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Network neighborhood for query Sequence : TPP2_MOUSE

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TPP2_MOUSE
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TPP2_HUMAN
θ value	0 (rank : 1)	NC score	0.997785 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	17
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

TPP2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

MBTP1_MOUSE
θ value	1.47974e-10 (rank : 3)	NC score	0.373180 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

MBTP1_HUMAN
θ value	2.52405e-10 (rank : 4)	NC score	0.370516 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

CSPG3_MOUSE
θ value	0.47712 (rank : 5)	NC score	0.021914 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	657	Shared Neighborhood Hits	5
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

HECD1_HUMAN
θ value	1.38821 (rank : 6)	NC score	0.027298 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	371	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

AL3B2_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.019685 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P48448, Q8NAL5, Q96IB2	Gene names	ALDH3B2, ALDH8
Domain Architecture
Description	Aldehyde dehydrogenase 3B2 (EC 1.2.1.5) (Aldehyde dehydrogenase 8).

TAXB1_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.014364 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	829	Shared Neighborhood Hits	5
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

CSKI1_MOUSE
θ value	2.36792 (rank : 9)	NC score	0.016142 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	1031	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

GSCR1_HUMAN
θ value	4.03905 (rank : 10)	NC score	0.026205 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	674	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

CSKI1_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.012728 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	997	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

LPXN_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.010866 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q99N69	Gene names	Lpxn
Domain Architecture	No domain graphic available
Description	Leupaxin.

PCSK9_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.041579 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

PTN13_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.008882 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	471	Shared Neighborhood Hits	4
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

CK5P2_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.008548 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	1151	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

FREM2_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.008076 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

LAMA2_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.004139 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	1198	Shared Neighborhood Hits	6
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LPPRC_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.031550 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	P42704	Gene names	LRPPRC, LRP130
Domain Architecture	No domain graphic available
Description	130 kDa leucine-rich protein (LRP 130) (GP130) (Leucine-rich PPR motif-containing protein).

PTPRR_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.013147 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

SPT5H_MOUSE
θ value	6.88961 (rank : 20)	NC score	0.018589 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	437	Shared Neighborhood Hits	6
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

TAXB1_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.010524 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	886	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

MARH2_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.011813 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P0N8, Q8N5A3, Q96B78	Gene names	MARCH2, RNF172
Domain Architecture	No domain graphic available
Description	Membrane-associated RING finger protein 2 (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172).

PCSK9_HUMAN
θ value	8.99809 (rank : 23)	NC score	0.034896 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

SPT5H_HUMAN
θ value	8.99809 (rank : 24)	NC score	0.017339 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	436	Shared Neighborhood Hits	6
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

Hits sorted by NC score

TPP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

TPP2_HUMAN
NC score	0.997785 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	17
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

MBTP1_MOUSE
NC score	0.373180 (rank : 3)	θ value	1.47974e-10 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

MBTP1_HUMAN
NC score	0.370516 (rank : 4)	θ value	2.52405e-10 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

PCSK9_MOUSE
NC score	0.041579 (rank : 5)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q80W65, Q3UEH7, Q8BXW9, Q8CFT6	Gene names	Pcsk9, Narc1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

PCSK9_HUMAN
NC score	0.034896 (rank : 6)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

LPPRC_HUMAN
NC score	0.031550 (rank : 7)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	P42704	Gene names	LRPPRC, LRP130
Domain Architecture	No domain graphic available
Description	130 kDa leucine-rich protein (LRP 130) (GP130) (Leucine-rich PPR motif-containing protein).

HECD1_HUMAN
NC score	0.027298 (rank : 8)	θ value	1.38821 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	371	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

GSCR1_HUMAN
NC score	0.026205 (rank : 9)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	674	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

CSPG3_MOUSE
NC score	0.021914 (rank : 10)	θ value	0.47712 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	657	Shared Neighborhood Hits	5
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

AL3B2_HUMAN
NC score	0.019685 (rank : 11)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P48448, Q8NAL5, Q96IB2	Gene names	ALDH3B2, ALDH8
Domain Architecture
Description	Aldehyde dehydrogenase 3B2 (EC 1.2.1.5) (Aldehyde dehydrogenase 8).

SPT5H_MOUSE
NC score	0.018589 (rank : 12)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	437	Shared Neighborhood Hits	6
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SPT5H_HUMAN
NC score	0.017339 (rank : 13)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	436	Shared Neighborhood Hits	6
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

CSKI1_MOUSE
NC score	0.016142 (rank : 14)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	1031	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

TAXB1_HUMAN
NC score	0.014364 (rank : 15)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	829	Shared Neighborhood Hits	5
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

PTPRR_HUMAN
NC score	0.013147 (rank : 16)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

CSKI1_HUMAN
NC score	0.012728 (rank : 17)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	997	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MARH2_HUMAN
NC score	0.011813 (rank : 18)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P0N8, Q8N5A3, Q96B78	Gene names	MARCH2, RNF172
Domain Architecture	No domain graphic available
Description	Membrane-associated RING finger protein 2 (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172).

LPXN_MOUSE
NC score	0.010866 (rank : 19)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q99N69	Gene names	Lpxn
Domain Architecture	No domain graphic available
Description	Leupaxin.

TAXB1_MOUSE
NC score	0.010524 (rank : 20)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	886	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

PTN13_HUMAN
NC score	0.008882 (rank : 21)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	471	Shared Neighborhood Hits	4
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

CK5P2_MOUSE
NC score	0.008548 (rank : 22)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	1151	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

FREM2_HUMAN
NC score	0.008076 (rank : 23)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

LAMA2_MOUSE
NC score	0.004139 (rank : 24)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	1198	Shared Neighborhood Hits	6
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).