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Network neighborhood for query Sequence : VIGLN_HUMAN

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VIGLN_HUMAN
SwissProt Accessions	Q00341, Q9UCY3	Gene names	HDLBP, HBP, VGL
Domain Architecture
Description	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

VIGLN_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q00341, Q9UCY3	Gene names	HDLBP, HBP, VGL
Domain Architecture
Description	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein).

VIGLN_MOUSE
θ value	0 (rank : 2)	NC score	0.997803 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	80	Shared Neighborhood Hits	65
SwissProt Accessions	Q8VDJ3	Gene names	Hdlbp
Domain Architecture
Description	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein).

FUBP2_HUMAN
θ value	4.30538e-10 (rank : 3)	NC score	0.471294 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	145	Shared Neighborhood Hits	29
SwissProt Accessions	Q92945, O00301, Q9UNT5, Q9UQH5	Gene names	KHSRP, FUBP2
Domain Architecture
Description	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75).

IF2B2_HUMAN
θ value	4.30538e-10 (rank : 4)	NC score	0.431849 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	142	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y6M1	Gene names	IGF2BP2, IMP2
Domain Architecture	No domain graphic available
Description	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF-II mRNA- binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62).

FUBP1_HUMAN
θ value	1.38499e-08 (rank : 5)	NC score	0.451934 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	136	Shared Neighborhood Hits	29
SwissProt Accessions	Q96AE4, Q12828	Gene names	FUBP1
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP) (DNA helicase V) (HDH V).

FUBP1_MOUSE
θ value	2.36244e-08 (rank : 6)	NC score	0.449753 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q91WJ8, Q8C0Y8	Gene names	Fubp1, D3Ertd330e
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP).

FUBP3_HUMAN
θ value	5.26297e-08 (rank : 7)	NC score	0.458971 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	68	Shared Neighborhood Hits	29
SwissProt Accessions	Q96I24, Q92946, Q9BVB6	Gene names	FUBP3
Domain Architecture
Description	Far upstream element-binding protein 3 (FUSE-binding protein 3).

IF2B2_MOUSE
θ value	9.92553e-07 (rank : 8)	NC score	0.395453 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SF07, Q3TCU4, Q7TQF9	Gene names	Igf2bp2, Imp2
Domain Architecture	No domain graphic available
Description	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF-II mRNA- binding protein 2) (IMP-2).

PCBP2_MOUSE
θ value	4.92598e-06 (rank : 9)	NC score	0.378367 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	Q61990, Q61383, Q62042	Gene names	Pcbp2, Cbp, Hnrnpx, Hnrpx
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (Putative heterogeneous nuclear ribonucleoprotein X) (hnRNP X) (CTBP) (CBP).

PCBP1_HUMAN
θ value	6.43352e-06 (rank : 10)	NC score	0.384472 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	Q15365, Q13157, Q14975	Gene names	PCBP1
Domain Architecture
Description	Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1) (Nucleic acid- binding protein SUB2.3).

PCBP1_MOUSE
θ value	6.43352e-06 (rank : 11)	NC score	0.384472 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	P60335	Gene names	Pcbp1
Domain Architecture
Description	Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1).

PCBP2_HUMAN
θ value	3.19293e-05 (rank : 12)	NC score	0.374170 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	26
SwissProt Accessions	Q15366, Q6PKG5	Gene names	PCBP2
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (hnRNP-E2).

TDRKH_HUMAN
θ value	0.000121331 (rank : 13)	NC score	0.328765 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y2W6, Q8N582, Q9NYV5	Gene names	TDRKH, TDRD2
Domain Architecture
Description	Tudor and KH domain-containing protein.

TDRKH_MOUSE
θ value	0.000270298 (rank : 14)	NC score	0.324720 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

HNRPK_HUMAN
θ value	0.000461057 (rank : 15)	NC score	0.367879 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P61978, Q07244, Q15671, Q60577, Q922Y7, Q96J62	Gene names	HNRPK, HNRNPK
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP).

HNRPK_MOUSE
θ value	0.000461057 (rank : 16)	NC score	0.367879 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P61979, Q07244, Q15671, Q60577, Q8BGQ8, Q922Y7, Q96J62	Gene names	Hnrpk, Hnrnpk
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K.

