_HUMAN
θ value	0.00869519 (rank : 20)	NC score	0.415509 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

EEA1_HUMAN
θ value	0.0113563 (rank : 21)	NC score	0.023772 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	1796	Shared Neighborhood Hits	18
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

FADD_HUMAN
θ value	0.0148317 (rank : 22)	NC score	0.252097 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

SLK_MOUSE
θ value	0.279714 (rank : 23)	NC score	0.010529 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	1798	Shared Neighborhood Hits	12
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

APOA4_HUMAN
θ value	0.365318 (rank : 24)	NC score	0.034210 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	399	Shared Neighborhood Hits	7
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

MYD88_MOUSE
θ value	0.365318 (rank : 25)	NC score	0.044227 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	P22366, O35916	Gene names	Myd88
Domain Architecture
Description	Myeloid differentiation primary response protein MyD88.

MACOI_HUMAN
θ value	0.47712 (rank : 26)	NC score	0.039916 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	650	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MACOI_MOUSE
θ value	0.62314 (rank : 27)	NC score	0.040168 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	620	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

SLK_HUMAN
θ value	0.62314 (rank : 28)	NC score	0.010007 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	1775	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STK10_MOUSE
θ value	0.813845 (rank : 29)	NC score	0.008810 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	2132	Shared Neighborhood Hits	15
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

IFT74_MOUSE
θ value	1.06291 (rank : 30)	NC score	0.021005 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	939	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

CASPE_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.485890 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

PEPL_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.018462 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	1141	Shared Neighborhood Hits	15
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

FADD_MOUSE
θ value	2.36792 (rank : 33)	NC score	0.196922 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

PP2BC_MOUSE
θ value	2.36792 (rank : 34)	NC score	0.015642 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P48455	Gene names	Ppp3cc, Calnc
Domain Architecture
Description	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (Calmodulin-dependent calcineurin A subunit gamma isoform) (Calcineurin, testis-specific catalytic subunit) (CAM- PRP catalytic subunit).

TACC1_MOUSE
θ value	2.36792 (rank : 35)	NC score	0.019154 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	667	Shared Neighborhood Hits	10
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

CASPE_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.475932 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CK5P2_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.013594 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	1433	Shared Neighborhood Hits	16
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

K0586_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.025509 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	311	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

PP2BC_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.014286 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P48454	Gene names	PPP3CC, CALNA3, CNA3
Domain Architecture
Description	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (Calmodulin-dependent calcineurin A subunit gamma isoform) (Calcineurin, testis-specific catalytic subunit) (CAM- PRP catalytic subunit).

TRI36_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.013705 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	282	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NQ86	Gene names	TRIM36, RBCC728, RNF98
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Zinc-binding protein Rbcc728) (RING finger protein 98).

ATRX_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.010548 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	682	Shared Neighborhood Hits	9
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

LPPRC_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.023555 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P42704	Gene names	LRPPRC, LRP130
Domain Architecture	No domain graphic available
Description	130 kDa leucine-rich protein (LRP 130) (GP130) (Leucine-rich PPR motif-containing protein).

BBS7_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.015090 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2G4, Q8C7G3, Q8CH00, Q9CXC2	Gene names	Bbs7, Bbs2l1
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 7 protein homolog (BBS2-like protein 1).

ZEP1_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.001351 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	1036	Shared Neighborhood Hits	2
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

CK035_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.015633 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	91	Shared Neighborhood Hits	6
SwissProt Accessions	Q0VET5, Q9CW10	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35 homolog.

RUFY2_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.011663 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	820	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TRI36_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.011416 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	266	Shared Neighborhood Hits	6
SwissProt Accessions	Q80WG7, Q7TNM1	Gene names	Trim36
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Haprin) (Acrosome RBCC protein).

ICBR_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.067311 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

PEA15_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.082262 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

PEA15_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.083026 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

Hits sorted by NC score

CFLAR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1	Gene names	CFLAR, CASH, CLARP, MRIT
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CFLAR_MOUSE
NC score	0.976500 (rank : 2)	θ value	1.36511e-173 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CASP8_MOUSE
NC score	0.786718 (rank : 3)	θ value	6.17384e-33 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	57	Shared Neighborhood Hits	24
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASP8_HUMAN
NC score	0.784602 (rank : 4)	θ value	1.0531e-32 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CASPA_HUMAN
NC score	0.752506 (rank : 5)	θ value	1.99067e-23 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7	Gene names	CASP10, MCH4
Domain Architecture
Description	Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].

CASP3_HUMAN
NC score	0.658315 (rank : 6)	θ value	1.133e-10 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	P42574, Q96AN1, Q96KP2	Gene names	CASP3, CPP32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP3_MOUSE
NC score	0.655983 (rank : 7)	θ value	1.133e-10 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P70677, O08668, Q8CHV5, Q9QWI4	Gene names	Casp3, Cpp32
Domain Architecture
Description	Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].

CASP7_MOUSE
NC score	0.651680 (rank : 8)	θ value	1.38499e-08 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P97864, O08669	Gene names	Casp7, Lice2, Mch3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP7_HUMAN
NC score	0.651113 (rank : 9)	θ value	2.79066e-09 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	P55210, Q13364, Q96BA0	Gene names	CASP7, MCH3
Domain Architecture
Description	Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].

CASP6_HUMAN
NC score	0.649141 (rank : 10)	θ value	2.52405e-10 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P55212, Q9BQE7	Gene names	CASP6, MCH2
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP6_MOUSE
NC score	0.640952 (rank : 11)	θ value	3.64472e-09 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08738	Gene names	Casp6
Domain Architecture
Description	Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].

