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Network neighborhood for query Sequence : DUS4_HUMAN

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DUS4_HUMAN
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DUS4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

DUS4_MOUSE
θ value	0 (rank : 2)	NC score	0.999559 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

DUS1_HUMAN
θ value	5.08302e-128 (rank : 3)	NC score	0.993125 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	73	Shared Neighborhood Hits	59
SwissProt Accessions	P28562, Q2V508	Gene names	DUSP1, CL100, MKP1, PTPN10, VH1
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) (Dual specificity protein phosphatase hVH1).

DUS1_MOUSE
θ value	4.30305e-127 (rank : 4)	NC score	0.992894 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	61
SwissProt Accessions	P28563	Gene names	Dusp1, 3ch134, Mkp1, Ptpn10, Ptpn16
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase 3CH134) (Protein-tyrosine phosphatase ERP).

DUS5_HUMAN
θ value	9.0981e-77 (rank : 5)	NC score	0.980753 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q16690, Q12997	Gene names	DUSP5, VH3
Domain Architecture
Description	Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH3).

DUS2_MOUSE
θ value	1.5519e-76 (rank : 6)	NC score	0.984430 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q05922, Q60640	Gene names	Dusp2, Pac-1, Pac1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DUS2_HUMAN
θ value	1.31376e-75 (rank : 7)	NC score	0.983575 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	56
SwissProt Accessions	Q05923	Gene names	DUSP2, PAC1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DUS7_HUMAN
θ value	9.18288e-45 (rank : 8)	NC score	0.940522 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	54
SwissProt Accessions	Q16829, Q8NFJ0	Gene names	DUSP7, PYST2
Domain Architecture
Description	Dual specificity protein phosphatase 7 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PYST2).

DUS9_HUMAN
θ value	7.77379e-44 (rank : 9)	NC score	0.948321 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	59	Shared Neighborhood Hits	51
SwissProt Accessions	Q99956	Gene names	DUSP9, MKP4
Domain Architecture
Description	Dual specificity protein phosphatase 9 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4).

DUS6_MOUSE
θ value	2.50074e-42 (rank : 10)	NC score	0.934055 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	Q9DBB1, Q542I5, Q9D7L4	Gene names	Dusp6, Mkp3
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3).

DUS6_HUMAN
θ value	7.27602e-42 (rank : 11)	NC score	0.933920 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	Q16828, O75109, Q53Y75, Q9BSH6	Gene names	DUSP6, MKP3, PYST1
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) (Dual specificity protein phosphatase PYST1).

DUS8_HUMAN
θ value	2.76489e-41 (rank : 12)	NC score	0.910617 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	161	Shared Neighborhood Hits	55
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

DUS10_HUMAN
θ value	1.79215e-40 (rank : 13)	NC score	0.931092 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6W6	Gene names	DUSP10, MKP5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS10_MOUSE
θ value	1.79215e-40 (rank : 14)	NC score	0.932647 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ESS0, Q9CZY9	Gene names	Dusp10, Mkp5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS16_HUMAN
θ value	3.99248e-40 (rank : 15)	NC score	0.925747 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	112	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

DUS8_MOUSE
θ value	4.41421e-39 (rank : 16)	NC score	0.913939 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	119	Shared Neighborhood Hits	55
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

DUS14_HUMAN
θ value	1.80048e-24 (rank : 17)	NC score	0.898475 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	54
SwissProt Accessions	O95147	Gene names	DUSP14, MKP6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1-like protein tyrosine phosphatase) (MKP- L).

DUS14_MOUSE
θ value	3.07116e-24 (rank : 18)	NC score	0.899580 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLY7, Q9D715	Gene names	Dusp14, Mkp6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6).

SSH1_HUMAN
θ value	1.42661e-21 (rank : 19)	NC score	0.781771 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	164	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

SSH1_MOUSE
θ value	9.24701e-21 (rank : 20)	NC score	0.783336 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	107	Shared Neighborhood Hits	49
SwissProt Accessions	Q76I79, Q3TDG3, Q69ZM4, Q811E5	Gene names	Ssh1, Kiaa1298, Ssh1l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (mSSH-1L).

