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Network neighborhood for query Sequence : CLCN2_HUMAN

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CLCN2_HUMAN
SwissProt Accessions	P51788, O14864, Q8WU13	Gene names	CLCN2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CLCN1_HUMAN
θ value	0 (rank : 1)	NC score	0.985702 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CLCN1_MOUSE
θ value	0 (rank : 2)	NC score	0.987254 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CLCN2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	P51788, O14864, Q8WU13	Gene names	CLCN2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

CLCN2_MOUSE
θ value	0 (rank : 4)	NC score	0.998050 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R0A1, Q9WUJ9	Gene names	Clcn2, Clc2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

CLCKA_HUMAN
θ value	3.6343e-134 (rank : 5)	NC score	0.960859 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	P51800, Q7Z6D1, Q86VT1	Gene names	CLCNKA
Domain Architecture
Description	Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1).

CLCKB_HUMAN
θ value	1.99421e-132 (rank : 6)	NC score	0.963852 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	P51801	Gene names	CLCNKB
Domain Architecture
Description	Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2).

CLCKA_MOUSE
θ value	1.5801e-129 (rank : 7)	NC score	0.965721 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	22	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUB7, Q6UB69, Q8JZU7	Gene names	Clcnka, Clcnk1
Domain Architecture	No domain graphic available
Description	Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1).

CLCKB_MOUSE
θ value	5.09482e-120 (rank : 8)	NC score	0.960960 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUB6, Q8VCF8	Gene names	Clcnkb, Clckb, Clcnk1l
Domain Architecture	No domain graphic available
Description	Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2).

CLCN5_MOUSE
θ value	3.72821e-46 (rank : 9)	NC score	0.829974 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVD4	Gene names	Clcn5, Clc5
Domain Architecture
Description	Chloride channel protein 5 (ClC-5).

CLCN5_HUMAN
θ value	2.41655e-45 (rank : 10)	NC score	0.827002 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	P51795, Q5JQD5	Gene names	CLCN5, CLCK2
Domain Architecture
Description	Chloride channel protein 5 (ClC-5).

CLCN4_HUMAN
θ value	5.03882e-43 (rank : 11)	NC score	0.821055 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	P51793, Q9UBU1	Gene names	CLCN4
Domain Architecture
Description	Chloride channel protein 4 (ClC-4).

CLCN3_MOUSE
θ value	6.58091e-43 (rank : 12)	NC score	0.816035 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	P51791	Gene names	Clcn3, Clc3
Domain Architecture
Description	Chloride channel protein 3 (ClC-3).

CLCN3_HUMAN
θ value	7.27602e-42 (rank : 13)	NC score	0.814909 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	P51790, O14918, Q86Z21	Gene names	CLCN3
Domain Architecture
Description	Chloride channel protein 3 (ClC-3).

CLCN4_MOUSE
θ value	2.11701e-41 (rank : 14)	NC score	0.816450 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	Q61418	Gene names	Clcn4, Clc4, Clcn4-2
Domain Architecture
Description	Chloride channel protein 4 (ClC-4).

CLCN7_HUMAN
θ value	1.20211e-36 (rank : 15)	NC score	0.823594 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	P51798, Q9NYX5	Gene names	CLCN7
Domain Architecture
Description	Chloride channel protein 7 (ClC-7).

CLCN7_MOUSE
θ value	7.79185e-36 (rank : 16)	NC score	0.822786 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	O70496	Gene names	Clcn7, Clc7
Domain Architecture
Description	Chloride channel protein 7 (ClC-7).

CLCN6_HUMAN
θ value	8.3442e-30 (rank : 17)	NC score	0.776870 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	P51797, O60818, O60819, O60820, O60821, P78520, P78521, Q5SNW2, Q5SNW3, Q5SNX1, Q5SNX2, Q5SNX3, Q99427, Q99428, Q99429	Gene names	CLCN6, KIAA0046
Domain Architecture
Description	Chloride channel protein 6 (ClC-6).

CLCN6_MOUSE
θ value	9.2256e-29 (rank : 18)	NC score	0.770721 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	O35454	Gene names	Clcn6, Clc6
Domain Architecture
Description	Chloride channel protein 6 (ClC-6).

SRRM2_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.017250 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	1296	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CDT1_MOUSE
θ value	1.81305 (rank : 20)	NC score	0.018576 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

KCNQ2_MOUSE
θ value	1.81305 (rank : 21)	NC score	0.007344 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

SO2A1_MOUSE
θ value	1.81305 (rank : 22)	NC score	0.016535 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPT5	Gene names	Slco2a1, Slc21a2
Domain Architecture
Description	Solute carrier organic anion transporter family member 2A1 (Solute carrier family 21 member 2) (Prostaglandin transporter) (PGT).

THA11_MOUSE
θ value	1.81305 (rank : 23)	NC score	0.023536 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJD0	Gene names	Thap11
Domain Architecture
Description	THAP domain-containing protein 11.

K1794_HUMAN
θ value	2.36792 (rank : 24)	NC score	0.020679 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVI1, Q96JN1, Q96ST0, Q9BT96	Gene names	KIAA1794
Domain Architecture	No domain graphic available
Description	Protein KIAA1794.