PCBP4_HUMAN
θ value	0.00175202 (rank : 17)	NC score	0.354875 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	27
SwissProt Accessions	P57723, Q96AH7	Gene names	PCBP4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

PCBP3_HUMAN
θ value	0.00298849 (rank : 18)	NC score	0.351994 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P57721, Q8N9K6, Q96EP6	Gene names	PCBP3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PCBP3_MOUSE
θ value	0.00298849 (rank : 19)	NC score	0.352115 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P57722, Q8BSB0, Q8C544	Gene names	Pcbp3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PCBP4_MOUSE
θ value	0.00390308 (rank : 20)	NC score	0.352093 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	P57724, Q91VR3	Gene names	Pcbp4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

NOVA2_HUMAN
θ value	0.0113563 (rank : 21)	NC score	0.368032 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	51	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UNW9, O43267, Q9UEA1	Gene names	NOVA2, ANOVA, NOVA3
Domain Architecture
Description	RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2) (Astrocytic NOVA1-like RNA-binding protein).

RKHD1_HUMAN
θ value	0.0113563 (rank : 22)	NC score	0.258870 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	163	Shared Neighborhood Hits	22
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

ASCC1_MOUSE
θ value	0.0330416 (rank : 23)	NC score	0.142013 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D8Z1, Q3TAC2	Gene names	Ascc1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

TMF1_HUMAN
θ value	0.0961366 (rank : 24)	NC score	0.038321 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	987	Shared Neighborhood Hits	17
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

NOVA1_HUMAN
θ value	0.125558 (rank : 25)	NC score	0.336821 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	50	Shared Neighborhood Hits	28
SwissProt Accessions	P51513	Gene names	NOVA1
Domain Architecture
Description	RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1).

ASCC1_HUMAN
θ value	0.163984 (rank : 26)	NC score	0.112771 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N9N2, Q96EI8, Q9Y307	Gene names	ASCC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

FMR1_MOUSE
θ value	0.163984 (rank : 27)	NC score	0.107618 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	P35922	Gene names	Fmr1, Fmr-1
Domain Architecture
Description	Fragile X mental retardation protein 1 homolog (Protein FMR-1) (FMRP) (mFmr1p).

PAR14_MOUSE
θ value	0.21417 (rank : 28)	NC score	0.057964 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

FMR1_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.105984 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	20
SwissProt Accessions	Q06787, Q16578, Q99054	Gene names	FMR1
Domain Architecture
Description	Fragile X mental retardation 1 protein (Protein FMR-1) (FMRP).

DDX43_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.045272 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

NFX1_HUMAN
θ value	0.365318 (rank : 31)	NC score	0.049633 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	405	Shared Neighborhood Hits	4
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

K0323_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.062326 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	O15037, Q86TZ6, Q8IUQ2, Q96BA9	Gene names	KIAA0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

DDX53_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.048570 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	23
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

E2F6_MOUSE
θ value	0.62314 (rank : 34)	NC score	0.045989 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O54917	Gene names	E2f6
Domain Architecture
Description	Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating activity protein) (EMA).

WNK1_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.011956 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	1158	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

FES_HUMAN
θ value	0.813845 (rank : 36)	NC score	0.007996 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	978	Shared Neighborhood Hits	12
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SM1L2_MOUSE
θ value	1.06291 (rank : 37)	NC score	0.023572 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	918	Shared Neighborhood Hits	16
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

CLIC6_MOUSE
θ value	1.38821 (rank : 38)	NC score	0.026420 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

FXR1_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.102480 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	50	Shared Neighborhood Hits	26
SwissProt Accessions	P51114, Q7Z450, Q8N6R8	Gene names	FXR1
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 1 (hFXR1P).

M3K4_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.008911 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	911	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

SCN8A_MOUSE
θ value	1.81305 (rank : 41)	NC score	0.014958 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CH60_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.021986 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P10809	Gene names	HSPD1, HSP60
Domain Architecture
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60).

EEA1_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.012339 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	1796	Shared Neighborhood Hits	21
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

KPCD1_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.005437 (rank : 74)
Query Neighborhood Hits	71	Target Neighborhood Hits	901	Shared Neighborhood Hits	8
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PFD4_HUMAN
θ value	2.36792 (rank : 45)	NC score	0.095413 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQP4, Q5TD11, Q92779	Gene names	PFDN4, PFD4
Domain Architecture	No domain graphic available
Description	Prefoldin subunit 4 (Protein C-1).