SSH2_HUMAN
θ value	9.24701e-21 (rank : 21)	NC score	0.767747 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

SSH2_MOUSE
θ value	9.24701e-21 (rank : 22)	NC score	0.769990 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	119	Shared Neighborhood Hits	46
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

DUS18_HUMAN
θ value	1.74391e-19 (rank : 23)	NC score	0.868530 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	52	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NEJ0	Gene names	DUSP18, LMWDSP20
Domain Architecture
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 20).

DUS18_MOUSE
θ value	2.97466e-19 (rank : 24)	NC score	0.870921 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VE01	Gene names	Dusp18
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16).

DUS19_HUMAN
θ value	4.29542e-18 (rank : 25)	NC score	0.884084 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	52	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WTR2, Q8WYN4	Gene names	DUSP19, DUSP17, SKRP1
Domain Architecture
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

DUS21_HUMAN
θ value	2.13179e-17 (rank : 26)	NC score	0.868686 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	52	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H596, Q6IAJ6, Q6YDQ8	Gene names	DUSP21, LMWDSP21
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 21 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 21).

SSH3_MOUSE
θ value	4.74913e-17 (rank : 27)	NC score	0.785252 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K330, Q3UDX0	Gene names	Ssh3, Ssh3l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (mSSH-3L).

DUS19_MOUSE
θ value	1.38178e-16 (rank : 28)	NC score	0.875646 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	58	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4T5	Gene names	Dusp19, Skrp1
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

DUS3_HUMAN
θ value	5.25075e-16 (rank : 29)	NC score	0.868777 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	58	Shared Neighborhood Hits	49
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

DUS3_MOUSE
θ value	6.85773e-16 (rank : 30)	NC score	0.867980 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	54	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D7X3	Gene names	Dusp3
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (T- DSP11).

SSH3_HUMAN
θ value	8.95645e-16 (rank : 31)	NC score	0.781194 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

DUS13_MOUSE
θ value	1.99529e-15 (rank : 32)	NC score	0.834632 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYJ7	Gene names	Dusp13, Tmdp
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal muscle-specific DSP) (Dual specificity tyrosine phosphatase TS-DSP6).

STYX_HUMAN
θ value	2.60593e-15 (rank : 33)	NC score	0.865145 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WUJ0, Q99850	Gene names	STYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein).

DUS13_HUMAN
θ value	3.40345e-15 (rank : 34)	NC score	0.833491 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	59	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UII6, Q5JSC6, Q96GC2	Gene names	DUSP13, TMDP
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal-muscle-specific DSP) (Dual specificity phosphatase SKRP4).

DUS22_HUMAN
θ value	4.44505e-15 (rank : 35)	NC score	0.862804 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	58	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NRW4, Q59GW2, Q5VWR2, Q96AR1	Gene names	DUSP22, JSP1, MKPX
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (JNK-stimulatory phosphatase-1) (JSP-1) (Mitogen-activated protein kinase phosphatase x) (LMW-DSP2).

DUS22_MOUSE
θ value	4.44505e-15 (rank : 36)	NC score	0.864433 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q99N11, Q5SQN9, Q5SQP0	Gene names	Dusp22
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (LMW-DSP2).

STYX_MOUSE
θ value	7.58209e-15 (rank : 37)	NC score	0.862374 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	55
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

DUS15_HUMAN
θ value	5.43371e-13 (rank : 38)	NC score	0.848954 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H1R2, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24	Gene names	DUSP15, C20orf57, VHY
Domain Architecture
Description	Dual specificity protein phosphatase 15 (EC 3.1.3.48) (EC 3.1.3.16) (Vaccinia virus VH1-related dual-specific protein phosphatase Y) (VH1- related member Y).

DUS12_MOUSE
θ value	6.00763e-12 (rank : 39)	NC score	0.796855 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9D0T2, Q9EQD3	Gene names	Dusp12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1).

STYL1_HUMAN
θ value	1.33837e-11 (rank : 40)	NC score	0.819003 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6J8, Q9UBP1, Q9UK06, Q9UK07, Q9UKG2, Q9UKG3	Gene names	STYXL1, DUSP24, MKSTYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity protein phosphatase 24) (Map kinase phosphatase-like protein MK-STYX) (Dual specificity phosphatase inhibitor MK-STYX).

DUS12_HUMAN
θ value	1.47974e-10 (rank : 41)	NC score	0.773992 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UNI6	Gene names	DUSP12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity tyrosine phosphatase YVH1).

