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Network neighborhood for query Sequence : CC14A_HUMAN

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CC14A_HUMAN
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CC14A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_MOUSE
θ value	0 (rank : 2)	NC score	0.989943 (rank : 2)
Query Neighborhood Hits	133	Target Neighborhood Hits	117	Shared Neighborhood Hits	104
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14B_HUMAN
θ value	1.41924e-154 (rank : 3)	NC score	0.973461 (rank : 3)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	101
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14B_MOUSE
θ value	1.56915e-153 (rank : 4)	NC score	0.970202 (rank : 4)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	91
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

DUS23_HUMAN
θ value	1.06045e-08 (rank : 5)	NC score	0.575233 (rank : 6)
Query Neighborhood Hits	133	Target Neighborhood Hits	98	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

DUS23_MOUSE
θ value	1.06045e-08 (rank : 6)	NC score	0.578376 (rank : 5)
Query Neighborhood Hits	133	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

TP4A3_HUMAN
θ value	1.99992e-07 (rank : 7)	NC score	0.456328 (rank : 7)
Query Neighborhood Hits	133	Target Neighborhood Hits	62	Shared Neighborhood Hits	55
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

TP4A1_HUMAN
θ value	7.59969e-07 (rank : 8)	NC score	0.427674 (rank : 9)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	55
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
θ value	7.59969e-07 (rank : 9)	NC score	0.427674 (rank : 10)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	55
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TP4A3_MOUSE
θ value	2.21117e-06 (rank : 10)	NC score	0.438467 (rank : 8)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

TP4A2_HUMAN
θ value	3.77169e-06 (rank : 11)	NC score	0.408243 (rank : 11)
Query Neighborhood Hits	133	Target Neighborhood Hits	56	Shared Neighborhood Hits	44
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
θ value	3.77169e-06 (rank : 12)	NC score	0.408243 (rank : 12)
Query Neighborhood Hits	133	Target Neighborhood Hits	56	Shared Neighborhood Hits	44
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

DUS16_HUMAN
θ value	0.000461057 (rank : 13)	NC score	0.295304 (rank : 21)
Query Neighborhood Hits	133	Target Neighborhood Hits	112	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

DUS18_MOUSE
θ value	0.000602161 (rank : 14)	NC score	0.320119 (rank : 13)
Query Neighborhood Hits	133	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VE01	Gene names	Dusp18
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16).

DUS10_HUMAN
θ value	0.00102713 (rank : 15)	NC score	0.299446 (rank : 17)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y6W6	Gene names	DUSP10, MKP5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS10_MOUSE
θ value	0.00102713 (rank : 16)	NC score	0.299594 (rank : 16)
Query Neighborhood Hits	133	Target Neighborhood Hits	62	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESS0, Q9CZY9	Gene names	Dusp10, Mkp5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS18_HUMAN
θ value	0.00102713 (rank : 17)	NC score	0.314386 (rank : 14)
Query Neighborhood Hits	133	Target Neighborhood Hits	52	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NEJ0	Gene names	DUSP18, LMWDSP20
Domain Architecture
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 20).

STYX_HUMAN
θ value	0.00175202 (rank : 18)	NC score	0.298615 (rank : 19)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WUJ0, Q99850	Gene names	STYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein).

STYX_MOUSE
θ value	0.00175202 (rank : 19)	NC score	0.297195 (rank : 20)
Query Neighborhood Hits	133	Target Neighborhood Hits	62	Shared Neighborhood Hits	50
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

PTEN_HUMAN
θ value	0.00228821 (rank : 20)	NC score	0.240658 (rank : 43)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	0.00228821 (rank : 21)	NC score	0.240659 (rank : 42)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	53
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

DUS14_MOUSE
θ value	0.00665767 (rank : 22)	NC score	0.301930 (rank : 15)
Query Neighborhood Hits	133	Target Neighborhood Hits	67	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLY7, Q9D715	Gene names	Dusp14, Mkp6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6).

DUS14_HUMAN
θ value	0.00869519 (rank : 23)	NC score	0.298759 (rank : 18)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	O95147	Gene names	DUSP14, MKP6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1-like protein tyrosine phosphatase) (MKP- L).

DUS1_HUMAN
θ value	0.0148317 (rank : 24)	NC score	0.272201 (rank : 23)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	56
SwissProt Accessions	P28562, Q2V508	Gene names	DUSP1, CL100, MKP1, PTPN10, VH1
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) (Dual specificity protein phosphatase hVH1).

DUS15_HUMAN
θ value	0.0330416 (rank : 25)	NC score	0.261184 (rank : 34)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H1R2, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24	Gene names	DUSP15, C20orf57, VHY
Domain Architecture
Description	Dual specificity protein phosphatase 15 (EC 3.1.3.48) (EC 3.1.3.16) (Vaccinia virus VH1-related dual-specific protein phosphatase Y) (VH1- related member Y).

DUS21_HUMAN
θ value	0.0330416 (rank : 26)	NC score	0.288759 (rank : 22)
Query Neighborhood Hits	133	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H596, Q6IAJ6, Q6YDQ8	Gene names	DUSP21, LMWDSP21
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 21 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 21).

PPRB_HUMAN
θ value	0.0330416 (rank : 27)	NC score	0.074832 (rank : 125)
Query Neighborhood Hits	133	Target Neighborhood Hits	311	Shared Neighborhood Hits	12
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

SSH3_MOUSE
θ value	0.0330416 (rank : 28)	NC score	0.237195 (rank : 44)
Query Neighborhood Hits	133	Target Neighborhood Hits	69	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K330, Q3UDX0	Gene names	Ssh3, Ssh3l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (mSSH-3L).

DUS19_MOUSE
θ value	0.0431538 (rank : 29)	NC score	0.257030 (rank : 38)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K4T5	Gene names	Dusp19, Skrp1
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

DUS2_MOUSE
θ value	0.0431538 (rank : 30)	NC score	0.271130 (rank : 25)
Query Neighborhood Hits	133	Target Neighborhood Hits	86	Shared Neighborhood Hits	63
SwissProt Accessions	Q05922, Q60640	Gene names	Dusp2, Pac-1, Pac1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

PPRB_MOUSE
θ value	0.0431538 (rank : 31)	NC score	0.072166 (rank : 127)
Query Neighborhood Hits	133	Target Neighborhood Hits	354	Shared Neighborhood Hits	13
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

DUS1_MOUSE
θ value	0.0563607 (rank : 32)	NC score	0.265180 (rank : 29)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	56
SwissProt Accessions	P28563	Gene names	Dusp1, 3ch134, Mkp1, Ptpn10, Ptpn16
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase 3CH134) (Protein-tyrosine phosphatase ERP).

DUS2_HUMAN
θ value	0.0563607 (rank : 33)	NC score	0.264148 (rank : 31)
Query Neighborhood Hits	133	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	Q05923	Gene names	DUSP2, PAC1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DUS5_HUMAN
θ value	0.0563607 (rank : 34)	NC score	0.265937 (rank : 28)
Query Neighborhood Hits	133	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	Q16690, Q12997	Gene names	DUSP5, VH3
Domain Architecture
Description	Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH3).