MEN1_MOUSE
θ value	2.36792 (rank : 25)	NC score	0.016199 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	O88559	Gene names	Men1
Domain Architecture
Description	Menin.

PRG4_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.006152 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	764	Shared Neighborhood Hits	9
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

AUP1_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.022548 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y679, Q9H866, Q9UNQ6, Q9Y685	Gene names	AUP1
Domain Architecture
Description	Ancient ubiquitous protein 1 precursor.

AUP1_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.022706 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P70295	Gene names	Aup1
Domain Architecture
Description	Ancient ubiquitous protein 1 precursor.

CENPT_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.016269 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q96BT3, Q96I29, Q96IC6, Q96NK9, Q9H901	Gene names	CENPT, C16orf56, ICEN22
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T) (Interphase centromere complex protein 22).

CSPG2_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.003184 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	711	Shared Neighborhood Hits	6
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

DHB8_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.007584 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q92506, Q9UIQ1	Gene names	HSD17B8, FABGL, HKE6, RING2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

LAMA1_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.003671 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	804	Shared Neighborhood Hits	5
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LDB3_MOUSE
θ value	3.0926 (rank : 33)	NC score	0.003422 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	510	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

PLK3_HUMAN
θ value	3.0926 (rank : 34)	NC score	-0.000219 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	865	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	3.0926 (rank : 35)	NC score	-0.000194 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	863	Shared Neighborhood Hits	5
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

ZCH10_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.020423 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

CJ078_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.008451 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	559	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

LGP2_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.011805 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

NCOR2_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.006036 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	870	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

SETX_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.009664 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	368	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

G6PT_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.019630 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P35575	Gene names	G6PC, G6PT
Domain Architecture
Description	Glucose-6-phosphatase (EC 3.1.3.9) (G6Pase) (G-6-Pase).

ITSN1_HUMAN
θ value	5.27518 (rank : 42)	NC score	-0.001053 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	1757	Shared Neighborhood Hits	9
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

OBSCN_HUMAN
θ value	6.88961 (rank : 43)	NC score	-0.001499 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	1931	Shared Neighborhood Hits	11
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

COG4_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.007026 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H9E3, Q96D40, Q9BRF0, Q9BVZ2, Q9H5Y4, Q9Y3W3	Gene names	COG4
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 4.

RGNEF_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.002551 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	641	Shared Neighborhood Hits	3
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

TXND2_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.002120 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	828	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

Hits sorted by NC score

CLCN2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	P51788, O14864, Q8WU13	Gene names	CLCN2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

CLCN2_MOUSE
NC score	0.998050 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R0A1, Q9WUJ9	Gene names	Clcn2, Clc2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

CLCN1_MOUSE
NC score	0.987254 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CLCN1_HUMAN
NC score	0.985702 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CLCKA_MOUSE
NC score	0.965721 (rank : 5)	θ value	1.5801e-129 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	22	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUB7, Q6UB69, Q8JZU7	Gene names	Clcnka, Clcnk1
Domain Architecture	No domain graphic available
Description	Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1).

CLCKB_HUMAN
NC score	0.963852 (rank : 6)	θ value	1.99421e-132 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	P51801	Gene names	CLCNKB
Domain Architecture
Description	Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2).

CLCKB_MOUSE
NC score	0.960960 (rank : 7)	θ value	5.09482e-120 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUB6, Q8VCF8	Gene names	Clcnkb, Clckb, Clcnk1l
Domain Architecture	No domain graphic available
Description	Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2).

CLCKA_HUMAN
NC score	0.960859 (rank : 8)	θ value	3.6343e-134 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	P51800, Q7Z6D1, Q86VT1	Gene names	CLCNKA
Domain Architecture
Description	Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1).

CLCN5_MOUSE
NC score	0.829974 (rank : 9)	θ value	3.72821e-46 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVD4	Gene names	Clcn5, Clc5
Domain Architecture
Description	Chloride channel protein 5 (ClC-5).

CLCN5_HUMAN
NC score	0.827002 (rank : 10)	θ value	2.41655e-45 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	P51795, Q5JQD5	Gene names	CLCN5, CLCK2
Domain Architecture
Description	Chloride channel protein 5 (ClC-5).

CLCN7_HUMAN
NC score	0.823594 (rank : 11)	θ value	1.20211e-36 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	P51798, Q9NYX5	Gene names	CLCN7
Domain Architecture
Description	Chloride channel protein 7 (ClC-7).

CLCN7_MOUSE
NC score	0.822786 (rank : 12)	θ value	7.79185e-36 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	O70496	Gene names	Clcn7, Clc7
Domain Architecture
Description	Chloride channel protein 7 (ClC-7).

CLCN4_HUMAN
NC score	0.821055 (rank : 13)	θ value	5.03882e-43 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	P51793, Q9UBU1	Gene names	CLCN4
Domain Architecture
Description	Chloride channel protein 4 (ClC-4).

CLCN4_MOUSE
NC score	0.816450 (rank : 14)	θ value	2.11701e-41 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	Q61418	Gene names	Clcn4, Clc4, Clcn4-2
Domain Architecture
Description	Chloride channel protein 4 (ClC-4).

