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Network neighborhood for query Sequence : FAS_HUMAN

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FAS_HUMAN
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FAS_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

FAS_MOUSE
θ value	0 (rank : 2)	NC score	0.989188 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

OXSM_MOUSE
θ value	2.59989e-23 (rank : 3)	NC score	0.538354 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D404	Gene names	Oxsm
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

OXSM_HUMAN
θ value	5.79196e-23 (rank : 4)	NC score	0.531709 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NWU1	Gene names	OXSM
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

QORX_HUMAN
θ value	7.56453e-23 (rank : 5)	NC score	0.651880 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	26
SwissProt Accessions	Q53FA7, O14679, O14685, Q38G78, Q6JLE7, Q9BWB8	Gene names	TP53I3, PIG3
Domain Architecture	No domain graphic available
Description	Putative quinone oxidoreductase (EC 1.-.-.-) (Tumor protein p53- inducible protein 3) (p53-induced protein 3).

QOR_HUMAN
θ value	8.10077e-17 (rank : 6)	NC score	0.572392 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	28
SwissProt Accessions	Q08257, Q53FT0, Q59EU7, Q6NSK9	Gene names	CRYZ
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

QOR_MOUSE
θ value	1.99529e-15 (rank : 7)	NC score	0.572604 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	28
SwissProt Accessions	P47199, Q62508, Q99L63	Gene names	Cryz
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

ZADH2_MOUSE
θ value	2.0648e-12 (rank : 8)	NC score	0.513211 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	32	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BGC4	Gene names	Zadh2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

K1576_HUMAN
θ value	7.84624e-12 (rank : 9)	NC score	0.518480 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCJ6, Q8IYW8	Gene names	KIAA1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

K1576_MOUSE
θ value	1.02475e-11 (rank : 10)	NC score	0.517674 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	26
SwissProt Accessions	Q80TB8, Q6PGM9	Gene names	Kiaa1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

ZADH2_HUMAN
θ value	1.33837e-11 (rank : 11)	NC score	0.503118 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N4Q0	Gene names	ZADH2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

VAT1_MOUSE
θ value	5.08577e-11 (rank : 12)	NC score	0.522728 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

VAT1_HUMAN
θ value	1.9326e-10 (rank : 13)	NC score	0.523413 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q99536, Q13035, Q96A39, Q9BUT8	Gene names	VAT1
Domain Architecture
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

QORL_MOUSE
θ value	3.41135e-07 (rank : 14)	NC score	0.406621 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	Q921W4, Q3UKX2, Q8VCS1, Q9CWR9	Gene names	Cryzl1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog).

QORL_HUMAN
θ value	1.29631e-06 (rank : 15)	NC score	0.403912 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	27
SwissProt Accessions	O95825, Q96DY0, Q9NVY7	Gene names	CRYZL1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog) (4P11).

LTB4D_MOUSE
θ value	2.21117e-06 (rank : 16)	NC score	0.362614 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q91YR9, Q3TKT6, Q9CPS1	Gene names	Ltb4dh
Domain Architecture	No domain graphic available
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

MECR_HUMAN
θ value	2.21117e-06 (rank : 17)	NC score	0.426381 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

LTB4D_HUMAN
θ value	1.43324e-05 (rank : 18)	NC score	0.352474 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q14914, Q8IYQ0, Q9H1X6	Gene names	LTB4DH
Domain Architecture
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

FABD_HUMAN
θ value	1.87187e-05 (rank : 19)	NC score	0.225827 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVS2, O95510, O95511	Gene names	MCAT, MT
Domain Architecture
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

MECR_MOUSE
θ value	0.000270298 (rank : 20)	NC score	0.403912 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DCS3, Q99L39	Gene names	Mecr, Nrbf1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38).

ADH1_MOUSE
θ value	0.00665767 (rank : 21)	NC score	0.168000 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	32	Shared Neighborhood Hits	25
SwissProt Accessions	P00329	Gene names	Adh1, Adh-1
Domain Architecture
Description	Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase A subunit) (ADH-A2).

