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Network neighborhood for query Sequence : SPAG6_HUMAN

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SPAG6_HUMAN
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPAG6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

SPAG6_MOUSE
θ value	0 (rank : 2)	NC score	0.992906 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	62	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

IMA5_HUMAN
θ value	8.95645e-16 (rank : 3)	NC score	0.640789 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	23
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA1_HUMAN
θ value	2.20605e-14 (rank : 4)	NC score	0.631192 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

IMA4_MOUSE
θ value	2.88119e-14 (rank : 5)	NC score	0.634731 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA1_MOUSE
θ value	3.76295e-14 (rank : 6)	NC score	0.630174 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	43	Shared Neighborhood Hits	20
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

IMA4_HUMAN
θ value	3.76295e-14 (rank : 7)	NC score	0.634408 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA7_HUMAN
θ value	1.09485e-13 (rank : 8)	NC score	0.625269 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	20
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA7_MOUSE
θ value	1.2105e-12 (rank : 9)	NC score	0.619299 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	18
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

IMA3_HUMAN
θ value	1.58096e-12 (rank : 10)	NC score	0.625368 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	53	Shared Neighborhood Hits	23
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

IMA3_MOUSE
θ value	2.0648e-12 (rank : 11)	NC score	0.625065 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

IMA2_MOUSE
θ value	6.00763e-12 (rank : 12)	NC score	0.635689 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

IMA2_HUMAN
θ value	1.02475e-11 (rank : 13)	NC score	0.634055 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

ARMC4_HUMAN
θ value	1.09739e-05 (rank : 14)	NC score	0.331200 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

SIL1_MOUSE
θ value	0.00134147 (rank : 15)	NC score	0.188213 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPK6, Q91V34	Gene names	Sil1
Domain Architecture	No domain graphic available
Description	Nucleotide exchange factor SIL1 precursor.

CTNB1_HUMAN
θ value	0.00509761 (rank : 16)	NC score	0.194220 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	22
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_MOUSE
θ value	0.00509761 (rank : 17)	NC score	0.194261 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	22
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

SIL1_HUMAN
θ value	0.00665767 (rank : 18)	NC score	0.184474 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H173, Q8N2L3	Gene names	SIL1
Domain Architecture	No domain graphic available
Description	Nucleotide exchange factor SIL1 precursor (BiP-associated protein) (BAP).

STK36_MOUSE
θ value	0.00665767 (rank : 19)	NC score	0.023863 (rank : 64)
Query Neighborhood Hits	58	Target Neighborhood Hits	877	Shared Neighborhood Hits	9
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_HUMAN
θ value	0.00869519 (rank : 20)	NC score	0.022317 (rank : 66)
Query Neighborhood Hits	58	Target Neighborhood Hits	896	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

RTDR1_HUMAN
θ value	0.0148317 (rank : 21)	NC score	0.173357 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UHP6	Gene names	RTDR1
Domain Architecture
Description	Rhabdoid tumor deletion region protein 1.

FRAP_MOUSE
θ value	0.0193708 (rank : 22)	NC score	0.086525 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	77	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

UN45A_MOUSE
θ value	0.0193708 (rank : 23)	NC score	0.084396 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KD5, Q3TKV6, Q8BFT3, Q8C157	Gene names	Unc45a, Smap1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Stromal membrane-associated protein 1) (Smap-1).

FRAP_HUMAN
θ value	0.0252991 (rank : 24)	NC score	0.085500 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

GDS1_HUMAN
θ value	0.0330416 (rank : 25)	NC score	0.273555 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	P52306, Q9NYM2, Q9NZA8	Gene names	RAP1GDS1
Domain Architecture
Description	Rap1 GTPase-GDP dissociation stimulator 1 (SMG P21 stimulatory GDP/GTP exchange protein) (SMG GDS protein) (Exchange factor smgGDS).

