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Network neighborhood for query Sequence : GRIPE_HUMAN

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GRIPE_HUMAN
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GRIPE_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_MOUSE
θ value	0 (rank : 2)	NC score	0.992795 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	70	Shared Neighborhood Hits	35
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

TSC2_HUMAN
θ value	4.58923e-20 (rank : 3)	NC score	0.527405 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TSC2_MOUSE
θ value	1.24977e-17 (rank : 4)	NC score	0.509368 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

RGP2_HUMAN
θ value	4.91457e-14 (rank : 5)	NC score	0.542469 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

SI1L2_HUMAN
θ value	3.18553e-13 (rank : 6)	NC score	0.463539 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	4.16044e-13 (rank : 7)	NC score	0.462192 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L1_HUMAN
θ value	7.09661e-13 (rank : 8)	NC score	0.458304 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	162	Shared Neighborhood Hits	15
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	7.09661e-13 (rank : 9)	NC score	0.456969 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SI1L3_HUMAN
θ value	2.0648e-12 (rank : 10)	NC score	0.453460 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SIPA1_MOUSE
θ value	1.133e-10 (rank : 11)	NC score	0.458431 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	158	Shared Neighborhood Hits	14
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SIPA1_HUMAN
θ value	9.59137e-10 (rank : 12)	NC score	0.446612 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	250	Shared Neighborhood Hits	17
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

K1219_HUMAN
θ value	1.99992e-07 (rank : 13)	NC score	0.236948 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	Q86X10, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9	Gene names	KIAA1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

K1219_MOUSE
θ value	1.69304e-06 (rank : 14)	NC score	0.228716 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BQZ4, Q80TH5, Q8BQN1	Gene names	Kiaa1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

ARHGC_MOUSE
θ value	0.163984 (rank : 15)	NC score	0.036046 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	344	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

JHD2B_HUMAN
θ value	0.21417 (rank : 16)	NC score	0.041172 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	171	Shared Neighborhood Hits	7
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

ZCH10_HUMAN
θ value	0.21417 (rank : 17)	NC score	0.078456 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	123	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

MUCDL_MOUSE
θ value	0.279714 (rank : 18)	NC score	0.030780 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	461	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

CHD9_MOUSE
θ value	0.47712 (rank : 19)	NC score	0.020062 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	427	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

FOLH1_MOUSE
θ value	0.62314 (rank : 20)	NC score	0.038742 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

GOGA4_MOUSE
θ value	0.813845 (rank : 21)	NC score	0.019727 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	1939	Shared Neighborhood Hits	24
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ARHGC_HUMAN
θ value	1.06291 (rank : 22)	NC score	0.030371 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	351	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FOLH1_HUMAN
θ value	1.06291 (rank : 23)	NC score	0.035399 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

RP1_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.022713 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	P56715	Gene names	RP1, ORP1
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein) (Retinitis pigmentosa 1 protein).

TPR_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.013516 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	1921	Shared Neighborhood Hits	22
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

ZN516_MOUSE
θ value	1.38821 (rank : 26)	NC score	0.007850 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	1197	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

THSD1_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.020391 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ZEP1_MOUSE
θ value	1.81305 (rank : 28)	NC score	0.011503 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	1063	Shared Neighborhood Hits	13
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

ZNF18_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.001879 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	748	Shared Neighborhood Hits	7
SwissProt Accessions	P17022, Q5QHQ3, Q8IYC4, Q8NAH6	Gene names	ZNF18, HDSG1, KOX11
Domain Architecture	No domain graphic available
Description	Zinc finger protein 18 (Zinc finger protein KOX11) (Heart development- specific gene 1 protein).

A20A1_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.017725 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	698	Shared Neighborhood Hits	11
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A3_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.017893 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	692	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.017716 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	710	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

OTU7A_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.031722 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

OTU7A_MOUSE
θ value	2.36792 (rank : 34)	NC score	0.031489 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R554	Gene names	Otud7a, Otud7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

HUWE1_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.019091 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	443	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

A20A2_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.017067 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	716	Shared Neighborhood Hits	11
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

CH3L1_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.018545 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P36222, P30923, Q8IVA4, Q96HI7	Gene names	CHI3L1
Domain Architecture
Description	Chitinase-3-like protein 1 precursor (Cartilage glycoprotein 39) (GP- 39) (39 kDa synovial protein) (HCgp-39) (YKL-40).

DBR1_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.020219 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q923B1, Q8C1T9, Q8C7J7, Q99MT1	Gene names	Dbr1
Domain Architecture	No domain graphic available
Description	Lariat debranching enzyme (EC 3.1.-.-).

