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Network neighborhood for query Sequence : IMA1_MOUSE

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IMA1_MOUSE
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IMA1_HUMAN
θ value	0 (rank : 1)	NC score	0.999672 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	37
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

IMA1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

IMA5_HUMAN
θ value	0 (rank : 3)	NC score	0.991340 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	68	Shared Neighborhood Hits	35
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA7_HUMAN
θ value	0 (rank : 4)	NC score	0.993596 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	32
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA7_MOUSE
θ value	0 (rank : 5)	NC score	0.992692 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA3_MOUSE
θ value	1.42914e-130 (rank : 6)	NC score	0.973563 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

IMA3_HUMAN
θ value	1.20984e-129 (rank : 7)	NC score	0.973867 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

IMA4_HUMAN
θ value	2.61056e-124 (rank : 8)	NC score	0.971817 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA4_MOUSE
θ value	1.69212e-123 (rank : 9)	NC score	0.971320 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA2_MOUSE
θ value	7.86017e-121 (rank : 10)	NC score	0.972831 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

IMA2_HUMAN
θ value	5.09482e-120 (rank : 11)	NC score	0.970130 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	25
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

SPAG6_HUMAN
θ value	3.76295e-14 (rank : 12)	NC score	0.630174 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

SPAG6_MOUSE
θ value	1.86753e-13 (rank : 13)	NC score	0.629213 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

PLAK_MOUSE
θ value	0.0193708 (rank : 14)	NC score	0.136531 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

PKP4_HUMAN
θ value	0.0961366 (rank : 15)	NC score	0.147584 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	107	Shared Neighborhood Hits	24
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

PKP4_MOUSE
θ value	0.0961366 (rank : 16)	NC score	0.147237 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	129	Shared Neighborhood Hits	24
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

PLAK_HUMAN
θ value	0.163984 (rank : 17)	NC score	0.099876 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

ARVC_HUMAN
θ value	0.365318 (rank : 18)	NC score	0.099217 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	95	Shared Neighborhood Hits	24
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

IMB1_MOUSE
θ value	0.365318 (rank : 19)	NC score	0.092956 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

ARVC_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.098213 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	23
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

CTND1_MOUSE
θ value	0.813845 (rank : 21)	NC score	0.099813 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CTND2_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.113633 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CTND2_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.114669 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

GDS1_HUMAN
θ value	0.813845 (rank : 24)	NC score	0.262823 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	P52306, Q9NYM2, Q9NZA8	Gene names	RAP1GDS1
Domain Architecture
Description	Rap1 GTPase-GDP dissociation stimulator 1 (SMG P21 stimulatory GDP/GTP exchange protein) (SMG GDS protein) (Exchange factor smgGDS).

RL35_HUMAN
θ value	0.813845 (rank : 25)	NC score	0.122562 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P42766, Q4VBY5, Q5JTN5, Q6IBC7, Q96QJ7, Q9BYF4	Gene names	RPL35
Domain Architecture	No domain graphic available
Description	60S ribosomal protein L35.

RELN_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.043609 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	235	Shared Neighborhood Hits	7
SwissProt Accessions	Q60841, Q9CUA6	Gene names	Reln, Rl
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-) (Reeler protein).

ZFY16_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.034338 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

CF081_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.052789 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T9G4, Q8NEB2, Q96LL8	Gene names	C6orf81
Domain Architecture	No domain graphic available
Description	Protein C6orf81.

THUM2_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.024038 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	139	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BTF0	Gene names	THUMPD2, C2orf8
Domain Architecture
Description	THUMP domain-containing protein 2.

TTC1_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.011894 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	417	Shared Neighborhood Hits	6
SwissProt Accessions	Q99614, Q9BVT3	Gene names	TTC1, TPR1
Domain Architecture
Description	Tetratricopeptide repeat protein 1 (TPR repeat protein 1).

ARMC4_HUMAN
θ value	4.03905 (rank : 31)	NC score	0.226186 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

BRCA1_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.016431 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	381	Shared Neighborhood Hits	5
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

RELN_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.031318 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	233	Shared Neighborhood Hits	6
SwissProt Accessions	P78509, Q86UJ0, Q86UJ8, Q8NDV0, Q9UDQ2	Gene names	RELN
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-).

