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Network neighborhood for query Sequence : FAS_MOUSE

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FAS_MOUSE
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FAS_HUMAN
θ value	0 (rank : 1)	NC score	0.989188 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

FAS_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

QORX_HUMAN
θ value	1.37858e-24 (rank : 3)	NC score	0.663596 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q53FA7, O14679, O14685, Q38G78, Q6JLE7, Q9BWB8	Gene names	TP53I3, PIG3
Domain Architecture	No domain graphic available
Description	Putative quinone oxidoreductase (EC 1.-.-.-) (Tumor protein p53- inducible protein 3) (p53-induced protein 3).

OXSM_MOUSE
θ value	1.99067e-23 (rank : 4)	NC score	0.530493 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D404	Gene names	Oxsm
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

OXSM_HUMAN
θ value	1.86321e-21 (rank : 5)	NC score	0.523513 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NWU1	Gene names	OXSM
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

QOR_HUMAN
θ value	1.13037e-18 (rank : 6)	NC score	0.573239 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	21
SwissProt Accessions	Q08257, Q53FT0, Q59EU7, Q6NSK9	Gene names	CRYZ
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

QOR_MOUSE
θ value	2.7842e-17 (rank : 7)	NC score	0.578890 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	21
SwissProt Accessions	P47199, Q62508, Q99L63	Gene names	Cryz
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

VAT1_HUMAN
θ value	1.42992e-13 (rank : 8)	NC score	0.535918 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q99536, Q13035, Q96A39, Q9BUT8	Gene names	VAT1
Domain Architecture
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

VAT1_MOUSE
θ value	3.18553e-13 (rank : 9)	NC score	0.536570 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

K1576_MOUSE
θ value	9.26847e-13 (rank : 10)	NC score	0.528385 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	19
SwissProt Accessions	Q80TB8, Q6PGM9	Gene names	Kiaa1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

K1576_HUMAN
θ value	1.2105e-12 (rank : 11)	NC score	0.529142 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCJ6, Q8IYW8	Gene names	KIAA1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

ZADH2_MOUSE
θ value	6.00763e-12 (rank : 12)	NC score	0.522013 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGC4	Gene names	Zadh2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

ZADH2_HUMAN
θ value	1.02475e-11 (rank : 13)	NC score	0.511460 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N4Q0	Gene names	ZADH2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

LTB4D_HUMAN
θ value	4.45536e-07 (rank : 14)	NC score	0.371258 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	Q14914, Q8IYQ0, Q9H1X6	Gene names	LTB4DH
Domain Architecture
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

QORL_MOUSE
θ value	4.45536e-07 (rank : 15)	NC score	0.409916 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	37	Shared Neighborhood Hits	21
SwissProt Accessions	Q921W4, Q3UKX2, Q8VCS1, Q9CWR9	Gene names	Cryzl1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog).

MECR_HUMAN
θ value	7.59969e-07 (rank : 16)	NC score	0.418426 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	39	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

QORL_HUMAN
θ value	1.69304e-06 (rank : 17)	NC score	0.406961 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	39	Shared Neighborhood Hits	21
SwissProt Accessions	O95825, Q96DY0, Q9NVY7	Gene names	CRYZL1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog) (4P11).

LTB4D_MOUSE
θ value	2.88788e-06 (rank : 18)	NC score	0.379232 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q91YR9, Q3TKT6, Q9CPS1	Gene names	Ltb4dh
Domain Architecture	No domain graphic available
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

FABD_HUMAN
θ value	1.43324e-05 (rank : 19)	NC score	0.196890 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVS2, O95510, O95511	Gene names	MCAT, MT
Domain Architecture
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

MECR_MOUSE
θ value	0.000121331 (rank : 20)	NC score	0.399643 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DCS3, Q99L39	Gene names	Mecr, Nrbf1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38).

DHB4_MOUSE
θ value	0.000158464 (rank : 21)	NC score	0.096451 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	78	Shared Neighborhood Hits	11
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

RT4I1_MOUSE
θ value	0.000602161 (rank : 22)	NC score	0.356884 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q924D0, Q8R1T0	Gene names	Rtn4ip1, Nimp
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

ADH1_MOUSE
θ value	0.0252991 (rank : 23)	NC score	0.107875 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	P00329	Gene names	Adh1, Adh-1
Domain Architecture
Description	Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase A subunit) (ADH-A2).