SARM1_MOUSE
θ value	0.0330416 (rank : 26)	NC score	0.155462 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

AP1B1_MOUSE
θ value	0.0563607 (rank : 27)	NC score	0.098284 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	59	Shared Neighborhood Hits	10
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP1B1_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.097264 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

SARM1_HUMAN
θ value	0.0736092 (rank : 29)	NC score	0.160056 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	12
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

AP2B1_HUMAN
θ value	0.125558 (rank : 30)	NC score	0.097830 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	0.125558 (rank : 31)	NC score	0.097832 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP3D1_MOUSE
θ value	0.125558 (rank : 32)	NC score	0.072644 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

ARMC6_HUMAN
θ value	0.125558 (rank : 33)	NC score	0.140028 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NXE6, O94999, Q9BTH5	Gene names	ARMC6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

ARMC6_MOUSE
θ value	0.125558 (rank : 34)	NC score	0.149961 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	28	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BNU0, Q8C4P5, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4	Gene names	Armc6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

ULK4_MOUSE
θ value	0.21417 (rank : 35)	NC score	0.023211 (rank : 65)
Query Neighborhood Hits	58	Target Neighborhood Hits	793	Shared Neighborhood Hits	10
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

AP3D1_HUMAN
θ value	0.279714 (rank : 36)	NC score	0.067302 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	254	Shared Neighborhood Hits	7
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

TBCD_HUMAN
θ value	0.365318 (rank : 37)	NC score	0.043146 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BTW9, O95458, Q7L8K1, Q8IXP6, Q8NAX0, Q8WYH4, Q96E74, Q9UF82, Q9UG46, Q9Y2J3	Gene names	TBCD, KIAA0988, SSD1, TFCD
Domain Architecture	No domain graphic available
Description	Tubulin-specific chaperone D (Tubulin-folding cofactor D) (Beta- tubulin cofactor D) (tfcD) (SSD-1).

IMB3_HUMAN
θ value	0.47712 (rank : 38)	NC score	0.087605 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IMB3_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.087950 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

K0406_HUMAN
θ value	0.47712 (rank : 40)	NC score	0.048012 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O43156, Q5JX67, Q96A38, Q9BR47, Q9H4K0	Gene names	KIAA0406
Domain Architecture	No domain graphic available
Description	Protein KIAA0406.

PLAK_MOUSE
θ value	0.47712 (rank : 41)	NC score	0.177602 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	55	Shared Neighborhood Hits	20
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

PX11A_HUMAN
θ value	0.62314 (rank : 42)	NC score	0.065513 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	O75192	Gene names	PEX11A, PEX11
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein 11A (Peroxin-11A) (Peroxisomal biogenesis factor 11A) (PEX11alpha) (Pex11palpha) (HsPEX11p) (28 kDa peroxisomal integral membrane protein) (PMP28).

RNBP6_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.078185 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

2AAB_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.043431 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

ECM29_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.061934 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

ECM29_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.060007 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

PLAK_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.152738 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	53	Shared Neighborhood Hits	18
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

BFSP1_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.020928 (rank : 67)
Query Neighborhood Hits	58	Target Neighborhood Hits	508	Shared Neighborhood Hits	3
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

UN45A_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.073134 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	122	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3U1, Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9	Gene names	UNC45A, SMAP1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Smooth muscle cell-associated protein 1) (SMAP-1).

K0355_HUMAN
θ value	2.36792 (rank : 50)	NC score	0.034069 (rank : 61)
Query Neighborhood Hits	58	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	O15063	Gene names	KIAA0355
Domain Architecture	No domain graphic available
Description	Protein KIAA0355.

IMB1_HUMAN
θ value	3.0926 (rank : 51)	NC score	0.076214 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	15
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

PSMD5_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.061447 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJY1, Q3UFV2, Q8BMA9, Q8VEE9	Gene names	Psmd5
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 5 (26S proteasome subunit S5B) (26S protease subunit S5 basic).

PKP1_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.029679 (rank : 62)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q13835, O00645, Q15152	Gene names	PKP1
Domain Architecture
Description	Plakophilin-1 (Band-6 protein) (B6P).

PKP1_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.028129 (rank : 63)
Query Neighborhood Hits	58	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	P97350	Gene names	Pkp1
Domain Architecture
Description	Plakophilin-1.

PSMD5_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.050839 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q16401, Q15045	Gene names	PSMD5, KIAA0072
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 5 (26S proteasome subunit S5B) (26S protease subunit S5 basic).

