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Network neighborhood for query Sequence : AP4E1_MOUSE

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AP4E1_MOUSE
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP4E1_HUMAN
θ value	0 (rank : 1)	NC score	0.995346 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP1G1_HUMAN
θ value	5.73848e-55 (rank : 3)	NC score	0.836973 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	5.73848e-55 (rank : 4)	NC score	0.839732 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_MOUSE
θ value	5.20228e-48 (rank : 5)	NC score	0.829265 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G2_HUMAN
θ value	1.32601e-43 (rank : 6)	NC score	0.829555 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A1_HUMAN
θ value	2.26182e-43 (rank : 7)	NC score	0.813787 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
θ value	2.95404e-43 (rank : 8)	NC score	0.808548 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A2_HUMAN
θ value	5.57106e-42 (rank : 9)	NC score	0.809964 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	1.62093e-41 (rank : 10)	NC score	0.808949 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP3D1_MOUSE
θ value	8.04462e-41 (rank : 11)	NC score	0.809541 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP3D1_HUMAN
θ value	7.52953e-39 (rank : 12)	NC score	0.782865 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	254	Shared Neighborhood Hits	27
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

COPB_HUMAN
θ value	1.80886e-08 (rank : 13)	NC score	0.415596 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_MOUSE
θ value	1.80886e-08 (rank : 14)	NC score	0.416005 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP1B1_HUMAN
θ value	5.26297e-08 (rank : 15)	NC score	0.463076 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_MOUSE
θ value	8.97725e-08 (rank : 16)	NC score	0.464551 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_HUMAN
θ value	2.61198e-07 (rank : 17)	NC score	0.453651 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	2.61198e-07 (rank : 18)	NC score	0.453666 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP3B1_MOUSE
θ value	5.44631e-05 (rank : 19)	NC score	0.292871 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_HUMAN
θ value	7.1131e-05 (rank : 20)	NC score	0.293768 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	283	Shared Neighborhood Hits	23
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B2_HUMAN
θ value	0.0113563 (rank : 21)	NC score	0.248362 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
θ value	0.0113563 (rank : 22)	NC score	0.246566 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

COPG2_MOUSE
θ value	0.0563607 (rank : 23)	NC score	0.188016 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

MLL3_HUMAN
θ value	0.0563607 (rank : 24)	NC score	0.024764 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	1644	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

COPG2_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.179590 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

LSP1_MOUSE
θ value	0.47712 (rank : 26)	NC score	0.038591 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65	Gene names	Lsp1, Pp52, S37, Wp34
Domain Architecture
Description	Lymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein) (Lymphocyte-specific antigen WP34) (S37 protein).

TNPO1_HUMAN
θ value	0.62314 (rank : 27)	NC score	0.058544 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	64	Shared Neighborhood Hits	6
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
θ value	0.62314 (rank : 28)	NC score	0.058614 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO2_HUMAN
θ value	0.62314 (rank : 29)	NC score	0.059013 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
θ value	0.62314 (rank : 30)	NC score	0.058929 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

LRRF1_MOUSE
θ value	0.813845 (rank : 31)	NC score	0.022150 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	440	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

APOA4_HUMAN
θ value	1.06291 (rank : 32)	NC score	0.024294 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	399	Shared Neighborhood Hits	3
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

BBS7_HUMAN
θ value	1.06291 (rank : 33)	NC score	0.046758 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWZ6, Q4W5P8, Q8N581, Q9NVI4	Gene names	BBS7, BBS2L1
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 7 protein (BBS2-like protein 1).

BBS7_MOUSE
θ value	1.06291 (rank : 34)	NC score	0.046910 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2G4, Q8C7G3, Q8CH00, Q9CXC2	Gene names	Bbs7, Bbs2l1
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 7 protein homolog (BBS2-like protein 1).