CC14B_HUMAN
θ value	0.000602161 (rank : 42)	NC score	0.329013 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	114	Shared Neighborhood Hits	60
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

PTPM1_MOUSE
θ value	0.000786445 (rank : 43)	NC score	0.512910 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	53
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

CC14B_MOUSE
θ value	0.00102713 (rank : 44)	NC score	0.295045 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	103	Shared Neighborhood Hits	55
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

PTPM1_HUMAN
θ value	0.00509761 (rank : 45)	NC score	0.473263 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

PTN3_HUMAN
θ value	0.0563607 (rank : 46)	NC score	0.043298 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

CC14A_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.263941 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	133	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_MOUSE
θ value	0.0736092 (rank : 48)	NC score	0.268732 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	117	Shared Neighborhood Hits	56
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

MTM1_HUMAN
θ value	0.0736092 (rank : 49)	NC score	0.047205 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q13496, Q8NEL1	Gene names	MTM1, CG2
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

MTM1_MOUSE
θ value	0.163984 (rank : 50)	NC score	0.046490 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z2C5	Gene names	Mtm1
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

PTN1_HUMAN
θ value	0.163984 (rank : 51)	NC score	0.056473 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	84	Shared Neighborhood Hits	24
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	0.21417 (rank : 52)	NC score	0.056107 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

MPIP3_MOUSE
θ value	0.47712 (rank : 53)	NC score	0.042590 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	P48967, Q99KG6	Gene names	Cdc25c, Cdc25m1
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

TP4A3_HUMAN
θ value	0.62314 (rank : 54)	NC score	0.134802 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

TP4A3_MOUSE
θ value	0.62314 (rank : 55)	NC score	0.131867 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

MPIP2_MOUSE
θ value	1.81305 (rank : 56)	NC score	0.038148 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	P30306, Q99LP3	Gene names	Cdc25b, Cdc25m2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

MTSS1_MOUSE
θ value	1.81305 (rank : 57)	NC score	0.012693 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	592	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

TP4A1_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.104009 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
θ value	1.81305 (rank : 59)	NC score	0.104009 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TP4A2_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.099771 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	56	Shared Neighborhood Hits	30
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
θ value	1.81305 (rank : 61)	NC score	0.099771 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	56	Shared Neighborhood Hits	30
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

PTPRA_HUMAN
θ value	2.36792 (rank : 62)	NC score	0.026271 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	2.36792 (rank : 63)	NC score	0.027844 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	93	Shared Neighborhood Hits	25
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

WASF1_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.007786 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

WNK4_HUMAN
θ value	2.36792 (rank : 65)	NC score	-0.003568 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	1043	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

PLVAP_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.010037 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	210	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

PTN14_MOUSE
θ value	3.0926 (rank : 67)	NC score	0.029813 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN6_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.029462 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	234	Shared Neighborhood Hits	26
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	3.0926 (rank : 69)	NC score	0.026924 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTPRE_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.028057 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTEN_HUMAN
θ value	4.03905 (rank : 71)	NC score	0.049399 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	4.03905 (rank : 72)	NC score	0.049397 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	73	Shared Neighborhood Hits	28
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

GSCR1_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.002875 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	674	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MPIP2_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.033814 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	P30305, O43551, Q13971, Q5JX77, Q6RSS1, Q9BRA6	Gene names	CDC25B, CDC25HU2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

HERC2_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.004933 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.004916 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

MPIP3_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.033789 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1	Gene names	CDC25C
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

DUS11_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.071878 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

DUS23_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.256825 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	98	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

DUS23_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.234029 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	48
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

EPM2A_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.231129 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95278, O95483, Q8IU96, Q8IX24, Q8IX25, Q9BS66, Q9UEN2	Gene names	EPM2A
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

EPM2A_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.230894 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUA5, Q8BY80	Gene names	Epm2a
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

Hits sorted by NC score

DUS4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

DUS4_MOUSE
NC score	0.999559 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

DUS1_HUMAN
NC score	0.993125 (rank : 3)	θ value	5.08302e-128 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	73	Shared Neighborhood Hits	59
SwissProt Accessions	P28562, Q2V508	Gene names	DUSP1, CL100, MKP1, PTPN10, VH1
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) (Dual specificity protein phosphatase hVH1).