DUS4_HUMAN
θ value	0.0736092 (rank : 35)	NC score	0.263941 (rank : 32)
Query Neighborhood Hits	133	Target Neighborhood Hits	77	Shared Neighborhood Hits	56
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

DUS4_MOUSE
θ value	0.0736092 (rank : 36)	NC score	0.264336 (rank : 30)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

SSH3_HUMAN
θ value	0.0736092 (rank : 37)	NC score	0.234303 (rank : 45)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

DUS11_MOUSE
θ value	0.0961366 (rank : 38)	NC score	0.195732 (rank : 50)
Query Neighborhood Hits	133	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

DUS13_HUMAN
θ value	0.0961366 (rank : 39)	NC score	0.263011 (rank : 33)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UII6, Q5JSC6, Q96GC2	Gene names	DUSP13, TMDP
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal-muscle-specific DSP) (Dual specificity phosphatase SKRP4).

DUS19_HUMAN
θ value	0.0961366 (rank : 40)	NC score	0.266956 (rank : 27)
Query Neighborhood Hits	133	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WTR2, Q8WYN4	Gene names	DUSP19, DUSP17, SKRP1
Domain Architecture
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

MCE1_HUMAN
θ value	0.0961366 (rank : 41)	NC score	0.192809 (rank : 52)
Query Neighborhood Hits	133	Target Neighborhood Hits	34	Shared Neighborhood Hits	28
SwissProt Accessions	O60942, O43483, O60257, O60351	Gene names	RNGTT, CAP1A
Domain Architecture
Description	mRNA capping enzyme (HCE) (HCAP1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

PTPM1_HUMAN
θ value	0.0961366 (rank : 42)	NC score	0.259125 (rank : 36)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

PTPM1_MOUSE
θ value	0.0961366 (rank : 43)	NC score	0.271680 (rank : 24)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	56
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

RYBP_HUMAN
θ value	0.0961366 (rank : 44)	NC score	0.069590 (rank : 128)
Query Neighborhood Hits	133	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N488, Q9P2W5, Q9UMW4	Gene names	RYBP, DEDAF, YEAF1
Domain Architecture	No domain graphic available
Description	RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) (Apoptin-associating protein 1) (APAP-1).

DUS22_MOUSE
θ value	0.125558 (rank : 45)	NC score	0.270114 (rank : 26)
Query Neighborhood Hits	133	Target Neighborhood Hits	57	Shared Neighborhood Hits	48
SwissProt Accessions	Q99N11, Q5SQN9, Q5SQP0	Gene names	Dusp22
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (LMW-DSP2).

TPTE2_HUMAN
θ value	0.125558 (rank : 46)	NC score	0.156648 (rank : 62)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

PTPRE_HUMAN
θ value	0.163984 (rank : 47)	NC score	0.156430 (rank : 63)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	67
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRR_MOUSE
θ value	0.163984 (rank : 48)	NC score	0.159355 (rank : 61)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	53
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

RYBP_MOUSE
θ value	0.163984 (rank : 49)	NC score	0.066654 (rank : 129)
Query Neighborhood Hits	133	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CCI5, Q9WVK2	Gene names	Rybp, Dedaf
Domain Architecture	No domain graphic available
Description	RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor).

GCR_MOUSE
θ value	0.21417 (rank : 50)	NC score	0.022093 (rank : 137)
Query Neighborhood Hits	133	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

MCE1_MOUSE
θ value	0.21417 (rank : 51)	NC score	0.179169 (rank : 59)
Query Neighborhood Hits	133	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	O55236	Gene names	Rngtt, Cap1a
Domain Architecture
Description	mRNA capping enzyme (HCE) (MCE1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

PTPRA_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.151700 (rank : 66)
Query Neighborhood Hits	133	Target Neighborhood Hits	101	Shared Neighborhood Hits	65
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRZ_HUMAN
θ value	0.21417 (rank : 53)	NC score	0.129942 (rank : 83)
Query Neighborhood Hits	133	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

DUS3_HUMAN
θ value	0.279714 (rank : 54)	NC score	0.260617 (rank : 35)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	48
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

PTPRR_HUMAN
θ value	0.279714 (rank : 55)	NC score	0.155852 (rank : 64)
Query Neighborhood Hits	133	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

DUS22_HUMAN
θ value	0.365318 (rank : 56)	NC score	0.254597 (rank : 41)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NRW4, Q59GW2, Q5VWR2, Q96AR1	Gene names	DUSP22, JSP1, MKPX
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (JNK-stimulatory phosphatase-1) (JSP-1) (Mitogen-activated protein kinase phosphatase x) (LMW-DSP2).

MUC13_MOUSE
θ value	0.365318 (rank : 57)	NC score	0.031233 (rank : 135)
Query Neighborhood Hits	133	Target Neighborhood Hits	447	Shared Neighborhood Hits	6
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

PTPRA_MOUSE
θ value	0.365318 (rank : 58)	NC score	0.150721 (rank : 67)
Query Neighborhood Hits	133	Target Neighborhood Hits	93	Shared Neighborhood Hits	67
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

UBP31_HUMAN
θ value	0.365318 (rank : 59)	NC score	0.020848 (rank : 138)
Query Neighborhood Hits	133	Target Neighborhood Hits	293	Shared Neighborhood Hits	10
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

CD45_HUMAN
θ value	0.47712 (rank : 60)	NC score	0.140383 (rank : 71)
Query Neighborhood Hits	133	Target Neighborhood Hits	243	Shared Neighborhood Hits	57
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	0.47712 (rank : 61)	NC score	0.139735 (rank : 72)
Query Neighborhood Hits	133	Target Neighborhood Hits	178	Shared Neighborhood Hits	52
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

MARK2_HUMAN
θ value	0.47712 (rank : 62)	NC score	0.004260 (rank : 152)
Query Neighborhood Hits	133	Target Neighborhood Hits	1056	Shared Neighborhood Hits	12
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

PTPRE_MOUSE
θ value	0.47712 (rank : 63)	NC score	0.152254 (rank : 65)
Query Neighborhood Hits	133	Target Neighborhood Hits	86	Shared Neighborhood Hits	64
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

DUS3_MOUSE
θ value	0.62314 (rank : 64)	NC score	0.256890 (rank : 39)
Query Neighborhood Hits	133	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D7X3	Gene names	Dusp3
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (T- DSP11).

DUS8_HUMAN
θ value	0.62314 (rank : 65)	NC score	0.255633 (rank : 40)
Query Neighborhood Hits	133	Target Neighborhood Hits	161	Shared Neighborhood Hits	54
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

DUS8_MOUSE
θ value	0.62314 (rank : 66)	NC score	0.257377 (rank : 37)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	53
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

PTPRV_MOUSE
θ value	0.62314 (rank : 67)	NC score	0.139400 (rank : 74)
Query Neighborhood Hits	133	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

BPTF_HUMAN
θ value	0.813845 (rank : 68)	NC score	0.016803 (rank : 140)
Query Neighborhood Hits	133	Target Neighborhood Hits	786	Shared Neighborhood Hits	10
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

DUS12_MOUSE
θ value	0.813845 (rank : 69)	NC score	0.218218 (rank : 47)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9D0T2, Q9EQD3	Gene names	Dusp12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1).