PO121_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.023768 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	344	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

ZN638_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.023570 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

ANR15_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.008826 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	478	Shared Neighborhood Hits	9
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ARFG3_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.011742 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ATN1_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.020047 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	676	Shared Neighborhood Hits	10
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

CP135_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.011194 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	1290	Shared Neighborhood Hits	17
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

REST_HUMAN
θ value	5.27518 (rank : 45)	NC score	0.007698 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	1605	Shared Neighborhood Hits	20
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

T2FB_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.020798 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0A0	Gene names	Gtf2f2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor IIF subunit beta (EC 3.6.1.-) (ATP- dependent helicase GTF2F2) (TFIIF-beta).

BRPF3_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.006506 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

CHD9_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.013105 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

HUWE1_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.016299 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	406	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

KI2L1_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.004987 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P43626, O43470	Gene names	KIR2DL1, CD158A, NKAT1
Domain Architecture	No domain graphic available
Description	Killer cell immunoglobulin-like receptor 2DL1 precursor (MHC class I NK cell receptor) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor) (p58.1 MHC class-I-specific NK receptor) (CD158a antigen).

SPTB2_MOUSE
θ value	6.88961 (rank : 51)	NC score	0.007669 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	770	Shared Neighborhood Hits	13
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TOX_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.010688 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

TRAP1_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.010602 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q12931, O43642, O75235, Q9UHL5	Gene names	TRAP1, HSP75
Domain Architecture
Description	Heat shock protein 75 kDa, mitochondrial precursor (HSP 75) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) (TNFR- associated protein 1).

TSH2_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.007447 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	467	Shared Neighborhood Hits	5
SwissProt Accessions	Q68FE9, Q5DTF1, Q6AXH5, Q9JL71	Gene names	Tshz2, Kiaa4248, Sdccag33l, Tsh2, Zfp218, Znf218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (SDCCAG33-like protein).

APC_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.023909 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	441	Shared Neighborhood Hits	11
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

DNL3_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.009411 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

FAT2_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.002122 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	507	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYQ8, O75091, Q9NSR7	Gene names	FAT2, CDHF8, KIAA0811, MEGF1
Domain Architecture
Description	Protocadherin Fat 2 precursor (hFat2) (Multiple epidermal growth factor-like domains 1).

GP152_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.007392 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	607	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

MAGAC_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.004113 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P43365, Q9NSD3	Gene names	MAGEA12, MAGE12
Domain Architecture
Description	Melanoma-associated antigen 12 (MAGE-12 antigen) (MAGE12F).

P52K_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.010107 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	O43422, Q8WTW1, Q9Y3Z4	Gene names	PRKRIR, DAP4, P52RIPK, THAP0
Domain Architecture
Description	52 kDa repressor of the inhibitor of the protein kinase (p58IPK- interacting protein) (58 kDa interferon-induced protein kinase- interacting protein) (P52rIPK) (Death-associated protein 4) (THAP domain-containing protein 0).

ROBO2_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.002591 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	479	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
θ value	8.99809 (rank : 62)	NC score	0.002620 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	504	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

SFRIP_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.009624 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	530	Shared Neighborhood Hits	8
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SMOO_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.016281 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	391	Shared Neighborhood Hits	7
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SPTB2_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.006728 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TAF3_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.012396 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	568	Shared Neighborhood Hits	9
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TAF3_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.012992 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	463	Shared Neighborhood Hits	9
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TRPS1_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.007745 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	539	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UHF7, Q9NWE1, Q9UHH6	Gene names	TRPS1
Domain Architecture
Description	Zinc finger transcription factor Trps1 (Zinc finger protein GC79) (Tricho-rhino-phalangeal syndrome type I protein).

TRS85_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.025945 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2L5, Q9H0L2	Gene names	KIAA1012
Domain Architecture	No domain graphic available
Description	Protein TRS85 homolog.

Hits sorted by NC score

GRIPE_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_MOUSE
NC score	0.992795 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	70	Shared Neighborhood Hits	35
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

RGP2_HUMAN
NC score	0.542469 (rank : 3)	θ value	4.91457e-14 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

TSC2_HUMAN
NC score	0.527405 (rank : 4)	θ value	4.58923e-20 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TSC2_MOUSE
NC score	0.509368 (rank : 5)	θ value	1.24977e-17 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

