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Network neighborhood for query Sequence : AP2A1_MOUSE

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AP2A1_MOUSE
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP2A1_HUMAN
θ value	0 (rank : 1)	NC score	0.996547 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	56	Shared Neighborhood Hits	42
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A2_HUMAN
θ value	0 (rank : 3)	NC score	0.993685 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	39	Shared Neighborhood Hits	22
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	0 (rank : 4)	NC score	0.993175 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	46	Shared Neighborhood Hits	23
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP1G1_HUMAN
θ value	3.34864e-71 (rank : 5)	NC score	0.841814 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	3.34864e-71 (rank : 6)	NC score	0.844862 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	67	Shared Neighborhood Hits	19
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_HUMAN
θ value	1.45591e-66 (rank : 7)	NC score	0.850590 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G2_MOUSE
θ value	4.23606e-66 (rank : 8)	NC score	0.841455 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	52	Shared Neighborhood Hits	18
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP4E1_MOUSE
θ value	2.95404e-43 (rank : 9)	NC score	0.808548 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_HUMAN
θ value	1.46607e-42 (rank : 10)	NC score	0.809083 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP3D1_MOUSE
θ value	1.79631e-32 (rank : 11)	NC score	0.761273 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	144	Shared Neighborhood Hits	19
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
θ value	3.06405e-32 (rank : 12)	NC score	0.736858 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP2B1_HUMAN
θ value	6.20254e-17 (rank : 13)	NC score	0.473435 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	6.20254e-17 (rank : 14)	NC score	0.473449 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_MOUSE
θ value	1.80466e-16 (rank : 15)	NC score	0.476931 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_HUMAN
θ value	3.07829e-16 (rank : 16)	NC score	0.475375 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

OGFR_HUMAN
θ value	0.0193708 (rank : 17)	NC score	0.033759 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	1582	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

MAGE1_HUMAN
θ value	0.0736092 (rank : 18)	NC score	0.017332 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	1389	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

GAK_MOUSE
θ value	0.279714 (rank : 19)	NC score	0.005174 (rank : 65)
Query Neighborhood Hits	57	Target Neighborhood Hits	964	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

SMAP1_MOUSE
θ value	0.365318 (rank : 20)	NC score	0.020389 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	120	Shared Neighborhood Hits	6
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

OGFR_MOUSE
θ value	0.813845 (rank : 21)	NC score	0.030958 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	584	Shared Neighborhood Hits	11
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

MISS_MOUSE
θ value	1.06291 (rank : 22)	NC score	0.022735 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	444	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MTSS1_MOUSE
θ value	1.06291 (rank : 23)	NC score	0.032793 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	592	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

OSBL8_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.025371 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

BSN_MOUSE
θ value	1.81305 (rank : 25)	NC score	0.012253 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	2057	Shared Neighborhood Hits	24
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CG1_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.025044 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	222	Shared Neighborhood Hits	9
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CNTRB_MOUSE
θ value	1.81305 (rank : 27)	NC score	0.016613 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	1029	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CO039_MOUSE
θ value	1.81305 (rank : 28)	NC score	0.026519 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	445	Shared Neighborhood Hits	14
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

GRIK5_MOUSE
θ value	1.81305 (rank : 29)	NC score	0.014597 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

NAF1_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.012521 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	852	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

SON_HUMAN
θ value	1.81305 (rank : 31)	NC score	0.012739 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	1568	Shared Neighborhood Hits	23
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

IF2P_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.007071 (rank : 63)
Query Neighborhood Hits	57	Target Neighborhood Hits	889	Shared Neighborhood Hits	5
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

JIP1_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.019174 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PLEC1_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.003849 (rank : 68)
Query Neighborhood Hits	57	Target Neighborhood Hits	1326	Shared Neighborhood Hits	8
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

AP4B1_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.250690 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

BIN1_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.015828 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	283	Shared Neighborhood Hits	9
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CO7A1_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.004742 (rank : 66)
Query Neighborhood Hits	57	Target Neighborhood Hits	807	Shared Neighborhood Hits	12
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

EGR4_MOUSE
θ value	3.0926 (rank : 38)	NC score	-0.000987 (rank : 72)
Query Neighborhood Hits	57	Target Neighborhood Hits	710	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUF2	Gene names	Egr4
Domain Architecture
Description	Early growth response protein 4 (EGR-4).

MGRN1_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.012795 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	192	Shared Neighborhood Hits	2
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

CU005_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.016553 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3R5, Q9UEZ3	Gene names	C21orf5, KIAA0933
Domain Architecture
Description	Protein C21orf5.

