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Network neighborhood for query Sequence : CASP1_MOUSE

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CASP1_MOUSE
 
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
Rank Plots


Hits sorted by θ


CASP1_MOUSE
 
θ value 0 (rank : 1) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 38 Target Neighborhood Hits 38 Shared Neighborhood Hits 38
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP1_HUMAN
 
θ value 1.33454e-136 (rank : 2) NC score 0.991541 (rank : 2)
Query Neighborhood Hits 38 Target Neighborhood Hits 41 Shared Neighborhood Hits 31
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP4_HUMAN
 
θ value 2.91321e-91 (rank : 3) NC score 0.967502 (rank : 3)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
CASP5_HUMAN
 
θ value 5.50685e-82 (rank : 4) NC score 0.963418 (rank : 4)
Query Neighborhood Hits 38 Target Neighborhood Hits 28 Shared Neighborhood Hits 21
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASPC_MOUSE
 
θ value 2.55803e-79 (rank : 5) NC score 0.959522 (rank : 6)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
CASP4_MOUSE
 
θ value 1.07473e-77 (rank : 6) NC score 0.962899 (rank : 5)
Query Neighborhood Hits 38 Target Neighborhood Hits 28 Shared Neighborhood Hits 22
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
CASP2_MOUSE
 
θ value 8.93572e-24 (rank : 7) NC score 0.799100 (rank : 7)
Query Neighborhood Hits 38 Target Neighborhood Hits 34 Shared Neighborhood Hits 25
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP2_HUMAN
 
θ value 4.9032e-22 (rank : 8) NC score 0.792619 (rank : 8)
Query Neighborhood Hits 38 Target Neighborhood Hits 31 Shared Neighborhood Hits 25
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP9_HUMAN
 
θ value 4.29542e-18 (rank : 9) NC score 0.768279 (rank : 10)
Query Neighborhood Hits 38 Target Neighborhood Hits 33 Shared Neighborhood Hits 22
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CASPA_HUMAN
 
θ value 7.32683e-18 (rank : 10) NC score 0.707534 (rank : 14)
Query Neighborhood Hits 38 Target Neighborhood Hits 53 Shared Neighborhood Hits 22
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASP3_HUMAN
 
θ value 1.24977e-17 (rank : 11) NC score 0.742895 (rank : 12)
Query Neighborhood Hits 38 Target Neighborhood Hits 27 Shared Neighborhood Hits 22
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
ICBR_HUMAN
 
θ value 2.7842e-17 (rank : 12) NC score 0.495282 (rank : 21)
Query Neighborhood Hits 38 Target Neighborhood Hits 11 Shared Neighborhood Hits 10
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.
CASP3_MOUSE
 
θ value 1.52774e-15 (rank : 13) NC score 0.735930 (rank : 13)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP6_HUMAN
 
θ value 2.88119e-14 (rank : 14) NC score 0.694431 (rank : 16)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASPE_HUMAN
 
θ value 3.76295e-14 (rank : 15) NC score 0.770180 (rank : 9)
Query Neighborhood Hits 38 Target Neighborhood Hits 26 Shared Neighborhood Hits 21
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASPE_MOUSE
 
θ value 1.86753e-13 (rank : 16) NC score 0.762680 (rank : 11)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP6_MOUSE
 
θ value 9.26847e-13 (rank : 17) NC score 0.692500 (rank : 17)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP8_HUMAN
 
θ value 4.59992e-12 (rank : 18) NC score 0.645743 (rank : 20)
Query Neighborhood Hits 38 Target Neighborhood Hits 62 Shared Neighborhood Hits 22
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP8_MOUSE
 
θ value 2.28291e-11 (rank : 19) NC score 0.664192 (rank : 19)
Query Neighborhood Hits 38 Target Neighborhood Hits 57 Shared Neighborhood Hits 22
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP7_MOUSE
 
θ value 8.67504e-11 (rank : 20) NC score 0.701204 (rank : 15)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP7_HUMAN
 
θ value 2.52405e-10 (rank : 21) NC score 0.692385 (rank : 18)
Query Neighborhood Hits 38 Target Neighborhood Hits 26 Shared Neighborhood Hits 22
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CFLAR_HUMAN
 
θ value 0.00228821 (rank : 22) NC score 0.464905 (rank : 22)
Query Neighborhood Hits 38 Target Neighborhood Hits 47 Shared Neighborhood Hits 22
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CFLAR_MOUSE
 