FABD_MOUSE
θ value	0.00869519 (rank : 22)	NC score	0.125105 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3F5, Q4FZH0	Gene names	Mcat, Mt
Domain Architecture	No domain graphic available
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

ADH1A_HUMAN
θ value	0.0148317 (rank : 23)	NC score	0.162426 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P07327	Gene names	ADH1A, ADH1
Domain Architecture
Description	Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase alpha subunit).

ADH1G_HUMAN
θ value	0.0193708 (rank : 24)	NC score	0.157297 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	24
SwissProt Accessions	P00326, Q4PJ18, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7	Gene names	ADH1C, ADH3
Domain Architecture
Description	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase gamma subunit).

ADH4_HUMAN
θ value	0.0252991 (rank : 25)	NC score	0.147815 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	P08319, Q8TCD7	Gene names	ADH4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain).

ADH1B_HUMAN
θ value	0.0431538 (rank : 26)	NC score	0.161055 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	P00325, Q13711, Q4ZGI9, Q96KI7	Gene names	ADH1B, ADH2
Domain Architecture
Description	Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase beta subunit).

DHB4_MOUSE
θ value	0.0431538 (rank : 27)	NC score	0.086835 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

RT4I1_MOUSE
θ value	0.0431538 (rank : 28)	NC score	0.329224 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q924D0, Q8R1T0	Gene names	Rtn4ip1, Nimp
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

HXK3_HUMAN
θ value	0.365318 (rank : 29)	NC score	0.031100 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	P52790	Gene names	HK3
Domain Architecture
Description	Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III).

ADH6_HUMAN
θ value	0.62314 (rank : 30)	NC score	0.128093 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	21
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ADH7_HUMAN
θ value	0.62314 (rank : 31)	NC score	0.131131 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	24
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

HXK3_MOUSE
θ value	0.62314 (rank : 32)	NC score	0.029626 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q3TRM8, Q3TAX6, Q3UDP1, Q3UEA4	Gene names	Hk3
Domain Architecture	No domain graphic available
Description	Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III).

SAST_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.055949 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NV23	Gene names	OLAH, THEDC1
Domain Architecture	No domain graphic available
Description	S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain- containing protein 1).

DHB4_HUMAN
θ value	0.813845 (rank : 34)	NC score	0.038945 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

ECHB_MOUSE
θ value	0.813845 (rank : 35)	NC score	0.048520 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

APOA_HUMAN
θ value	1.06291 (rank : 36)	NC score	0.010307 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

RT4I1_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.301466 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

TDRD6_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.043746 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

FIP1_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.044380 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

ADH7_MOUSE
θ value	2.36792 (rank : 40)	NC score	0.117485 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

GOGA5_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.002999 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	1168	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

ARID2_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.027745 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	302	Shared Neighborhood Hits	5
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

CAN9_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.006980 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D805, O35919	Gene names	Capn9, Ncl4
Domain Architecture
Description	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (nCL-4).

MINT_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.007346 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	1291	Shared Neighborhood Hits	4
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ADHX_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.129724 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

CB032_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.027461 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q5M8N0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C2orf32 homolog.

CF165_HUMAN
θ value	5.27518 (rank : 47)	NC score	0.023090 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IYR0, Q8N9U4	Gene names	C6orf165
Domain Architecture	No domain graphic available
Description	Protein C6orf165.

FIP1_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.027080 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D824, Q8BWX7, Q99LH0, Q9DBB2	Gene names	Fip1l1
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1).

SAMH1_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.016982 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

TLR5_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.008801 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

AP1G1_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.010123 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.010152 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

CB032_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.025185 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q96F85, Q9UFZ0	Gene names	C2orf32
Domain Architecture	No domain graphic available
Description	Protein C2orf32.

CJ033_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.013605 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U4I7, Q8CAN2, Q9D630	Gene names
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 homolog (EC 1.-.-.-).

ECHB_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.032116 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

INMT_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.019294 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0	Gene names	INMT
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

MIA40_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.019924 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEA4	Gene names	Chchd4, Mia40
Domain Architecture	No domain graphic available
Description	Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4).