DUS1_MOUSE
NC score	0.992894 (rank : 4)	θ value	4.30305e-127 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	61
SwissProt Accessions	P28563	Gene names	Dusp1, 3ch134, Mkp1, Ptpn10, Ptpn16
Domain Architecture
Description	Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1.3.16) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase 3CH134) (Protein-tyrosine phosphatase ERP).

DUS2_MOUSE
NC score	0.984430 (rank : 5)	θ value	1.5519e-76 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q05922, Q60640	Gene names	Dusp2, Pac-1, Pac1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DUS2_HUMAN
NC score	0.983575 (rank : 6)	θ value	1.31376e-75 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	56
SwissProt Accessions	Q05923	Gene names	DUSP2, PAC1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DUS5_HUMAN
NC score	0.980753 (rank : 7)	θ value	9.0981e-77 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q16690, Q12997	Gene names	DUSP5, VH3
Domain Architecture
Description	Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH3).

DUS9_HUMAN
NC score	0.948321 (rank : 8)	θ value	7.77379e-44 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	59	Shared Neighborhood Hits	51
SwissProt Accessions	Q99956	Gene names	DUSP9, MKP4
Domain Architecture
Description	Dual specificity protein phosphatase 9 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4).

DUS7_HUMAN
NC score	0.940522 (rank : 9)	θ value	9.18288e-45 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	54
SwissProt Accessions	Q16829, Q8NFJ0	Gene names	DUSP7, PYST2
Domain Architecture
Description	Dual specificity protein phosphatase 7 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PYST2).

DUS6_MOUSE
NC score	0.934055 (rank : 10)	θ value	2.50074e-42 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	Q9DBB1, Q542I5, Q9D7L4	Gene names	Dusp6, Mkp3
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3).

DUS6_HUMAN
NC score	0.933920 (rank : 11)	θ value	7.27602e-42 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	Q16828, O75109, Q53Y75, Q9BSH6	Gene names	DUSP6, MKP3, PYST1
Domain Architecture
Description	Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) (Dual specificity protein phosphatase PYST1).

DUS10_MOUSE
NC score	0.932647 (rank : 12)	θ value	1.79215e-40 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ESS0, Q9CZY9	Gene names	Dusp10, Mkp5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS10_HUMAN
NC score	0.931092 (rank : 13)	θ value	1.79215e-40 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6W6	Gene names	DUSP10, MKP5
Domain Architecture
Description	Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5).

DUS16_HUMAN
NC score	0.925747 (rank : 14)	θ value	3.99248e-40 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	112	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

DUS8_MOUSE
NC score	0.913939 (rank : 15)	θ value	4.41421e-39 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	119	Shared Neighborhood Hits	55
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

DUS8_HUMAN
NC score	0.910617 (rank : 16)	θ value	2.76489e-41 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	161	Shared Neighborhood Hits	55
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

DUS14_MOUSE
NC score	0.899580 (rank : 17)	θ value	3.07116e-24 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLY7, Q9D715	Gene names	Dusp14, Mkp6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6).

DUS14_HUMAN
NC score	0.898475 (rank : 18)	θ value	1.80048e-24 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	54
SwissProt Accessions	O95147	Gene names	DUSP14, MKP6
Domain Architecture
Description	Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1-like protein tyrosine phosphatase) (MKP- L).

DUS19_HUMAN
NC score	0.884084 (rank : 19)	θ value	4.29542e-18 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	52	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WTR2, Q8WYN4	Gene names	DUSP19, DUSP17, SKRP1
Domain Architecture
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

DUS19_MOUSE
NC score	0.875646 (rank : 20)	θ value	1.38178e-16 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	58	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4T5	Gene names	Dusp19, Skrp1
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 19 (EC 3.1.3.48) (EC 3.1.3.16) (Stress-activated protein kinase pathway-regulating phosphatase 1) (Protein phosphatase SKRP1).

DUS18_MOUSE
NC score	0.870921 (rank : 21)	θ value	2.97466e-19 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VE01	Gene names	Dusp18
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16).

DUS3_HUMAN
NC score	0.868777 (rank : 22)	θ value	5.25075e-16 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	58	Shared Neighborhood Hits	49
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

DUS21_HUMAN
NC score	0.868686 (rank : 23)	θ value	2.13179e-17 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	52	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H596, Q6IAJ6, Q6YDQ8	Gene names	DUSP21, LMWDSP21
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 21 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 21).

