Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : STAG3_MOUSE

For an explanation of this page, click here

STAG3_MOUSE
SwissProt Accessions	O70576	Gene names	Stag3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

STAG1_HUMAN
θ value	0 (rank : 1)	NC score	0.982568 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

STAG1_MOUSE
θ value	0 (rank : 2)	NC score	0.983083 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

STAG2_HUMAN
θ value	0 (rank : 3)	NC score	0.984214 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N3U4, O00540, Q5JTI6, Q9H1N8	Gene names	STAG2, SA2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

STAG2_MOUSE
θ value	0 (rank : 4)	NC score	0.984081 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	35	Shared Neighborhood Hits	7
SwissProt Accessions	O35638, Q6NZN7	Gene names	Stag2, Sa2, Sap2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

STAG3_HUMAN
θ value	0 (rank : 5)	NC score	0.996144 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

STAG3_MOUSE
θ value	0 (rank : 6)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	O70576	Gene names	Stag3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

BRWD1_HUMAN
θ value	0.813845 (rank : 7)	NC score	0.010585 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	448	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

WDR46_MOUSE
θ value	1.06291 (rank : 8)	NC score	0.026766 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	243	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

XRCC1_MOUSE
θ value	1.06291 (rank : 9)	NC score	0.031939 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

GBP1_HUMAN
θ value	1.38821 (rank : 10)	NC score	0.012355 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	339	Shared Neighborhood Hits	3
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

SYNE2_HUMAN
θ value	1.38821 (rank : 11)	NC score	0.017543 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	1323	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

PKHG1_HUMAN
θ value	1.81305 (rank : 12)	NC score	0.013824 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

TNPO1_MOUSE
θ value	1.81305 (rank : 13)	NC score	0.016186 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

DMRTD_HUMAN
θ value	2.36792 (rank : 14)	NC score	0.015896 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	216	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

K1958_HUMAN
θ value	2.36792 (rank : 15)	NC score	0.023511 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N8K9, Q5T252, Q8TF43, Q96N02	Gene names	KIAA1958
Domain Architecture	No domain graphic available
Description	Protein KIAA1958.

CAC1G_HUMAN
θ value	3.0926 (rank : 16)	NC score	0.006228 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	587	Shared Neighborhood Hits	3
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

DPEP3_MOUSE
θ value	3.0926 (rank : 17)	NC score	0.011980 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DA79	Gene names	Dpep3, Mbd3
Domain Architecture	No domain graphic available
Description	Dipeptidase 3 precursor (EC 3.4.13.19) (Membrane-bound dipeptidase 3) (MBD-3).

TDRD5_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.017239 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NAT2, Q5VTV0	Gene names	TDRD5
Domain Architecture
Description	Tudor domain-containing protein 5.

DYM_MOUSE
θ value	5.27518 (rank : 19)	NC score	0.018886 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CHY3	Gene names	Dym
Domain Architecture	No domain graphic available
Description	Dymeclin.

GCM2_HUMAN
θ value	5.27518 (rank : 20)	NC score	0.011859 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	O75603	Gene names	GCM2, GCMB
Domain Architecture
Description	Chorion-specific transcription factor GCMb (Glial cells missing homolog 2) (GCM motif protein 2) (hGCMb).

K1958_MOUSE
θ value	5.27518 (rank : 21)	NC score	0.020857 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C4P0, Q8BN62, Q8K1X8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1958 homolog.

WDR46_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.021212 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	O15213, Q5STK5	Gene names	WDR46, BING4, C6orf11
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

AOAH_HUMAN
θ value	6.88961 (rank : 23)	NC score	0.020606 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P28039, Q53F13	Gene names	AOAH
Domain Architecture
Description	Acyloxyacyl hydrolase precursor (EC 3.1.1.77) [Contains: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit].