CLCN3_MOUSE
NC score	0.816035 (rank : 15)	θ value	6.58091e-43 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	P51791	Gene names	Clcn3, Clc3
Domain Architecture
Description	Chloride channel protein 3 (ClC-3).

CLCN3_HUMAN
NC score	0.814909 (rank : 16)	θ value	7.27602e-42 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	P51790, O14918, Q86Z21	Gene names	CLCN3
Domain Architecture
Description	Chloride channel protein 3 (ClC-3).

CLCN6_HUMAN
NC score	0.776870 (rank : 17)	θ value	8.3442e-30 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	P51797, O60818, O60819, O60820, O60821, P78520, P78521, Q5SNW2, Q5SNW3, Q5SNX1, Q5SNX2, Q5SNX3, Q99427, Q99428, Q99429	Gene names	CLCN6, KIAA0046
Domain Architecture
Description	Chloride channel protein 6 (ClC-6).

CLCN6_MOUSE
NC score	0.770721 (rank : 18)	θ value	9.2256e-29 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	O35454	Gene names	Clcn6, Clc6
Domain Architecture
Description	Chloride channel protein 6 (ClC-6).

THA11_MOUSE
NC score	0.023536 (rank : 19)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJD0	Gene names	Thap11
Domain Architecture
Description	THAP domain-containing protein 11.

AUP1_MOUSE
NC score	0.022706 (rank : 20)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P70295	Gene names	Aup1
Domain Architecture
Description	Ancient ubiquitous protein 1 precursor.

AUP1_HUMAN
NC score	0.022548 (rank : 21)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y679, Q9H866, Q9UNQ6, Q9Y685	Gene names	AUP1
Domain Architecture
Description	Ancient ubiquitous protein 1 precursor.

K1794_HUMAN
NC score	0.020679 (rank : 22)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVI1, Q96JN1, Q96ST0, Q9BT96	Gene names	KIAA1794
Domain Architecture	No domain graphic available
Description	Protein KIAA1794.

ZCH10_HUMAN
NC score	0.020423 (rank : 23)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

G6PT_HUMAN
NC score	0.019630 (rank : 24)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P35575	Gene names	G6PC, G6PT
Domain Architecture
Description	Glucose-6-phosphatase (EC 3.1.3.9) (G6Pase) (G-6-Pase).

CDT1_MOUSE
NC score	0.018576 (rank : 25)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

SRRM2_HUMAN
NC score	0.017250 (rank : 26)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	1296	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SO2A1_MOUSE
NC score	0.016535 (rank : 27)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPT5	Gene names	Slco2a1, Slc21a2
Domain Architecture
Description	Solute carrier organic anion transporter family member 2A1 (Solute carrier family 21 member 2) (Prostaglandin transporter) (PGT).

CENPT_HUMAN
NC score	0.016269 (rank : 28)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q96BT3, Q96I29, Q96IC6, Q96NK9, Q9H901	Gene names	CENPT, C16orf56, ICEN22
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T) (Interphase centromere complex protein 22).

MEN1_MOUSE
NC score	0.016199 (rank : 29)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	O88559	Gene names	Men1
Domain Architecture
Description	Menin.

LGP2_HUMAN
NC score	0.011805 (rank : 30)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

SETX_HUMAN
NC score	0.009664 (rank : 31)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	368	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

CJ078_MOUSE
NC score	0.008451 (rank : 32)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	559	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

DHB8_HUMAN
NC score	0.007584 (rank : 33)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q92506, Q9UIQ1	Gene names	HSD17B8, FABGL, HKE6, RING2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

KCNQ2_MOUSE
NC score	0.007344 (rank : 34)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

COG4_HUMAN
NC score	0.007026 (rank : 35)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H9E3, Q96D40, Q9BRF0, Q9BVZ2, Q9H5Y4, Q9Y3W3	Gene names	COG4
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 4.

PRG4_HUMAN
NC score	0.006152 (rank : 36)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	764	Shared Neighborhood Hits	9
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

NCOR2_HUMAN
NC score	0.006036 (rank : 37)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	870	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

LAMA1_HUMAN
NC score	0.003671 (rank : 38)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	804	Shared Neighborhood Hits	5
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LDB3_MOUSE
NC score	0.003422 (rank : 39)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	510	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

CSPG2_MOUSE
NC score	0.003184 (rank : 40)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	711	Shared Neighborhood Hits	6
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

RGNEF_MOUSE
NC score	0.002551 (rank : 41)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	641	Shared Neighborhood Hits	3
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

TXND2_MOUSE
NC score	0.002120 (rank : 42)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	828	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

PLK3_MOUSE
NC score	-0.000194 (rank : 43)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	863	Shared Neighborhood Hits	5
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK3_HUMAN
NC score	-0.000219 (rank : 44)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	865	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

ITSN1_HUMAN
NC score	-0.001053 (rank : 45)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	1757	Shared Neighborhood Hits	9
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

OBSCN_HUMAN
NC score	-0.001499 (rank : 46)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	1931	Shared Neighborhood Hits	11
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).