θ value 0.00665767 (rank : 23) NC score 0.404021 (rank : 23)
Query Neighborhood Hits 38 Target Neighborhood Hits 32 Shared Neighborhood Hits 19
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CARD8_HUMAN
 
θ value 0.0736092 (rank : 24) NC score 0.110151 (rank : 24)
Query Neighborhood Hits 38 Target Neighborhood Hits 22 Shared Neighborhood Hits 10
SwissProt Accessions Q9Y2G2, Q6PGP8, Q96P82 Gene names CARD8, KIAA0955, NDPP1
Domain
Architecture
Description Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).
CARD4_MOUSE
 
θ value 0.365318 (rank : 25) NC score 0.032496 (rank : 32)
Query Neighborhood Hits 38 Target Neighborhood Hits 85 Shared Neighborhood Hits 8
SwissProt Accessions Q8BHB0, Q8BUT6 Gene names Card4
Domain
Architecture
Description Caspase recruitment domain-containing protein 4.
BIRC3_HUMAN
 
θ value 0.813845 (rank : 26) NC score 0.034551 (rank : 31)
Query Neighborhood Hits 38 Target Neighborhood Hits 133 Shared Neighborhood Hits 8
SwissProt Accessions Q13489, Q16628, Q9HC27, Q9UP46 Gene names BIRC3, API2, IAP1, MIHC
Domain
Architecture
Description Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).
CARD6_HUMAN
 
θ value 0.813845 (rank : 27) NC score 0.057729 (rank : 26)
Query Neighborhood Hits 38 Target Neighborhood Hits 145 Shared Neighborhood Hits 11
SwissProt Accessions Q9BX69 Gene names CARD6
Domain
Architecture
Description Caspase recruitment domain-containing protein 6.
BIRC2_HUMAN
 
θ value 1.06291 (rank : 28) NC score 0.044843 (rank : 28)
Query Neighborhood Hits 38 Target Neighborhood Hits 142 Shared Neighborhood Hits 11
SwissProt Accessions Q13490, Q16516, Q4TTG0 Gene names BIRC2, API1, IAP2, MIHB
Domain
Architecture
Description Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).
BIRC2_MOUSE
 
θ value 2.36792 (rank : 29) NC score 0.044789 (rank : 29)
Query Neighborhood Hits 38 Target Neighborhood Hits 137 Shared Neighborhood Hits 13
SwissProt Accessions Q62210, O08864 Gene names Birc2, Birc3, Iap2
Domain
Architecture
Description Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).
ZMY15_HUMAN
 
θ value 3.0926 (rank : 30) NC score 0.024925 (rank : 36)
Query Neighborhood Hits 38 Target Neighborhood Hits 53 Shared Neighborhood Hits 2
SwissProt Accessions Q9H091 Gene names ZMYND15
Domain
Architecture

No domain graphic available

Description Zinc finger MYND domain-containing protein 15.
CARD4_HUMAN
 
θ value 4.03905 (rank : 31) NC score 0.028042 (rank : 33)
Query Neighborhood Hits 38 Target Neighborhood Hits 102 Shared Neighborhood Hits 10
SwissProt Accessions Q9Y239, Q8IWF5 Gene names CARD4, NOD1
Domain
Architecture
Description Caspase recruitment domain-containing protein 4 (Protein Nod1).
CAR12_HUMAN
 
θ value 5.27518 (rank : 32) NC score 0.041596 (rank : 30)
Query Neighborhood Hits 38 Target Neighborhood Hits 132 Shared Neighborhood Hits 12
SwissProt Accessions Q9NPP4, Q96J81, Q96J82, Q96J83 Gene names CARD12, CLAN, CLAN1
Domain
Architecture
Description Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).
CAR15_HUMAN
 
θ value 5.27518 (rank : 33) NC score 0.027474 (rank : 34)
Query Neighborhood Hits 38 Target Neighborhood Hits 77 Shared Neighborhood Hits 10
SwissProt Accessions Q9HC29, Q96RH5, Q96RH6, Q96RH8 Gene names CARD15, IBD1, NOD2
Domain
Architecture
Description Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).
CAR15_MOUSE
 
θ value 8.99809 (rank : 34) NC score 0.027079 (rank : 35)
Query Neighborhood Hits 38 Target Neighborhood Hits 93 Shared Neighborhood Hits 9
SwissProt Accessions Q8K3Z0 Gene names Card15, Nod2
Domain
Architecture
Description Caspase recruitment domain-containing protein 15 (Protein Nod2).
CELR2_HUMAN
 
