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Network neighborhood for query Sequence : MEF2A_HUMAN

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MEF2A_HUMAN
SwissProt Accessions	Q02078, O43814, Q14223, Q14224, Q96D14	Gene names	MEF2A, MEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MEF2A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q02078, O43814, Q14223, Q14224, Q96D14	Gene names	MEF2A, MEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1).

MEF2A_MOUSE
θ value	0 (rank : 2)	NC score	0.990652 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	Q60929	Gene names	Mef2a
Domain Architecture
Description	Myocyte-specific enhancer factor 2A.

MEF2C_HUMAN
θ value	9.89713e-132 (rank : 3)	NC score	0.968260 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q06413	Gene names	MEF2C
Domain Architecture
Description	Myocyte-specific enhancer factor 2C.

MEF2C_MOUSE
θ value	9.89713e-132 (rank : 4)	NC score	0.969960 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	92	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFN5, Q8R0H1, Q9D7L0, Q9QW20	Gene names	Mef2c
Domain Architecture	No domain graphic available
Description	Myocyte-specific enhancer factor 2C.

MEF2D_HUMAN
θ value	5.45601e-114 (rank : 5)	NC score	0.953939 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	18
SwissProt Accessions	Q14814, Q14815	Gene names	MEF2D
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

MEF2D_MOUSE
θ value	2.6227e-108 (rank : 6)	NC score	0.954101 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	146	Shared Neighborhood Hits	18
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

MEF2B_HUMAN
θ value	9.50281e-42 (rank : 7)	NC score	0.894618 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

MEF2B_MOUSE
θ value	1.05066e-40 (rank : 8)	NC score	0.846448 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	218	Shared Neighborhood Hits	16
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

SRF_HUMAN
θ value	2.88788e-06 (rank : 9)	NC score	0.459180 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	P11831	Gene names	SRF
Domain Architecture
Description	Serum response factor (SRF).

SRF_MOUSE
θ value	2.88788e-06 (rank : 10)	NC score	0.462985 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JM73	Gene names	Srf
Domain Architecture	No domain graphic available
Description	Serum response factor (SRF).

MAGE1_HUMAN
θ value	0.125558 (rank : 11)	NC score	0.035569 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	1389	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

LCOR_MOUSE
θ value	0.163984 (rank : 12)	NC score	0.063308 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPI3, Q3U302, Q5CZW7, Q80VA8, Q8BGT2, Q8C9Q0	Gene names	Lcor, Kiaa1795, Mlr2
Domain Architecture	No domain graphic available
Description	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2).

LCOR_HUMAN
θ value	0.21417 (rank : 13)	NC score	0.062366 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JN0, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6	Gene names	LCOR, KIAA1795, MLR2
Domain Architecture	No domain graphic available
Description	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2).

DOT1L_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.047152 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	660	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

SPEG_MOUSE
θ value	0.365318 (rank : 15)	NC score	0.009420 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	1959	Shared Neighborhood Hits	25
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ARI1A_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.037760 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	787	Shared Neighborhood Hits	28
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

CNOT4_MOUSE
θ value	0.47712 (rank : 17)	NC score	0.040341 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	277	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

HRX_HUMAN
θ value	0.62314 (rank : 18)	NC score	0.024149 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	825	Shared Neighborhood Hits	19
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

PTN22_MOUSE
θ value	0.62314 (rank : 19)	NC score	0.010844 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	179	Shared Neighborhood Hits	6
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

HDAC5_HUMAN
θ value	0.813845 (rank : 20)	NC score	0.020233 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	353	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

NCOA6_HUMAN
θ value	0.813845 (rank : 21)	NC score	0.059380 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	1202	Shared Neighborhood Hits	39
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SON_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.023819 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	1568	Shared Neighborhood Hits	31
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

PSL1_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.029000 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	650	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

STK10_MOUSE
θ value	1.38821 (rank : 24)	NC score	0.001249 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	2132	Shared Neighborhood Hits	17
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

THAP4_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.022763 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

DC1L2_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.017160 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	O43237, Q8TAT3	Gene names	DYNC1LI2, DNCLI2, LIC2
Domain Architecture
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC53/55) (LIC-2).