MAP2_MOUSE
θ value	4.03905 (rank : 41)	NC score	0.012361 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	342	Shared Neighborhood Hits	9
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

MYO15_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.004154 (rank : 67)
Query Neighborhood Hits	57	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ANR25_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.008077 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	398	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ASPP1_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.009933 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	1244	Shared Neighborhood Hits	19
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CFAD_HUMAN
θ value	5.27518 (rank : 45)	NC score	0.000871 (rank : 71)
Query Neighborhood Hits	57	Target Neighborhood Hits	176	Shared Neighborhood Hits	2
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

NEK11_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.002372 (rank : 70)
Query Neighborhood Hits	57	Target Neighborhood Hits	1043	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PRRT3_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.011565 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	998	Shared Neighborhood Hits	18
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SRCA_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.011747 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	380	Shared Neighborhood Hits	9
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SSH1_HUMAN
θ value	6.88961 (rank : 49)	NC score	0.006664 (rank : 64)
Query Neighborhood Hits	57	Target Neighborhood Hits	164	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

STAT2_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.007800 (rank : 62)
Query Neighborhood Hits	57	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	P52630, Q16430, Q16431	Gene names	STAT2
Domain Architecture
Description	Signal transducer and activator of transcription 2 (p113).

TAU_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.024246 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	448	Shared Neighborhood Hits	14
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

AP4B1_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.229519 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

FMN2_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.009992 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	484	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

GRIK5_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.011305 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

RIB1_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.012073 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YQ5, Q3U985	Gene names	Rpn1
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit precursor (EC 2.4.1.119) (Ribophorin I) (RPN-I).

SYYC_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.016686 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P54577, O43276, Q53EN1	Gene names	YARS
Domain Architecture
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

USH1C_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.003087 (rank : 69)
Query Neighborhood Hits	57	Target Neighborhood Hits	557	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

AP3B1_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.195956 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	283	Shared Neighborhood Hits	16
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.195534 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	302	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.162869 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	246	Shared Neighborhood Hits	16
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.163410 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	246	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

COPB_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.220058 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.220548 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPG2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.114828 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.122486 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.109712 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

GGA1_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.091228 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA1_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.089195 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	128	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA2_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.104267 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

GGA2_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.108116 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

GGA3_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.100293 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA3_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.102301 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

Hits sorted by NC score

AP2A1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_HUMAN
NC score	0.996547 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	56	Shared Neighborhood Hits	42
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A2_HUMAN
NC score	0.993685 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	39	Shared Neighborhood Hits	22
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
NC score	0.993175 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	46	Shared Neighborhood Hits	23
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP1G2_HUMAN
NC score	0.850590 (rank : 5)	θ value	1.45591e-66 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G1_MOUSE
NC score	0.844862 (rank : 6)	θ value	3.34864e-71 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	67	Shared Neighborhood Hits	19
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.841814 (rank : 7)	θ value	3.34864e-71 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_MOUSE
NC score	0.841455 (rank : 8)	θ value	4.23606e-66 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	52	Shared Neighborhood Hits	18
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP4E1_HUMAN
NC score	0.809083 (rank : 9)	θ value	1.46607e-42 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
NC score	0.808548 (rank : 10)	θ value	2.95404e-43 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP3D1_MOUSE
NC score	0.761273 (rank : 11)	θ value	1.79631e-32 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	144	Shared Neighborhood Hits	19
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
NC score	0.736858 (rank : 12)	θ value	3.06405e-32 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP1B1_MOUSE
NC score	0.476931 (rank : 13)	θ value	1.80466e-16 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_HUMAN
NC score	0.475375 (rank : 14)	θ value	3.07829e-16 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_MOUSE
NC score	0.473449 (rank : 15)	θ value	6.20254e-17 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.473435 (rank : 16)	θ value	6.20254e-17 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP4B1_MOUSE
NC score	0.250690 (rank : 17)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
NC score	0.229519 (rank : 18)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

COPB_MOUSE
NC score	0.220548 (rank : 19)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_HUMAN
NC score	0.220058 (rank : 20)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	57	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP3B1_HUMAN
NC score	0.195956 (rank : 21)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	283	Shared Neighborhood Hits	16
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_MOUSE
NC score	0.195534 (rank : 22)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	302	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_MOUSE
NC score	0.163410 (rank : 23)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	246	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP3B2_HUMAN
NC score	0.162869 (rank : 24)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	246	Shared Neighborhood Hits	16
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

COPG2_MOUSE
NC score	0.122486 (rank : 25)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	57	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
NC score	0.114828 (rank : 26)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	57	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
NC score	0.109712 (rank : 27)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	57	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

GGA2_MOUSE
NC score	0.108116 (rank : 28)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	57	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

GGA2_HUMAN
NC score	0.104267 (rank : 29)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	57	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