θ value 8.99809 (rank : 35) NC score -0.001123 (rank : 39)
Query Neighborhood Hits 38 Target Neighborhood Hits 657 Shared Neighborhood Hits 2
SwissProt Accessions Q9HCU4, Q92566 Gene names CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain
Architecture
Description Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).
CENPR_HUMAN
 
θ value 8.99809 (rank : 36) NC score 0.012360 (rank : 37)
Query Neighborhood Hits 38 Target Neighborhood Hits 43 Shared Neighborhood Hits 2
SwissProt Accessions Q13352, Q13353, Q5RJ42, Q5RJ44, Q5RJ45, Q7KYX2, Q96CD5, Q9UKB6 Gene names ITGB3BP, CENPR, NRIF3
Domain
Architecture

No domain graphic available

Description Centromere protein R (CENP-R) (Nuclear receptor-interacting factor 3) (Integrin beta-3-binding protein) (Beta3-endonexin).
PKD1_HUMAN
 
θ value 8.99809 (rank : 37) NC score 0.003852 (rank : 38)
Query Neighborhood Hits 38 Target Neighborhood Hits 387 Shared Neighborhood Hits 2
SwissProt Accessions P98161, Q15140, Q15141 Gene names PKD1
Domain
Architecture
Description Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).
ZN438_HUMAN
 
θ value 8.99809 (rank : 38) NC score -0.001435 (rank : 40)
Query Neighborhood Hits 38 Target Neighborhood Hits 906 Shared Neighborhood Hits 2
SwissProt Accessions Q7Z4V0, Q5T426, Q658Q4, Q6ZN65 Gene names ZNF438
Domain
Architecture

No domain graphic available

Description Zinc finger protein 438.
FADD_HUMAN
 
θ value θ > 10 (rank : 39) NC score 0.068437 (rank : 25)
Query Neighborhood Hits 38 Target Neighborhood Hits 20 Shared Neighborhood Hits 5
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
FADD_MOUSE
 
θ value θ > 10 (rank : 40) NC score 0.057001 (rank : 27)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 5
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

Hits sorted by NC score


CASP1_MOUSE
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 1)
Query Neighborhood Hits 38 Target Neighborhood Hits 38 Shared Neighborhood Hits 38
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP1_HUMAN
 
NC score 0.991541 (rank : 2) θ value 1.33454e-136 (rank : 2)
Query Neighborhood Hits 38 Target Neighborhood Hits 41 Shared Neighborhood Hits 31
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP4_HUMAN
 
NC score 0.967502 (rank : 3) θ value 2.91321e-91 (rank : 3)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
CASP5_HUMAN
 
NC score 0.963418 (rank : 4) θ value 5.50685e-82 (rank : 4)
Query Neighborhood Hits 38 Target Neighborhood Hits 28 Shared Neighborhood Hits 21
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASP4_MOUSE
 
NC score 0.962899 (rank : 5) θ value 1.07473e-77 (rank : 6)
Query Neighborhood Hits 38 Target Neighborhood Hits 28 Shared Neighborhood Hits 22
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
CASPC_MOUSE
 
NC score 0.959522 (rank : 6) θ value 2.55803e-79 (rank : 5)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
CASP2_MOUSE
 
NC score 0.799100 (rank : 7) θ value 8.93572e-24 (rank : 7)
Query Neighborhood Hits 38 Target Neighborhood Hits 34 Shared Neighborhood Hits 25
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP2_HUMAN
 
NC score 0.792619 (rank : 8) θ value 4.9032e-22 (rank : 8)
Query Neighborhood Hits 38 Target Neighborhood Hits 31 Shared Neighborhood Hits 25
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASPE_HUMAN
 
NC score 0.770180 (rank : 9) θ value 3.76295e-14 (rank : 15)
Query Neighborhood Hits 38 Target Neighborhood Hits 26 Shared Neighborhood Hits 21
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP9_HUMAN
 
NC score 0.768279 (rank : 10) θ value 4.29542e-18 (rank : 9)
Query Neighborhood Hits 38 Target Neighborhood Hits 33 Shared Neighborhood Hits 22
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CASPE_MOUSE
 
NC score 0.762680 (rank : 11) θ value 1.86753e-13 (rank : 16)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP3_HUMAN
 