HDAC5_MOUSE
θ value	1.81305 (rank : 27)	NC score	0.019106 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

PER2_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.025267 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	11
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	1.81305 (rank : 29)	NC score	0.027528 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	325	Shared Neighborhood Hits	9
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

TREF1_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.014921 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	682	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

EPN2_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.014461 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

SRRM2_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.030524 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	1470	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

WNK1_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.008369 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	1158	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ZO1_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.009973 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ADA29_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.005328 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	247	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

CBP_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.025422 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	1051	Shared Neighborhood Hits	29
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

NCOA6_MOUSE
θ value	3.0926 (rank : 37)	NC score	0.041758 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	1076	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SAS6_HUMAN
θ value	3.0926 (rank : 38)	NC score	0.017263 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	791	Shared Neighborhood Hits	7
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

CNOT4_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.032376 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

GAK7_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.013147 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

JPH2_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.011330 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	639	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

MUCDL_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.013180 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	461	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NCOA2_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.011362 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	281	Shared Neighborhood Hits	9
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

ZAR1_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.019146 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	254	Shared Neighborhood Hits	11
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

CSF1_HUMAN
θ value	5.27518 (rank : 45)	NC score	0.024840 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	258	Shared Neighborhood Hits	14
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

GAK5_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.013246 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	429	Shared Neighborhood Hits	16
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ITB4_HUMAN
θ value	5.27518 (rank : 47)	NC score	0.004723 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	458	Shared Neighborhood Hits	4
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

JHD2C_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.008534 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	297	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9	Gene names	Jmjd1c, Jhdm2c, Kiaa1380
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C).

MELPH_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.013109 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MYO1E_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.002678 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	5
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NDUV2_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.016284 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P19404, Q9BV41	Gene names	NDUFV2
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit).

PHLPP_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.010887 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	604	Shared Neighborhood Hits	16
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

GRIN1_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.011141 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	681	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

NUMB_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.010937 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

TCF20_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.015987 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	323	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TENX_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.001391 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	789	Shared Neighborhood Hits	5
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

ATF6B_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.008326 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

CO1A2_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.008260 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	388	Shared Neighborhood Hits	13
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

DDEF1_MOUSE
θ value	8.99809 (rank : 59)	NC score	0.006889 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	592	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ECM29_MOUSE
θ value	8.99809 (rank : 60)	NC score	0.008248 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

FREM3_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.005061 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

K1914_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.008189 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MTG8_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.007650 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q61909	Gene names	Runx1t1, Cbfa2t1, Cbfa2t1h, Mtg8
Domain Architecture
Description	Protein CBFA2T1 (Protein MTG8).

PHLPP_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.006893 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	394	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

RGS3_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.010632 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	1375	Shared Neighborhood Hits	29
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SPEG_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.005713 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	1762	Shared Neighborhood Hits	28
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SUHW4_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.000176 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	860	Shared Neighborhood Hits	5
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

T22D4_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.017125 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	403	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

TTLL7_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.007370 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

ATN1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.052521 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	676	Shared Neighborhood Hits	25
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BAT2_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.056348 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	947	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CNOT3_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.050682 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	425	Shared Neighborhood Hits	23
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

Hits sorted by NC score

MEF2A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q02078, O43814, Q14223, Q14224, Q96D14	Gene names	MEF2A, MEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1).

MEF2A_MOUSE
NC score	0.990652 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	Q60929	Gene names	Mef2a
Domain Architecture
Description	Myocyte-specific enhancer factor 2A.

MEF2C_MOUSE
NC score	0.969960 (rank : 3)	θ value	9.89713e-132 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	92	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFN5, Q8R0H1, Q9D7L0, Q9QW20	Gene names	Mef2c
Domain Architecture	No domain graphic available
Description	Myocyte-specific enhancer factor 2C.