LIPA3_MOUSE
θ value	0.813845 (rank : 70)	NC score	0.017300 (rank : 139)
Query Neighborhood Hits	133	Target Neighborhood Hits	636	Shared Neighborhood Hits	5
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

PODXL_MOUSE
θ value	0.813845 (rank : 71)	NC score	0.034804 (rank : 132)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0M4, Q9ESZ1	Gene names	Podxl, Pclp1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

PTN13_HUMAN
θ value	0.813845 (rank : 72)	NC score	0.104515 (rank : 115)
Query Neighborhood Hits	133	Target Neighborhood Hits	471	Shared Neighborhood Hits	60
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
θ value	0.813845 (rank : 73)	NC score	0.105736 (rank : 112)
Query Neighborhood Hits	133	Target Neighborhood Hits	426	Shared Neighborhood Hits	60
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN6_HUMAN
θ value	0.813845 (rank : 74)	NC score	0.139563 (rank : 73)
Query Neighborhood Hits	133	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	0.813845 (rank : 75)	NC score	0.139055 (rank : 75)
Query Neighborhood Hits	133	Target Neighborhood Hits	225	Shared Neighborhood Hits	65
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	0.813845 (rank : 76)	NC score	0.145211 (rank : 69)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	0.813845 (rank : 77)	NC score	0.142617 (rank : 70)
Query Neighborhood Hits	133	Target Neighborhood Hits	71	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTPRG_HUMAN
θ value	0.813845 (rank : 78)	NC score	0.124662 (rank : 88)
Query Neighborhood Hits	133	Target Neighborhood Hits	231	Shared Neighborhood Hits	54
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRJ_HUMAN
θ value	0.813845 (rank : 79)	NC score	0.136415 (rank : 76)
Query Neighborhood Hits	133	Target Neighborhood Hits	207	Shared Neighborhood Hits	67
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
θ value	0.813845 (rank : 80)	NC score	0.135253 (rank : 77)
Query Neighborhood Hits	133	Target Neighborhood Hits	188	Shared Neighborhood Hits	64
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRO_HUMAN
θ value	0.813845 (rank : 81)	NC score	0.145322 (rank : 68)
Query Neighborhood Hits	133	Target Neighborhood Hits	139	Shared Neighborhood Hits	61
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

TPTE_HUMAN
θ value	0.813845 (rank : 82)	NC score	0.131974 (rank : 80)
Query Neighborhood Hits	133	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

MARK2_MOUSE
θ value	1.06291 (rank : 83)	NC score	0.003818 (rank : 153)
Query Neighborhood Hits	133	Target Neighborhood Hits	1018	Shared Neighborhood Hits	13
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

PTN11_HUMAN
θ value	1.06291 (rank : 84)	NC score	0.129994 (rank : 82)
Query Neighborhood Hits	133	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	1.06291 (rank : 85)	NC score	0.130069 (rank : 81)
Query Neighborhood Hits	133	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

SSH1_HUMAN
θ value	1.06291 (rank : 86)	NC score	0.188487 (rank : 54)
Query Neighborhood Hits	133	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

SSH1_MOUSE
θ value	1.06291 (rank : 87)	NC score	0.188496 (rank : 53)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	42
SwissProt Accessions	Q76I79, Q3TDG3, Q69ZM4, Q811E5	Gene names	Ssh1, Kiaa1298, Ssh1l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (mSSH-1L).

CDSN_HUMAN
θ value	1.38821 (rank : 88)	NC score	0.032630 (rank : 133)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q15517, O43509, Q5SQ85, Q5STD2, Q7LA70, Q7LA71, Q86Z04, Q8IZU4, Q8IZU5, Q8IZU6, Q8N5P3, Q95IF9, Q9NP52, Q9NPE0, Q9NPG5, Q9NRH4, Q9NRH5, Q9NRH6, Q9NRH7, Q9NRH8, Q9UBH8, Q9UIN6, Q9UIN7, Q9UIN8, Q9UIN9, Q9UIP0	Gene names	CDSN
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor (S protein).

DUS11_HUMAN
θ value	1.38821 (rank : 89)	NC score	0.120060 (rank : 95)
Query Neighborhood Hits	133	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

PTN18_MOUSE
θ value	1.38821 (rank : 90)	NC score	0.132607 (rank : 78)
Query Neighborhood Hits	133	Target Neighborhood Hits	134	Shared Neighborhood Hits	58
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTPRB_HUMAN
θ value	1.38821 (rank : 91)	NC score	0.132522 (rank : 79)
Query Neighborhood Hits	133	Target Neighborhood Hits	242	Shared Neighborhood Hits	64
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRD_HUMAN
θ value	1.38821 (rank : 92)	NC score	0.104239 (rank : 117)
Query Neighborhood Hits	133	Target Neighborhood Hits	485	Shared Neighborhood Hits	63
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	1.38821 (rank : 93)	NC score	0.105249 (rank : 113)
Query Neighborhood Hits	133	Target Neighborhood Hits	491	Shared Neighborhood Hits	63
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRG_MOUSE
θ value	1.38821 (rank : 94)	NC score	0.123858 (rank : 90)
Query Neighborhood Hits	133	Target Neighborhood Hits	260	Shared Neighborhood Hits	56
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRT_HUMAN
θ value	1.38821 (rank : 95)	NC score	0.119242 (rank : 99)
Query Neighborhood Hits	133	Target Neighborhood Hits	217	Shared Neighborhood Hits	52
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	1.38821 (rank : 96)	NC score	0.119261 (rank : 98)
Query Neighborhood Hits	133	Target Neighborhood Hits	219	Shared Neighborhood Hits	52
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

SRRM2_HUMAN
θ value	1.38821 (rank : 97)	NC score	0.031930 (rank : 134)
Query Neighborhood Hits	133	Target Neighborhood Hits	1296	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM2_MOUSE
θ value	1.38821 (rank : 98)	NC score	0.027353 (rank : 136)
Query Neighborhood Hits	133	Target Neighborhood Hits	1470	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ZFY16_HUMAN
θ value	1.38821 (rank : 99)	NC score	0.016739 (rank : 141)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

DUS13_MOUSE
θ value	1.81305 (rank : 100)	NC score	0.222924 (rank : 46)
Query Neighborhood Hits	133	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QYJ7	Gene names	Dusp13, Tmdp
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal muscle-specific DSP) (Dual specificity tyrosine phosphatase TS-DSP6).

