Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : GRIPE_MOUSE

For an explanation of this page, click here

GRIPE_MOUSE
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GRIPE_HUMAN
θ value	0 (rank : 1)	NC score	0.992795 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	69	Shared Neighborhood Hits	35
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

TSC2_HUMAN
θ value	5.99374e-20 (rank : 3)	NC score	0.524967 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TSC2_MOUSE
θ value	2.13179e-17 (rank : 4)	NC score	0.507090 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

RGP2_HUMAN
θ value	1.42992e-13 (rank : 5)	NC score	0.533043 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

SI1L2_HUMAN
θ value	2.69671e-12 (rank : 6)	NC score	0.450216 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	3.52202e-12 (rank : 7)	NC score	0.449222 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	124	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L1_HUMAN
θ value	6.00763e-12 (rank : 8)	NC score	0.445664 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	162	Shared Neighborhood Hits	13
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	6.00763e-12 (rank : 9)	NC score	0.444570 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	189	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SI1L3_HUMAN
θ value	1.74796e-11 (rank : 10)	NC score	0.441591 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	305	Shared Neighborhood Hits	17
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SIPA1_MOUSE
θ value	9.59137e-10 (rank : 11)	NC score	0.446232 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	158	Shared Neighborhood Hits	13
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SIPA1_HUMAN
θ value	8.11959e-09 (rank : 12)	NC score	0.434337 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	250	Shared Neighborhood Hits	14
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

K1219_HUMAN
θ value	8.40245e-06 (rank : 13)	NC score	0.223203 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q86X10, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9	Gene names	KIAA1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

K1219_MOUSE
θ value	2.44474e-05 (rank : 14)	NC score	0.214507 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BQZ4, Q80TH5, Q8BQN1	Gene names	Kiaa1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

GOGA4_MOUSE
θ value	0.0431538 (rank : 15)	NC score	0.021546 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	1939	Shared Neighborhood Hits	22
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

KAISO_HUMAN
θ value	0.0961366 (rank : 16)	NC score	0.012623 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

JHD2B_HUMAN
θ value	0.279714 (rank : 17)	NC score	0.040953 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

ABCF1_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.020323 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NE71, O14897, Q69YP6	Gene names	ABCF1, ABC50
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein).

APC_MOUSE
θ value	0.813845 (rank : 19)	NC score	0.032977 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	441	Shared Neighborhood Hits	10
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

CD2L1_HUMAN
θ value	1.38821 (rank : 20)	NC score	0.003492 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	1467	Shared Neighborhood Hits	14
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

FOLH1_MOUSE
θ value	1.38821 (rank : 21)	NC score	0.035295 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

HUWE1_HUMAN
θ value	1.38821 (rank : 22)	NC score	0.023759 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	443	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

ZN516_MOUSE
θ value	1.38821 (rank : 23)	NC score	0.008479 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	1197	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

AMOL1_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.023057 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	435	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

CCNB3_HUMAN
θ value	1.81305 (rank : 25)	NC score	0.020425 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	368	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

SRRM2_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.027885 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	1296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

FOLH1_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.031857 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

HUWE1_MOUSE
θ value	2.36792 (rank : 28)	NC score	0.021174 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	406	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

SETD2_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.017474 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	412	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

AMOL1_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.022141 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	445	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

CH3L1_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.019299 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P36222, P30923, Q8IVA4, Q96HI7	Gene names	CHI3L1
Domain Architecture
Description	Chitinase-3-like protein 1 precursor (Cartilage glycoprotein 39) (GP- 39) (39 kDa synovial protein) (HCgp-39) (YKL-40).

IKKB_MOUSE
θ value	3.0926 (rank : 32)	NC score	0.002972 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	984	Shared Neighborhood Hits	7
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KPCD2_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.001919 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	910	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

RANB3_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.023004 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H6Z4, O60405, O75759, O75760, Q9BT47, Q9UG74	Gene names	RANBP3
Domain Architecture	No domain graphic available
Description	Ran-binding protein 3 (RanBP3).

SP1_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.003103 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	722	Shared Neighborhood Hits	7
SwissProt Accessions	P08047, Q86TN8, Q9H3Q5, Q9NR51, Q9NY21, Q9NYE7	Gene names	SP1, TSFP1
Domain Architecture
Description	Transcription factor Sp1.