RT4I1_HUMAN
θ value	0.0961366 (rank : 24)	NC score	0.327953 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

CK5P2_HUMAN
θ value	0.21417 (rank : 25)	NC score	0.012464 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	1433	Shared Neighborhood Hits	9
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

ANR38_MOUSE
θ value	0.47712 (rank : 26)	NC score	0.017631 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	512	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

DECR2_HUMAN
θ value	0.47712 (rank : 27)	NC score	0.036501 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NUI1, Q6ZRS7, Q96ET0	Gene names	DECR2, PDCR
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2) (pDCR).

ZADH1_HUMAN
θ value	0.47712 (rank : 28)	NC score	0.145847 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N8N7, Q6MZH8	Gene names	ZADH1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

ADH4_HUMAN
θ value	0.813845 (rank : 29)	NC score	0.089721 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P08319, Q8TCD7	Gene names	ADH4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain).

ECHB_MOUSE
θ value	0.813845 (rank : 30)	NC score	0.047958 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

LAMA1_HUMAN
θ value	0.813845 (rank : 31)	NC score	0.007876 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	804	Shared Neighborhood Hits	4
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

NEK1_MOUSE
θ value	1.06291 (rank : 32)	NC score	0.000892 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	1311	Shared Neighborhood Hits	4
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

ATS2_HUMAN
θ value	1.38821 (rank : 33)	NC score	0.010408 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

DHRS3_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.035425 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	O75911, Q6UY38, Q9BUC8	Gene names	DHRS3
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1) (DD83.1).

DHRS3_MOUSE
θ value	1.38821 (rank : 35)	NC score	0.039788 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

NNMT_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.027085 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P40261	Gene names	NNMT
Domain Architecture
Description	Nicotinamide N-methyltransferase (EC 2.1.1.1).

RDH12_MOUSE
θ value	1.38821 (rank : 37)	NC score	0.024063 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

COPB2_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.011473 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	P35606	Gene names	COPB2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

IL3B2_MOUSE
θ value	1.81305 (rank : 39)	NC score	0.018052 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	372	Shared Neighborhood Hits	3
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

APOA_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.009038 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	221	Shared Neighborhood Hits	4
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

MMTA2_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.031237 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LX5, Q9CSK6	Gene names	Mmtag2
Domain Architecture	No domain graphic available
Description	Multiple myeloma tumor-associated protein 2 homolog.

PPOX_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.024522 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P50336	Gene names	PPOX
Domain Architecture
Description	Protoporphyrinogen oxidase (EC 1.3.3.4) (PPO).

TDRD6_MOUSE
θ value	2.36792 (rank : 43)	NC score	0.039594 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

TLR5_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.009931 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

ZN553_MOUSE
θ value	2.36792 (rank : 45)	NC score	-0.000705 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	744	Shared Neighborhood Hits	4
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

ARID2_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.028363 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	302	Shared Neighborhood Hits	4
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

BIRC6_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.014881 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

DDR2_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.000172 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	818	Shared Neighborhood Hits	3
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DHRS4_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.023683 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	70	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BTZ2, O95162, Q6UWU3, Q8TD03, Q9H3N5, Q9NV08	Gene names	DHRS4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (SCAD-SRL) (humNRDR) (PSCD).

RDH12_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.019382 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

ATS2_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.008269 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

COPB2_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.009238 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	O55029, Q3U5Z9	Gene names	Copb2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

FANCG_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.017456 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O15287	Gene names	FANCG, XRCC9
Domain Architecture	No domain graphic available
Description	Fanconi anemia group G protein (Protein FACG) (DNA-repair protein XRCC9).

FIP1_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.034215 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

MTF1_HUMAN
θ value	5.27518 (rank : 55)	NC score	-0.000722 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	814	Shared Neighborhood Hits	5
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

NEP_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.008416 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

PARC_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.009548 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

RPGR1_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.009224 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	578	Shared Neighborhood Hits	5
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SNPC4_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.013820 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	237	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

TACC3_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.007521 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	779	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

ZP2_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.012749 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q05996	Gene names	ZP2, ZPA
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

CN135_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.018639 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q63HM2, Q9BQG8, Q9H9F2	Gene names	C14orf135, FBP2
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf135 precursor (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2).

