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Network neighborhood for query Sequence : AP2A2_MOUSE

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AP2A2_MOUSE
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP2A1_HUMAN
θ value	0 (rank : 1)	NC score	0.991037 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
θ value	0 (rank : 2)	NC score	0.993175 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A2_HUMAN
θ value	0 (rank : 3)	NC score	0.998406 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	39	Shared Neighborhood Hits	31
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP1G1_MOUSE
θ value	2.3998e-69 (rank : 5)	NC score	0.847247 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	67	Shared Neighborhood Hits	18
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
θ value	3.13423e-69 (rank : 6)	NC score	0.844503 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_HUMAN
θ value	5.53243e-66 (rank : 7)	NC score	0.853566 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G2_MOUSE
θ value	1.6097e-65 (rank : 8)	NC score	0.846148 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	52	Shared Neighborhood Hits	19
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP4E1_MOUSE
θ value	1.62093e-41 (rank : 9)	NC score	0.808949 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_HUMAN
θ value	8.04462e-41 (rank : 10)	NC score	0.809434 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP3D1_MOUSE
θ value	1.57e-36 (rank : 11)	NC score	0.774125 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
θ value	7.79185e-36 (rank : 12)	NC score	0.749127 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	254	Shared Neighborhood Hits	19
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP2B1_HUMAN
θ value	2.27762e-19 (rank : 13)	NC score	0.499275 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	2.27762e-19 (rank : 14)	NC score	0.499290 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_MOUSE
θ value	8.65492e-19 (rank : 15)	NC score	0.502620 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_HUMAN
θ value	1.47631e-18 (rank : 16)	NC score	0.500551 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP4B1_HUMAN
θ value	0.00509761 (rank : 17)	NC score	0.267802 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_MOUSE
θ value	0.0113563 (rank : 18)	NC score	0.287544 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

CNTRB_MOUSE
θ value	0.0252991 (rank : 19)	NC score	0.021000 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	1029	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

MLL3_MOUSE
θ value	0.0252991 (rank : 20)	NC score	0.026357 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	1399	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SAPS3_HUMAN
θ value	0.365318 (rank : 21)	NC score	0.034594 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q5H9R7, Q3B7I1, Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3	Gene names	SAPS3, C11orf23, KIAA1558, PP6R3, SAPL
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3 (Sporulation-induced transcript 4- associated protein SAPL) (Protein phosphatase 6 regulatory subunit 3).

CAND2_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.021382 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

SAPS3_MOUSE
θ value	1.38821 (rank : 23)	NC score	0.029237 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	Q922D4, Q6ZPM9, Q8BTW6, Q9D2X9	Gene names	Saps3, D19Ertd703e, Kiaa1558
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3.

PI5PA_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.019907 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	749	Shared Neighborhood Hits	10
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

NEK11_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.002150 (rank : 60)
Query Neighborhood Hits	46	Target Neighborhood Hits	1043	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PI4KA_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.018199 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

MLL3_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.021032 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	1644	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

TB182_HUMAN
θ value	3.0926 (rank : 28)	NC score	0.022536 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	414	Shared Neighborhood Hits	8
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TCEA1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.010309 (rank : 48)
Query Neighborhood Hits	46	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P23193, Q15563, Q6FG87	Gene names	TCEA1, TFIIS
Domain Architecture
Description	Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o).

EVI1_MOUSE
θ value	4.03905 (rank : 30)	NC score	-0.001740 (rank : 61)
Query Neighborhood Hits	46	Target Neighborhood Hits	826	Shared Neighborhood Hits	2
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

NBN_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.014944 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

OSBL8_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.022938 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

BAT3_MOUSE
θ value	5.27518 (rank : 33)	NC score	0.016901 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	518	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

CEL_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.002298 (rank : 58)
Query Neighborhood Hits	46	Target Neighborhood Hits	896	Shared Neighborhood Hits	8
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

GRIK5_HUMAN
θ value	5.27518 (rank : 35)	NC score	0.010369 (rank : 47)
Query Neighborhood Hits	46	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

SM1L2_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.002958 (rank : 55)
Query Neighborhood Hits	46	Target Neighborhood Hits	1019	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

GRIK5_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.013372 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