MEF2C_HUMAN
NC score	0.968260 (rank : 4)	θ value	9.89713e-132 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q06413	Gene names	MEF2C
Domain Architecture
Description	Myocyte-specific enhancer factor 2C.

MEF2D_MOUSE
NC score	0.954101 (rank : 5)	θ value	2.6227e-108 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	146	Shared Neighborhood Hits	18
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

MEF2D_HUMAN
NC score	0.953939 (rank : 6)	θ value	5.45601e-114 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	18
SwissProt Accessions	Q14814, Q14815	Gene names	MEF2D
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

MEF2B_HUMAN
NC score	0.894618 (rank : 7)	θ value	9.50281e-42 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

MEF2B_MOUSE
NC score	0.846448 (rank : 8)	θ value	1.05066e-40 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	218	Shared Neighborhood Hits	16
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

SRF_MOUSE
NC score	0.462985 (rank : 9)	θ value	2.88788e-06 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JM73	Gene names	Srf
Domain Architecture	No domain graphic available
Description	Serum response factor (SRF).

SRF_HUMAN
NC score	0.459180 (rank : 10)	θ value	2.88788e-06 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	P11831	Gene names	SRF
Domain Architecture
Description	Serum response factor (SRF).

LCOR_MOUSE
NC score	0.063308 (rank : 11)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPI3, Q3U302, Q5CZW7, Q80VA8, Q8BGT2, Q8C9Q0	Gene names	Lcor, Kiaa1795, Mlr2
Domain Architecture	No domain graphic available
Description	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2).

LCOR_HUMAN
NC score	0.062366 (rank : 12)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JN0, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6	Gene names	LCOR, KIAA1795, MLR2
Domain Architecture	No domain graphic available
Description	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2).

NCOA6_HUMAN
NC score	0.059380 (rank : 13)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	1202	Shared Neighborhood Hits	39
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

BAT2_MOUSE
NC score	0.056348 (rank : 14)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	947	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

ATN1_HUMAN
NC score	0.052521 (rank : 15)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	676	Shared Neighborhood Hits	25
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

CNOT3_HUMAN
NC score	0.050682 (rank : 16)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	425	Shared Neighborhood Hits	23
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

DOT1L_HUMAN
NC score	0.047152 (rank : 17)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	660	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

NCOA6_MOUSE
NC score	0.041758 (rank : 18)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	1076	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

CNOT4_MOUSE
NC score	0.040341 (rank : 19)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	277	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

ARI1A_HUMAN
NC score	0.037760 (rank : 20)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	787	Shared Neighborhood Hits	28
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

MAGE1_HUMAN
NC score	0.035569 (rank : 21)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	1389	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CNOT4_HUMAN
NC score	0.032376 (rank : 22)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

SRRM2_MOUSE
NC score	0.030524 (rank : 23)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	1470	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PSL1_HUMAN
NC score	0.029000 (rank : 24)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	650	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PER2_MOUSE
NC score	0.027528 (rank : 25)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	325	Shared Neighborhood Hits	9
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

CBP_MOUSE
NC score	0.025422 (rank : 26)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	1051	Shared Neighborhood Hits	29
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

PER2_HUMAN
NC score	0.025267 (rank : 27)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	11
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

CSF1_HUMAN
NC score	0.024840 (rank : 28)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	258	Shared Neighborhood Hits	14
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

HRX_HUMAN
NC score	0.024149 (rank : 29)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	825	Shared Neighborhood Hits	19
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

SON_HUMAN
NC score	0.023819 (rank : 30)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	1568	Shared Neighborhood Hits	31
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

THAP4_MOUSE
NC score	0.022763 (rank : 31)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

HDAC5_HUMAN
NC score	0.020233 (rank : 32)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	353	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

ZAR1_MOUSE
NC score	0.019146 (rank : 33)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	254	Shared Neighborhood Hits	11
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

HDAC5_MOUSE
NC score	0.019106 (rank : 34)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

SAS6_HUMAN
NC score	0.017263 (rank : 35)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	791	Shared Neighborhood Hits	7
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

DC1L2_HUMAN
NC score	0.017160 (rank : 36)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	O43237, Q8TAT3	Gene names	DYNC1LI2, DNCLI2, LIC2
Domain Architecture
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC53/55) (LIC-2).