ECHB_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.031689 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

INMT_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.026119 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0	Gene names	INMT
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

NU160_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.012502 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q12769, Q96GB3, Q9H660	Gene names	NUP160, KIAA0197, NUP120
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup160 (Nucleoporin Nup160) (160 kDa nucleoporin).

SAST_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.044769 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NV23	Gene names	OLAH, THEDC1
Domain Architecture	No domain graphic available
Description	S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain- containing protein 1).

CA026_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.010318 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T5J6, Q8NEK9, Q9BZQ7, Q9NXQ0	Gene names	C1orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf26.

GLE1_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.007434 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	445	Shared Neighborhood Hits	3
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

GPR64_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.003417 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CJ12, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10	Gene names	Gpr64, Me6
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (Me6 receptor).

HCD2_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.021882 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	73	Shared Neighborhood Hits	10
SwissProt Accessions	Q99714, Q8TCV9, Q96HD5	Gene names	HADH2, ERAB, HSD17B10, SCHAD, XH98G2
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2).

ITIH1_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.006353 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

K1849_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.005875 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	220	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

KCRS_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.006221 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P17540, Q8N1E1	Gene names	CKMT2
Domain Architecture
Description	Creatine kinase, sarcomeric mitochondrial precursor (EC 2.7.3.2) (S- MtCK) (Mib-CK) (Basic-type mitochondrial creatine kinase).

RAB36_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.001258 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	264	Shared Neighborhood Hits	2
SwissProt Accessions	O95755, Q7Z4A9, Q9UHP5	Gene names	RAB36
Domain Architecture
Description	Ras-related protein Rab-36.

RTDR1_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.017045 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHP6	Gene names	RTDR1
Domain Architecture
Description	Rhabdoid tumor deletion region protein 1.

ZBTB2_HUMAN
θ value	8.99809 (rank : 76)	NC score	-0.000334 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	752	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N680, Q5SZ81, Q9P245	Gene names	ZBTB2, KIAA1483, ZNF437
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 2.

ADH1A_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.101979 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	P07327	Gene names	ADH1A, ADH1
Domain Architecture
Description	Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase alpha subunit).

ADH1B_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.100567 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	18
SwissProt Accessions	P00325, Q13711, Q4ZGI9, Q96KI7	Gene names	ADH1B, ADH2
Domain Architecture
Description	Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase beta subunit).

ADH1G_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.096260 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P00326, Q4PJ18, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7	Gene names	ADH1C, ADH3
Domain Architecture
Description	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase gamma subunit).

ADH4_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.054176 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QYY9	Gene names	Adh4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II) (Alcohol dehydrogenase II) (ADH2).

ADH6_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.067685 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ADH7_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.070247 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

ADH7_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.056199 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

ADHX_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.073102 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	28	Shared Neighborhood Hits	15
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

ADHX_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.071921 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

DHSO_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.141230 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	15
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

FABD_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.092302 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3F5, Q4FZH0	Gene names	Mcat, Mt
Domain Architecture	No domain graphic available
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

ZADH1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.115239 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VDQ1, Q8BZA2, Q9D1W8	Gene names	Zadh1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

Hits sorted by NC score

FAS_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

FAS_HUMAN
NC score	0.989188 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

QORX_HUMAN
NC score	0.663596 (rank : 3)	θ value	1.37858e-24 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	22
SwissProt Accessions	Q53FA7, O14679, O14685, Q38G78, Q6JLE7, Q9BWB8	Gene names	TP53I3, PIG3
Domain Architecture	No domain graphic available
Description	Putative quinone oxidoreductase (EC 1.-.-.-) (Tumor protein p53- inducible protein 3) (p53-induced protein 3).