APC_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.031471 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	603	Shared Neighborhood Hits	18
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

APC_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.032591 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	441	Shared Neighborhood Hits	18
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

CF081_MOUSE
θ value	5.27518 (rank : 36)	NC score	0.023013 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X86, Q9D564, Q9DAN7	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf81 homolog.

IMB1_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.070775 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

UN45A_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.049957 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	122	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3U1, Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9	Gene names	UNC45A, SMAP1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Smooth muscle cell-associated protein 1) (SMAP-1).

UN45A_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.040119 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KD5, Q3TKV6, Q8BFT3, Q8C157	Gene names	Unc45a, Smap1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Stromal membrane-associated protein 1) (Smap-1).

CE290_HUMAN
θ value	8.99809 (rank : 40)	NC score	-0.000217 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	1553	Shared Neighborhood Hits	7
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

NPHP4_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.006604 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	O75161	Gene names	NPHP4, KIAA0673
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

OTOAN_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.009630 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q7RTW8, Q8NA86, Q96M76	Gene names	OTOA
Domain Architecture	No domain graphic available
Description	Otoancorin precursor.

PHLD2_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.004556 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

CTNB1_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.135472 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	25
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.135502 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	25
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTND1_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.090647 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	24
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

SARM1_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.060839 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

SARM1_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.061702 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

TNPO1_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.067245 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	9
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.063375 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO2_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.051094 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.052197 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TRIPC_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.091477 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	319	Shared Neighborhood Hits	8
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

Hits sorted by NC score

IMA1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

IMA1_HUMAN
NC score	0.999672 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	37
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

IMA7_HUMAN
NC score	0.993596 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	32
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA7_MOUSE
NC score	0.992692 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA5_HUMAN
NC score	0.991340 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	68	Shared Neighborhood Hits	35
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA3_HUMAN
NC score	0.973867 (rank : 6)	θ value	1.20984e-129 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

IMA3_MOUSE
NC score	0.973563 (rank : 7)	θ value	1.42914e-130 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

IMA2_MOUSE
NC score	0.972831 (rank : 8)	θ value	7.86017e-121 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

IMA4_HUMAN
NC score	0.971817 (rank : 9)	θ value	2.61056e-124 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA4_MOUSE
NC score	0.971320 (rank : 10)	θ value	1.69212e-123 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA2_HUMAN
NC score	0.970130 (rank : 11)	θ value	5.09482e-120 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	25
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

SPAG6_HUMAN
NC score	0.630174 (rank : 12)	θ value	3.76295e-14 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

SPAG6_MOUSE
NC score	0.629213 (rank : 13)	θ value	1.86753e-13 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

GDS1_HUMAN
NC score	0.262823 (rank : 14)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	P52306, Q9NYM2, Q9NZA8	Gene names	RAP1GDS1
Domain Architecture
Description	Rap1 GTPase-GDP dissociation stimulator 1 (SMG P21 stimulatory GDP/GTP exchange protein) (SMG GDS protein) (Exchange factor smgGDS).

ARMC4_HUMAN
NC score	0.226186 (rank : 15)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

PKP4_HUMAN
NC score	0.147584 (rank : 16)	θ value	0.0961366 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	107	Shared Neighborhood Hits	24
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

PKP4_MOUSE
NC score	0.147237 (rank : 17)	θ value	0.0961366 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	129	Shared Neighborhood Hits	24
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

PLAK_MOUSE
NC score	0.136531 (rank : 18)	θ value	0.0193708 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

CTNB1_MOUSE
NC score	0.135502 (rank : 19)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	25
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_HUMAN
NC score	0.135472 (rank : 20)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	25
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

RL35_HUMAN
NC score	0.122562 (rank : 21)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P42766, Q4VBY5, Q5JTN5, Q6IBC7, Q96QJ7, Q9BYF4	Gene names	RPL35
Domain Architecture	No domain graphic available
Description	60S ribosomal protein L35.