PININ_HUMAN
θ value	1.81305 (rank : 101)	NC score	0.015675 (rank : 143)
Query Neighborhood Hits	133	Target Neighborhood Hits	753	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PTN14_HUMAN
θ value	1.81305 (rank : 102)	NC score	0.109905 (rank : 107)
Query Neighborhood Hits	133	Target Neighborhood Hits	163	Shared Neighborhood Hits	63
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTPRF_HUMAN
θ value	1.81305 (rank : 103)	NC score	0.102167 (rank : 118)
Query Neighborhood Hits	133	Target Neighborhood Hits	489	Shared Neighborhood Hits	62
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRK_HUMAN
θ value	1.81305 (rank : 104)	NC score	0.121379 (rank : 91)
Query Neighborhood Hits	133	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	1.81305 (rank : 105)	NC score	0.121239 (rank : 92)
Query Neighborhood Hits	133	Target Neighborhood Hits	223	Shared Neighborhood Hits	51
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRS_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.105116 (rank : 114)
Query Neighborhood Hits	133	Target Neighborhood Hits	472	Shared Neighborhood Hits	62
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

LIPA3_HUMAN
θ value	2.36792 (rank : 107)	NC score	0.011825 (rank : 149)
Query Neighborhood Hits	133	Target Neighborhood Hits	828	Shared Neighborhood Hits	6
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

SAFB1_HUMAN
θ value	2.36792 (rank : 108)	NC score	0.012327 (rank : 148)
Query Neighborhood Hits	133	Target Neighborhood Hits	493	Shared Neighborhood Hits	5
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

KI21A_HUMAN
θ value	3.0926 (rank : 109)	NC score	0.000936 (rank : 158)
Query Neighborhood Hits	133	Target Neighborhood Hits	1543	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

PO121_MOUSE
θ value	3.0926 (rank : 110)	NC score	0.015910 (rank : 142)
Query Neighborhood Hits	133	Target Neighborhood Hits	345	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

PTN4_HUMAN
θ value	3.0926 (rank : 111)	NC score	0.104259 (rank : 116)
Query Neighborhood Hits	133	Target Neighborhood Hits	303	Shared Neighborhood Hits	60
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

SSH2_HUMAN
θ value	3.0926 (rank : 112)	NC score	0.182057 (rank : 58)
Query Neighborhood Hits	133	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

SSH2_MOUSE
θ value	3.0926 (rank : 113)	NC score	0.182291 (rank : 57)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

GCR_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.012870 (rank : 146)
Query Neighborhood Hits	133	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

COIA1_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.003804 (rank : 154)
Query Neighborhood Hits	133	Target Neighborhood Hits	481	Shared Neighborhood Hits	4
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

MARK3_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.002261 (rank : 156)
Query Neighborhood Hits	133	Target Neighborhood Hits	893	Shared Neighborhood Hits	7
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PTPRM_HUMAN
θ value	5.27518 (rank : 117)	NC score	0.115197 (rank : 103)
Query Neighborhood Hits	133	Target Neighborhood Hits	244	Shared Neighborhood Hits	55
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRU_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.119396 (rank : 97)
Query Neighborhood Hits	133	Target Neighborhood Hits	237	Shared Neighborhood Hits	54
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

ABCD1_MOUSE
θ value	6.88961 (rank : 119)	NC score	0.006130 (rank : 151)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	P48410, Q9QY41, Q9QZ32	Gene names	Abcd1, Ald, Aldgh
Domain Architecture
Description	ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy protein) (ALDP).

HD_HUMAN
θ value	6.88961 (rank : 120)	NC score	0.011136 (rank : 150)
Query Neighborhood Hits	133	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

PININ_MOUSE
θ value	6.88961 (rank : 121)	NC score	0.012841 (rank : 147)
Query Neighborhood Hits	133	Target Neighborhood Hits	777	Shared Neighborhood Hits	10
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PTN21_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.095892 (rank : 121)
Query Neighborhood Hits	133	Target Neighborhood Hits	143	Shared Neighborhood Hits	51
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN9_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.124270 (rank : 89)
Query Neighborhood Hits	133	Target Neighborhood Hits	79	Shared Neighborhood Hits	51
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.124847 (rank : 87)
Query Neighborhood Hits	133	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPRM_MOUSE
θ value	6.88961 (rank : 125)	NC score	0.115399 (rank : 101)
Query Neighborhood Hits	133	Target Neighborhood Hits	238	Shared Neighborhood Hits	55
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

TARA_HUMAN
θ value	6.88961 (rank : 126)	NC score	0.013568 (rank : 145)
Query Neighborhood Hits	133	Target Neighborhood Hits	1626	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

A2AP_MOUSE
θ value	8.99809 (rank : 127)	NC score	0.002309 (rank : 155)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q61247	Gene names	Serpinf2, Pli
Domain Architecture
Description	Alpha-2-antiplasmin precursor (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Alpha-2-AP).

DACT1_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.015049 (rank : 144)
Query Neighborhood Hits	133	Target Neighborhood Hits	228	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

MARK3_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.001324 (rank : 157)
Query Neighborhood Hits	133	Target Neighborhood Hits	919	Shared Neighborhood Hits	7
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

PTN14_MOUSE
θ value	8.99809 (rank : 130)	NC score	0.101250 (rank : 119)
Query Neighborhood Hits	133	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN1_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.126931 (rank : 86)
Query Neighborhood Hits	133	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN5_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.128334 (rank : 84)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	8.99809 (rank : 133)	NC score	0.127470 (rank : 85)
Query Neighborhood Hits	133	Target Neighborhood Hits	85	Shared Neighborhood Hits	55
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

CDKN3_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.073477 (rank : 126)
Query Neighborhood Hits	133	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

DUS12_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.194402 (rank : 51)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UNI6	Gene names	DUSP12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity tyrosine phosphatase YVH1).

DUS6_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.186061 (rank : 55)
Query Neighborhood Hits	133	Target Neighborhood Hits	57	Shared Neighborhood Hits	42
SwissProt Accessions	Q16828, O75109, Q53Y75, Q9BSH6	Gene names	DUSP6, MKP3, PYST1
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) (Dual specificity protein phosphatase PYST1).

DUS6_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.186055 (rank : 56)
Query Neighborhood Hits	133	Target Neighborhood Hits	57	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DBB1, Q542I5, Q9D7L4	Gene names	Dusp6, Mkp3
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3).

DUS7_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.205468 (rank : 48)
Query Neighborhood Hits	133	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	Q16829, Q8NFJ0	Gene names	DUSP7, PYST2
Domain Architecture
Description	Dual specificity protein phosphatase 7 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PYST2).

DUS9_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.204393 (rank : 49)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q99956	Gene names	DUSP9, MKP4
Domain Architecture
Description	Dual specificity protein phosphatase 9 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4).