PAR14_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.040911 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q460N5, Q460N4, Q8J027, Q9H9X9, Q9NV60, Q9ULF2	Gene names	PARP14, BAL2, KIAA1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (B aggressive lymphoma protein 2).

AT1A1_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.012682 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	P05023, Q16689, Q6LDM4, Q9UJ20, Q9UJ21	Gene names	ATP1A1
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-1 chain precursor (EC 3.6.3.9) (Sodium pump 1) (Na+/K+ ATPase 1).

AT1A1_MOUSE
θ value	4.03905 (rank : 48)	NC score	0.012659 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VDN2, Q91Z09	Gene names	Atp1a1
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-1 chain precursor (EC 3.6.3.9) (Sodium pump 1) (Na+/K+ ATPase 1).

GAS8_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.016576 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	819	Shared Neighborhood Hits	14
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

HIP1_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.011226 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	1016	Shared Neighborhood Hits	16
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

LMBL3_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.027356 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	212	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

M3K4_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.007493 (rank : 73)
Query Neighborhood Hits	71	Target Neighborhood Hits	924	Shared Neighborhood Hits	8
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

CMTA1_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.020428 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

DPF3_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.015640 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q92784, Q9H7Y5	Gene names	DPF3, CERD4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein DPF3 (cer-d4).

FXR1_MOUSE
θ value	5.27518 (rank : 55)	NC score	0.094667 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	26
SwissProt Accessions	Q61584, Q8VCU4, Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9	Gene names	Fxr1, Fxr1h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 1 (mFxr1p).

IKKB_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.003449 (rank : 77)
Query Neighborhood Hits	71	Target Neighborhood Hits	984	Shared Neighborhood Hits	9
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

LAMC1_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.008620 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	856	Shared Neighborhood Hits	15
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

NCOR2_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.015529 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	790	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

SYCP1_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.013230 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	1313	Shared Neighborhood Hits	16
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CF060_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.011476 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	1270	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CI039_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.017081 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	1171	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CP27B_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.004388 (rank : 76)
Query Neighborhood Hits	71	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	O35084	Gene names	Cyp27b1, Cyp27b, Cyp40
Domain Architecture
Description	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (EC 1.14.13.13) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha- hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha).

HOOK1_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.012477 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	910	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

MAP2_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.016785 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	348	Shared Neighborhood Hits	7
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

SEN2_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.031686 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P7W5, Q3UYG6	Gene names	Tsen2, Sen2
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen2 (EC 3.1.27.9) (tRNA-intron endonuclease Sen2).

CJ118_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.011164 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	1132	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

HMMR_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.010013 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	1178	Shared Neighborhood Hits	16
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

KI21B_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.005208 (rank : 75)
Query Neighborhood Hits	71	Target Neighborhood Hits	1017	Shared Neighborhood Hits	13
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

MATN1_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.007555 (rank : 72)
Query Neighborhood Hits	71	Target Neighborhood Hits	191	Shared Neighborhood Hits	3
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

RM44_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.023617 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CY73, Q8VE61	Gene names	Mrpl44
Domain Architecture	No domain graphic available
Description	39S ribosomal protein L44, mitochondrial precursor (EC 3.1.26.-) (L44mt) (MRP-L44).

SCN8A_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.008787 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

AKAP1_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.081874 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	88	Shared Neighborhood Hits	25
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

AKAP1_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.077026 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

FXR2_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.074491 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

FXR2_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.052187 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	66	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

SAM68_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.053103 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	68	Shared Neighborhood Hits	18
SwissProt Accessions	Q07666, Q6PJX7, Q8NB97, Q99760	Gene names	KHDRBS1, SAM68
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

SAM68_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.050791 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	Q60749, Q3U8T3, Q60735, Q99M33	Gene names	Khdrbs1
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

Hits sorted by NC score

VIGLN_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q00341, Q9UCY3	Gene names	HDLBP, HBP, VGL
Domain Architecture
Description	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein).

VIGLN_MOUSE
NC score	0.997803 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	80	Shared Neighborhood Hits	65
SwissProt Accessions	Q8VDJ3	Gene names	Hdlbp
Domain Architecture
Description	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein).