GGA3_MOUSE
NC score	0.102301 (rank : 30)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	57	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA3_HUMAN
NC score	0.100293 (rank : 31)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	57	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA1_HUMAN
NC score	0.091228 (rank : 32)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	57	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA1_MOUSE
NC score	0.089195 (rank : 33)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	57	Target Neighborhood Hits	128	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

OGFR_HUMAN
NC score	0.033759 (rank : 34)	θ value	0.0193708 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	1582	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

MTSS1_MOUSE
NC score	0.032793 (rank : 35)	θ value	1.06291 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	592	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

OGFR_MOUSE
NC score	0.030958 (rank : 36)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	584	Shared Neighborhood Hits	11
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

CO039_MOUSE
NC score	0.026519 (rank : 37)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	445	Shared Neighborhood Hits	14
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

OSBL8_HUMAN
NC score	0.025371 (rank : 38)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

CG1_HUMAN
NC score	0.025044 (rank : 39)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	222	Shared Neighborhood Hits	9
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

TAU_HUMAN
NC score	0.024246 (rank : 40)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	448	Shared Neighborhood Hits	14
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

MISS_MOUSE
NC score	0.022735 (rank : 41)	θ value	1.06291 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	444	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

SMAP1_MOUSE
NC score	0.020389 (rank : 42)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	120	Shared Neighborhood Hits	6
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

JIP1_HUMAN
NC score	0.019174 (rank : 43)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MAGE1_HUMAN
NC score	0.017332 (rank : 44)	θ value	0.0736092 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	1389	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SYYC_HUMAN
NC score	0.016686 (rank : 45)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P54577, O43276, Q53EN1	Gene names	YARS
Domain Architecture
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

CNTRB_MOUSE
NC score	0.016613 (rank : 46)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	1029	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CU005_HUMAN
NC score	0.016553 (rank : 47)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3R5, Q9UEZ3	Gene names	C21orf5, KIAA0933
Domain Architecture
Description	Protein C21orf5.

BIN1_MOUSE
NC score	0.015828 (rank : 48)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	283	Shared Neighborhood Hits	9
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

GRIK5_MOUSE
NC score	0.014597 (rank : 49)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

MGRN1_HUMAN
NC score	0.012795 (rank : 50)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	192	Shared Neighborhood Hits	2
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

SON_HUMAN
NC score	0.012739 (rank : 51)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	1568	Shared Neighborhood Hits	23
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NAF1_MOUSE
NC score	0.012521 (rank : 52)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	852	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

MAP2_MOUSE
NC score	0.012361 (rank : 53)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	342	Shared Neighborhood Hits	9
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

BSN_MOUSE
NC score	0.012253 (rank : 54)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	2057	Shared Neighborhood Hits	24
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

RIB1_MOUSE
NC score	0.012073 (rank : 55)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YQ5, Q3U985	Gene names	Rpn1
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit precursor (EC 2.4.1.119) (Ribophorin I) (RPN-I).

SRCA_HUMAN
NC score	0.011747 (rank : 56)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	380	Shared Neighborhood Hits	9
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

PRRT3_HUMAN
NC score	0.011565 (rank : 57)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	998	Shared Neighborhood Hits	18
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

GRIK5_HUMAN
NC score	0.011305 (rank : 58)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

FMN2_HUMAN
NC score	0.009992 (rank : 59)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	484	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

ASPP1_MOUSE
NC score	0.009933 (rank : 60)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	1244	Shared Neighborhood Hits	19
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ANR25_MOUSE
NC score	0.008077 (rank : 61)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	398	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

STAT2_HUMAN
NC score	0.007800 (rank : 62)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	P52630, Q16430, Q16431	Gene names	STAT2
Domain Architecture
Description	Signal transducer and activator of transcription 2 (p113).

IF2P_HUMAN
NC score	0.007071 (rank : 63)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	889	Shared Neighborhood Hits	5
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

SSH1_HUMAN
NC score	0.006664 (rank : 64)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	164	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

GAK_MOUSE
NC score	0.005174 (rank : 65)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	964	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

CO7A1_HUMAN
NC score	0.004742 (rank : 66)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	807	Shared Neighborhood Hits	12
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

MYO15_HUMAN
NC score	0.004154 (rank : 67)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PLEC1_HUMAN
NC score	0.003849 (rank : 68)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	1326	Shared Neighborhood Hits	8
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

USH1C_MOUSE
NC score	0.003087 (rank : 69)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	557	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

NEK11_HUMAN
NC score	0.002372 (rank : 70)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	1043	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

CFAD_HUMAN
NC score	0.000871 (rank : 71)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	176	Shared Neighborhood Hits	2
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

EGR4_MOUSE
NC score	-0.000987 (rank : 72)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	710	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUF2	Gene names	Egr4
Domain Architecture
Description	Early growth response protein 4 (EGR-4).