DHRS3_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.023895 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

HEM0_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.006989 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P22557, Q13735	Gene names	ALAS2, ALASE, ASB
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

NAT6_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.014144 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q93015, Q93014	Gene names	NAT6, FUS2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

NPM3_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.012755 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O75607, Q9UNY6	Gene names	NPM3
Domain Architecture
Description	Nucleoplasmin-3.

REC8L_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.011853 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O95072, Q8WUV8, Q9BTF2, Q9NVQ9	Gene names	REC8L1, REC8
Domain Architecture
Description	Meiotic recombination protein REC8-like 1 (Cohesin Rec8p).

RFPL2_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.003918 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

STAT6_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.006177 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	P42226	Gene names	STAT6
Domain Architecture
Description	Signal transducer and activator of transcription 6 (IL-4 Stat).

SYNJ2_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.006098 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

TRAK1_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.003761 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	660	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

ADH4_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.111514 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	25	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QYY9	Gene names	Adh4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II) (Alcohol dehydrogenase II) (ADH2).

ADHX_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.130835 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

DHSO_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.176973 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

ZADH1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.127357 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N8N7, Q6MZH8	Gene names	ZADH1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

ZADH1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.097932 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VDQ1, Q8BZA2, Q9D1W8	Gene names	Zadh1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

Hits sorted by NC score

FAS_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

FAS_MOUSE
NC score	0.989188 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

QORX_HUMAN
NC score	0.651880 (rank : 3)	θ value	7.56453e-23 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	26
SwissProt Accessions	Q53FA7, O14679, O14685, Q38G78, Q6JLE7, Q9BWB8	Gene names	TP53I3, PIG3
Domain Architecture	No domain graphic available
Description	Putative quinone oxidoreductase (EC 1.-.-.-) (Tumor protein p53- inducible protein 3) (p53-induced protein 3).

QOR_MOUSE
NC score	0.572604 (rank : 4)	θ value	1.99529e-15 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	28
SwissProt Accessions	P47199, Q62508, Q99L63	Gene names	Cryz
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

QOR_HUMAN
NC score	0.572392 (rank : 5)	θ value	8.10077e-17 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	28
SwissProt Accessions	Q08257, Q53FT0, Q59EU7, Q6NSK9	Gene names	CRYZ
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

OXSM_MOUSE
NC score	0.538354 (rank : 6)	θ value	2.59989e-23 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D404	Gene names	Oxsm
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

OXSM_HUMAN
NC score	0.531709 (rank : 7)	θ value	5.79196e-23 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NWU1	Gene names	OXSM
Domain Architecture	No domain graphic available
Description	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor (EC 2.3.1.41) (Beta-ketoacyl synthase).

VAT1_HUMAN
NC score	0.523413 (rank : 8)	θ value	1.9326e-10 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q99536, Q13035, Q96A39, Q9BUT8	Gene names	VAT1
Domain Architecture
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

VAT1_MOUSE
NC score	0.522728 (rank : 9)	θ value	5.08577e-11 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

K1576_HUMAN
NC score	0.518480 (rank : 10)	θ value	7.84624e-12 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCJ6, Q8IYW8	Gene names	KIAA1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

K1576_MOUSE
NC score	0.517674 (rank : 11)	θ value	1.02475e-11 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	26
SwissProt Accessions	Q80TB8, Q6PGM9	Gene names	Kiaa1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

ZADH2_MOUSE
NC score	0.513211 (rank : 12)	θ value	2.0648e-12 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	32	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BGC4	Gene names	Zadh2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

ZADH2_HUMAN
NC score	0.503118 (rank : 13)	θ value	1.33837e-11 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N4Q0	Gene names	ZADH2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

MECR_HUMAN
NC score	0.426381 (rank : 14)	θ value	2.21117e-06 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

QORL_MOUSE
NC score	0.406621 (rank : 15)	θ value	3.41135e-07 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	Q921W4, Q3UKX2, Q8VCS1, Q9CWR9	Gene names	Cryzl1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog).

MECR_MOUSE
NC score	0.403912 (rank : 16)	θ value	0.000270298 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DCS3, Q99L39	Gene names	Mecr, Nrbf1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38).