KCC1D_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.005064 (rank : 70)
Query Neighborhood Hits	58	Target Neighborhood Hits	846	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.005073 (rank : 69)
Query Neighborhood Hits	58	Target Neighborhood Hits	847	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

LRRK2_MOUSE
θ value	6.88961 (rank : 58)	NC score	0.007901 (rank : 68)
Query Neighborhood Hits	58	Target Neighborhood Hits	1359	Shared Neighborhood Hits	10
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

AP4B1_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.051954 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.050945 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

ARVC_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.052603 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	95	Shared Neighborhood Hits	22
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

ARVC_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.051448 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	67	Shared Neighborhood Hits	21
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

CTND2_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.054831 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	333	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CTND2_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.053749 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

GCN1L_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.060400 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	112	Shared Neighborhood Hits	21
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

IMB1_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.073266 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

PKP4_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.068854 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

PKP4_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.070126 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	129	Shared Neighborhood Hits	20
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

RL35_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.052510 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	P42766, Q4VBY5, Q5JTN5, Q6IBC7, Q96QJ7, Q9BYF4	Gene names	RPL35
Domain Architecture	No domain graphic available
Description	60S ribosomal protein L35.

TNPO1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.051620 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

Hits sorted by NC score

SPAG6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

SPAG6_MOUSE
NC score	0.992906 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	62	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

IMA5_HUMAN
NC score	0.640789 (rank : 3)	θ value	8.95645e-16 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	23
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

IMA2_MOUSE
NC score	0.635689 (rank : 4)	θ value	6.00763e-12 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	P52293, Q64292	Gene names	Kpna2, Rch1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1).

IMA4_MOUSE
NC score	0.634731 (rank : 5)	θ value	2.88119e-14 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	O35343	Gene names	Kpna4
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin alpha Q1).

IMA4_HUMAN
NC score	0.634408 (rank : 6)	θ value	3.76295e-14 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	59	Shared Neighborhood Hits	25
SwissProt Accessions	O00629, O00190	Gene names	KPNA4, QIP1
Domain Architecture
Description	Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1 protein).

IMA2_HUMAN
NC score	0.634055 (rank : 7)	θ value	1.02475e-11 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	P52292, Q9BRU5	Gene names	KPNA2, RCH1, SRP1
Domain Architecture
Description	Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1).

IMA1_HUMAN
NC score	0.631192 (rank : 8)	θ value	2.20605e-14 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	P52294, Q9BQ56	Gene names	KPNA1, RCH2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (NPI-1).

IMA1_MOUSE
NC score	0.630174 (rank : 9)	θ value	3.76295e-14 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	43	Shared Neighborhood Hits	20
SwissProt Accessions	Q60960, Q3TF32	Gene names	Kpna1, Rch2
Domain Architecture
Description	Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1).

IMA3_HUMAN
NC score	0.625368 (rank : 10)	θ value	1.58096e-12 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	53	Shared Neighborhood Hits	23
SwissProt Accessions	O00505, O00191, O43195, Q96AA7	Gene names	KPNA3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma).

IMA7_HUMAN
NC score	0.625269 (rank : 11)	θ value	1.09485e-13 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	20
SwissProt Accessions	O60684	Gene names	KPNA6, IPOA7
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6).

IMA3_MOUSE
NC score	0.625065 (rank : 12)	θ value	2.0648e-12 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O35344	Gene names	Kpna3
Domain Architecture
Description	Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin alpha Q2).

IMA7_MOUSE
NC score	0.619299 (rank : 13)	θ value	1.2105e-12 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	18
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

ARMC4_HUMAN
NC score	0.331200 (rank : 14)	θ value	1.09739e-05 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

GDS1_HUMAN
NC score	0.273555 (rank : 15)	θ value	0.0330416 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	P52306, Q9NYM2, Q9NZA8	Gene names	RAP1GDS1
Domain Architecture
Description	Rap1 GTPase-GDP dissociation stimulator 1 (SMG P21 stimulatory GDP/GTP exchange protein) (SMG GDS protein) (Exchange factor smgGDS).

CTNB1_MOUSE
NC score	0.194261 (rank : 16)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	22
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_HUMAN
NC score	0.194220 (rank : 17)	θ value	0.00509761 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	22
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

SIL1_MOUSE
NC score	0.188213 (rank : 18)	θ value	0.00134147 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPK6, Q91V34	Gene names	Sil1
Domain Architecture	No domain graphic available
Description	Nucleotide exchange factor SIL1 precursor.

