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Network neighborhood for query Sequence : AP1B1_MOUSE

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AP1B1_MOUSE
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP1B1_HUMAN
θ value	0 (rank : 1)	NC score	0.998411 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	52
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_HUMAN
θ value	0 (rank : 3)	NC score	0.996343 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	44
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	0 (rank : 4)	NC score	0.996363 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP4B1_MOUSE
θ value	3.34088e-79 (rank : 5)	NC score	0.889868 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
θ value	1.40363e-77 (rank : 6)	NC score	0.882734 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP3B1_MOUSE
θ value	5.51964e-74 (rank : 7)	NC score	0.806690 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
θ value	2.73936e-73 (rank : 8)	NC score	0.805846 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	283	Shared Neighborhood Hits	23
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_MOUSE
θ value	3.34864e-71 (rank : 9)	NC score	0.800754 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3B2_HUMAN
θ value	1.27248e-70 (rank : 10)	NC score	0.802210 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP2A2_HUMAN
θ value	3.88503e-19 (rank : 11)	NC score	0.503958 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	39	Shared Neighborhood Hits	18
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	8.65492e-19 (rank : 12)	NC score	0.502620 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP3D1_MOUSE
θ value	2.5182e-18 (rank : 13)	NC score	0.584853 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
θ value	8.10077e-17 (rank : 14)	NC score	0.560077 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	254	Shared Neighborhood Hits	29
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP2A1_MOUSE
θ value	1.80466e-16 (rank : 15)	NC score	0.476931 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_HUMAN
θ value	2.35696e-16 (rank : 16)	NC score	0.479838 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP1G1_HUMAN
θ value	4.44505e-15 (rank : 17)	NC score	0.518751 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	3.76295e-14 (rank : 18)	NC score	0.519713 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

COPB_HUMAN
θ value	3.76295e-14 (rank : 19)	NC score	0.545669 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	23
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	4.91457e-14 (rank : 20)	NC score	0.545512 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	50	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPG2_MOUSE
θ value	6.64225e-11 (rank : 21)	NC score	0.415731 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
θ value	8.67504e-11 (rank : 22)	NC score	0.411351 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

AP1G2_MOUSE
θ value	1.47974e-10 (rank : 23)	NC score	0.509849 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	52	Shared Neighborhood Hits	27
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

COPG_HUMAN
θ value	2.52405e-10 (rank : 24)	NC score	0.373406 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

AP4E1_HUMAN
θ value	2.13673e-09 (rank : 25)	NC score	0.469197 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP1G2_HUMAN
θ value	1.80886e-08 (rank : 26)	NC score	0.465199 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	25
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP4E1_MOUSE
θ value	8.97725e-08 (rank : 27)	NC score	0.464551 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

GLI1_MOUSE
θ value	0.0431538 (rank : 28)	NC score	0.003482 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	785	Shared Neighborhood Hits	3
SwissProt Accessions	P47806, Q9QYK1	Gene names	Gli1, Gli
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene homolog).

TRIM7_HUMAN
θ value	0.0431538 (rank : 29)	NC score	0.028985 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	336	Shared Neighborhood Hits	8
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

SPAG6_HUMAN
θ value	0.0563607 (rank : 30)	NC score	0.098284 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

TPR_HUMAN
θ value	0.0736092 (rank : 31)	NC score	0.012129 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	1921	Shared Neighborhood Hits	13
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

FGD3_HUMAN
θ value	0.163984 (rank : 32)	NC score	0.012806 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	249	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

SPAG6_MOUSE
θ value	0.163984 (rank : 33)	NC score	0.086130 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

AAK1_MOUSE
θ value	0.21417 (rank : 34)	NC score	0.003523 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	1051	Shared Neighborhood Hits	4
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

K0056_HUMAN
θ value	0.21417 (rank : 35)	NC score	0.075088 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

ZFY28_HUMAN
θ value	0.279714 (rank : 36)	NC score	0.027649 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

RPTOR_HUMAN
θ value	0.365318 (rank : 37)	NC score	0.057789 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