QORL_HUMAN
NC score	0.403912 (rank : 17)	θ value	1.29631e-06 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	27
SwissProt Accessions	O95825, Q96DY0, Q9NVY7	Gene names	CRYZL1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog) (4P11).

LTB4D_MOUSE
NC score	0.362614 (rank : 18)	θ value	2.21117e-06 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q91YR9, Q3TKT6, Q9CPS1	Gene names	Ltb4dh
Domain Architecture	No domain graphic available
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

LTB4D_HUMAN
NC score	0.352474 (rank : 19)	θ value	1.43324e-05 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q14914, Q8IYQ0, Q9H1X6	Gene names	LTB4DH
Domain Architecture
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

RT4I1_MOUSE
NC score	0.329224 (rank : 20)	θ value	0.0431538 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q924D0, Q8R1T0	Gene names	Rtn4ip1, Nimp
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

RT4I1_HUMAN
NC score	0.301466 (rank : 21)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

FABD_HUMAN
NC score	0.225827 (rank : 22)	θ value	1.87187e-05 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVS2, O95510, O95511	Gene names	MCAT, MT
Domain Architecture
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

DHSO_HUMAN
NC score	0.176973 (rank : 23)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

ADH1_MOUSE
NC score	0.168000 (rank : 24)	θ value	0.00665767 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	32	Shared Neighborhood Hits	25
SwissProt Accessions	P00329	Gene names	Adh1, Adh-1
Domain Architecture
Description	Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase A subunit) (ADH-A2).

ADH1A_HUMAN
NC score	0.162426 (rank : 25)	θ value	0.0148317 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P07327	Gene names	ADH1A, ADH1
Domain Architecture
Description	Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase alpha subunit).

ADH1B_HUMAN
NC score	0.161055 (rank : 26)	θ value	0.0431538 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	P00325, Q13711, Q4ZGI9, Q96KI7	Gene names	ADH1B, ADH2
Domain Architecture
Description	Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase beta subunit).

ADH1G_HUMAN
NC score	0.157297 (rank : 27)	θ value	0.0193708 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	24
SwissProt Accessions	P00326, Q4PJ18, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7	Gene names	ADH1C, ADH3
Domain Architecture
Description	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase gamma subunit).

ADH4_HUMAN
NC score	0.147815 (rank : 28)	θ value	0.0252991 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	P08319, Q8TCD7	Gene names	ADH4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain).

ADH7_HUMAN
NC score	0.131131 (rank : 29)	θ value	0.62314 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	24
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

ADHX_HUMAN
NC score	0.130835 (rank : 30)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

ADHX_MOUSE
NC score	0.129724 (rank : 31)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

ADH6_HUMAN
NC score	0.128093 (rank : 32)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	21
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ZADH1_HUMAN
NC score	0.127357 (rank : 33)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N8N7, Q6MZH8	Gene names	ZADH1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

FABD_MOUSE
NC score	0.125105 (rank : 34)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3F5, Q4FZH0	Gene names	Mcat, Mt
Domain Architecture	No domain graphic available
Description	Malonyl CoA-acyl carrier protein transacylase, mitochondrial precursor (EC 2.3.1.39) (MCT) (Mitochondrial malonyltransferase).

ADH7_MOUSE
NC score	0.117485 (rank : 35)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

ADH4_MOUSE
NC score	0.111514 (rank : 36)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	25	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QYY9	Gene names	Adh4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II) (Alcohol dehydrogenase II) (ADH2).

ZADH1_MOUSE
NC score	0.097932 (rank : 37)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VDQ1, Q8BZA2, Q9D1W8	Gene names	Zadh1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

DHB4_MOUSE
NC score	0.086835 (rank : 38)	θ value	0.0431538 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

SAST_HUMAN
NC score	0.055949 (rank : 39)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NV23	Gene names	OLAH, THEDC1
Domain Architecture	No domain graphic available
Description	S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain- containing protein 1).