FUBP2_HUMAN
NC score	0.471294 (rank : 3)	θ value	4.30538e-10 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	145	Shared Neighborhood Hits	29
SwissProt Accessions	Q92945, O00301, Q9UNT5, Q9UQH5	Gene names	KHSRP, FUBP2
Domain Architecture
Description	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75).

FUBP3_HUMAN
NC score	0.458971 (rank : 4)	θ value	5.26297e-08 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	68	Shared Neighborhood Hits	29
SwissProt Accessions	Q96I24, Q92946, Q9BVB6	Gene names	FUBP3
Domain Architecture
Description	Far upstream element-binding protein 3 (FUSE-binding protein 3).

FUBP1_HUMAN
NC score	0.451934 (rank : 5)	θ value	1.38499e-08 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	136	Shared Neighborhood Hits	29
SwissProt Accessions	Q96AE4, Q12828	Gene names	FUBP1
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP) (DNA helicase V) (HDH V).

FUBP1_MOUSE
NC score	0.449753 (rank : 6)	θ value	2.36244e-08 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q91WJ8, Q8C0Y8	Gene names	Fubp1, D3Ertd330e
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP).

IF2B2_HUMAN
NC score	0.431849 (rank : 7)	θ value	4.30538e-10 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	142	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y6M1	Gene names	IGF2BP2, IMP2
Domain Architecture	No domain graphic available
Description	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF-II mRNA- binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62).

IF2B2_MOUSE
NC score	0.395453 (rank : 8)	θ value	9.92553e-07 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SF07, Q3TCU4, Q7TQF9	Gene names	Igf2bp2, Imp2
Domain Architecture	No domain graphic available
Description	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF-II mRNA- binding protein 2) (IMP-2).

PCBP1_HUMAN
NC score	0.384472 (rank : 9)	θ value	6.43352e-06 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	Q15365, Q13157, Q14975	Gene names	PCBP1
Domain Architecture
Description	Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1) (Nucleic acid- binding protein SUB2.3).

PCBP1_MOUSE
NC score	0.384472 (rank : 10)	θ value	6.43352e-06 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	P60335	Gene names	Pcbp1
Domain Architecture
Description	Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1).

PCBP2_MOUSE
NC score	0.378367 (rank : 11)	θ value	4.92598e-06 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	Q61990, Q61383, Q62042	Gene names	Pcbp2, Cbp, Hnrnpx, Hnrpx
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (Putative heterogeneous nuclear ribonucleoprotein X) (hnRNP X) (CTBP) (CBP).

PCBP2_HUMAN
NC score	0.374170 (rank : 12)	θ value	3.19293e-05 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	26
SwissProt Accessions	Q15366, Q6PKG5	Gene names	PCBP2
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (hnRNP-E2).

NOVA2_HUMAN
NC score	0.368032 (rank : 13)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	51	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UNW9, O43267, Q9UEA1	Gene names	NOVA2, ANOVA, NOVA3
Domain Architecture
Description	RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2) (Astrocytic NOVA1-like RNA-binding protein).

HNRPK_HUMAN
NC score	0.367879 (rank : 14)	θ value	0.000461057 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P61978, Q07244, Q15671, Q60577, Q922Y7, Q96J62	Gene names	HNRPK, HNRNPK
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP).

HNRPK_MOUSE
NC score	0.367879 (rank : 15)	θ value	0.000461057 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P61979, Q07244, Q15671, Q60577, Q8BGQ8, Q922Y7, Q96J62	Gene names	Hnrpk, Hnrnpk
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K.

PCBP4_HUMAN
NC score	0.354875 (rank : 16)	θ value	0.00175202 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	27
SwissProt Accessions	P57723, Q96AH7	Gene names	PCBP4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

PCBP3_MOUSE
NC score	0.352115 (rank : 17)	θ value	0.00298849 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P57722, Q8BSB0, Q8C544	Gene names	Pcbp3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PCBP4_MOUSE
NC score	0.352093 (rank : 18)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	P57724, Q91VR3	Gene names	Pcbp4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

PCBP3_HUMAN
NC score	0.351994 (rank : 19)	θ value	0.00298849 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P57721, Q8N9K6, Q96EP6	Gene names	PCBP3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

NOVA1_HUMAN
NC score	0.336821 (rank : 20)	θ value	0.125558 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	50	Shared Neighborhood Hits	28
SwissProt Accessions	P51513	Gene names	NOVA1
Domain Architecture
Description	RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1).