TRIM7_MOUSE
θ value	0.365318 (rank : 38)	NC score	0.021476 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	358	Shared Neighborhood Hits	8
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

EVPL_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.025402 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	952	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

RPTOR_MOUSE
θ value	0.62314 (rank : 40)	NC score	0.053172 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

SPTB2_HUMAN
θ value	0.62314 (rank : 41)	NC score	0.018521 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	0.62314 (rank : 42)	NC score	0.018355 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	770	Shared Neighborhood Hits	10
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

K0226_HUMAN
θ value	0.813845 (rank : 43)	NC score	0.020527 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

KAD7_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.033150 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2H2, Q8BVH3	Gene names	Ak7
Domain Architecture
Description	Putative adenylate kinase 7 (EC 2.7.4.3).

ARID2_HUMAN
θ value	1.06291 (rank : 45)	NC score	0.029301 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	4
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

K0056_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.080393 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

TMED8_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.028376 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PL24, Q9P1V9	Gene names	TMED8
Domain Architecture	No domain graphic available
Description	Protein TMED8.

RRP5_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.044440 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

ARMC4_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.035676 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

CHD3_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.001471 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	397	Shared Neighborhood Hits	2
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

DYH5_MOUSE
θ value	6.88961 (rank : 51)	NC score	0.017402 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

FANCC_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.016442 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P50652	Gene names	Fancc, Fac, Facc
Domain Architecture
Description	Fanconi anemia group C protein homolog (Protein FACC).

ULK4_MOUSE
θ value	6.88961 (rank : 53)	NC score	-0.000365 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	793	Shared Neighborhood Hits	7
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

MACF1_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.007102 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	1341	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	8.99809 (rank : 55)	NC score	0.006936 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	1321	Shared Neighborhood Hits	10
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

NF1_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.014138 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.014091 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

PK3CA_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.011657 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

RFWD2_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.004244 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	518	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

IWS1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.051442 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	1241	Shared Neighborhood Hits	11
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.051556 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	1258	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

Hits sorted by NC score

AP1B1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_HUMAN
NC score	0.998411 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	52
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_MOUSE
NC score	0.996363 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.996343 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	44
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP4B1_MOUSE
NC score	0.889868 (rank : 5)	θ value	3.34088e-79 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
NC score	0.882734 (rank : 6)	θ value	1.40363e-77 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP3B1_MOUSE
NC score	0.806690 (rank : 7)	θ value	5.51964e-74 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
NC score	0.805846 (rank : 8)	θ value	2.73936e-73 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	283	Shared Neighborhood Hits	23
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
NC score	0.802210 (rank : 9)	θ value	1.27248e-70 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
NC score	0.800754 (rank : 10)	θ value	3.34864e-71 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3D1_MOUSE
NC score	0.584853 (rank : 11)	θ value	2.5182e-18 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
NC score	0.560077 (rank : 12)	θ value	8.10077e-17 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	254	Shared Neighborhood Hits	29
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

COPB_HUMAN
NC score	0.545669 (rank : 13)	θ value	3.76295e-14 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	23
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
NC score	0.545512 (rank : 14)	θ value	4.91457e-14 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	50	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP1G1_MOUSE
NC score	0.519713 (rank : 15)	θ value	3.76295e-14 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.518751 (rank : 16)	θ value	4.44505e-15 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_MOUSE
NC score	0.509849 (rank : 17)	θ value	1.47974e-10 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	52	Shared Neighborhood Hits	27
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A2_HUMAN
NC score	0.503958 (rank : 18)	θ value	3.88503e-19 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	39	Shared Neighborhood Hits	18
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
NC score	0.502620 (rank : 19)	θ value	8.65492e-19 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A1_HUMAN
NC score	0.479838 (rank : 20)	θ value	2.35696e-16 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
NC score	0.476931 (rank : 21)	θ value	1.80466e-16 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP4E1_HUMAN
NC score	0.469197 (rank : 22)	θ value	2.13673e-09 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP1G2_HUMAN
NC score	0.465199 (rank : 23)	θ value	1.80886e-08 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	25
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP4E1_MOUSE
NC score	0.464551 (rank : 24)	θ value	8.97725e-08 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