SYTL2_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.010903 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	248	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CP135_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.008879 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	1290	Shared Neighborhood Hits	10
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

ENPL_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.012477 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	P14625, Q96A97	Gene names	HSP90B1, TRA1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (gp96 homolog) (Tumor rejection antigen 1).

GRB14_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.009808 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	137	Shared Neighborhood Hits	2
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SMOO_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.016547 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	391	Shared Neighborhood Hits	7
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

TMED8_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.023893 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PL24, Q9P1V9	Gene names	TMED8
Domain Architecture	No domain graphic available
Description	Protein TMED8.

ZEP1_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.011577 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	1063	Shared Neighborhood Hits	13
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

ZN638_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.025022 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

CABL1_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.014762 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ESJ1, Q9EPR8	Gene names	Cables1, Cables
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

CSPG2_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.005014 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	711	Shared Neighborhood Hits	7
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

FA54A_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.018691 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VED8	Gene names	Fam54a, Dufd1
Domain Architecture	No domain graphic available
Description	Protein FAM54A (DUF729 domain-containing protein 1).

ITPR1_MOUSE
θ value	5.27518 (rank : 47)	NC score	0.011723 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

P2RX4_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.010078 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q99571, O00450, O14722, Q9UBG9	Gene names	P2RX4
Domain Architecture
Description	P2X purinoceptor 4 (ATP receptor) (P2X4) (Purinergic receptor).

TITIN_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.002463 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	2923	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TRS85_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.029475 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2L5, Q9H0L2	Gene names	KIAA1012
Domain Architecture	No domain graphic available
Description	Protein TRS85 homolog.

UB2Q2_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.013669 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WVN8, Q8N4G6, Q96J08	Gene names	UBE2Q2
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2).

ATN1_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.019213 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	676	Shared Neighborhood Hits	11
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

CBX4_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.010634 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	O00257, Q96C04	Gene names	CBX4
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (hPc2).

CHD9_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.013081 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	427	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

GP152_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.008360 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	607	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

MATR3_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.014439 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

MYST3_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.010808 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

MYST3_MOUSE
θ value	6.88961 (rank : 58)	NC score	0.010001 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	688	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

P80C_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.020252 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	P38432	Gene names	COIL, CLN80
Domain Architecture	No domain graphic available
Description	Coilin (p80).

TRI59_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.006143 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

WFS1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.013919 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

Z297B_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.002035 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	792	Shared Neighborhood Hits	10
SwissProt Accessions	O43298	Gene names	ZNF297B, KIAA0414, ZBTB22B
Domain Architecture
Description	Zinc finger protein 297B (ZnF-x) (Zinc finger and BTB domain- containing protein 22B).

ITPR1_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.010513 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

KPB2_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.007045 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BWJ3, Q3TN65, Q810J6	Gene names	Phka2
Domain Architecture
Description	Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit).

LRRK2_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.000209 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	1359	Shared Neighborhood Hits	6
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

MUCDL_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.021803 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	461	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

OTU7A_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.023046 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

OTU7A_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.022870 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R554	Gene names	Otud7a, Otud7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

SEZ6L_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.005270 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	289	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

ZNF18_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.002152 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	748	Shared Neighborhood Hits	8
SwissProt Accessions	P17022, Q5QHQ3, Q8IYC4, Q8NAH6	Gene names	ZNF18, HDSG1, KOX11
Domain Architecture	No domain graphic available
Description	Zinc finger protein 18 (Zinc finger protein KOX11) (Heart development- specific gene 1 protein).

ZCH10_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.058128 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

Hits sorted by NC score

GRIPE_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_HUMAN
NC score	0.992795 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	69	Shared Neighborhood Hits	35
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

RGP2_HUMAN
NC score	0.533043 (rank : 3)	θ value	1.42992e-13 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

TSC2_HUMAN
NC score	0.524967 (rank : 4)	θ value	5.99374e-20 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TSC2_MOUSE
NC score	0.507090 (rank : 5)	θ value	2.13179e-17 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