TDRKH_HUMAN
NC score	0.328765 (rank : 21)	θ value	0.000121331 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y2W6, Q8N582, Q9NYV5	Gene names	TDRKH, TDRD2
Domain Architecture
Description	Tudor and KH domain-containing protein.

TDRKH_MOUSE
NC score	0.324720 (rank : 22)	θ value	0.000270298 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

RKHD1_HUMAN
NC score	0.258870 (rank : 23)	θ value	0.0113563 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	163	Shared Neighborhood Hits	22
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

ASCC1_MOUSE
NC score	0.142013 (rank : 24)	θ value	0.0330416 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D8Z1, Q3TAC2	Gene names	Ascc1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

ASCC1_HUMAN
NC score	0.112771 (rank : 25)	θ value	0.163984 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N9N2, Q96EI8, Q9Y307	Gene names	ASCC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

FMR1_MOUSE
NC score	0.107618 (rank : 26)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	P35922	Gene names	Fmr1, Fmr-1
Domain Architecture
Description	Fragile X mental retardation protein 1 homolog (Protein FMR-1) (FMRP) (mFmr1p).

FMR1_HUMAN
NC score	0.105984 (rank : 27)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	20
SwissProt Accessions	Q06787, Q16578, Q99054	Gene names	FMR1
Domain Architecture
Description	Fragile X mental retardation 1 protein (Protein FMR-1) (FMRP).

FXR1_HUMAN
NC score	0.102480 (rank : 28)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	50	Shared Neighborhood Hits	26
SwissProt Accessions	P51114, Q7Z450, Q8N6R8	Gene names	FXR1
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 1 (hFXR1P).

PFD4_HUMAN
NC score	0.095413 (rank : 29)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQP4, Q5TD11, Q92779	Gene names	PFDN4, PFD4
Domain Architecture	No domain graphic available
Description	Prefoldin subunit 4 (Protein C-1).

FXR1_MOUSE
NC score	0.094667 (rank : 30)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	26
SwissProt Accessions	Q61584, Q8VCU4, Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9	Gene names	Fxr1, Fxr1h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 1 (mFxr1p).

AKAP1_HUMAN
NC score	0.081874 (rank : 31)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	71	Target Neighborhood Hits	88	Shared Neighborhood Hits	25
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

AKAP1_MOUSE
NC score	0.077026 (rank : 32)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	71	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

FXR2_HUMAN
NC score	0.074491 (rank : 33)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	71	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

K0323_HUMAN
NC score	0.062326 (rank : 34)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	O15037, Q86TZ6, Q8IUQ2, Q96BA9	Gene names	KIAA0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

PAR14_MOUSE
NC score	0.057964 (rank : 35)	θ value	0.21417 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

SAM68_HUMAN
NC score	0.053103 (rank : 36)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	71	Target Neighborhood Hits	68	Shared Neighborhood Hits	18
SwissProt Accessions	Q07666, Q6PJX7, Q8NB97, Q99760	Gene names	KHDRBS1, SAM68
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

FXR2_MOUSE
NC score	0.052187 (rank : 37)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	71	Target Neighborhood Hits	66	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

SAM68_MOUSE
NC score	0.050791 (rank : 38)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	71	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	Q60749, Q3U8T3, Q60735, Q99M33	Gene names	Khdrbs1
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

NFX1_HUMAN
NC score	0.049633 (rank : 39)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	405	Shared Neighborhood Hits	4
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

DDX53_HUMAN
NC score	0.048570 (rank : 40)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	23
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

E2F6_MOUSE
NC score	0.045989 (rank : 41)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O54917	Gene names	E2f6
Domain Architecture
Description	Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating activity protein) (EMA).

DDX43_HUMAN
NC score	0.045272 (rank : 42)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

PAR14_HUMAN
NC score	0.040911 (rank : 43)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q460N5, Q460N4, Q8J027, Q9H9X9, Q9NV60, Q9ULF2	Gene names	PARP14, BAL2, KIAA1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (B aggressive lymphoma protein 2).