COPG2_MOUSE
NC score	0.415731 (rank : 25)	θ value	6.64225e-11 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
NC score	0.411351 (rank : 26)	θ value	8.67504e-11 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
NC score	0.373406 (rank : 27)	θ value	2.52405e-10 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

SPAG6_HUMAN
NC score	0.098284 (rank : 28)	θ value	0.0563607 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

SPAG6_MOUSE
NC score	0.086130 (rank : 29)	θ value	0.163984 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

K0056_MOUSE
NC score	0.080393 (rank : 30)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

K0056_HUMAN
NC score	0.075088 (rank : 31)	θ value	0.21417 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

RPTOR_HUMAN
NC score	0.057789 (rank : 32)	θ value	0.365318 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

RPTOR_MOUSE
NC score	0.053172 (rank : 33)	θ value	0.62314 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

IWS1_MOUSE
NC score	0.051556 (rank : 34)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	1258	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_HUMAN
NC score	0.051442 (rank : 35)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	1241	Shared Neighborhood Hits	11
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

RRP5_HUMAN
NC score	0.044440 (rank : 36)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

ARMC4_HUMAN
NC score	0.035676 (rank : 37)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

KAD7_MOUSE
NC score	0.033150 (rank : 38)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2H2, Q8BVH3	Gene names	Ak7
Domain Architecture
Description	Putative adenylate kinase 7 (EC 2.7.4.3).

ARID2_HUMAN
NC score	0.029301 (rank : 39)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	4
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

TRIM7_HUMAN
NC score	0.028985 (rank : 40)	θ value	0.0431538 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	336	Shared Neighborhood Hits	8
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TMED8_HUMAN
NC score	0.028376 (rank : 41)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PL24, Q9P1V9	Gene names	TMED8
Domain Architecture	No domain graphic available
Description	Protein TMED8.

ZFY28_HUMAN
NC score	0.027649 (rank : 42)	θ value	0.279714 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

EVPL_MOUSE
NC score	0.025402 (rank : 43)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	952	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

TRIM7_MOUSE
NC score	0.021476 (rank : 44)	θ value	0.365318 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	358	Shared Neighborhood Hits	8
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

K0226_HUMAN
NC score	0.020527 (rank : 45)	θ value	0.813845 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

SPTB2_HUMAN
NC score	0.018521 (rank : 46)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.018355 (rank : 47)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	770	Shared Neighborhood Hits	10
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

DYH5_MOUSE
NC score	0.017402 (rank : 48)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

FANCC_MOUSE
NC score	0.016442 (rank : 49)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P50652	Gene names	Fancc, Fac, Facc
Domain Architecture
Description	Fanconi anemia group C protein homolog (Protein FACC).

NF1_HUMAN
NC score	0.014138 (rank : 50)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

NF1_MOUSE
NC score	0.014091 (rank : 51)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

FGD3_HUMAN
NC score	0.012806 (rank : 52)	θ value	0.163984 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	249	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

TPR_HUMAN
NC score	0.012129 (rank : 53)	θ value	0.0736092 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	1921	Shared Neighborhood Hits	13
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

PK3CA_MOUSE
NC score	0.011657 (rank : 54)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

MACF1_HUMAN
NC score	0.007102 (rank : 55)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	1341	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
NC score	0.006936 (rank : 56)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	1321	Shared Neighborhood Hits	10
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

RFWD2_HUMAN
NC score	0.004244 (rank : 57)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	518	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

AAK1_MOUSE
NC score	0.003523 (rank : 58)	θ value	0.21417 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	1051	Shared Neighborhood Hits	4
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

GLI1_MOUSE
NC score	0.003482 (rank : 59)	θ value	0.0431538 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	785	Shared Neighborhood Hits	3
SwissProt Accessions	P47806, Q9QYK1	Gene names	Gli1, Gli
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene homolog).

CHD3_HUMAN
NC score	0.001471 (rank : 60)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	397	Shared Neighborhood Hits	2
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

ULK4_MOUSE
NC score	-0.000365 (rank : 61)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	793	Shared Neighborhood Hits	7
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).