EPM2A_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.061800 (rank : 130)
Query Neighborhood Hits	133	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	O95278, O95483, Q8IU96, Q8IX24, Q8IX25, Q9BS66, Q9UEN2	Gene names	EPM2A
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

EPM2A_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.059825 (rank : 131)
Query Neighborhood Hits	133	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WUA5, Q8BY80	Gene names	Epm2a
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

PTN12_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.119680 (rank : 96)
Query Neighborhood Hits	133	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.117756 (rank : 100)
Query Neighborhood Hits	133	Target Neighborhood Hits	123	Shared Neighborhood Hits	57
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN18_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.113156 (rank : 106)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	47
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.120666 (rank : 94)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	62
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN21_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.091721 (rank : 122)
Query Neighborhood Hits	133	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN22_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.120732 (rank : 93)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.113561 (rank : 105)
Query Neighborhood Hits	133	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.089997 (rank : 123)
Query Neighborhood Hits	133	Target Neighborhood Hits	646	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.089918 (rank : 124)
Query Neighborhood Hits	133	Target Neighborhood Hits	726	Shared Neighborhood Hits	52
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.115252 (rank : 102)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	52
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.114497 (rank : 104)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	53
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN3_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.098395 (rank : 120)
Query Neighborhood Hits	133	Target Neighborhood Hits	258	Shared Neighborhood Hits	66
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTPR2_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.109032 (rank : 109)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	52
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.109480 (rank : 108)
Query Neighborhood Hits	133	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRN_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.106572 (rank : 110)
Query Neighborhood Hits	133	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.106299 (rank : 111)
Query Neighborhood Hits	133	Target Neighborhood Hits	240	Shared Neighborhood Hits	55
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

STYL1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.169232 (rank : 60)
Query Neighborhood Hits	133	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6J8, Q9UBP1, Q9UK06, Q9UK07, Q9UKG2, Q9UKG3	Gene names	STYXL1, DUSP24, MKSTYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity protein phosphatase 24) (Map kinase phosphatase-like protein MK-STYX) (Dual specificity phosphatase inhibitor MK-STYX).

Hits sorted by NC score

CC14A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_MOUSE
NC score	0.989943 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	133	Target Neighborhood Hits	117	Shared Neighborhood Hits	104
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14B_HUMAN
NC score	0.973461 (rank : 3)	θ value	1.41924e-154 (rank : 3)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	101
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14B_MOUSE
NC score	0.970202 (rank : 4)	θ value	1.56915e-153 (rank : 4)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	91
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

DUS23_MOUSE
NC score	0.578376 (rank : 5)	θ value	1.06045e-08 (rank : 6)
Query Neighborhood Hits	133	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

DUS23_HUMAN
NC score	0.575233 (rank : 6)	θ value	1.06045e-08 (rank : 5)
Query Neighborhood Hits	133	Target Neighborhood Hits	98	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

TP4A3_HUMAN
NC score	0.456328 (rank : 7)	θ value	1.99992e-07 (rank : 7)
Query Neighborhood Hits	133	Target Neighborhood Hits	62	Shared Neighborhood Hits	55
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

TP4A3_MOUSE
NC score	0.438467 (rank : 8)	θ value	2.21117e-06 (rank : 10)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

TP4A1_HUMAN
NC score	0.427674 (rank : 9)	θ value	7.59969e-07 (rank : 8)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	55
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
NC score	0.427674 (rank : 10)	θ value	7.59969e-07 (rank : 9)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	55
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TP4A2_HUMAN
NC score	0.408243 (rank : 11)	θ value	3.77169e-06 (rank : 11)
Query Neighborhood Hits	133	Target Neighborhood Hits	56	Shared Neighborhood Hits	44
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
NC score	0.408243 (rank : 12)	θ value	3.77169e-06 (rank : 12)
Query Neighborhood Hits	133	Target Neighborhood Hits	56	Shared Neighborhood Hits	44
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

DUS18_MOUSE
NC score	0.320119 (rank : 13)	θ value	0.000602161 (rank : 14)
Query Neighborhood Hits	133	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VE01	Gene names	Dusp18
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16).

DUS18_HUMAN
NC score	0.314386 (rank : 14)	θ value	0.00102713 (rank : 17)
Query Neighborhood Hits	133	Target Neighborhood Hits	52	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NEJ0	Gene names	DUSP18, LMWDSP20
Domain Architecture
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 20).

DUS14_MOUSE
NC score	0.301930 (rank : 15)	θ value	0.00665767 (rank : 22)
Query Neighborhood Hits	133	Target Neighborhood Hits	67	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLY7, Q9D715	Gene names	Dusp14, Mkp6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6).

DUS10_MOUSE
NC score	0.299594 (rank : 16)	θ value	0.00102713 (rank : 16)
Query Neighborhood Hits	133	Target Neighborhood Hits	62	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESS0, Q9CZY9	Gene names	Dusp10, Mkp5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS10_HUMAN
NC score	0.299446 (rank : 17)	θ value	0.00102713 (rank : 15)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y6W6	Gene names	DUSP10, MKP5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS14_HUMAN
NC score	0.298759 (rank : 18)	θ value	0.00869519 (rank : 23)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	O95147	Gene names	DUSP14, MKP6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1-like protein tyrosine phosphatase) (MKP- L).

STYX_HUMAN
NC score	0.298615 (rank : 19)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WUJ0, Q99850	Gene names	STYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein).

STYX_MOUSE
NC score	0.297195 (rank : 20)	θ value	0.00175202 (rank : 19)
Query Neighborhood Hits	133	Target Neighborhood Hits	62	Shared Neighborhood Hits	50
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

DUS16_HUMAN
NC score	0.295304 (rank : 21)	θ value	0.000461057 (rank : 13)
Query Neighborhood Hits	133	Target Neighborhood Hits	112	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

DUS21_HUMAN
NC score	0.288759 (rank : 22)	θ value	0.0330416 (rank : 26)
Query Neighborhood Hits	133	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H596, Q6IAJ6, Q6YDQ8	Gene names	DUSP21, LMWDSP21
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 21 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 21).

DUS1_HUMAN
NC score	0.272201 (rank : 23)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	56
SwissProt Accessions	P28562, Q2V508	Gene names	DUSP1, CL100, MKP1, PTPN10, VH1
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) (Dual specificity protein phosphatase hVH1).

PTPM1_MOUSE
NC score	0.271680 (rank : 24)	θ value	0.0961366 (rank : 43)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	56
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

DUS2_MOUSE
NC score	0.271130 (rank : 25)	θ value	0.0431538 (rank : 30)
Query Neighborhood Hits	133	Target Neighborhood Hits	86	Shared Neighborhood Hits	63
SwissProt Accessions	Q05922, Q60640	Gene names	Dusp2, Pac-1, Pac1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DUS22_MOUSE
NC score	0.270114 (rank : 26)	θ value	0.125558 (rank : 45)
Query Neighborhood Hits	133	Target Neighborhood Hits	57	Shared Neighborhood Hits	48
SwissProt Accessions	Q99N11, Q5SQN9, Q5SQP0	Gene names	Dusp22
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (LMW-DSP2).

DUS19_HUMAN
NC score	0.266956 (rank : 27)	θ value	0.0961366 (rank : 40)
Query Neighborhood Hits	133	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WTR2, Q8WYN4	Gene names	DUSP19, DUSP17, SKRP1
Domain Architecture
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

DUS5_HUMAN
NC score	0.265937 (rank : 28)	θ value	0.0563607 (rank : 34)
Query Neighborhood Hits	133	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	Q16690, Q12997	Gene names	DUSP5, VH3
Domain Architecture
Description	Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH3).