SI1L2_HUMAN
NC score	0.450216 (rank : 6)	θ value	2.69671e-12 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
NC score	0.449222 (rank : 7)	θ value	3.52202e-12 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	124	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SIPA1_MOUSE
NC score	0.446232 (rank : 8)	θ value	9.59137e-10 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	158	Shared Neighborhood Hits	13
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SI1L1_HUMAN
NC score	0.445664 (rank : 9)	θ value	6.00763e-12 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	162	Shared Neighborhood Hits	13
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
NC score	0.444570 (rank : 10)	θ value	6.00763e-12 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	189	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SI1L3_HUMAN
NC score	0.441591 (rank : 11)	θ value	1.74796e-11 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	305	Shared Neighborhood Hits	17
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SIPA1_HUMAN
NC score	0.434337 (rank : 12)	θ value	8.11959e-09 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	250	Shared Neighborhood Hits	14
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

K1219_HUMAN
NC score	0.223203 (rank : 13)	θ value	8.40245e-06 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q86X10, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9	Gene names	KIAA1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

K1219_MOUSE
NC score	0.214507 (rank : 14)	θ value	2.44474e-05 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BQZ4, Q80TH5, Q8BQN1	Gene names	Kiaa1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

ZCH10_HUMAN
NC score	0.058128 (rank : 15)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

JHD2B_HUMAN
NC score	0.040953 (rank : 16)	θ value	0.279714 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

FOLH1_MOUSE
NC score	0.035295 (rank : 17)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

APC_MOUSE
NC score	0.032977 (rank : 18)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	441	Shared Neighborhood Hits	10
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

FOLH1_HUMAN
NC score	0.031857 (rank : 19)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

TRS85_HUMAN
NC score	0.029475 (rank : 20)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2L5, Q9H0L2	Gene names	KIAA1012
Domain Architecture	No domain graphic available
Description	Protein TRS85 homolog.

SRRM2_HUMAN
NC score	0.027885 (rank : 21)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	1296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ZN638_HUMAN
NC score	0.025022 (rank : 22)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

TMED8_HUMAN
NC score	0.023893 (rank : 23)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PL24, Q9P1V9	Gene names	TMED8
Domain Architecture	No domain graphic available
Description	Protein TMED8.

HUWE1_HUMAN
NC score	0.023759 (rank : 24)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	443	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

AMOL1_HUMAN
NC score	0.023057 (rank : 25)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	435	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

OTU7A_HUMAN
NC score	0.023046 (rank : 26)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

RANB3_HUMAN
NC score	0.023004 (rank : 27)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H6Z4, O60405, O75759, O75760, Q9BT47, Q9UG74	Gene names	RANBP3
Domain Architecture	No domain graphic available
Description	Ran-binding protein 3 (RanBP3).

OTU7A_MOUSE
NC score	0.022870 (rank : 28)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R554	Gene names	Otud7a, Otud7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

AMOL1_MOUSE
NC score	0.022141 (rank : 29)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	445	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

MUCDL_MOUSE
NC score	0.021803 (rank : 30)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	461	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

GOGA4_MOUSE
NC score	0.021546 (rank : 31)	θ value	0.0431538 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	1939	Shared Neighborhood Hits	22
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

HUWE1_MOUSE
NC score	0.021174 (rank : 32)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	406	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

CCNB3_HUMAN
NC score	0.020425 (rank : 33)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	368	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

ABCF1_HUMAN
NC score	0.020323 (rank : 34)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NE71, O14897, Q69YP6	Gene names	ABCF1, ABC50
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein).

P80C_HUMAN
NC score	0.020252 (rank : 35)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	P38432	Gene names	COIL, CLN80
Domain Architecture	No domain graphic available
Description	Coilin (p80).

CH3L1_HUMAN
NC score	0.019299 (rank : 36)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P36222, P30923, Q8IVA4, Q96HI7	Gene names	CHI3L1
Domain Architecture
Description	Chitinase-3-like protein 1 precursor (Cartilage glycoprotein 39) (GP- 39) (39 kDa synovial protein) (HCgp-39) (YKL-40).

ATN1_HUMAN
NC score	0.019213 (rank : 37)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	676	Shared Neighborhood Hits	11
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

FA54A_MOUSE
NC score	0.018691 (rank : 38)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VED8	Gene names	Fam54a, Dufd1
Domain Architecture	No domain graphic available
Description	Protein FAM54A (DUF729 domain-containing protein 1).