COPG_HUMAN
θ value	1.06291 (rank : 35)	NC score	0.162367 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

CEP35_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.028185 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	811	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CNGB1_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.013898 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	222	Shared Neighborhood Hits	5
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

ARGI1_MOUSE
θ value	1.81305 (rank : 38)	NC score	0.019083 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q61176, Q80VI4	Gene names	Arg1
Domain Architecture
Description	Arginase-1 (EC 3.5.3.1) (Type I arginase) (Liver-type arginase).

EGR2_MOUSE
θ value	1.81305 (rank : 39)	NC score	-0.000141 (rank : 67)
Query Neighborhood Hits	59	Target Neighborhood Hits	745	Shared Neighborhood Hits	2
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

PDXL2_MOUSE
θ value	1.81305 (rank : 40)	NC score	0.021789 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

KCNH8_HUMAN
θ value	2.36792 (rank : 41)	NC score	0.009701 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

PGCA_HUMAN
θ value	3.0926 (rank : 42)	NC score	0.005830 (rank : 63)
Query Neighborhood Hits	59	Target Neighborhood Hits	821	Shared Neighborhood Hits	7
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

RAI2_MOUSE
θ value	3.0926 (rank : 43)	NC score	0.019077 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QVY8	Gene names	Rai2
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 2 (3f8).

FA21C_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.018826 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

MBB1A_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.017229 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	233	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

NOE1_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.009522 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	266	Shared Neighborhood Hits	4
SwissProt Accessions	Q99784, Q969S7, Q99452	Gene names	OLFM1, NOE1, NOEL1
Domain Architecture
Description	Noelin precursor (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1).

SOX6_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.006430 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	341	Shared Neighborhood Hits	2
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

ZF106_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.009486 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	470	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

NHS_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.015639 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

PDE8B_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.005865 (rank : 62)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

BCAS1_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.012956 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

GP115_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.005467 (rank : 65)
Query Neighborhood Hits	59	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZF3, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6	Gene names	GPR115, PGR18
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 (G-protein coupled receptor PGR18).

MYST3_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.006526 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	772	Shared Neighborhood Hits	6
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

PP1R8_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.023730 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3G1, Q8C087	Gene names	Ppp1r8, Nipp1
Domain Architecture	No domain graphic available
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8).

AKAP1_HUMAN
θ value	8.99809 (rank : 55)	NC score	0.008421 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

GP125_MOUSE
θ value	8.99809 (rank : 56)	NC score	0.001422 (rank : 66)
Query Neighborhood Hits	59	Target Neighborhood Hits	329	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

KLOT_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.005510 (rank : 64)
Query Neighborhood Hits	59	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UEF7, Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0	Gene names	KL
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

NOE1_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.007712 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	258	Shared Neighborhood Hits	4
SwissProt Accessions	O88998, O35429, O88999, Q91XK8, Q9QWQ9, Q9QWR0	Gene names	Olfm1, Noe1, Noel, Noel1
Domain Architecture
Description	Noelin precursor (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin).

SUFU_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.031409 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMX1, Q7LCP7, Q9NT90, Q9NZ07, Q9UHK2, Q9UHM8, Q9UMY0	Gene names	SUFU
Domain Architecture	No domain graphic available
Description	Suppressor of fused homolog (SUFUH).

AP4B1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.231340 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.254318 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

GGA1_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.095262 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA1_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.090017 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	128	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.107974 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

GGA2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.110644 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

GGA3_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.103131 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA3_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.102867 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	148	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

Hits sorted by NC score

AP4E1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP4E1_HUMAN
NC score	0.995346 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

AP1G1_MOUSE
NC score	0.839732 (rank : 3)	θ value	5.73848e-55 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.836973 (rank : 4)	θ value	5.73848e-55 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G2_HUMAN
NC score	0.829555 (rank : 5)	θ value	1.32601e-43 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	44	Shared Neighborhood Hits	23
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP1G2_MOUSE
NC score	0.829265 (rank : 6)	θ value	5.20228e-48 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O88512	Gene names	Ap1g2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