DUS1_MOUSE
NC score	0.265180 (rank : 29)	θ value	0.0563607 (rank : 32)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	56
SwissProt Accessions	P28563	Gene names	Dusp1, 3ch134, Mkp1, Ptpn10, Ptpn16
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase 3CH134) (Protein-tyrosine phosphatase ERP).

DUS4_MOUSE
NC score	0.264336 (rank : 30)	θ value	0.0736092 (rank : 36)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

DUS2_HUMAN
NC score	0.264148 (rank : 31)	θ value	0.0563607 (rank : 33)
Query Neighborhood Hits	133	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	Q05923	Gene names	DUSP2, PAC1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DUS4_HUMAN
NC score	0.263941 (rank : 32)	θ value	0.0736092 (rank : 35)
Query Neighborhood Hits	133	Target Neighborhood Hits	77	Shared Neighborhood Hits	56
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

DUS13_HUMAN
NC score	0.263011 (rank : 33)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UII6, Q5JSC6, Q96GC2	Gene names	DUSP13, TMDP
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal-muscle-specific DSP) (Dual specificity phosphatase SKRP4).

DUS15_HUMAN
NC score	0.261184 (rank : 34)	θ value	0.0330416 (rank : 25)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H1R2, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24	Gene names	DUSP15, C20orf57, VHY
Domain Architecture
Description	Dual specificity protein phosphatase 15 (EC 3.1.3.48) (EC 3.1.3.16) (Vaccinia virus VH1-related dual-specific protein phosphatase Y) (VH1- related member Y).

DUS3_HUMAN
NC score	0.260617 (rank : 35)	θ value	0.279714 (rank : 54)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	48
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

PTPM1_HUMAN
NC score	0.259125 (rank : 36)	θ value	0.0961366 (rank : 42)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

DUS8_MOUSE
NC score	0.257377 (rank : 37)	θ value	0.62314 (rank : 66)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	53
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

DUS19_MOUSE
NC score	0.257030 (rank : 38)	θ value	0.0431538 (rank : 29)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K4T5	Gene names	Dusp19, Skrp1
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

DUS3_MOUSE
NC score	0.256890 (rank : 39)	θ value	0.62314 (rank : 64)
Query Neighborhood Hits	133	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D7X3	Gene names	Dusp3
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (T- DSP11).

DUS8_HUMAN
NC score	0.255633 (rank : 40)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	133	Target Neighborhood Hits	161	Shared Neighborhood Hits	54
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

DUS22_HUMAN
NC score	0.254597 (rank : 41)	θ value	0.365318 (rank : 56)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NRW4, Q59GW2, Q5VWR2, Q96AR1	Gene names	DUSP22, JSP1, MKPX
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (JNK-stimulatory phosphatase-1) (JSP-1) (Mitogen-activated protein kinase phosphatase x) (LMW-DSP2).

PTEN_MOUSE
NC score	0.240659 (rank : 42)	θ value	0.00228821 (rank : 21)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	53
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

PTEN_HUMAN
NC score	0.240658 (rank : 43)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

SSH3_MOUSE
NC score	0.237195 (rank : 44)	θ value	0.0330416 (rank : 28)
Query Neighborhood Hits	133	Target Neighborhood Hits	69	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K330, Q3UDX0	Gene names	Ssh3, Ssh3l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (mSSH-3L).

SSH3_HUMAN
NC score	0.234303 (rank : 45)	θ value	0.0736092 (rank : 37)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

DUS13_MOUSE
NC score	0.222924 (rank : 46)	θ value	1.81305 (rank : 100)
Query Neighborhood Hits	133	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QYJ7	Gene names	Dusp13, Tmdp
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal muscle-specific DSP) (Dual specificity tyrosine phosphatase TS-DSP6).

DUS12_MOUSE
NC score	0.218218 (rank : 47)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9D0T2, Q9EQD3	Gene names	Dusp12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1).

DUS7_HUMAN
NC score	0.205468 (rank : 48)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	133	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	Q16829, Q8NFJ0	Gene names	DUSP7, PYST2
Domain Architecture
Description	Dual specificity protein phosphatase 7 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PYST2).

DUS9_HUMAN
NC score	0.204393 (rank : 49)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q99956	Gene names	DUSP9, MKP4
Domain Architecture
Description	Dual specificity protein phosphatase 9 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4).

DUS11_MOUSE
NC score	0.195732 (rank : 50)	θ value	0.0961366 (rank : 38)
Query Neighborhood Hits	133	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

DUS12_HUMAN
NC score	0.194402 (rank : 51)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UNI6	Gene names	DUSP12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity tyrosine phosphatase YVH1).

MCE1_HUMAN
NC score	0.192809 (rank : 52)	θ value	0.0961366 (rank : 41)
Query Neighborhood Hits	133	Target Neighborhood Hits	34	Shared Neighborhood Hits	28
SwissProt Accessions	O60942, O43483, O60257, O60351	Gene names	RNGTT, CAP1A
Domain Architecture
Description	mRNA capping enzyme (HCE) (HCAP1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

SSH1_MOUSE
NC score	0.188496 (rank : 53)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	42
SwissProt Accessions	Q76I79, Q3TDG3, Q69ZM4, Q811E5	Gene names	Ssh1, Kiaa1298, Ssh1l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (mSSH-1L).

SSH1_HUMAN
NC score	0.188487 (rank : 54)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	133	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

DUS6_HUMAN
NC score	0.186061 (rank : 55)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	133	Target Neighborhood Hits	57	Shared Neighborhood Hits	42
SwissProt Accessions	Q16828, O75109, Q53Y75, Q9BSH6	Gene names	DUSP6, MKP3, PYST1
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) (Dual specificity protein phosphatase PYST1).

DUS6_MOUSE
NC score	0.186055 (rank : 56)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	133	Target Neighborhood Hits	57	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DBB1, Q542I5, Q9D7L4	Gene names	Dusp6, Mkp3
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3).

SSH2_MOUSE
NC score	0.182291 (rank : 57)	θ value	3.0926 (rank : 113)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

SSH2_HUMAN
NC score	0.182057 (rank : 58)	θ value	3.0926 (rank : 112)
Query Neighborhood Hits	133	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

MCE1_MOUSE
NC score	0.179169 (rank : 59)	θ value	0.21417 (rank : 51)
Query Neighborhood Hits	133	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	O55236	Gene names	Rngtt, Cap1a
Domain Architecture
Description	mRNA capping enzyme (HCE) (MCE1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

STYL1_HUMAN
NC score	0.169232 (rank : 60)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	133	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6J8, Q9UBP1, Q9UK06, Q9UK07, Q9UKG2, Q9UKG3	Gene names	STYXL1, DUSP24, MKSTYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity protein phosphatase 24) (Map kinase phosphatase-like protein MK-STYX) (Dual specificity phosphatase inhibitor MK-STYX).