SIL1_HUMAN
NC score	0.184474 (rank : 19)	θ value	0.00665767 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H173, Q8N2L3	Gene names	SIL1
Domain Architecture	No domain graphic available
Description	Nucleotide exchange factor SIL1 precursor (BiP-associated protein) (BAP).

PLAK_MOUSE
NC score	0.177602 (rank : 20)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	55	Shared Neighborhood Hits	20
SwissProt Accessions	Q02257, Q8CGD3	Gene names	Jup
Domain Architecture	No domain graphic available
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

RTDR1_HUMAN
NC score	0.173357 (rank : 21)	θ value	0.0148317 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UHP6	Gene names	RTDR1
Domain Architecture
Description	Rhabdoid tumor deletion region protein 1.

SARM1_HUMAN
NC score	0.160056 (rank : 22)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	12
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

SARM1_MOUSE
NC score	0.155462 (rank : 23)	θ value	0.0330416 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

PLAK_HUMAN
NC score	0.152738 (rank : 24)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	53	Shared Neighborhood Hits	18
SwissProt Accessions	P14923, Q9HCX9	Gene names	JUP, DP3
Domain Architecture
Description	Junction plakoglobin (Desmoplakin-3) (Desmoplakin III).

ARMC6_MOUSE
NC score	0.149961 (rank : 25)	θ value	0.125558 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	28	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BNU0, Q8C4P5, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4	Gene names	Armc6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

ARMC6_HUMAN
NC score	0.140028 (rank : 26)	θ value	0.125558 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NXE6, O94999, Q9BTH5	Gene names	ARMC6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

AP1B1_MOUSE
NC score	0.098284 (rank : 27)	θ value	0.0563607 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	59	Shared Neighborhood Hits	10
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

AP2B1_MOUSE
NC score	0.097832 (rank : 28)	θ value	0.125558 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.097830 (rank : 29)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP1B1_HUMAN
NC score	0.097264 (rank : 30)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	Q10567, P78436	Gene names	AP1B1, ADTB1, BAM22
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

IMB3_MOUSE
NC score	0.087950 (rank : 31)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IMB3_HUMAN
NC score	0.087605 (rank : 32)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

FRAP_MOUSE
NC score	0.086525 (rank : 33)	θ value	0.0193708 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	77	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.085500 (rank : 34)	θ value	0.0252991 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

UN45A_MOUSE
NC score	0.084396 (rank : 35)	θ value	0.0193708 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KD5, Q3TKV6, Q8BFT3, Q8C157	Gene names	Unc45a, Smap1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Stromal membrane-associated protein 1) (Smap-1).

RNBP6_HUMAN
NC score	0.078185 (rank : 36)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	O60518, Q5T7X4, Q7Z3V2, Q96E78	Gene names	RANBP6
Domain Architecture	No domain graphic available
Description	Ran-binding protein 6 (RanBP6).

IMB1_HUMAN
NC score	0.076214 (rank : 37)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	15
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

IMB1_MOUSE
NC score	0.073266 (rank : 38)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

UN45A_HUMAN
NC score	0.073134 (rank : 39)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	122	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3U1, Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9	Gene names	UNC45A, SMAP1
Domain Architecture	No domain graphic available
Description	UNC45 homolog A (UNC-45A) (Smooth muscle cell-associated protein 1) (SMAP-1).

AP3D1_MOUSE
NC score	0.072644 (rank : 40)	θ value	0.125558 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

PKP4_MOUSE
NC score	0.070126 (rank : 41)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	58	Target Neighborhood Hits	129	Shared Neighborhood Hits	20
SwissProt Accessions	Q68FH0, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3	Gene names	Pkp4, Armrp
Domain Architecture	No domain graphic available
Description	Plakophilin-4 (Armadillo-related protein).

PKP4_HUMAN
NC score	0.068854 (rank : 42)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	58	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

AP3D1_HUMAN
NC score	0.067302 (rank : 43)	θ value	0.279714 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	254	Shared Neighborhood Hits	7
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

PX11A_HUMAN
NC score	0.065513 (rank : 44)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	O75192	Gene names	PEX11A, PEX11
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein 11A (Peroxin-11A) (Peroxisomal biogenesis factor 11A) (PEX11alpha) (Pex11palpha) (HsPEX11p) (28 kDa peroxisomal integral membrane protein) (PMP28).