NC score 0.742895 (rank : 12) θ value 1.24977e-17 (rank : 11)
Query Neighborhood Hits 38 Target Neighborhood Hits 27 Shared Neighborhood Hits 22
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP3_MOUSE
 
NC score 0.735930 (rank : 13) θ value 1.52774e-15 (rank : 13)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASPA_HUMAN
 
NC score 0.707534 (rank : 14) θ value 7.32683e-18 (rank : 10)
Query Neighborhood Hits 38 Target Neighborhood Hits 53 Shared Neighborhood Hits 22
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASP7_MOUSE
 
NC score 0.701204 (rank : 15) θ value 8.67504e-11 (rank : 20)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP6_HUMAN
 
NC score 0.694431 (rank : 16) θ value 2.88119e-14 (rank : 14)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP6_MOUSE
 
NC score 0.692500 (rank : 17) θ value 9.26847e-13 (rank : 17)
Query Neighborhood Hits 38 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP7_HUMAN
 
NC score 0.692385 (rank : 18) θ value 2.52405e-10 (rank : 21)
Query Neighborhood Hits 38 Target Neighborhood Hits 26 Shared Neighborhood Hits 22
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP8_MOUSE
 
NC score 0.664192 (rank : 19) θ value 2.28291e-11 (rank : 19)
Query Neighborhood Hits 38 Target Neighborhood Hits 57 Shared Neighborhood Hits 22
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP8_HUMAN
 
NC score 0.645743 (rank : 20) θ value 4.59992e-12 (rank : 18)
Query Neighborhood Hits 38 Target Neighborhood Hits 62 Shared Neighborhood Hits 22
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
ICBR_HUMAN
 
NC score 0.495282 (rank : 21) θ value 2.7842e-17 (rank : 12)
Query Neighborhood Hits 38 Target Neighborhood Hits 11 Shared Neighborhood Hits 10
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.
CFLAR_HUMAN
 
NC score 0.464905 (rank : 22) θ value 0.00228821 (rank : 22)
Query Neighborhood Hits 38 Target Neighborhood Hits 47 Shared Neighborhood Hits 22
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CFLAR_MOUSE
 
NC score 0.404021 (rank : 23) θ value 0.00665767 (rank : 23)
Query Neighborhood Hits 38 Target Neighborhood Hits 32 Shared Neighborhood Hits 19
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CARD8_HUMAN
 
NC score 0.110151 (rank : 24) θ value 0.0736092 (rank : 24)
Query Neighborhood Hits 38 Target Neighborhood Hits 22 Shared Neighborhood Hits 10
SwissProt Accessions Q9Y2G2, Q6PGP8, Q96P82 Gene names CARD8, KIAA0955, NDPP1
Domain
Architecture
Description Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).
FADD_HUMAN
 
NC score 0.068437 (rank : 25) θ value θ > 10 (rank : 39)
Query Neighborhood Hits 38 Target Neighborhood Hits 20 Shared Neighborhood Hits 5
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
CARD6_HUMAN
 
NC score 0.057729 (rank : 26) θ value 0.813845 (rank : 27)
Query Neighborhood Hits 38 Target Neighborhood Hits 145 Shared Neighborhood Hits 11
SwissProt Accessions Q9BX69 Gene names CARD6
Domain
Architecture
Description Caspase recruitment domain-containing protein 6.
FADD_MOUSE
 
NC score 0.057001 (rank : 27) θ value θ > 10 (rank : 40)
Query Neighborhood Hits 38 Target Neighborhood Hits 23 Shared Neighborhood Hits 5
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
BIRC2_HUMAN
 
NC score 0.044843 (rank : 28) θ value 1.06291 (rank : 28)
Query Neighborhood Hits 38 Target Neighborhood Hits 142 Shared Neighborhood Hits 11
SwissProt Accessions Q13490, Q16516, Q4TTG0 Gene names BIRC2, API1, IAP2, MIHB
Domain
Architecture
Description Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).
BIRC2_MOUSE
 
NC score 0.044789 (rank : 29) θ value 2.36792 (rank : 29)
Query Neighborhood Hits 38 Target Neighborhood Hits 137 Shared Neighborhood Hits 13
SwissProt Accessions Q62210, O08864 Gene names Birc2, Birc3, Iap2
Domain
Architecture
Description Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).
CAR12_HUMAN
 