PTPRR_MOUSE
NC score	0.159355 (rank : 61)	θ value	0.163984 (rank : 48)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	53
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

TPTE2_HUMAN
NC score	0.156648 (rank : 62)	θ value	0.125558 (rank : 46)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

PTPRE_HUMAN
NC score	0.156430 (rank : 63)	θ value	0.163984 (rank : 47)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	67
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRR_HUMAN
NC score	0.155852 (rank : 64)	θ value	0.279714 (rank : 55)
Query Neighborhood Hits	133	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRE_MOUSE
NC score	0.152254 (rank : 65)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	133	Target Neighborhood Hits	86	Shared Neighborhood Hits	64
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_HUMAN
NC score	0.151700 (rank : 66)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	133	Target Neighborhood Hits	101	Shared Neighborhood Hits	65
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
NC score	0.150721 (rank : 67)	θ value	0.365318 (rank : 58)
Query Neighborhood Hits	133	Target Neighborhood Hits	93	Shared Neighborhood Hits	67
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRO_HUMAN
NC score	0.145322 (rank : 68)	θ value	0.813845 (rank : 81)
Query Neighborhood Hits	133	Target Neighborhood Hits	139	Shared Neighborhood Hits	61
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTN7_HUMAN
NC score	0.145211 (rank : 69)	θ value	0.813845 (rank : 76)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
NC score	0.142617 (rank : 70)	θ value	0.813845 (rank : 77)
Query Neighborhood Hits	133	Target Neighborhood Hits	71	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

CD45_HUMAN
NC score	0.140383 (rank : 71)	θ value	0.47712 (rank : 60)
Query Neighborhood Hits	133	Target Neighborhood Hits	243	Shared Neighborhood Hits	57
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
NC score	0.139735 (rank : 72)	θ value	0.47712 (rank : 61)
Query Neighborhood Hits	133	Target Neighborhood Hits	178	Shared Neighborhood Hits	52
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTN6_HUMAN
NC score	0.139563 (rank : 73)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	133	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTPRV_MOUSE
NC score	0.139400 (rank : 74)	θ value	0.62314 (rank : 67)
Query Neighborhood Hits	133	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTN6_MOUSE
NC score	0.139055 (rank : 75)	θ value	0.813845 (rank : 75)
Query Neighborhood Hits	133	Target Neighborhood Hits	225	Shared Neighborhood Hits	65
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTPRJ_HUMAN
NC score	0.136415 (rank : 76)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	133	Target Neighborhood Hits	207	Shared Neighborhood Hits	67
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
NC score	0.135253 (rank : 77)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	133	Target Neighborhood Hits	188	Shared Neighborhood Hits	64
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTN18_MOUSE
NC score	0.132607 (rank : 78)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	133	Target Neighborhood Hits	134	Shared Neighborhood Hits	58
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTPRB_HUMAN
NC score	0.132522 (rank : 79)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	133	Target Neighborhood Hits	242	Shared Neighborhood Hits	64
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

TPTE_HUMAN
NC score	0.131974 (rank : 80)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	133	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

PTN11_MOUSE
NC score	0.130069 (rank : 81)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	133	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.129994 (rank : 82)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	133	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTPRZ_HUMAN
NC score	0.129942 (rank : 83)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	133	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTN5_HUMAN
NC score	0.128334 (rank : 84)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
NC score	0.127470 (rank : 85)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	133	Target Neighborhood Hits	85	Shared Neighborhood Hits	55
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN1_MOUSE
NC score	0.126931 (rank : 86)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	133	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN9_MOUSE
NC score	0.124847 (rank : 87)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	133	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPRG_HUMAN
NC score	0.124662 (rank : 88)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	133	Target Neighborhood Hits	231	Shared Neighborhood Hits	54
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTN9_HUMAN
NC score	0.124270 (rank : 89)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	133	Target Neighborhood Hits	79	Shared Neighborhood Hits	51
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPRG_MOUSE
NC score	0.123858 (rank : 90)	θ value	1.38821 (rank : 94)
Query Neighborhood Hits	133	Target Neighborhood Hits	260	Shared Neighborhood Hits	56
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRK_HUMAN
NC score	0.121379 (rank : 91)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	133	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
NC score	0.121239 (rank : 92)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	133	Target Neighborhood Hits	223	Shared Neighborhood Hits	51
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTN22_HUMAN
NC score	0.120732 (rank : 93)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN1_HUMAN
NC score	0.120666 (rank : 94)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	62
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

DUS11_HUMAN
NC score	0.120060 (rank : 95)	θ value	1.38821 (rank : 89)
Query Neighborhood Hits	133	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

PTN12_HUMAN
NC score	0.119680 (rank : 96)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	133	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTPRU_HUMAN
NC score	0.119396 (rank : 97)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	133	Target Neighborhood Hits	237	Shared Neighborhood Hits	54
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRT_MOUSE
NC score	0.119261 (rank : 98)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	133	Target Neighborhood Hits	219	Shared Neighborhood Hits	52
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRT_HUMAN
NC score	0.119242 (rank : 99)	θ value	1.38821 (rank : 95)
Query Neighborhood Hits	133	Target Neighborhood Hits	217	Shared Neighborhood Hits	52
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTN12_MOUSE
NC score	0.117756 (rank : 100)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	133	Target Neighborhood Hits	123	Shared Neighborhood Hits	57
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTPRM_MOUSE
NC score	0.115399 (rank : 101)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	133	Target Neighborhood Hits	238	Shared Neighborhood Hits	55
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTN2_HUMAN
NC score	0.115252 (rank : 102)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	52
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTPRM_HUMAN
NC score	0.115197 (rank : 103)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	133	Target Neighborhood Hits	244	Shared Neighborhood Hits	55
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTN2_MOUSE
NC score	0.114497 (rank : 104)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	53
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN22_MOUSE
NC score	0.113561 (rank : 105)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	133	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN18_HUMAN
NC score	0.113156 (rank : 106)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	47
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN14_HUMAN
NC score	0.109905 (rank : 107)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	133	Target Neighborhood Hits	163	Shared Neighborhood Hits	63
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTPR2_MOUSE
NC score	0.109480 (rank : 108)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	133	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPR2_HUMAN
NC score	0.109032 (rank : 109)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	52
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPRN_HUMAN
NC score	0.106572 (rank : 110)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	133	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
NC score	0.106299 (rank : 111)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	133	Target Neighborhood Hits	240	Shared Neighborhood Hits	55
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTN13_MOUSE
NC score	0.105736 (rank : 112)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	133	Target Neighborhood Hits	426	Shared Neighborhood Hits	60
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTPRD_MOUSE
NC score	0.105249 (rank : 113)	θ value	1.38821 (rank : 93)
Query Neighborhood Hits	133	Target Neighborhood Hits	491	Shared Neighborhood Hits	63
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRS_HUMAN
NC score	0.105116 (rank : 114)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	133	Target Neighborhood Hits	472	Shared Neighborhood Hits	62
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTN13_HUMAN
NC score	0.104515 (rank : 115)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	133	Target Neighborhood Hits	471	Shared Neighborhood Hits	60
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN4_HUMAN
NC score	0.104259 (rank : 116)	θ value	3.0926 (rank : 111)
Query Neighborhood Hits	133	Target Neighborhood Hits	303	Shared Neighborhood Hits	60
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTPRD_HUMAN
NC score	0.104239 (rank : 117)	θ value	1.38821 (rank : 92)
Query Neighborhood Hits	133	Target Neighborhood Hits	485	Shared Neighborhood Hits	63
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
NC score	0.102167 (rank : 118)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	133	Target Neighborhood Hits	489	Shared Neighborhood Hits	62
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTN14_MOUSE
NC score	0.101250 (rank : 119)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	133	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN3_HUMAN
NC score	0.098395 (rank : 120)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	133	Target Neighborhood Hits	258	Shared Neighborhood Hits	66
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN21_HUMAN
NC score	0.095892 (rank : 121)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	133	Target Neighborhood Hits	143	Shared Neighborhood Hits	51
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN21_MOUSE
NC score	0.091721 (rank : 122)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	133	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN23_HUMAN
NC score	0.089997 (rank : 123)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	133	Target Neighborhood Hits	646	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
NC score	0.089918 (rank : 124)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	133	Target Neighborhood Hits	726	Shared Neighborhood Hits	52
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PPRB_HUMAN
NC score	0.074832 (rank : 125)	θ value	0.0330416 (rank : 27)
Query Neighborhood Hits	133	Target Neighborhood Hits	311	Shared Neighborhood Hits	12
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