M3K2_MOUSE
θ value	8.99809 (rank : 24)	NC score	-0.001265 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	846	Shared Neighborhood Hits	2
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

SMOO_HUMAN
θ value	8.99809 (rank : 25)	NC score	0.006726 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	391	Shared Neighborhood Hits	5
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

WFDC8_HUMAN
θ value	8.99809 (rank : 26)	NC score	0.008486 (rank : 24)
Query Neighborhood Hits	26	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

CJ068_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.050062 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	316	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

Hits sorted by NC score

STAG3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	O70576	Gene names	Stag3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

STAG3_HUMAN
NC score	0.996144 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

STAG2_HUMAN
NC score	0.984214 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N3U4, O00540, Q5JTI6, Q9H1N8	Gene names	STAG2, SA2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

STAG2_MOUSE
NC score	0.984081 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	35	Shared Neighborhood Hits	7
SwissProt Accessions	O35638, Q6NZN7	Gene names	Stag2, Sa2, Sap2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

STAG1_MOUSE
NC score	0.983083 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

STAG1_HUMAN
NC score	0.982568 (rank : 6)	θ value	0 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

CJ068_HUMAN
NC score	0.050062 (rank : 7)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	316	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

XRCC1_MOUSE
NC score	0.031939 (rank : 8)	θ value	1.06291 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

WDR46_MOUSE
NC score	0.026766 (rank : 9)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	243	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

K1958_HUMAN
NC score	0.023511 (rank : 10)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N8K9, Q5T252, Q8TF43, Q96N02	Gene names	KIAA1958
Domain Architecture	No domain graphic available
Description	Protein KIAA1958.

WDR46_HUMAN
NC score	0.021212 (rank : 11)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	O15213, Q5STK5	Gene names	WDR46, BING4, C6orf11
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

K1958_MOUSE
NC score	0.020857 (rank : 12)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C4P0, Q8BN62, Q8K1X8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1958 homolog.

AOAH_HUMAN
NC score	0.020606 (rank : 13)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P28039, Q53F13	Gene names	AOAH
Domain Architecture
Description	Acyloxyacyl hydrolase precursor (EC 3.1.1.77) [Contains: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit].

DYM_MOUSE
NC score	0.018886 (rank : 14)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CHY3	Gene names	Dym
Domain Architecture	No domain graphic available
Description	Dymeclin.

SYNE2_HUMAN
NC score	0.017543 (rank : 15)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	1323	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TDRD5_HUMAN
NC score	0.017239 (rank : 16)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NAT2, Q5VTV0	Gene names	TDRD5
Domain Architecture
Description	Tudor domain-containing protein 5.

TNPO1_MOUSE
NC score	0.016186 (rank : 17)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

DMRTD_HUMAN
NC score	0.015896 (rank : 18)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	216	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

PKHG1_HUMAN
NC score	0.013824 (rank : 19)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

GBP1_HUMAN
NC score	0.012355 (rank : 20)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	339	Shared Neighborhood Hits	3
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

DPEP3_MOUSE
NC score	0.011980 (rank : 21)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DA79	Gene names	Dpep3, Mbd3
Domain Architecture	No domain graphic available
Description	Dipeptidase 3 precursor (EC 3.4.13.19) (Membrane-bound dipeptidase 3) (MBD-3).

GCM2_HUMAN
NC score	0.011859 (rank : 22)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	O75603	Gene names	GCM2, GCMB
Domain Architecture
Description	Chorion-specific transcription factor GCMb (Glial cells missing homolog 2) (GCM motif protein 2) (hGCMb).

BRWD1_HUMAN
NC score	0.010585 (rank : 23)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	448	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

WFDC8_HUMAN
NC score	0.008486 (rank : 24)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

SMOO_HUMAN
NC score	0.006726 (rank : 25)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	391	Shared Neighborhood Hits	5
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

CAC1G_HUMAN
NC score	0.006228 (rank : 26)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	587	Shared Neighborhood Hits	3
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

M3K2_MOUSE
NC score	-0.001265 (rank : 27)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	26	Target Neighborhood Hits	846	Shared Neighborhood Hits	2
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).