NC score 0.041596 (rank : 30) θ value 5.27518 (rank : 32)
Query Neighborhood Hits 38 Target Neighborhood Hits 132 Shared Neighborhood Hits 12
SwissProt Accessions Q9NPP4, Q96J81, Q96J82, Q96J83 Gene names CARD12, CLAN, CLAN1
Domain
Architecture
Description Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).
BIRC3_HUMAN
 
NC score 0.034551 (rank : 31) θ value 0.813845 (rank : 26)
Query Neighborhood Hits 38 Target Neighborhood Hits 133 Shared Neighborhood Hits 8
SwissProt Accessions Q13489, Q16628, Q9HC27, Q9UP46 Gene names BIRC3, API2, IAP1, MIHC
Domain
Architecture
Description Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).
CARD4_MOUSE
 
NC score 0.032496 (rank : 32) θ value 0.365318 (rank : 25)
Query Neighborhood Hits 38 Target Neighborhood Hits 85 Shared Neighborhood Hits 8
SwissProt Accessions Q8BHB0, Q8BUT6 Gene names Card4
Domain
Architecture
Description Caspase recruitment domain-containing protein 4.
CARD4_HUMAN
 
NC score 0.028042 (rank : 33) θ value 4.03905 (rank : 31)
Query Neighborhood Hits 38 Target Neighborhood Hits 102 Shared Neighborhood Hits 10
SwissProt Accessions Q9Y239, Q8IWF5 Gene names CARD4, NOD1
Domain
Architecture
Description Caspase recruitment domain-containing protein 4 (Protein Nod1).
CAR15_HUMAN
 
NC score 0.027474 (rank : 34) θ value 5.27518 (rank : 33)
Query Neighborhood Hits 38 Target Neighborhood Hits 77 Shared Neighborhood Hits 10
SwissProt Accessions Q9HC29, Q96RH5, Q96RH6, Q96RH8 Gene names CARD15, IBD1, NOD2
Domain
Architecture
Description Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).
CAR15_MOUSE
 
NC score 0.027079 (rank : 35) θ value 8.99809 (rank : 34)
Query Neighborhood Hits 38 Target Neighborhood Hits 93 Shared Neighborhood Hits 9
SwissProt Accessions Q8K3Z0 Gene names Card15, Nod2
Domain
Architecture
Description Caspase recruitment domain-containing protein 15 (Protein Nod2).
ZMY15_HUMAN
 
NC score 0.024925 (rank : 36) θ value 3.0926 (rank : 30)
Query Neighborhood Hits 38 Target Neighborhood Hits 53 Shared Neighborhood Hits 2
SwissProt Accessions Q9H091 Gene names ZMYND15
Domain
Architecture

No domain graphic available

Description Zinc finger MYND domain-containing protein 15.
CENPR_HUMAN
 
NC score 0.012360 (rank : 37) θ value 8.99809 (rank : 36)
Query Neighborhood Hits 38 Target Neighborhood Hits 43 Shared Neighborhood Hits 2
SwissProt Accessions Q13352, Q13353, Q5RJ42, Q5RJ44, Q5RJ45, Q7KYX2, Q96CD5, Q9UKB6 Gene names ITGB3BP, CENPR, NRIF3
Domain
Architecture

No domain graphic available

Description Centromere protein R (CENP-R) (Nuclear receptor-interacting factor 3) (Integrin beta-3-binding protein) (Beta3-endonexin).
PKD1_HUMAN
 
NC score 0.003852 (rank : 38) θ value 8.99809 (rank : 37)
Query Neighborhood Hits 38 Target Neighborhood Hits 387 Shared Neighborhood Hits 2
SwissProt Accessions P98161, Q15140, Q15141 Gene names PKD1
Domain
Architecture
Description Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).
CELR2_HUMAN
 
NC score -0.001123 (rank : 39) θ value 8.99809 (rank : 35)
Query Neighborhood Hits 38 Target Neighborhood Hits 657 Shared Neighborhood Hits 2
SwissProt Accessions Q9HCU4, Q92566 Gene names CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain
Architecture
Description Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).
ZN438_HUMAN
 
NC score -0.001435 (rank : 40) θ value 8.99809 (rank : 38)
Query Neighborhood Hits 38 Target Neighborhood Hits 906 Shared Neighborhood Hits 2
SwissProt Accessions Q7Z4V0, Q5T426, Q658Q4, Q6ZN65 Gene names ZNF438
Domain
Architecture

No domain graphic available

Description Zinc finger protein 438.