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Network neighborhood for query Sequence : TNPO2_HUMAN

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TNPO2_HUMAN
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TNPO1_HUMAN
θ value	0 (rank : 1)	NC score	0.993483 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
θ value	0 (rank : 2)	NC score	0.993657 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	63	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
θ value	0 (rank : 4)	NC score	0.999824 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

IMB1_HUMAN
θ value	1.16704e-23 (rank : 5)	NC score	0.622912 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

IMB1_MOUSE
θ value	5.79196e-23 (rank : 6)	NC score	0.621484 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

RNBP6_HUMAN
θ value	1.47974e-10 (rank : 7)	NC score	0.408303 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

IMB3_MOUSE
θ value	1.9326e-10 (rank : 8)	NC score	0.416509 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	58	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IMB3_HUMAN
θ value	4.30538e-10 (rank : 9)	NC score	0.415321 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IPO4_HUMAN
θ value	8.40245e-06 (rank : 10)	NC score	0.337441 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

IPO11_HUMAN
θ value	4.1701e-05 (rank : 11)	NC score	0.264334 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO11_MOUSE
θ value	4.1701e-05 (rank : 12)	NC score	0.265218 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO4_MOUSE
θ value	4.1701e-05 (rank : 13)	NC score	0.332499 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

IPO9_HUMAN
θ value	4.1701e-05 (rank : 14)	NC score	0.246902 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	28	Shared Neighborhood Hits	13
SwissProt Accessions	Q96P70, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8	Gene names	IPO9, IMP9, KIAA1192, RANBP9
Domain Architecture
Description	Importin-9 (Imp9) (Ran-binding protein 9) (RanbP9).

IPO9_MOUSE
θ value	4.1701e-05 (rank : 15)	NC score	0.246487 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q91YE6, Q924M3, Q924M4	Gene names	Ipo9, Imp9, Ranbp9
Domain Architecture
Description	Importin-9 (Importin 9a) (Imp9a) (Importin 9b) (Imp9b) (Ran-binding protein 9) (RanBP9).

XPO2_HUMAN
θ value	0.000786445 (rank : 16)	NC score	0.248057 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	30	Shared Neighborhood Hits	17
SwissProt Accessions	P55060, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0	Gene names	CSE1L, CAS, XPO2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein) (Cellular apoptosis susceptibility protein).

XPO2_MOUSE
θ value	0.000786445 (rank : 17)	NC score	0.246741 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ERK4	Gene names	Cse1l, Xpo2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein).

ECM29_MOUSE
θ value	0.00390308 (rank : 18)	NC score	0.164595 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

ECM29_HUMAN
θ value	0.0148317 (rank : 19)	NC score	0.160878 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

IMA4_MOUSE
θ value	0.0252991 (rank : 20)	NC score	0.106366 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA4_HUMAN
θ value	0.0330416 (rank : 21)	NC score	0.104601 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

XPO1_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.129587 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	O14980, Q63HP8, Q68CP3, Q99433	Gene names	XPO1, CRM1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

XPO1_MOUSE
θ value	0.0330416 (rank : 23)	NC score	0.130284 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5F9	Gene names	Xpo1, Crm1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

PMF1_MOUSE
θ value	0.0431538 (rank : 24)	NC score	0.172659 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CPV5, Q3UCB8, Q8K237, Q924B3, Q9D6E2	Gene names	Pmf1
Domain Architecture	No domain graphic available
Description	Polyamine-modulated factor 1 (PMF-1).

IMA7_MOUSE
θ value	0.0736092 (rank : 25)	NC score	0.106989 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	12
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA7_HUMAN
θ value	0.0961366 (rank : 26)	NC score	0.109475 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

2AAB_HUMAN
θ value	0.163984 (rank : 27)	NC score	0.068935 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

AP4E1_HUMAN
θ value	0.47712 (rank : 28)	NC score	0.061494 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

BTAF1_HUMAN
θ value	0.47712 (rank : 29)	NC score	0.035835 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	97	Shared Neighborhood Hits	14
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

AP4E1_MOUSE
θ value	0.62314 (rank : 30)	NC score	0.059013 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

HEAT2_HUMAN
θ value	0.62314 (rank : 31)	NC score	0.104889 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	Q86Y56, Q69YL1, Q96FI9, Q9NX75	Gene names	HEATR2
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 2.