SI1L2_HUMAN
NC score	0.463539 (rank : 6)	θ value	3.18553e-13 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
NC score	0.462192 (rank : 7)	θ value	4.16044e-13 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SIPA1_MOUSE
NC score	0.458431 (rank : 8)	θ value	1.133e-10 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	158	Shared Neighborhood Hits	14
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SI1L1_HUMAN
NC score	0.458304 (rank : 9)	θ value	7.09661e-13 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	162	Shared Neighborhood Hits	15
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
NC score	0.456969 (rank : 10)	θ value	7.09661e-13 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SI1L3_HUMAN
NC score	0.453460 (rank : 11)	θ value	2.0648e-12 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SIPA1_HUMAN
NC score	0.446612 (rank : 12)	θ value	9.59137e-10 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	250	Shared Neighborhood Hits	17
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

K1219_HUMAN
NC score	0.236948 (rank : 13)	θ value	1.99992e-07 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	Q86X10, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9	Gene names	KIAA1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

K1219_MOUSE
NC score	0.228716 (rank : 14)	θ value	1.69304e-06 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BQZ4, Q80TH5, Q8BQN1	Gene names	Kiaa1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

ZCH10_HUMAN
NC score	0.078456 (rank : 15)	θ value	0.21417 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	123	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

JHD2B_HUMAN
NC score	0.041172 (rank : 16)	θ value	0.21417 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	171	Shared Neighborhood Hits	7
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

FOLH1_MOUSE
NC score	0.038742 (rank : 17)	θ value	0.62314 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

ARHGC_MOUSE
NC score	0.036046 (rank : 18)	θ value	0.163984 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	344	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FOLH1_HUMAN
NC score	0.035399 (rank : 19)	θ value	1.06291 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

OTU7A_HUMAN
NC score	0.031722 (rank : 20)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

OTU7A_MOUSE
NC score	0.031489 (rank : 21)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R554	Gene names	Otud7a, Otud7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

MUCDL_MOUSE
NC score	0.030780 (rank : 22)	θ value	0.279714 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	461	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

ARHGC_HUMAN
NC score	0.030371 (rank : 23)	θ value	1.06291 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	351	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TRS85_HUMAN
NC score	0.025945 (rank : 24)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2L5, Q9H0L2	Gene names	KIAA1012
Domain Architecture	No domain graphic available
Description	Protein TRS85 homolog.

APC_MOUSE
NC score	0.023909 (rank : 25)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	441	Shared Neighborhood Hits	11
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

PO121_HUMAN
NC score	0.023768 (rank : 26)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	344	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

ZN638_HUMAN
NC score	0.023570 (rank : 27)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

RP1_HUMAN
NC score	0.022713 (rank : 28)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	P56715	Gene names	RP1, ORP1
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein) (Retinitis pigmentosa 1 protein).

T2FB_MOUSE
NC score	0.020798 (rank : 29)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0A0	Gene names	Gtf2f2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor IIF subunit beta (EC 3.6.1.-) (ATP- dependent helicase GTF2F2) (TFIIF-beta).

THSD1_HUMAN
NC score	0.020391 (rank : 30)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

DBR1_MOUSE
NC score	0.020219 (rank : 31)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q923B1, Q8C1T9, Q8C7J7, Q99MT1	Gene names	Dbr1
Domain Architecture	No domain graphic available
Description	Lariat debranching enzyme (EC 3.1.-.-).

CHD9_MOUSE
NC score	0.020062 (rank : 32)	θ value	0.47712 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	427	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

ATN1_HUMAN
NC score	0.020047 (rank : 33)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	676	Shared Neighborhood Hits	10
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

GOGA4_MOUSE
NC score	0.019727 (rank : 34)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	1939	Shared Neighborhood Hits	24
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

HUWE1_HUMAN
NC score	0.019091 (rank : 35)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	443	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

CH3L1_HUMAN
NC score	0.018545 (rank : 36)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P36222, P30923, Q8IVA4, Q96HI7	Gene names	CHI3L1
Domain Architecture
Description	Chitinase-3-like protein 1 precursor (Cartilage glycoprotein 39) (GP- 39) (39 kDa synovial protein) (HCgp-39) (YKL-40).

A20A3_HUMAN
NC score	0.017893 (rank : 37)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	692	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A1_HUMAN
NC score	0.017725 (rank : 38)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	698	Shared Neighborhood Hits	11
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A4_HUMAN
NC score	0.017716 (rank : 39)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	710	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

A20A2_HUMAN
NC score	0.017067 (rank : 40)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	716	Shared Neighborhood Hits	11
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

HUWE1_MOUSE
NC score	0.016299 (rank : 41)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	406	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

SMOO_HUMAN
NC score	0.016281 (rank : 42)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	391	Shared Neighborhood Hits	7
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

TPR_HUMAN
NC score	0.013516 (rank : 43)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	1921	Shared Neighborhood Hits	22
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CHD9_HUMAN
NC score	0.013105 (rank : 44)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