QOR_MOUSE
NC score	0.578890 (rank : 4)	θ value	2.7842e-17 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	21
SwissProt Accessions	P47199, Q62508, Q99L63	Gene names	Cryz
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

QOR_HUMAN
NC score	0.573239 (rank : 5)	θ value	1.13037e-18 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	21
SwissProt Accessions	Q08257, Q53FT0, Q59EU7, Q6NSK9	Gene names	CRYZ
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

VAT1_MOUSE
NC score	0.536570 (rank : 6)	θ value	3.18553e-13 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

VAT1_HUMAN
NC score	0.535918 (rank : 7)	θ value	1.42992e-13 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q99536, Q13035, Q96A39, Q9BUT8	Gene names	VAT1
Domain Architecture
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

OXSM_MOUSE
NC score	0.530493 (rank : 8)	θ value	1.99067e-23 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D404	Gene names	Oxsm
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

K1576_HUMAN
NC score	0.529142 (rank : 9)	θ value	1.2105e-12 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCJ6, Q8IYW8	Gene names	KIAA1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

K1576_MOUSE
NC score	0.528385 (rank : 10)	θ value	9.26847e-13 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	19
SwissProt Accessions	Q80TB8, Q6PGM9	Gene names	Kiaa1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

OXSM_HUMAN
NC score	0.523513 (rank : 11)	θ value	1.86321e-21 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NWU1	Gene names	OXSM
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

ZADH2_MOUSE
NC score	0.522013 (rank : 12)	θ value	6.00763e-12 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGC4	Gene names	Zadh2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

ZADH2_HUMAN
NC score	0.511460 (rank : 13)	θ value	1.02475e-11 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	33	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N4Q0	Gene names	ZADH2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

MECR_HUMAN
NC score	0.418426 (rank : 14)	θ value	7.59969e-07 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	39	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

QORL_MOUSE
NC score	0.409916 (rank : 15)	θ value	4.45536e-07 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	37	Shared Neighborhood Hits	21
SwissProt Accessions	Q921W4, Q3UKX2, Q8VCS1, Q9CWR9	Gene names	Cryzl1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog).

QORL_HUMAN
NC score	0.406961 (rank : 16)	θ value	1.69304e-06 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	39	Shared Neighborhood Hits	21
SwissProt Accessions	O95825, Q96DY0, Q9NVY7	Gene names	CRYZL1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog) (4P11).

MECR_MOUSE
NC score	0.399643 (rank : 17)	θ value	0.000121331 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DCS3, Q99L39	Gene names	Mecr, Nrbf1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38).

LTB4D_MOUSE
NC score	0.379232 (rank : 18)	θ value	2.88788e-06 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q91YR9, Q3TKT6, Q9CPS1	Gene names	Ltb4dh
Domain Architecture	No domain graphic available
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

LTB4D_HUMAN
NC score	0.371258 (rank : 19)	θ value	4.45536e-07 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	Q14914, Q8IYQ0, Q9H1X6	Gene names	LTB4DH
Domain Architecture
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

RT4I1_MOUSE
NC score	0.356884 (rank : 20)	θ value	0.000602161 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q924D0, Q8R1T0	Gene names	Rtn4ip1, Nimp
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

RT4I1_HUMAN
NC score	0.327953 (rank : 21)	θ value	0.0961366 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

FABD_HUMAN
NC score	0.196890 (rank : 22)	θ value	1.43324e-05 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVS2, O95510, O95511	Gene names	MCAT, MT
Domain Architecture
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

ZADH1_HUMAN
NC score	0.145847 (rank : 23)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N8N7, Q6MZH8	Gene names	ZADH1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

DHSO_HUMAN
NC score	0.141230 (rank : 24)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	15
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

ZADH1_MOUSE
NC score	0.115239 (rank : 25)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VDQ1, Q8BZA2, Q9D1W8	Gene names	Zadh1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

ADH1_MOUSE
NC score	0.107875 (rank : 26)	θ value	0.0252991 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	P00329	Gene names	Adh1, Adh-1
Domain Architecture
Description	Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase A subunit) (ADH-A2).

ADH1A_HUMAN
NC score	0.101979 (rank : 27)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	P07327	Gene names	ADH1A, ADH1
Domain Architecture
Description	Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase alpha subunit).

ADH1B_HUMAN
NC score	0.100567 (rank : 28)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	18
SwissProt Accessions	P00325, Q13711, Q4ZGI9, Q96KI7	Gene names	ADH1B, ADH2
Domain Architecture
Description	Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase beta subunit).