CASP2_HUMAN
NC score	0.625213 (rank : 12)	θ value	1.47974e-10 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_MOUSE
NC score	0.622614 (rank : 13)	θ value	3.29651e-10 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP9_HUMAN
NC score	0.620466 (rank : 14)	θ value	8.40245e-06 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	33	Shared Neighborhood Hits	22
SwissProt Accessions	P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8	Gene names	CASP9, MCH6
Domain Architecture
Description	Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].

CASPE_MOUSE
NC score	0.485890 (rank : 15)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	O89094	Gene names	Casp14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASPE_HUMAN
NC score	0.475932 (rank : 16)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P31944, O95823, Q3SYC9	Gene names	CASP14
Domain Architecture
Description	Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].

CASP1_MOUSE
NC score	0.464905 (rank : 17)	θ value	0.00228821 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP1_HUMAN
NC score	0.463917 (rank : 18)	θ value	0.00035302 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP4_MOUSE
NC score	0.462670 (rank : 19)	θ value	0.00020696 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP5_HUMAN
NC score	0.441687 (rank : 20)	θ value	9.29e-05 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASPC_MOUSE
NC score	0.440316 (rank : 21)	θ value	0.000786445 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

CASP4_HUMAN
NC score	0.415509 (rank : 22)	θ value	0.00869519 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	21
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

FADD_HUMAN
NC score	0.252097 (rank : 23)	θ value	0.0148317 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FADD_MOUSE
NC score	0.196922 (rank : 24)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

PEA15_MOUSE
NC score	0.083026 (rank : 25)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q62048, Q3U5N7	Gene names	Pea15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15.

PEA15_HUMAN
NC score	0.082262 (rank : 26)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q15121, O00511	Gene names	PEA15
Domain Architecture
Description	Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).

ICBR_HUMAN
NC score	0.067311 (rank : 27)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

MYD88_MOUSE
NC score	0.044227 (rank : 28)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	P22366, O35916	Gene names	Myd88
Domain Architecture
Description	Myeloid differentiation primary response protein MyD88.

MACOI_MOUSE
NC score	0.040168 (rank : 29)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	620	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MACOI_HUMAN
NC score	0.039916 (rank : 30)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	650	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

APOA4_HUMAN
NC score	0.034210 (rank : 31)	θ value	0.365318 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	399	Shared Neighborhood Hits	7
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

K0586_HUMAN
NC score	0.025509 (rank : 32)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	311	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

EEA1_HUMAN
NC score	0.023772 (rank : 33)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	1796	Shared Neighborhood Hits	18
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

LPPRC_HUMAN
NC score	0.023555 (rank : 34)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P42704	Gene names	LRPPRC, LRP130
Domain Architecture	No domain graphic available
Description	130 kDa leucine-rich protein (LRP 130) (GP130) (Leucine-rich PPR motif-containing protein).

IFT74_MOUSE
NC score	0.021005 (rank : 35)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	939	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

TACC1_MOUSE
NC score	0.019154 (rank : 36)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	667	Shared Neighborhood Hits	10
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

PEPL_HUMAN
NC score	0.018462 (rank : 37)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	1141	Shared Neighborhood Hits	15
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PP2BC_MOUSE
NC score	0.015642 (rank : 38)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P48455	Gene names	Ppp3cc, Calnc
Domain Architecture
Description	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (Calmodulin-dependent calcineurin A subunit gamma isoform) (Calcineurin, testis-specific catalytic subunit) (CAM- PRP catalytic subunit).

CK035_MOUSE
NC score	0.015633 (rank : 39)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	91	Shared Neighborhood Hits	6
SwissProt Accessions	Q0VET5, Q9CW10	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35 homolog.

BBS7_MOUSE
NC score	0.015090 (rank : 40)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2G4, Q8C7G3, Q8CH00, Q9CXC2	Gene names	Bbs7, Bbs2l1
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 7 protein homolog (BBS2-like protein 1).

PP2BC_HUMAN
NC score	0.014286 (rank : 41)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P48454	Gene names	PPP3CC, CALNA3, CNA3
Domain Architecture
Description	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (Calmodulin-dependent calcineurin A subunit gamma isoform) (Calcineurin, testis-specific catalytic subunit) (CAM- PRP catalytic subunit).

TRI36_HUMAN
NC score	0.013705 (rank : 42)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	282	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NQ86	Gene names	TRIM36, RBCC728, RNF98
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Zinc-binding protein Rbcc728) (RING finger protein 98).

CK5P2_HUMAN
NC score	0.013594 (rank : 43)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	1433	Shared Neighborhood Hits	16
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

RUFY2_MOUSE
NC score	0.011663 (rank : 44)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	820	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TRI36_MOUSE
NC score	0.011416 (rank : 45)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	266	Shared Neighborhood Hits	6
SwissProt Accessions	Q80WG7, Q7TNM1	Gene names	Trim36
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Haprin) (Acrosome RBCC protein).

ATRX_MOUSE
NC score	0.010548 (rank : 46)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	682	Shared Neighborhood Hits	9
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

SLK_MOUSE
NC score	0.010529 (rank : 47)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	1798	Shared Neighborhood Hits	12
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SLK_HUMAN
NC score	0.010007 (rank : 48)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	1775	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STK10_MOUSE
NC score	0.008810 (rank : 49)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	2132	Shared Neighborhood Hits	15
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

ZEP1_HUMAN
NC score	0.001351 (rank : 50)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	1036	Shared Neighborhood Hits	2
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).