IMA3_MOUSE
θ value	0.62314 (rank : 32)	NC score	0.091212 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

IPO8_MOUSE
θ value	0.813845 (rank : 33)	NC score	0.059008 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7	Gene names	Ipo8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

GCN1L_HUMAN
θ value	1.06291 (rank : 34)	NC score	0.119163 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	112	Shared Neighborhood Hits	29
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

PKP3_HUMAN
θ value	1.06291 (rank : 35)	NC score	0.037917 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

SF3B1_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.067058 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	1.38821 (rank : 37)	NC score	0.067498 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	352	Shared Neighborhood Hits	18
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

CAND2_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.060358 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	40	Shared Neighborhood Hits	18
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

IMA3_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.079421 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

CAND2_MOUSE
θ value	3.0926 (rank : 40)	NC score	0.064266 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

PKP3_MOUSE
θ value	3.0926 (rank : 41)	NC score	0.032914 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QY23	Gene names	Pkp3
Domain Architecture
Description	Plakophilin-3.

CAND1_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.041566 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

FTHFD_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.010147 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	O75891, Q68CS1	Gene names	ALDH1L1, FTHFD
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

MSTRO_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.031409 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYG7, Q8N6K5	Gene names	MRO, B29, C18orf3
Domain Architecture	No domain graphic available
Description	Protein maestro (Male-specific transcription in the developing reproductive organs) (Protein B29).

2AAB_MOUSE
θ value	6.88961 (rank : 45)	NC score	0.083216 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

2AAA_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.082132 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	P30153, Q13773	Gene names	PPP2R1A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein).

2AAA_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.090636 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q76MZ3	Gene names	Ppp2r1a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform).

IMA1_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.050042 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

IMA1_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.051094 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	8
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

IMA5_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.081527 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

PP4RL_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.056028 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P1A2, Q9BZ17, Q9BZ18	Gene names	PPP4R1L, C20orf192
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1-like.

Hits sorted by NC score

TNPO2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
NC score	0.999824 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO1_MOUSE
NC score	0.993657 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	63	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO1_HUMAN
NC score	0.993483 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

IMB1_HUMAN
NC score	0.622912 (rank : 5)	θ value	1.16704e-23 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

IMB1_MOUSE
NC score	0.621484 (rank : 6)	θ value	5.79196e-23 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB3_MOUSE
NC score	0.416509 (rank : 7)	θ value	1.9326e-10 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	58	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IMB3_HUMAN
NC score	0.415321 (rank : 8)	θ value	4.30538e-10 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	57	Shared Neighborhood Hits	23
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

RNBP6_HUMAN
NC score	0.408303 (rank : 9)	θ value	1.47974e-10 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

IPO4_HUMAN
NC score	0.337441 (rank : 10)	θ value	8.40245e-06 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

IPO4_MOUSE
NC score	0.332499 (rank : 11)	θ value	4.1701e-05 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

IPO11_MOUSE
NC score	0.265218 (rank : 12)	θ value	4.1701e-05 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO11_HUMAN
NC score	0.264334 (rank : 13)	θ value	4.1701e-05 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

XPO2_HUMAN
NC score	0.248057 (rank : 14)	θ value	0.000786445 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	30	Shared Neighborhood Hits	17
SwissProt Accessions	P55060, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0	Gene names	CSE1L, CAS, XPO2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein) (Cellular apoptosis susceptibility protein).

IPO9_HUMAN
NC score	0.246902 (rank : 15)	θ value	4.1701e-05 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	28	Shared Neighborhood Hits	13
SwissProt Accessions	Q96P70, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8	Gene names	IPO9, IMP9, KIAA1192, RANBP9
Domain Architecture
Description	Importin-9 (Imp9) (Ran-binding protein 9) (RanbP9).

XPO2_MOUSE
NC score	0.246741 (rank : 16)	θ value	0.000786445 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ERK4	Gene names	Cse1l, Xpo2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein).

IPO9_MOUSE
NC score	0.246487 (rank : 17)	θ value	4.1701e-05 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q91YE6, Q924M3, Q924M4	Gene names	Ipo9, Imp9, Ranbp9
Domain Architecture
Description	Importin-9 (Importin 9a) (Imp9a) (Importin 9b) (Imp9b) (Ran-binding protein 9) (RanBP9).