AP2A1_HUMAN
NC score	0.813787 (rank : 7)	θ value	2.26182e-43 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A2_HUMAN
NC score	0.809964 (rank : 8)	θ value	5.57106e-42 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP3D1_MOUSE
NC score	0.809541 (rank : 9)	θ value	8.04462e-41 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

AP2A2_MOUSE
NC score	0.808949 (rank : 10)	θ value	1.62093e-41 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

AP2A1_MOUSE
NC score	0.808548 (rank : 11)	θ value	2.95404e-43 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP3D1_HUMAN
NC score	0.782865 (rank : 12)	θ value	7.52953e-39 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	254	Shared Neighborhood Hits	27
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AP1B1_MOUSE
NC score	0.464551 (rank : 13)	θ value	8.97725e-08 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_HUMAN
NC score	0.463076 (rank : 14)	θ value	5.26297e-08 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_MOUSE
NC score	0.453666 (rank : 15)	θ value	2.61198e-07 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.453651 (rank : 16)	θ value	2.61198e-07 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

COPB_MOUSE
NC score	0.416005 (rank : 17)	θ value	1.80886e-08 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIF7	Gene names	Copb1, Copb
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

COPB_HUMAN
NC score	0.415596 (rank : 18)	θ value	1.80886e-08 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	P53618, Q6GTT7, Q9NTK2, Q9UNW7	Gene names	COPB1, COPB
Domain Architecture
Description	Coatomer subunit beta (Beta-coat protein) (Beta-COP).

AP3B1_HUMAN
NC score	0.293768 (rank : 19)	θ value	7.1131e-05 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	283	Shared Neighborhood Hits	23
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP3B1_MOUSE
NC score	0.292871 (rank : 20)	θ value	5.44631e-05 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	302	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

AP4B1_MOUSE
NC score	0.254318 (rank : 21)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP3B2_HUMAN
NC score	0.248362 (rank : 22)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

AP3B2_MOUSE
NC score	0.246566 (rank : 23)	θ value	0.0113563 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	246	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

AP4B1_HUMAN
NC score	0.231340 (rank : 24)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

COPG2_MOUSE
NC score	0.188016 (rank : 25)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXK3	Gene names	Copg2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG2_HUMAN
NC score	0.179590 (rank : 26)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBF2	Gene names	COPG2
Domain Architecture
Description	Coatomer subunit gamma-2 (Gamma-2 coat protein) (Gamma-2 COP).

COPG_HUMAN
NC score	0.162367 (rank : 27)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

GGA2_MOUSE
NC score	0.110644 (rank : 28)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	59	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

GGA2_HUMAN
NC score	0.107974 (rank : 29)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	59	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

GGA3_HUMAN
NC score	0.103131 (rank : 30)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	59	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA3_MOUSE
NC score	0.102867 (rank : 31)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	59	Target Neighborhood Hits	148	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GGA1_HUMAN
NC score	0.095262 (rank : 32)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	59	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA1_MOUSE
NC score	0.090017 (rank : 33)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	59	Target Neighborhood Hits	128	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

TNPO2_HUMAN
NC score	0.059013 (rank : 34)	θ value	0.62314 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
NC score	0.058929 (rank : 35)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO1_MOUSE
NC score	0.058614 (rank : 36)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO1_HUMAN
NC score	0.058544 (rank : 37)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	64	Shared Neighborhood Hits	6
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

BBS7_MOUSE
NC score	0.046910 (rank : 38)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2G4, Q8C7G3, Q8CH00, Q9CXC2	Gene names	Bbs7, Bbs2l1
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 7 protein homolog (BBS2-like protein 1).

BBS7_HUMAN
NC score	0.046758 (rank : 39)	θ value	1.06291 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWZ6, Q4W5P8, Q8N581, Q9NVI4	Gene names	BBS7, BBS2L1
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 7 protein (BBS2-like protein 1).