DUS18_HUMAN
NC score	0.868530 (rank : 24)	θ value	1.74391e-19 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	52	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NEJ0	Gene names	DUSP18, LMWDSP20
Domain Architecture
Description	Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 20).

DUS3_MOUSE
NC score	0.867980 (rank : 25)	θ value	6.85773e-16 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	54	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D7X3	Gene names	Dusp3
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (T- DSP11).

STYX_HUMAN
NC score	0.865145 (rank : 26)	θ value	2.60593e-15 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WUJ0, Q99850	Gene names	STYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein).

DUS22_MOUSE
NC score	0.864433 (rank : 27)	θ value	4.44505e-15 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q99N11, Q5SQN9, Q5SQP0	Gene names	Dusp22
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (LMW-DSP2).

DUS22_HUMAN
NC score	0.862804 (rank : 28)	θ value	4.44505e-15 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	58	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NRW4, Q59GW2, Q5VWR2, Q96AR1	Gene names	DUSP22, JSP1, MKPX
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 22 (EC 3.1.3.48) (EC 3.1.3.16) (JNK-stimulatory phosphatase-1) (JSP-1) (Mitogen-activated protein kinase phosphatase x) (LMW-DSP2).

STYX_MOUSE
NC score	0.862374 (rank : 29)	θ value	7.58209e-15 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	55
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

DUS15_HUMAN
NC score	0.848954 (rank : 30)	θ value	5.43371e-13 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H1R2, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24	Gene names	DUSP15, C20orf57, VHY
Domain Architecture
Description	Dual specificity protein phosphatase 15 (EC 3.1.3.48) (EC 3.1.3.16) (Vaccinia virus VH1-related dual-specific protein phosphatase Y) (VH1- related member Y).

DUS13_MOUSE
NC score	0.834632 (rank : 31)	θ value	1.99529e-15 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYJ7	Gene names	Dusp13, Tmdp
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal muscle-specific DSP) (Dual specificity tyrosine phosphatase TS-DSP6).

DUS13_HUMAN
NC score	0.833491 (rank : 32)	θ value	3.40345e-15 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	59	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UII6, Q5JSC6, Q96GC2	Gene names	DUSP13, TMDP
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal-muscle-specific DSP) (Dual specificity phosphatase SKRP4).

STYL1_HUMAN
NC score	0.819003 (rank : 33)	θ value	1.33837e-11 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6J8, Q9UBP1, Q9UK06, Q9UK07, Q9UKG2, Q9UKG3	Gene names	STYXL1, DUSP24, MKSTYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity protein phosphatase 24) (Map kinase phosphatase-like protein MK-STYX) (Dual specificity phosphatase inhibitor MK-STYX).

DUS12_MOUSE
NC score	0.796855 (rank : 34)	θ value	6.00763e-12 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9D0T2, Q9EQD3	Gene names	Dusp12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1).

SSH3_MOUSE
NC score	0.785252 (rank : 35)	θ value	4.74913e-17 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K330, Q3UDX0	Gene names	Ssh3, Ssh3l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (mSSH-3L).

SSH1_MOUSE
NC score	0.783336 (rank : 36)	θ value	9.24701e-21 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	107	Shared Neighborhood Hits	49
SwissProt Accessions	Q76I79, Q3TDG3, Q69ZM4, Q811E5	Gene names	Ssh1, Kiaa1298, Ssh1l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (mSSH-1L).

SSH1_HUMAN
NC score	0.781771 (rank : 37)	θ value	1.42661e-21 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	164	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

SSH3_HUMAN
NC score	0.781194 (rank : 38)	θ value	8.95645e-16 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

DUS12_HUMAN
NC score	0.773992 (rank : 39)	θ value	1.47974e-10 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UNI6	Gene names	DUSP12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity tyrosine phosphatase YVH1).