CTND2_MOUSE
NC score	0.114669 (rank : 22)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

CTND2_HUMAN
NC score	0.113633 (rank : 23)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

PLAK_HUMAN
NC score	0.099876 (rank : 24)	θ value	0.163984 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

CTND1_MOUSE
NC score	0.099813 (rank : 25)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

ARVC_HUMAN
NC score	0.099217 (rank : 26)	θ value	0.365318 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	95	Shared Neighborhood Hits	24
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

ARVC_MOUSE
NC score	0.098213 (rank : 27)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	23
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

IMB1_MOUSE
NC score	0.092956 (rank : 28)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

TRIPC_HUMAN
NC score	0.091477 (rank : 29)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	319	Shared Neighborhood Hits	8
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

CTND1_HUMAN
NC score	0.090647 (rank : 30)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	24
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

IMB1_HUMAN
NC score	0.070775 (rank : 31)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

TNPO1_HUMAN
NC score	0.067245 (rank : 32)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	9
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
NC score	0.063375 (rank : 33)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

SARM1_MOUSE
NC score	0.061702 (rank : 34)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SARM1_HUMAN
NC score	0.060839 (rank : 35)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

CF081_HUMAN
NC score	0.052789 (rank : 36)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T9G4, Q8NEB2, Q96LL8	Gene names	C6orf81
Domain Architecture	No domain graphic available
Description	Protein C6orf81.

TNPO2_MOUSE
NC score	0.052197 (rank : 37)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	Q99LG2, Q8C0U9	Gene names	Tnpo2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

TNPO2_HUMAN
NC score	0.051094 (rank : 38)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	O14787, O14655	Gene names	TNPO2
Domain Architecture
Description	Transportin-2 (Karyopherin beta-2b).

UN45A_HUMAN
NC score	0.049957 (rank : 39)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	122	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3U1, Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9	Gene names	UNC45A, SMAP1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Smooth muscle cell-associated protein 1) (SMAP-1).

RELN_MOUSE
NC score	0.043609 (rank : 40)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	235	Shared Neighborhood Hits	7
SwissProt Accessions	Q60841, Q9CUA6	Gene names	Reln, Rl
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-) (Reeler protein).

UN45A_MOUSE
NC score	0.040119 (rank : 41)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KD5, Q3TKV6, Q8BFT3, Q8C157	Gene names	Unc45a, Smap1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Stromal membrane-associated protein 1) (Smap-1).

ZFY16_HUMAN
NC score	0.034338 (rank : 42)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

APC_MOUSE
NC score	0.032591 (rank : 43)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	441	Shared Neighborhood Hits	18
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

APC_HUMAN
NC score	0.031471 (rank : 44)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	603	Shared Neighborhood Hits	18
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

RELN_HUMAN
NC score	0.031318 (rank : 45)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	233	Shared Neighborhood Hits	6
SwissProt Accessions	P78509, Q86UJ0, Q86UJ8, Q8NDV0, Q9UDQ2	Gene names	RELN
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-).

THUM2_HUMAN
NC score	0.024038 (rank : 46)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	139	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BTF0	Gene names	THUMPD2, C2orf8
Domain Architecture
Description	THUMP domain-containing protein 2.

CF081_MOUSE
NC score	0.023013 (rank : 47)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X86, Q9D564, Q9DAN7	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf81 homolog.

BRCA1_HUMAN
NC score	0.016431 (rank : 48)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	381	Shared Neighborhood Hits	5
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

TTC1_HUMAN
NC score	0.011894 (rank : 49)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	417	Shared Neighborhood Hits	6
SwissProt Accessions	Q99614, Q9BVT3	Gene names	TTC1, TPR1
Domain Architecture
Description	Tetratricopeptide repeat protein 1 (TPR repeat protein 1).

OTOAN_HUMAN
NC score	0.009630 (rank : 50)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q7RTW8, Q8NA86, Q96M76	Gene names	OTOA
Domain Architecture	No domain graphic available
Description	Otoancorin precursor.

NPHP4_HUMAN
NC score	0.006604 (rank : 51)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	O75161	Gene names	NPHP4, KIAA0673
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

PHLD2_HUMAN
NC score	0.004556 (rank : 52)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

CE290_HUMAN
NC score	-0.000217 (rank : 53)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	1553	Shared Neighborhood Hits	7
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).