CDKN3_HUMAN
NC score	0.073477 (rank : 126)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	133	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

PPRB_MOUSE
NC score	0.072166 (rank : 127)	θ value	0.0431538 (rank : 31)
Query Neighborhood Hits	133	Target Neighborhood Hits	354	Shared Neighborhood Hits	13
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

RYBP_HUMAN
NC score	0.069590 (rank : 128)	θ value	0.0961366 (rank : 44)
Query Neighborhood Hits	133	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N488, Q9P2W5, Q9UMW4	Gene names	RYBP, DEDAF, YEAF1
Domain Architecture	No domain graphic available
Description	RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) (Apoptin-associating protein 1) (APAP-1).

RYBP_MOUSE
NC score	0.066654 (rank : 129)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	133	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CCI5, Q9WVK2	Gene names	Rybp, Dedaf
Domain Architecture	No domain graphic available
Description	RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor).

EPM2A_HUMAN
NC score	0.061800 (rank : 130)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	133	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	O95278, O95483, Q8IU96, Q8IX24, Q8IX25, Q9BS66, Q9UEN2	Gene names	EPM2A
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

EPM2A_MOUSE
NC score	0.059825 (rank : 131)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	133	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WUA5, Q8BY80	Gene names	Epm2a
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

PODXL_MOUSE
NC score	0.034804 (rank : 132)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0M4, Q9ESZ1	Gene names	Podxl, Pclp1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

CDSN_HUMAN
NC score	0.032630 (rank : 133)	θ value	1.38821 (rank : 88)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q15517, O43509, Q5SQ85, Q5STD2, Q7LA70, Q7LA71, Q86Z04, Q8IZU4, Q8IZU5, Q8IZU6, Q8N5P3, Q95IF9, Q9NP52, Q9NPE0, Q9NPG5, Q9NRH4, Q9NRH5, Q9NRH6, Q9NRH7, Q9NRH8, Q9UBH8, Q9UIN6, Q9UIN7, Q9UIN8, Q9UIN9, Q9UIP0	Gene names	CDSN
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor (S protein).

SRRM2_HUMAN
NC score	0.031930 (rank : 134)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	133	Target Neighborhood Hits	1296	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

MUC13_MOUSE
NC score	0.031233 (rank : 135)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	133	Target Neighborhood Hits	447	Shared Neighborhood Hits	6
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

SRRM2_MOUSE
NC score	0.027353 (rank : 136)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	133	Target Neighborhood Hits	1470	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

GCR_MOUSE
NC score	0.022093 (rank : 137)	θ value	0.21417 (rank : 50)
Query Neighborhood Hits	133	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

UBP31_HUMAN
NC score	0.020848 (rank : 138)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	133	Target Neighborhood Hits	293	Shared Neighborhood Hits	10
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

LIPA3_MOUSE
NC score	0.017300 (rank : 139)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	133	Target Neighborhood Hits	636	Shared Neighborhood Hits	5
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

BPTF_HUMAN
NC score	0.016803 (rank : 140)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	133	Target Neighborhood Hits	786	Shared Neighborhood Hits	10
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

ZFY16_HUMAN
NC score	0.016739 (rank : 141)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

PO121_MOUSE
NC score	0.015910 (rank : 142)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	133	Target Neighborhood Hits	345	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

PININ_HUMAN
NC score	0.015675 (rank : 143)	θ value	1.81305 (rank : 101)
Query Neighborhood Hits	133	Target Neighborhood Hits	753	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

DACT1_HUMAN
NC score	0.015049 (rank : 144)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	133	Target Neighborhood Hits	228	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

TARA_HUMAN
NC score	0.013568 (rank : 145)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	133	Target Neighborhood Hits	1626	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

GCR_HUMAN
NC score	0.012870 (rank : 146)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	133	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

PININ_MOUSE
NC score	0.012841 (rank : 147)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	133	Target Neighborhood Hits	777	Shared Neighborhood Hits	10
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

SAFB1_HUMAN
NC score	0.012327 (rank : 148)	θ value	2.36792 (rank : 108)
Query Neighborhood Hits	133	Target Neighborhood Hits	493	Shared Neighborhood Hits	5
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

LIPA3_HUMAN
NC score	0.011825 (rank : 149)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	133	Target Neighborhood Hits	828	Shared Neighborhood Hits	6
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

HD_HUMAN
NC score	0.011136 (rank : 150)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	133	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

ABCD1_MOUSE
NC score	0.006130 (rank : 151)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	P48410, Q9QY41, Q9QZ32	Gene names	Abcd1, Ald, Aldgh
Domain Architecture
Description	ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy protein) (ALDP).

MARK2_HUMAN
NC score	0.004260 (rank : 152)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	133	Target Neighborhood Hits	1056	Shared Neighborhood Hits	12
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
NC score	0.003818 (rank : 153)	θ value	1.06291 (rank : 83)
Query Neighborhood Hits	133	Target Neighborhood Hits	1018	Shared Neighborhood Hits	13
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

COIA1_MOUSE
NC score	0.003804 (rank : 154)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	133	Target Neighborhood Hits	481	Shared Neighborhood Hits	4
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

A2AP_MOUSE
NC score	0.002309 (rank : 155)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q61247	Gene names	Serpinf2, Pli
Domain Architecture
Description	Alpha-2-antiplasmin precursor (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Alpha-2-AP).

MARK3_HUMAN
NC score	0.002261 (rank : 156)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	133	Target Neighborhood Hits	893	Shared Neighborhood Hits	7
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
NC score	0.001324 (rank : 157)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	133	Target Neighborhood Hits	919	Shared Neighborhood Hits	7
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KI21A_HUMAN
NC score	0.000936 (rank : 158)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	133	Target Neighborhood Hits	1543	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).