T22D4_HUMAN
NC score	0.017125 (rank : 37)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	403	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

NDUV2_HUMAN
NC score	0.016284 (rank : 38)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P19404, Q9BV41	Gene names	NDUFV2
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit).

TCF20_HUMAN
NC score	0.015987 (rank : 39)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	323	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TREF1_MOUSE
NC score	0.014921 (rank : 40)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	682	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

EPN2_HUMAN
NC score	0.014461 (rank : 41)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

GAK5_HUMAN
NC score	0.013246 (rank : 42)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	429	Shared Neighborhood Hits	16
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MUCDL_MOUSE
NC score	0.013180 (rank : 43)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	461	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

GAK7_HUMAN
NC score	0.013147 (rank : 44)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

MELPH_MOUSE
NC score	0.013109 (rank : 45)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

NCOA2_HUMAN
NC score	0.011362 (rank : 46)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	281	Shared Neighborhood Hits	9
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

JPH2_HUMAN
NC score	0.011330 (rank : 47)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	639	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

GRIN1_HUMAN
NC score	0.011141 (rank : 48)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	681	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

NUMB_MOUSE
NC score	0.010937 (rank : 49)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

PHLPP_HUMAN
NC score	0.010887 (rank : 50)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	604	Shared Neighborhood Hits	16
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PTN22_MOUSE
NC score	0.010844 (rank : 51)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	179	Shared Neighborhood Hits	6
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

RGS3_HUMAN
NC score	0.010632 (rank : 52)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	1375	Shared Neighborhood Hits	29
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ZO1_HUMAN
NC score	0.009973 (rank : 53)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SPEG_MOUSE
NC score	0.009420 (rank : 54)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	1959	Shared Neighborhood Hits	25
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

JHD2C_MOUSE
NC score	0.008534 (rank : 55)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	297	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9	Gene names	Jmjd1c, Jhdm2c, Kiaa1380
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C).

WNK1_HUMAN
NC score	0.008369 (rank : 56)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	1158	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ATF6B_HUMAN
NC score	0.008326 (rank : 57)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

CO1A2_MOUSE
NC score	0.008260 (rank : 58)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	388	Shared Neighborhood Hits	13
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

ECM29_MOUSE
NC score	0.008248 (rank : 59)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

K1914_HUMAN
NC score	0.008189 (rank : 60)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MTG8_MOUSE
NC score	0.007650 (rank : 61)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q61909	Gene names	Runx1t1, Cbfa2t1, Cbfa2t1h, Mtg8
Domain Architecture
Description	Protein CBFA2T1 (Protein MTG8).

TTLL7_HUMAN
NC score	0.007370 (rank : 62)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

PHLPP_MOUSE
NC score	0.006893 (rank : 63)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	394	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

DDEF1_MOUSE
NC score	0.006889 (rank : 64)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	592	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SPEG_HUMAN
NC score	0.005713 (rank : 65)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	1762	Shared Neighborhood Hits	28
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ADA29_HUMAN
NC score	0.005328 (rank : 66)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	247	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

FREM3_HUMAN
NC score	0.005061 (rank : 67)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

ITB4_HUMAN
NC score	0.004723 (rank : 68)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	458	Shared Neighborhood Hits	4
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

MYO1E_HUMAN
NC score	0.002678 (rank : 69)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	5
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

TENX_HUMAN
NC score	0.001391 (rank : 70)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	789	Shared Neighborhood Hits	5
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

STK10_MOUSE
NC score	0.001249 (rank : 71)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	2132	Shared Neighborhood Hits	17
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

SUHW4_HUMAN
NC score	0.000176 (rank : 72)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	860	Shared Neighborhood Hits	5
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.