PER3_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.010241 (rank : 49)
Query Neighborhood Hits	46	Target Neighborhood Hits	479	Shared Neighborhood Hits	9
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

TBX21_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.003444 (rank : 54)
Query Neighborhood Hits	46	Target Neighborhood Hits	146	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

ENAH_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.005572 (rank : 52)
Query Neighborhood Hits	46	Target Neighborhood Hits	784	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

JIP2_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.005522 (rank : 53)
Query Neighborhood Hits	46	Target Neighborhood Hits	288	Shared Neighborhood Hits	5
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

KI13B_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.002588 (rank : 57)
Query Neighborhood Hits	46	Target Neighborhood Hits	492	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

LPP_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.002198 (rank : 59)
Query Neighborhood Hits	46	Target Neighborhood Hits	775	Shared Neighborhood Hits	9
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MNAB_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.005941 (rank : 51)
Query Neighborhood Hits	46	Target Neighborhood Hits	231	Shared Neighborhood Hits	5
SwissProt Accessions	P0C090	Gene names	Mnab
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein.

PGCA_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.002725 (rank : 56)
Query Neighborhood Hits	46	Target Neighborhood Hits	821	Shared Neighborhood Hits	8
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

VPS54_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.007591 (rank : 50)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P1Q0, Q5VIR5, Q86YF7, Q8N6G3, Q9NPV0, Q9NT07, Q9NUJ0	Gene names	VPS54, HCC8
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 54 (Tumor antigen SLP-8p) (Hepatocellular carcinoma protein 8).

AP3B1_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.213945 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	283	Shared Neighborhood Hits	15
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.213526 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	302	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.181942 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	246	Shared Neighborhood Hits	16
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.181386 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	246	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

COPB_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.230500 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.230949 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPG2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.125137 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	33	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.133078 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.118720 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

GGA1_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.092474 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	169	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA1_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.087034 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA2_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.104360 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

GGA2_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.107941 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

GGA3_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.100153 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA3_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.099963 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	148	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

Hits sorted by NC score

AP2A2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A2_HUMAN
NC score	0.998406 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	39	Shared Neighborhood Hits	31
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A1_MOUSE
NC score	0.993175 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_HUMAN
NC score	0.991037 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP1G2_HUMAN
NC score	0.853566 (rank : 5)	θ value	5.53243e-66 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G1_MOUSE
NC score	0.847247 (rank : 6)	θ value	2.3998e-69 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	67	Shared Neighborhood Hits	18
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_MOUSE
NC score	0.846148 (rank : 7)	θ value	1.6097e-65 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	52	Shared Neighborhood Hits	19
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G1_HUMAN
NC score	0.844503 (rank : 8)	θ value	3.13423e-69 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP4E1_HUMAN
NC score	0.809434 (rank : 9)	θ value	8.04462e-41 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
NC score	0.808949 (rank : 10)	θ value	1.62093e-41 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP3D1_MOUSE
NC score	0.774125 (rank : 11)	θ value	1.57e-36 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
NC score	0.749127 (rank : 12)	θ value	7.79185e-36 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	254	Shared Neighborhood Hits	19
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP1B1_MOUSE
NC score	0.502620 (rank : 13)	θ value	8.65492e-19 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_HUMAN
NC score	0.500551 (rank : 14)	θ value	1.47631e-18 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_MOUSE
NC score	0.499290 (rank : 15)	θ value	2.27762e-19 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.499275 (rank : 16)	θ value	2.27762e-19 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	59	Shared Neighborhood Hits	18
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP4B1_MOUSE
NC score	0.287544 (rank : 17)	θ value	0.0113563 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
NC score	0.267802 (rank : 18)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

COPB_MOUSE
NC score	0.230949 (rank : 19)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	46	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_HUMAN
NC score	0.230500 (rank : 20)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP3B1_HUMAN
NC score	0.213945 (rank : 21)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	46	Target Neighborhood Hits	283	Shared Neighborhood Hits	15
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_MOUSE
NC score	0.213526 (rank : 22)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	46	Target Neighborhood Hits	302	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
NC score	0.181942 (rank : 23)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	46	Target Neighborhood Hits	246	Shared Neighborhood Hits	16
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
NC score	0.181386 (rank : 24)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	46	Target Neighborhood Hits	246	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