DHB4_MOUSE
NC score	0.096451 (rank : 29)	θ value	0.000158464 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	78	Shared Neighborhood Hits	11
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

ADH1G_HUMAN
NC score	0.096260 (rank : 30)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P00326, Q4PJ18, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7	Gene names	ADH1C, ADH3
Domain Architecture
Description	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase gamma subunit).

FABD_MOUSE
NC score	0.092302 (rank : 31)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3F5, Q4FZH0	Gene names	Mcat, Mt
Domain Architecture	No domain graphic available
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

ADH4_HUMAN
NC score	0.089721 (rank : 32)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P08319, Q8TCD7	Gene names	ADH4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain).

ADHX_HUMAN
NC score	0.073102 (rank : 33)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	28	Shared Neighborhood Hits	15
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

ADHX_MOUSE
NC score	0.071921 (rank : 34)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

ADH7_HUMAN
NC score	0.070247 (rank : 35)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

ADH6_HUMAN
NC score	0.067685 (rank : 36)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ADH7_MOUSE
NC score	0.056199 (rank : 37)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

ADH4_MOUSE
NC score	0.054176 (rank : 38)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QYY9	Gene names	Adh4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II) (Alcohol dehydrogenase II) (ADH2).

ECHB_MOUSE
NC score	0.047958 (rank : 39)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

SAST_HUMAN
NC score	0.044769 (rank : 40)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NV23	Gene names	OLAH, THEDC1
Domain Architecture	No domain graphic available
Description	S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain- containing protein 1).

DHRS3_MOUSE
NC score	0.039788 (rank : 41)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

TDRD6_MOUSE
NC score	0.039594 (rank : 42)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

DECR2_HUMAN
NC score	0.036501 (rank : 43)	θ value	0.47712 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NUI1, Q6ZRS7, Q96ET0	Gene names	DECR2, PDCR
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2) (pDCR).

DHRS3_HUMAN
NC score	0.035425 (rank : 44)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	O75911, Q6UY38, Q9BUC8	Gene names	DHRS3
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1) (DD83.1).

FIP1_HUMAN
NC score	0.034215 (rank : 45)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

ECHB_HUMAN
NC score	0.031689 (rank : 46)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

MMTA2_MOUSE
NC score	0.031237 (rank : 47)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LX5, Q9CSK6	Gene names	Mmtag2
Domain Architecture	No domain graphic available
Description	Multiple myeloma tumor-associated protein 2 homolog.

ARID2_HUMAN
NC score	0.028363 (rank : 48)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	302	Shared Neighborhood Hits	4
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

NNMT_HUMAN
NC score	0.027085 (rank : 49)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P40261	Gene names	NNMT
Domain Architecture
Description	Nicotinamide N-methyltransferase (EC 2.1.1.1).

INMT_HUMAN
NC score	0.026119 (rank : 50)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0	Gene names	INMT
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

PPOX_HUMAN
NC score	0.024522 (rank : 51)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P50336	Gene names	PPOX
Domain Architecture
Description	Protoporphyrinogen oxidase (EC 1.3.3.4) (PPO).

RDH12_MOUSE
NC score	0.024063 (rank : 52)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

DHRS4_HUMAN
NC score	0.023683 (rank : 53)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	70	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BTZ2, O95162, Q6UWU3, Q8TD03, Q9H3N5, Q9NV08	Gene names	DHRS4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (SCAD-SRL) (humNRDR) (PSCD).

HCD2_HUMAN
NC score	0.021882 (rank : 54)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	73	Shared Neighborhood Hits	10
SwissProt Accessions	Q99714, Q8TCV9, Q96HD5	Gene names	HADH2, ERAB, HSD17B10, SCHAD, XH98G2
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2).

RDH12_HUMAN
NC score	0.019382 (rank : 55)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

CN135_HUMAN
NC score	0.018639 (rank : 56)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q63HM2, Q9BQG8, Q9H9F2	Gene names	C14orf135, FBP2
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf135 precursor (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2).