SSH2_MOUSE
NC score	0.769990 (rank : 40)	θ value	9.24701e-21 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	119	Shared Neighborhood Hits	46
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

SSH2_HUMAN
NC score	0.767747 (rank : 41)	θ value	9.24701e-21 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

PTPM1_MOUSE
NC score	0.512910 (rank : 42)	θ value	0.000786445 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	53
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

PTPM1_HUMAN
NC score	0.473263 (rank : 43)	θ value	0.00509761 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

CC14B_HUMAN
NC score	0.329013 (rank : 44)	θ value	0.000602161 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	114	Shared Neighborhood Hits	60
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14B_MOUSE
NC score	0.295045 (rank : 45)	θ value	0.00102713 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	103	Shared Neighborhood Hits	55
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14A_MOUSE
NC score	0.268732 (rank : 46)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	117	Shared Neighborhood Hits	56
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_HUMAN
NC score	0.263941 (rank : 47)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	133	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

DUS23_HUMAN
NC score	0.256825 (rank : 48)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	98	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

DUS23_MOUSE
NC score	0.234029 (rank : 49)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	48
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

EPM2A_HUMAN
NC score	0.231129 (rank : 50)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95278, O95483, Q8IU96, Q8IX24, Q8IX25, Q9BS66, Q9UEN2	Gene names	EPM2A
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

EPM2A_MOUSE
NC score	0.230894 (rank : 51)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUA5, Q8BY80	Gene names	Epm2a
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

TP4A3_HUMAN
NC score	0.134802 (rank : 52)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

TP4A3_MOUSE
NC score	0.131867 (rank : 53)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

TP4A1_HUMAN
NC score	0.104009 (rank : 54)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
NC score	0.104009 (rank : 55)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TP4A2_HUMAN
NC score	0.099771 (rank : 56)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	56	Shared Neighborhood Hits	30
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
NC score	0.099771 (rank : 57)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	56	Shared Neighborhood Hits	30
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

DUS11_MOUSE
NC score	0.071878 (rank : 58)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

PTN1_HUMAN
NC score	0.056473 (rank : 59)	θ value	0.163984 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	84	Shared Neighborhood Hits	24
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
NC score	0.056107 (rank : 60)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTEN_HUMAN
NC score	0.049399 (rank : 61)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
NC score	0.049397 (rank : 62)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	73	Shared Neighborhood Hits	28
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

MTM1_HUMAN
NC score	0.047205 (rank : 63)	θ value	0.0736092 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q13496, Q8NEL1	Gene names	MTM1, CG2
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

MTM1_MOUSE
NC score	0.046490 (rank : 64)	θ value	0.163984 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z2C5	Gene names	Mtm1
Domain Architecture
Description	Myotubularin (EC 3.1.3.48).

PTN3_HUMAN
NC score	0.043298 (rank : 65)	θ value	0.0563607 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

MPIP3_MOUSE
NC score	0.042590 (rank : 66)	θ value	0.47712 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	P48967, Q99KG6	Gene names	Cdc25c, Cdc25m1
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

MPIP2_MOUSE
NC score	0.038148 (rank : 67)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	P30306, Q99LP3	Gene names	Cdc25b, Cdc25m2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

MPIP2_HUMAN
NC score	0.033814 (rank : 68)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	P30305, O43551, Q13971, Q5JX77, Q6RSS1, Q9BRA6	Gene names	CDC25B, CDC25HU2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

MPIP3_HUMAN
NC score	0.033789 (rank : 69)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1	Gene names	CDC25C
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

PTN14_MOUSE
NC score	0.029813 (rank : 70)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN6_HUMAN
NC score	0.029462 (rank : 71)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	234	Shared Neighborhood Hits	26
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTPRE_HUMAN
NC score	0.028057 (rank : 72)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_MOUSE
NC score	0.027844 (rank : 73)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	93	Shared Neighborhood Hits	25
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTN6_MOUSE
NC score	0.026924 (rank : 74)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTPRA_HUMAN
NC score	0.026271 (rank : 75)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

MTSS1_MOUSE
NC score	0.012693 (rank : 76)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	592	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

PLVAP_MOUSE
NC score	0.010037 (rank : 77)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	210	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

WASF1_MOUSE
NC score	0.007786 (rank : 78)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

HERC2_HUMAN
NC score	0.004933 (rank : 79)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
NC score	0.004916 (rank : 80)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

GSCR1_HUMAN
NC score	0.002875 (rank : 81)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	674	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

WNK4_HUMAN
NC score	-0.003568 (rank : 82)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	1043	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).