PMF1_MOUSE
NC score	0.172659 (rank : 18)	θ value	0.0431538 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CPV5, Q3UCB8, Q8K237, Q924B3, Q9D6E2	Gene names	Pmf1
Domain Architecture	No domain graphic available
Description	Polyamine-modulated factor 1 (PMF-1).

ECM29_MOUSE
NC score	0.164595 (rank : 19)	θ value	0.00390308 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

ECM29_HUMAN
NC score	0.160878 (rank : 20)	θ value	0.0148317 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

XPO1_MOUSE
NC score	0.130284 (rank : 21)	θ value	0.0330416 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5F9	Gene names	Xpo1, Crm1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

XPO1_HUMAN
NC score	0.129587 (rank : 22)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	O14980, Q63HP8, Q68CP3, Q99433	Gene names	XPO1, CRM1
Domain Architecture	No domain graphic available
Description	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog).

GCN1L_HUMAN
NC score	0.119163 (rank : 23)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	112	Shared Neighborhood Hits	29
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

IMA7_HUMAN
NC score	0.109475 (rank : 24)	θ value	0.0961366 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA7_MOUSE
NC score	0.106989 (rank : 25)	θ value	0.0736092 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	12
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA4_MOUSE
NC score	0.106366 (rank : 26)	θ value	0.0252991 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

HEAT2_HUMAN
NC score	0.104889 (rank : 27)	θ value	0.62314 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	Q86Y56, Q69YL1, Q96FI9, Q9NX75	Gene names	HEATR2
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 2.

IMA4_HUMAN
NC score	0.104601 (rank : 28)	θ value	0.0330416 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA3_MOUSE
NC score	0.091212 (rank : 29)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

2AAA_MOUSE
NC score	0.090636 (rank : 30)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q76MZ3	Gene names	Ppp2r1a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform).

2AAB_MOUSE
NC score	0.083216 (rank : 31)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

2AAA_HUMAN
NC score	0.082132 (rank : 32)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	P30153, Q13773	Gene names	PPP2R1A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein).

IMA5_HUMAN
NC score	0.081527 (rank : 33)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA3_HUMAN
NC score	0.079421 (rank : 34)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

2AAB_HUMAN
NC score	0.068935 (rank : 35)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

SF3B1_MOUSE
NC score	0.067498 (rank : 36)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	352	Shared Neighborhood Hits	18
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_HUMAN
NC score	0.067058 (rank : 37)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

CAND2_MOUSE
NC score	0.064266 (rank : 38)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

AP4E1_HUMAN
NC score	0.061494 (rank : 39)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPM8, Q9Y588	Gene names	AP4E1
Domain Architecture
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

CAND2_HUMAN
NC score	0.060358 (rank : 40)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	40	Shared Neighborhood Hits	18
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

AP4E1_MOUSE
NC score	0.059013 (rank : 41)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

IPO8_MOUSE
NC score	0.059008 (rank : 42)	θ value	0.813845 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7	Gene names	Ipo8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

PP4RL_HUMAN
NC score	0.056028 (rank : 43)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P1A2, Q9BZ17, Q9BZ18	Gene names	PPP4R1L, C20orf192
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1-like.

IMA1_MOUSE
NC score	0.051094 (rank : 44)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	8
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

IMA1_HUMAN
NC score	0.050042 (rank : 45)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

CAND1_HUMAN
NC score	0.041566 (rank : 46)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

PKP3_HUMAN
NC score	0.037917 (rank : 47)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

BTAF1_HUMAN
NC score	0.035835 (rank : 48)	θ value	0.47712 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	97	Shared Neighborhood Hits	14
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

PKP3_MOUSE
NC score	0.032914 (rank : 49)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QY23	Gene names	Pkp3
Domain Architecture
Description	Plakophilin-3.

MSTRO_HUMAN
NC score	0.031409 (rank : 50)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYG7, Q8N6K5	Gene names	MRO, B29, C18orf3
Domain Architecture	No domain graphic available
Description	Protein maestro (Male-specific transcription in the developing reproductive organs) (Protein B29).

FTHFD_HUMAN
NC score	0.010147 (rank : 51)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	O75891, Q68CS1	Gene names	ALDH1L1, FTHFD
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).