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Network neighborhood for query Sequence : GUAA_HUMAN

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GUAA_HUMAN
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GUAA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

CPSM_HUMAN
θ value	0.0148317 (rank : 2)	NC score	0.163707 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
θ value	0.0431538 (rank : 3)	NC score	0.158470 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
θ value	0.0961366 (rank : 4)	NC score	0.142600 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

ARHGB_HUMAN
θ value	0.62314 (rank : 5)	NC score	0.033338 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	375	Shared Neighborhood Hits	3
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

MYBB_HUMAN
θ value	0.62314 (rank : 6)	NC score	0.061978 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P10244	Gene names	MYBL2, BMYB
Domain Architecture
Description	Myb-related protein B (B-Myb).

MYBB_MOUSE
θ value	1.81305 (rank : 7)	NC score	0.054710 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	P48972	Gene names	Mybl2, Bmyb
Domain Architecture
Description	Myb-related protein B (B-Myb).

PP2BC_MOUSE
θ value	4.03905 (rank : 8)	NC score	0.014853 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	P48455	Gene names	Ppp3cc, Calnc
Domain Architecture
Description	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (Calmodulin-dependent calcineurin A subunit gamma isoform) (Calcineurin, testis-specific catalytic subunit) (CAM- PRP catalytic subunit).

ROCK2_HUMAN
θ value	5.27518 (rank : 9)	NC score	0.003402 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	2073	Shared Neighborhood Hits	5
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

TRMU_MOUSE
θ value	5.27518 (rank : 10)	NC score	0.031830 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DAT5	Gene names	Trmu, Trmt1
Domain Architecture
Description	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61).

GOGB1_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.006558 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	2297	Shared Neighborhood Hits	6
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

SEP11_MOUSE
θ value	6.88961 (rank : 12)	NC score	0.014760 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	300	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C1B7, Q6P2K5, Q6P6I0	Gene names	Sept11, D5Ertd606e
Domain Architecture	No domain graphic available
Description	Septin-11.

SEPT6_HUMAN
θ value	6.88961 (rank : 13)	NC score	0.015027 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q14141, Q5JTK0, Q969W5, Q96A13, Q96GR1, Q96P86, Q96P87	Gene names	SEPT6, KIAA0128, SEP2
Domain Architecture
Description	Septin-6.

Hits sorted by NC score

GUAA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

CPSM_HUMAN
NC score	0.163707 (rank : 2)	θ value	0.0148317 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
NC score	0.158470 (rank : 3)	θ value	0.0431538 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
NC score	0.142600 (rank : 4)	θ value	0.0961366 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

MYBB_HUMAN
NC score	0.061978 (rank : 5)	θ value	0.62314 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P10244	Gene names	MYBL2, BMYB
Domain Architecture
Description	Myb-related protein B (B-Myb).

MYBB_MOUSE
NC score	0.054710 (rank : 6)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	P48972	Gene names	Mybl2, Bmyb
Domain Architecture
Description	Myb-related protein B (B-Myb).

ARHGB_HUMAN
NC score	0.033338 (rank : 7)	θ value	0.62314 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	375	Shared Neighborhood Hits	3
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

TRMU_MOUSE
NC score	0.031830 (rank : 8)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DAT5	Gene names	Trmu, Trmt1
Domain Architecture
Description	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61).

SEPT6_HUMAN
NC score	0.015027 (rank : 9)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q14141, Q5JTK0, Q969W5, Q96A13, Q96GR1, Q96P86, Q96P87	Gene names	SEPT6, KIAA0128, SEP2
Domain Architecture
Description	Septin-6.

PP2BC_MOUSE
NC score	0.014853 (rank : 10)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	P48455	Gene names	Ppp3cc, Calnc
Domain Architecture
Description	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (Calmodulin-dependent calcineurin A subunit gamma isoform) (Calcineurin, testis-specific catalytic subunit) (CAM- PRP catalytic subunit).

SEP11_MOUSE
NC score	0.014760 (rank : 11)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	300	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C1B7, Q6P2K5, Q6P6I0	Gene names	Sept11, D5Ertd606e
Domain Architecture	No domain graphic available
Description	Septin-11.

GOGB1_HUMAN
NC score	0.006558 (rank : 12)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	2297	Shared Neighborhood Hits	6
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ROCK2_HUMAN
NC score	0.003402 (rank : 13)	θ value	5.27518 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	2073	Shared Neighborhood Hits	5
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).