SETD2_HUMAN
NC score	0.017474 (rank : 39)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	412	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SMOO_HUMAN
NC score	0.016547 (rank : 40)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	391	Shared Neighborhood Hits	7
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

CABL1_MOUSE
NC score	0.014762 (rank : 41)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ESJ1, Q9EPR8	Gene names	Cables1, Cables
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

MATR3_HUMAN
NC score	0.014439 (rank : 42)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

WFS1_HUMAN
NC score	0.013919 (rank : 43)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

UB2Q2_HUMAN
NC score	0.013669 (rank : 44)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WVN8, Q8N4G6, Q96J08	Gene names	UBE2Q2
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2).

CHD9_MOUSE
NC score	0.013081 (rank : 45)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	427	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

KAISO_HUMAN
NC score	0.012623 (rank : 46)	θ value	0.0961366 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

ENPL_HUMAN
NC score	0.012477 (rank : 47)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	P14625, Q96A97	Gene names	HSP90B1, TRA1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (gp96 homolog) (Tumor rejection antigen 1).

ITPR1_MOUSE
NC score	0.011723 (rank : 48)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

ZEP1_MOUSE
NC score	0.011577 (rank : 49)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	1063	Shared Neighborhood Hits	13
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

SYTL2_HUMAN
NC score	0.010903 (rank : 50)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	248	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

MYST3_HUMAN
NC score	0.010808 (rank : 51)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

CBX4_HUMAN
NC score	0.010634 (rank : 52)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	O00257, Q96C04	Gene names	CBX4
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (hPc2).

ITPR1_HUMAN
NC score	0.010513 (rank : 53)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

P2RX4_HUMAN
NC score	0.010078 (rank : 54)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q99571, O00450, O14722, Q9UBG9	Gene names	P2RX4
Domain Architecture
Description	P2X purinoceptor 4 (ATP receptor) (P2X4) (Purinergic receptor).

MYST3_MOUSE
NC score	0.010001 (rank : 55)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	688	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

GRB14_HUMAN
NC score	0.009808 (rank : 56)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	137	Shared Neighborhood Hits	2
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

CP135_HUMAN
NC score	0.008879 (rank : 57)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	1290	Shared Neighborhood Hits	10
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

ZN516_MOUSE
NC score	0.008479 (rank : 58)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	1197	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

GP152_MOUSE
NC score	0.008360 (rank : 59)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	607	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

KPB2_MOUSE
NC score	0.007045 (rank : 60)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BWJ3, Q3TN65, Q810J6	Gene names	Phka2
Domain Architecture
Description	Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit).

TRI59_HUMAN
NC score	0.006143 (rank : 61)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

SEZ6L_HUMAN
NC score	0.005270 (rank : 62)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	289	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

CSPG2_MOUSE
NC score	0.005014 (rank : 63)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	711	Shared Neighborhood Hits	7
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CD2L1_HUMAN
NC score	0.003492 (rank : 64)	θ value	1.38821 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	1467	Shared Neighborhood Hits	14
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

SP1_HUMAN
NC score	0.003103 (rank : 65)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	722	Shared Neighborhood Hits	7
SwissProt Accessions	P08047, Q86TN8, Q9H3Q5, Q9NR51, Q9NY21, Q9NYE7	Gene names	SP1, TSFP1
Domain Architecture
Description	Transcription factor Sp1.

IKKB_MOUSE
NC score	0.002972 (rank : 66)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	984	Shared Neighborhood Hits	7
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

TITIN_HUMAN
NC score	0.002463 (rank : 67)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	2923	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZNF18_HUMAN
NC score	0.002152 (rank : 68)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	748	Shared Neighborhood Hits	8
SwissProt Accessions	P17022, Q5QHQ3, Q8IYC4, Q8NAH6	Gene names	ZNF18, HDSG1, KOX11
Domain Architecture	No domain graphic available
Description	Zinc finger protein 18 (Zinc finger protein KOX11) (Heart development- specific gene 1 protein).

Z297B_HUMAN
NC score	0.002035 (rank : 69)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	792	Shared Neighborhood Hits	10
SwissProt Accessions	O43298	Gene names	ZNF297B, KIAA0414, ZBTB22B
Domain Architecture
Description	Zinc finger protein 297B (ZnF-x) (Zinc finger and BTB domain- containing protein 22B).

KPCD2_HUMAN
NC score	0.001919 (rank : 70)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	910	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

LRRK2_MOUSE
NC score	0.000209 (rank : 71)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	1359	Shared Neighborhood Hits	6
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).