TMF1_HUMAN
NC score	0.038321 (rank : 44)	θ value	0.0961366 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	987	Shared Neighborhood Hits	17
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

SEN2_MOUSE
NC score	0.031686 (rank : 45)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P7W5, Q3UYG6	Gene names	Tsen2, Sen2
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen2 (EC 3.1.27.9) (tRNA-intron endonuclease Sen2).

LMBL3_MOUSE
NC score	0.027356 (rank : 46)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	212	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

CLIC6_MOUSE
NC score	0.026420 (rank : 47)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

RM44_MOUSE
NC score	0.023617 (rank : 48)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CY73, Q8VE61	Gene names	Mrpl44
Domain Architecture	No domain graphic available
Description	39S ribosomal protein L44, mitochondrial precursor (EC 3.1.26.-) (L44mt) (MRP-L44).

SM1L2_MOUSE
NC score	0.023572 (rank : 49)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	918	Shared Neighborhood Hits	16
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

CH60_HUMAN
NC score	0.021986 (rank : 50)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P10809	Gene names	HSPD1, HSP60
Domain Architecture
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60).

CMTA1_HUMAN
NC score	0.020428 (rank : 51)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

CI039_HUMAN
NC score	0.017081 (rank : 52)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	1171	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

MAP2_HUMAN
NC score	0.016785 (rank : 53)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	348	Shared Neighborhood Hits	7
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

GAS8_HUMAN
NC score	0.016576 (rank : 54)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	819	Shared Neighborhood Hits	14
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

DPF3_HUMAN
NC score	0.015640 (rank : 55)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q92784, Q9H7Y5	Gene names	DPF3, CERD4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein DPF3 (cer-d4).

NCOR2_MOUSE
NC score	0.015529 (rank : 56)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	790	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

SCN8A_MOUSE
NC score	0.014958 (rank : 57)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SYCP1_HUMAN
NC score	0.013230 (rank : 58)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	1313	Shared Neighborhood Hits	16
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

AT1A1_HUMAN
NC score	0.012682 (rank : 59)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	P05023, Q16689, Q6LDM4, Q9UJ20, Q9UJ21	Gene names	ATP1A1
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-1 chain precursor (EC 3.6.3.9) (Sodium pump 1) (Na+/K+ ATPase 1).

AT1A1_MOUSE
NC score	0.012659 (rank : 60)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VDN2, Q91Z09	Gene names	Atp1a1
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-1 chain precursor (EC 3.6.3.9) (Sodium pump 1) (Na+/K+ ATPase 1).

HOOK1_MOUSE
NC score	0.012477 (rank : 61)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	910	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

EEA1_HUMAN
NC score	0.012339 (rank : 62)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	1796	Shared Neighborhood Hits	21
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

WNK1_HUMAN
NC score	0.011956 (rank : 63)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	1158	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

CF060_HUMAN
NC score	0.011476 (rank : 64)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	1270	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

HIP1_HUMAN
NC score	0.011226 (rank : 65)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	1016	Shared Neighborhood Hits	16
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

CJ118_MOUSE
NC score	0.011164 (rank : 66)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	1132	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

HMMR_MOUSE
NC score	0.010013 (rank : 67)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	1178	Shared Neighborhood Hits	16
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

M3K4_HUMAN
NC score	0.008911 (rank : 68)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	911	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

SCN8A_HUMAN
NC score	0.008787 (rank : 69)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

LAMC1_MOUSE
NC score	0.008620 (rank : 70)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	856	Shared Neighborhood Hits	15
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

FES_HUMAN
NC score	0.007996 (rank : 71)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	978	Shared Neighborhood Hits	12
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MATN1_HUMAN
NC score	0.007555 (rank : 72)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	191	Shared Neighborhood Hits	3
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

M3K4_MOUSE
NC score	0.007493 (rank : 73)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	924	Shared Neighborhood Hits	8
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

KPCD1_HUMAN
NC score	0.005437 (rank : 74)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	901	Shared Neighborhood Hits	8
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KI21B_HUMAN
NC score	0.005208 (rank : 75)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	1017	Shared Neighborhood Hits	13
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

CP27B_MOUSE
NC score	0.004388 (rank : 76)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	O35084	Gene names	Cyp27b1, Cyp27b, Cyp40
Domain Architecture
Description	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (EC 1.14.13.13) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha- hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha).

IKKB_MOUSE
NC score	0.003449 (rank : 77)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	984	Shared Neighborhood Hits	9
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).