IL3B2_MOUSE
NC score	0.018052 (rank : 57)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	372	Shared Neighborhood Hits	3
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

ANR38_MOUSE
NC score	0.017631 (rank : 58)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	512	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

FANCG_HUMAN
NC score	0.017456 (rank : 59)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O15287	Gene names	FANCG, XRCC9
Domain Architecture	No domain graphic available
Description	Fanconi anemia group G protein (Protein FACG) (DNA-repair protein XRCC9).

RTDR1_HUMAN
NC score	0.017045 (rank : 60)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHP6	Gene names	RTDR1
Domain Architecture
Description	Rhabdoid tumor deletion region protein 1.

BIRC6_HUMAN
NC score	0.014881 (rank : 61)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

SNPC4_MOUSE
NC score	0.013820 (rank : 62)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	237	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

ZP2_HUMAN
NC score	0.012749 (rank : 63)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q05996	Gene names	ZP2, ZPA
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

NU160_HUMAN
NC score	0.012502 (rank : 64)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q12769, Q96GB3, Q9H660	Gene names	NUP160, KIAA0197, NUP120
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup160 (Nucleoporin Nup160) (160 kDa nucleoporin).

CK5P2_HUMAN
NC score	0.012464 (rank : 65)	θ value	0.21417 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	1433	Shared Neighborhood Hits	9
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

COPB2_HUMAN
NC score	0.011473 (rank : 66)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	P35606	Gene names	COPB2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

ATS2_HUMAN
NC score	0.010408 (rank : 67)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

CA026_HUMAN
NC score	0.010318 (rank : 68)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T5J6, Q8NEK9, Q9BZQ7, Q9NXQ0	Gene names	C1orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf26.

TLR5_HUMAN
NC score	0.009931 (rank : 69)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

PARC_HUMAN
NC score	0.009548 (rank : 70)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

COPB2_MOUSE
NC score	0.009238 (rank : 71)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	O55029, Q3U5Z9	Gene names	Copb2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

RPGR1_HUMAN
NC score	0.009224 (rank : 72)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	578	Shared Neighborhood Hits	5
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

APOA_HUMAN
NC score	0.009038 (rank : 73)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	221	Shared Neighborhood Hits	4
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

NEP_MOUSE
NC score	0.008416 (rank : 74)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

ATS2_MOUSE
NC score	0.008269 (rank : 75)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

LAMA1_HUMAN
NC score	0.007876 (rank : 76)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	804	Shared Neighborhood Hits	4
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

TACC3_HUMAN
NC score	0.007521 (rank : 77)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	779	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

GLE1_HUMAN
NC score	0.007434 (rank : 78)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	445	Shared Neighborhood Hits	3
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

ITIH1_HUMAN
NC score	0.006353 (rank : 79)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

KCRS_HUMAN
NC score	0.006221 (rank : 80)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P17540, Q8N1E1	Gene names	CKMT2
Domain Architecture
Description	Creatine kinase, sarcomeric mitochondrial precursor (EC 2.7.3.2) (S- MtCK) (Mib-CK) (Basic-type mitochondrial creatine kinase).

K1849_HUMAN
NC score	0.005875 (rank : 81)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	220	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

GPR64_MOUSE
NC score	0.003417 (rank : 82)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CJ12, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10	Gene names	Gpr64, Me6
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (Me6 receptor).

RAB36_HUMAN
NC score	0.001258 (rank : 83)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	264	Shared Neighborhood Hits	2
SwissProt Accessions	O95755, Q7Z4A9, Q9UHP5	Gene names	RAB36
Domain Architecture
Description	Ras-related protein Rab-36.

NEK1_MOUSE
NC score	0.000892 (rank : 84)	θ value	1.06291 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	1311	Shared Neighborhood Hits	4
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

DDR2_HUMAN
NC score	0.000172 (rank : 85)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	818	Shared Neighborhood Hits	3
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ZBTB2_HUMAN
NC score	-0.000334 (rank : 86)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	752	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N680, Q5SZ81, Q9P245	Gene names	ZBTB2, KIAA1483, ZNF437
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 2.

ZN553_MOUSE
NC score	-0.000705 (rank : 87)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	744	Shared Neighborhood Hits	4
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

MTF1_HUMAN
NC score	-0.000722 (rank : 88)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	814	Shared Neighborhood Hits	5
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).