ECM29_HUMAN
NC score	0.061934 (rank : 45)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

PSMD5_MOUSE
NC score	0.061447 (rank : 46)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJY1, Q3UFV2, Q8BMA9, Q8VEE9	Gene names	Psmd5
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 5 (26S proteasome subunit S5B) (26S protease subunit S5 basic).

GCN1L_HUMAN
NC score	0.060400 (rank : 47)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	58	Target Neighborhood Hits	112	Shared Neighborhood Hits	21
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

ECM29_MOUSE
NC score	0.060007 (rank : 48)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

CTND2_HUMAN
NC score	0.054831 (rank : 49)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	58	Target Neighborhood Hits	333	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CTND2_MOUSE
NC score	0.053749 (rank : 50)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	58	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

ARVC_HUMAN
NC score	0.052603 (rank : 51)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	58	Target Neighborhood Hits	95	Shared Neighborhood Hits	22
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

RL35_HUMAN
NC score	0.052510 (rank : 52)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	58	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	P42766, Q4VBY5, Q5JTN5, Q6IBC7, Q96QJ7, Q9BYF4	Gene names	RPL35
Domain Architecture	No domain graphic available
Description	60S ribosomal protein L35.

AP4B1_HUMAN
NC score	0.051954 (rank : 53)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

TNPO1_HUMAN
NC score	0.051620 (rank : 54)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	58	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

ARVC_MOUSE
NC score	0.051448 (rank : 55)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	58	Target Neighborhood Hits	67	Shared Neighborhood Hits	21
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

AP4B1_MOUSE
NC score	0.050945 (rank : 56)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

PSMD5_HUMAN
NC score	0.050839 (rank : 57)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q16401, Q15045	Gene names	PSMD5, KIAA0072
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 5 (26S proteasome subunit S5B) (26S protease subunit S5 basic).

K0406_HUMAN
NC score	0.048012 (rank : 58)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O43156, Q5JX67, Q96A38, Q9BR47, Q9H4K0	Gene names	KIAA0406
Domain Architecture	No domain graphic available
Description	Protein KIAA0406.

2AAB_MOUSE
NC score	0.043431 (rank : 59)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

TBCD_HUMAN
NC score	0.043146 (rank : 60)	θ value	0.365318 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BTW9, O95458, Q7L8K1, Q8IXP6, Q8NAX0, Q8WYH4, Q96E74, Q9UF82, Q9UG46, Q9Y2J3	Gene names	TBCD, KIAA0988, SSD1, TFCD
Domain Architecture	No domain graphic available
Description	Tubulin-specific chaperone D (Tubulin-folding cofactor D) (Beta- tubulin cofactor D) (tfcD) (SSD-1).

K0355_HUMAN
NC score	0.034069 (rank : 61)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	O15063	Gene names	KIAA0355
Domain Architecture	No domain graphic available
Description	Protein KIAA0355.

PKP1_HUMAN
NC score	0.029679 (rank : 62)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q13835, O00645, Q15152	Gene names	PKP1
Domain Architecture
Description	Plakophilin-1 (Band-6 protein) (B6P).

PKP1_MOUSE
NC score	0.028129 (rank : 63)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	P97350	Gene names	Pkp1
Domain Architecture
Description	Plakophilin-1.

STK36_MOUSE
NC score	0.023863 (rank : 64)	θ value	0.00665767 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	877	Shared Neighborhood Hits	9
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ULK4_MOUSE
NC score	0.023211 (rank : 65)	θ value	0.21417 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	793	Shared Neighborhood Hits	10
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

STK36_HUMAN
NC score	0.022317 (rank : 66)	θ value	0.00869519 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	896	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

BFSP1_HUMAN
NC score	0.020928 (rank : 67)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	508	Shared Neighborhood Hits	3
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

LRRK2_MOUSE
NC score	0.007901 (rank : 68)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	1359	Shared Neighborhood Hits	10
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

KCC1D_MOUSE
NC score	0.005073 (rank : 69)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	847	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.005064 (rank : 70)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	846	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).