ECHB_MOUSE
NC score	0.048520 (rank : 40)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

FIP1_HUMAN
NC score	0.044380 (rank : 41)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

TDRD6_MOUSE
NC score	0.043746 (rank : 42)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

DHB4_HUMAN
NC score	0.038945 (rank : 43)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

ECHB_HUMAN
NC score	0.032116 (rank : 44)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

HXK3_HUMAN
NC score	0.031100 (rank : 45)	θ value	0.365318 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	P52790	Gene names	HK3
Domain Architecture
Description	Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III).

HXK3_MOUSE
NC score	0.029626 (rank : 46)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q3TRM8, Q3TAX6, Q3UDP1, Q3UEA4	Gene names	Hk3
Domain Architecture	No domain graphic available
Description	Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III).

ARID2_HUMAN
NC score	0.027745 (rank : 47)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	302	Shared Neighborhood Hits	5
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

CB032_MOUSE
NC score	0.027461 (rank : 48)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q5M8N0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C2orf32 homolog.

FIP1_MOUSE
NC score	0.027080 (rank : 49)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D824, Q8BWX7, Q99LH0, Q9DBB2	Gene names	Fip1l1
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1).

CB032_HUMAN
NC score	0.025185 (rank : 50)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q96F85, Q9UFZ0	Gene names	C2orf32
Domain Architecture	No domain graphic available
Description	Protein C2orf32.

DHRS3_MOUSE
NC score	0.023895 (rank : 51)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

CF165_HUMAN
NC score	0.023090 (rank : 52)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IYR0, Q8N9U4	Gene names	C6orf165
Domain Architecture	No domain graphic available
Description	Protein C6orf165.

MIA40_MOUSE
NC score	0.019924 (rank : 53)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEA4	Gene names	Chchd4, Mia40
Domain Architecture	No domain graphic available
Description	Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4).

INMT_HUMAN
NC score	0.019294 (rank : 54)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0	Gene names	INMT
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

SAMH1_HUMAN
NC score	0.016982 (rank : 55)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

NAT6_HUMAN
NC score	0.014144 (rank : 56)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q93015, Q93014	Gene names	NAT6, FUS2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

CJ033_MOUSE
NC score	0.013605 (rank : 57)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U4I7, Q8CAN2, Q9D630	Gene names
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 homolog (EC 1.-.-.-).

NPM3_HUMAN
NC score	0.012755 (rank : 58)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O75607, Q9UNY6	Gene names	NPM3
Domain Architecture
Description	Nucleoplasmin-3.

REC8L_HUMAN
NC score	0.011853 (rank : 59)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O95072, Q8WUV8, Q9BTF2, Q9NVQ9	Gene names	REC8L1, REC8
Domain Architecture
Description	Meiotic recombination protein REC8-like 1 (Cohesin Rec8p).

APOA_HUMAN
NC score	0.010307 (rank : 60)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

AP1G1_MOUSE
NC score	0.010152 (rank : 61)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	P22892	Gene names	Ap1g1, Adtg, Clapg1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

AP1G1_HUMAN
NC score	0.010123 (rank : 62)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	O43747, O75709, O75842, Q9UG09, Q9Y3U4	Gene names	AP1G1, ADTG, CLAPG1
Domain Architecture
Description	AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma- 1 subunit) (Gamma-adaptin) (Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).

TLR5_HUMAN
NC score	0.008801 (rank : 63)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

MINT_HUMAN
NC score	0.007346 (rank : 64)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	1291	Shared Neighborhood Hits	4
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

HEM0_HUMAN
NC score	0.006989 (rank : 65)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P22557, Q13735	Gene names	ALAS2, ALASE, ASB
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

CAN9_MOUSE
NC score	0.006980 (rank : 66)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D805, O35919	Gene names	Capn9, Ncl4
Domain Architecture
Description	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (nCL-4).

STAT6_HUMAN
NC score	0.006177 (rank : 67)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	P42226	Gene names	STAT6
Domain Architecture
Description	Signal transducer and activator of transcription 6 (IL-4 Stat).

SYNJ2_MOUSE
NC score	0.006098 (rank : 68)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

RFPL2_HUMAN
NC score	0.003918 (rank : 69)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

TRAK1_HUMAN
NC score	0.003761 (rank : 70)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	660	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

GOGA5_HUMAN
NC score	0.002999 (rank : 71)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	1168	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).