TAF3_MOUSE
NC score	0.012992 (rank : 45)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	463	Shared Neighborhood Hits	9
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TAF3_HUMAN
NC score	0.012396 (rank : 46)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	568	Shared Neighborhood Hits	9
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

ARFG3_HUMAN
NC score	0.011742 (rank : 47)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ZEP1_MOUSE
NC score	0.011503 (rank : 48)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	1063	Shared Neighborhood Hits	13
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

CP135_HUMAN
NC score	0.011194 (rank : 49)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	1290	Shared Neighborhood Hits	17
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

TOX_MOUSE
NC score	0.010688 (rank : 50)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

TRAP1_HUMAN
NC score	0.010602 (rank : 51)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q12931, O43642, O75235, Q9UHL5	Gene names	TRAP1, HSP75
Domain Architecture
Description	Heat shock protein 75 kDa, mitochondrial precursor (HSP 75) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) (TNFR- associated protein 1).

P52K_HUMAN
NC score	0.010107 (rank : 52)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	O43422, Q8WTW1, Q9Y3Z4	Gene names	PRKRIR, DAP4, P52RIPK, THAP0
Domain Architecture
Description	52 kDa repressor of the inhibitor of the protein kinase (p58IPK- interacting protein) (58 kDa interferon-induced protein kinase- interacting protein) (P52rIPK) (Death-associated protein 4) (THAP domain-containing protein 0).

SFRIP_HUMAN
NC score	0.009624 (rank : 53)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	530	Shared Neighborhood Hits	8
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

DNL3_HUMAN
NC score	0.009411 (rank : 54)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

ANR15_HUMAN
NC score	0.008826 (rank : 55)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	478	Shared Neighborhood Hits	9
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ZN516_MOUSE
NC score	0.007850 (rank : 56)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	1197	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

TRPS1_HUMAN
NC score	0.007745 (rank : 57)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	539	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UHF7, Q9NWE1, Q9UHH6	Gene names	TRPS1
Domain Architecture
Description	Zinc finger transcription factor Trps1 (Zinc finger protein GC79) (Tricho-rhino-phalangeal syndrome type I protein).

REST_HUMAN
NC score	0.007698 (rank : 58)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	1605	Shared Neighborhood Hits	20
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SPTB2_MOUSE
NC score	0.007669 (rank : 59)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	770	Shared Neighborhood Hits	13
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TSH2_MOUSE
NC score	0.007447 (rank : 60)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	467	Shared Neighborhood Hits	5
SwissProt Accessions	Q68FE9, Q5DTF1, Q6AXH5, Q9JL71	Gene names	Tshz2, Kiaa4248, Sdccag33l, Tsh2, Zfp218, Znf218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (SDCCAG33-like protein).

GP152_MOUSE
NC score	0.007392 (rank : 61)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	607	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

SPTB2_HUMAN
NC score	0.006728 (rank : 62)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

BRPF3_HUMAN
NC score	0.006506 (rank : 63)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

KI2L1_HUMAN
NC score	0.004987 (rank : 64)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P43626, O43470	Gene names	KIR2DL1, CD158A, NKAT1
Domain Architecture	No domain graphic available
Description	Killer cell immunoglobulin-like receptor 2DL1 precursor (MHC class I NK cell receptor) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor) (p58.1 MHC class-I-specific NK receptor) (CD158a antigen).

MAGAC_HUMAN
NC score	0.004113 (rank : 65)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P43365, Q9NSD3	Gene names	MAGEA12, MAGE12
Domain Architecture
Description	Melanoma-associated antigen 12 (MAGE-12 antigen) (MAGE12F).

ROBO2_MOUSE
NC score	0.002620 (rank : 66)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	504	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_HUMAN
NC score	0.002591 (rank : 67)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	479	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

FAT2_HUMAN
NC score	0.002122 (rank : 68)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	507	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYQ8, O75091, Q9NSR7	Gene names	FAT2, CDHF8, KIAA0811, MEGF1
Domain Architecture
Description	Protocadherin Fat 2 precursor (hFat2) (Multiple epidermal growth factor-like domains 1).

ZNF18_HUMAN
NC score	0.001879 (rank : 69)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	748	Shared Neighborhood Hits	7
SwissProt Accessions	P17022, Q5QHQ3, Q8IYC4, Q8NAH6	Gene names	ZNF18, HDSG1, KOX11
Domain Architecture	No domain graphic available
Description	Zinc finger protein 18 (Zinc finger protein KOX11) (Heart development- specific gene 1 protein).