COPG2_MOUSE
NC score	0.133078 (rank : 25)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
NC score	0.125137 (rank : 26)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	46	Target Neighborhood Hits	33	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
NC score	0.118720 (rank : 27)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

GGA2_MOUSE
NC score	0.107941 (rank : 28)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	46	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

GGA2_HUMAN
NC score	0.104360 (rank : 29)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	46	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

GGA3_HUMAN
NC score	0.100153 (rank : 30)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	46	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA3_MOUSE
NC score	0.099963 (rank : 31)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	46	Target Neighborhood Hits	148	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA1_HUMAN
NC score	0.092474 (rank : 32)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	46	Target Neighborhood Hits	169	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA1_MOUSE
NC score	0.087034 (rank : 33)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	46	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

SAPS3_HUMAN
NC score	0.034594 (rank : 34)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q5H9R7, Q3B7I1, Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3	Gene names	SAPS3, C11orf23, KIAA1558, PP6R3, SAPL
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3 (Sporulation-induced transcript 4- associated protein SAPL) (Protein phosphatase 6 regulatory subunit 3).

SAPS3_MOUSE
NC score	0.029237 (rank : 35)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	Q922D4, Q6ZPM9, Q8BTW6, Q9D2X9	Gene names	Saps3, D19Ertd703e, Kiaa1558
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3.

MLL3_MOUSE
NC score	0.026357 (rank : 36)	θ value	0.0252991 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	1399	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

OSBL8_HUMAN
NC score	0.022938 (rank : 37)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

TB182_HUMAN
NC score	0.022536 (rank : 38)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	414	Shared Neighborhood Hits	8
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

CAND2_MOUSE
NC score	0.021382 (rank : 39)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

MLL3_HUMAN
NC score	0.021032 (rank : 40)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	1644	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CNTRB_MOUSE
NC score	0.021000 (rank : 41)	θ value	0.0252991 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	1029	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

PI5PA_HUMAN
NC score	0.019907 (rank : 42)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	749	Shared Neighborhood Hits	10
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PI4KA_HUMAN
NC score	0.018199 (rank : 43)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

BAT3_MOUSE
NC score	0.016901 (rank : 44)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	518	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

NBN_MOUSE
NC score	0.014944 (rank : 45)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

GRIK5_MOUSE
NC score	0.013372 (rank : 46)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

GRIK5_HUMAN
NC score	0.010369 (rank : 47)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

TCEA1_HUMAN
NC score	0.010309 (rank : 48)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P23193, Q15563, Q6FG87	Gene names	TCEA1, TFIIS
Domain Architecture
Description	Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o).

PER3_HUMAN
NC score	0.010241 (rank : 49)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	479	Shared Neighborhood Hits	9
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

VPS54_HUMAN
NC score	0.007591 (rank : 50)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P1Q0, Q5VIR5, Q86YF7, Q8N6G3, Q9NPV0, Q9NT07, Q9NUJ0	Gene names	VPS54, HCC8
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 54 (Tumor antigen SLP-8p) (Hepatocellular carcinoma protein 8).

MNAB_MOUSE
NC score	0.005941 (rank : 51)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	231	Shared Neighborhood Hits	5
SwissProt Accessions	P0C090	Gene names	Mnab
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein.

ENAH_HUMAN
NC score	0.005572 (rank : 52)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	784	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

JIP2_HUMAN
NC score	0.005522 (rank : 53)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	288	Shared Neighborhood Hits	5
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

TBX21_HUMAN
NC score	0.003444 (rank : 54)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	146	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

SM1L2_HUMAN
NC score	0.002958 (rank : 55)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	1019	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

PGCA_HUMAN
NC score	0.002725 (rank : 56)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	821	Shared Neighborhood Hits	8
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

KI13B_HUMAN
NC score	0.002588 (rank : 57)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	492	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

CEL_HUMAN
NC score	0.002298 (rank : 58)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	896	Shared Neighborhood Hits	8
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

LPP_HUMAN
NC score	0.002198 (rank : 59)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	775	Shared Neighborhood Hits	9
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

NEK11_HUMAN
NC score	0.002150 (rank : 60)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	1043	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

EVI1_MOUSE
NC score	-0.001740 (rank : 61)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	826	Shared Neighborhood Hits	2
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.