LSP1_MOUSE
NC score	0.038591 (rank : 40)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65	Gene names	Lsp1, Pp52, S37, Wp34
Domain Architecture
Description	Lymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein) (Lymphocyte-specific antigen WP34) (S37 protein).

SUFU_HUMAN
NC score	0.031409 (rank : 41)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMX1, Q7LCP7, Q9NT90, Q9NZ07, Q9UHK2, Q9UHM8, Q9UMY0	Gene names	SUFU
Domain Architecture	No domain graphic available
Description	Suppressor of fused homolog (SUFUH).

CEP35_HUMAN
NC score	0.028185 (rank : 42)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	811	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

MLL3_HUMAN
NC score	0.024764 (rank : 43)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	1644	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

APOA4_HUMAN
NC score	0.024294 (rank : 44)	θ value	1.06291 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	399	Shared Neighborhood Hits	3
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

PP1R8_MOUSE
NC score	0.023730 (rank : 45)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3G1, Q8C087	Gene names	Ppp1r8, Nipp1
Domain Architecture	No domain graphic available
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8).

LRRF1_MOUSE
NC score	0.022150 (rank : 46)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	440	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

PDXL2_MOUSE
NC score	0.021789 (rank : 47)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

ARGI1_MOUSE
NC score	0.019083 (rank : 48)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q61176, Q80VI4	Gene names	Arg1
Domain Architecture
Description	Arginase-1 (EC 3.5.3.1) (Type I arginase) (Liver-type arginase).

RAI2_MOUSE
NC score	0.019077 (rank : 49)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QVY8	Gene names	Rai2
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 2 (3f8).

FA21C_HUMAN
NC score	0.018826 (rank : 50)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

MBB1A_MOUSE
NC score	0.017229 (rank : 51)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	233	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

NHS_HUMAN
NC score	0.015639 (rank : 52)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

CNGB1_HUMAN
NC score	0.013898 (rank : 53)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	222	Shared Neighborhood Hits	5
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

BCAS1_HUMAN
NC score	0.012956 (rank : 54)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

KCNH8_HUMAN
NC score	0.009701 (rank : 55)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

NOE1_HUMAN
NC score	0.009522 (rank : 56)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	266	Shared Neighborhood Hits	4
SwissProt Accessions	Q99784, Q969S7, Q99452	Gene names	OLFM1, NOE1, NOEL1
Domain Architecture
Description	Noelin precursor (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1).

ZF106_HUMAN
NC score	0.009486 (rank : 57)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	470	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

AKAP1_HUMAN
NC score	0.008421 (rank : 58)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

NOE1_MOUSE
NC score	0.007712 (rank : 59)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	258	Shared Neighborhood Hits	4
SwissProt Accessions	O88998, O35429, O88999, Q91XK8, Q9QWQ9, Q9QWR0	Gene names	Olfm1, Noe1, Noel, Noel1
Domain Architecture
Description	Noelin precursor (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin).

MYST3_HUMAN
NC score	0.006526 (rank : 60)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	772	Shared Neighborhood Hits	6
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

SOX6_MOUSE
NC score	0.006430 (rank : 61)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	341	Shared Neighborhood Hits	2
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

PDE8B_HUMAN
NC score	0.005865 (rank : 62)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PGCA_HUMAN
NC score	0.005830 (rank : 63)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	821	Shared Neighborhood Hits	7
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

KLOT_HUMAN
NC score	0.005510 (rank : 64)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UEF7, Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0	Gene names	KL
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

GP115_HUMAN
NC score	0.005467 (rank : 65)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZF3, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6	Gene names	GPR115, PGR18
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 (G-protein coupled receptor PGR18).

GP125_MOUSE
NC score	0.001422 (rank : 66)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	329	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

EGR2_MOUSE
NC score	-0.000141 (rank : 67)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	745	Shared Neighborhood Hits	2
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).