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Network neighborhood for query Sequence : MSH6_HUMAN

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MSH6_HUMAN
SwissProt Accessions	P52701, O43706, O43917, Q8TCX4, Q9BTB5	Gene names	MSH6, GTBP
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MSH6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	P52701, O43706, O43917, Q8TCX4, Q9BTB5	Gene names	MSH6, GTBP
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

MSH6_MOUSE
θ value	0 (rank : 2)	NC score	0.991263 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	P54276, O54710	Gene names	Msh6, Gtmbp
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

MSH3_MOUSE
θ value	1.65806e-78 (rank : 3)	NC score	0.855877 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	P13705	Gene names	Msh3, Rep-3
Domain Architecture
Description	DNA mismatch repair protein Msh3 (Repair-3 protein) (REP-1).

MSH3_HUMAN
θ value	2.1655e-78 (rank : 4)	NC score	0.853283 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	P20585, Q6PJT5, Q86UQ6, Q92867	Gene names	MSH3, DUC1, DUG
Domain Architecture
Description	DNA mismatch repair protein Msh3 (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1).

MSH2_HUMAN
θ value	3.0428e-56 (rank : 5)	NC score	0.822710 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P43246, O75488	Gene names	MSH2
Domain Architecture
Description	DNA mismatch repair protein Msh2 (MutS protein homolog 2).

MSH2_MOUSE
θ value	3.36421e-55 (rank : 6)	NC score	0.821127 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P43247	Gene names	Msh2
Domain Architecture
Description	DNA mismatch repair protein Msh2 (MutS protein homolog 2).

MSH5_HUMAN
θ value	1.16434e-31 (rank : 7)	NC score	0.754730 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	O43196, O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7	Gene names	MSH5
Domain Architecture
Description	MutS protein homolog 5.

MSH5_MOUSE
θ value	2.59387e-31 (rank : 8)	NC score	0.753003 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QUM7, Q9Z1Q6	Gene names	Msh5
Domain Architecture	No domain graphic available
Description	MutS protein homolog 5.

MSH4_HUMAN
θ value	8.3442e-30 (rank : 9)	NC score	0.755530 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	O15457, Q8NEB3, Q9UNP8	Gene names	MSH4
Domain Architecture
Description	MutS protein homolog 4.

MSH4_MOUSE
θ value	1.4233e-29 (rank : 10)	NC score	0.751674 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MT2, Q920J1	Gene names	Msh4
Domain Architecture
Description	MutS protein homolog 4 (mMsh4).

ZCPW1_HUMAN
θ value	7.59969e-07 (rank : 11)	NC score	0.252764 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	116	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

NSD1_HUMAN
θ value	9.92553e-07 (rank : 12)	NC score	0.119524 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	427	Shared Neighborhood Hits	28
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

ZCPW1_MOUSE
θ value	9.92553e-07 (rank : 13)	NC score	0.227892 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

PSIP1_MOUSE
θ value	1.43324e-05 (rank : 14)	NC score	0.192523 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	313	Shared Neighborhood Hits	28
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

PSIP1_HUMAN
θ value	0.000461057 (rank : 15)	NC score	0.182423 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

PWWP2_HUMAN
θ value	0.0113563 (rank : 16)	NC score	0.195746 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

SVIL_MOUSE
θ value	0.0113563 (rank : 17)	NC score	0.042336 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	439	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

DNM3B_HUMAN
θ value	0.0148317 (rank : 18)	NC score	0.112596 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	59	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBC3, Q9UBD4, Q9UJQ5, Q9UKA6, Q9UNE5, Q9Y5R9, Q9Y5S0	Gene names	DNMT3B
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB).

DNM3B_MOUSE
θ value	0.0193708 (rank : 19)	NC score	0.110759 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	61	Shared Neighborhood Hits	22
SwissProt Accessions	O88509, O88510, O88511	Gene names	Dnmt3b
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase MmuIIIB) (DNA MTase MmuIIIB) (M.MmuIIIB).

HDGF_HUMAN
θ value	0.0252991 (rank : 20)	NC score	0.177498 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	P51858, Q5SZ09	Gene names	HDGF, HMG1L2
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF) (High-mobility group protein 1- like 2) (HMG-1L2).

HDGF_MOUSE
θ value	0.0252991 (rank : 21)	NC score	0.173942 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	P51859, Q8BPG7, Q9CYA4, Q9JK87	Gene names	Hdgf, Tdrm1
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF).

HDGR3_HUMAN
θ value	0.0563607 (rank : 22)	NC score	0.169029 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

IWS1_MOUSE
θ value	0.0563607 (rank : 23)	NC score	0.038593 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	1258	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PHF20_MOUSE
θ value	0.0563607 (rank : 24)	NC score	0.045583 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	513	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

HDGR3_MOUSE
θ value	0.0736092 (rank : 25)	NC score	0.167971 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JMG7, Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7	Gene names	Hdgfrp3
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3).

SRRM2_HUMAN
θ value	0.0736092 (rank : 26)	NC score	0.044096 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	1296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM2_MOUSE
θ value	0.163984 (rank : 27)	NC score	0.039255 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	1470	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

DNM3A_HUMAN
θ value	0.21417 (rank : 28)	NC score	0.094313 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

NKTR_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.029255 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	658	Shared Neighborhood Hits	25
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

AFF4_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.032513 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	611	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

TRPS1_MOUSE
θ value	0.365318 (rank : 31)	NC score	0.024630 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	609	Shared Neighborhood Hits	11
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

AP3B1_MOUSE
θ value	0.62314 (rank : 32)	NC score	0.025356 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	302	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

BRPF1_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.038752 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	259	Shared Neighborhood Hits	9
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

CLSPN_HUMAN
θ value	0.62314 (rank : 34)	NC score	0.030330 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	433	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

DNM3A_MOUSE
θ value	0.813845 (rank : 35)	NC score	0.094091 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	91	Shared Neighborhood Hits	19
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

HORN_MOUSE
θ value	0.813845 (rank : 36)	NC score	0.021639 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHD8	Gene names	Hrnr
Domain Architecture
Description	Hornerin.

ZMY11_HUMAN
θ value	0.813845 (rank : 37)	NC score	0.081592 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	201	Shared Neighborhood Hits	24
SwissProt Accessions	Q15326	Gene names	ZMYND11, BS69
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A- binding protein) (BS69 protein).

ZMY11_MOUSE
θ value	0.813845 (rank : 38)	NC score	0.082063 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R5C8, Q8C155	Gene names	Zmynd11
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11.

BRPF3_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.030803 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	217	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

PKCB1_HUMAN
θ value	1.06291 (rank : 40)	NC score	0.070009 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	488	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

SPAG5_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.017392 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	612	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

ZCH10_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.049870 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

ATRX_MOUSE
θ value	1.38821 (rank : 43)	NC score	0.037751 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	682	Shared Neighborhood Hits	38
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

SALL1_HUMAN
θ value	1.38821 (rank : 44)	NC score	0.002808 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	821	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

ZN318_HUMAN
θ value	1.38821 (rank : 45)	NC score	0.026562 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	497	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

SYMM_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.030738 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GW9, Q76E79, Q8IW62, Q8N7N4	Gene names	MARS2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

TXND2_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.032145 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	828	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

UBP34_MOUSE
θ value	1.81305 (rank : 48)	NC score	0.018867 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

NU214_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.019720 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	657	Shared Neighborhood Hits	8
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

RABE1_HUMAN
θ value	2.36792 (rank : 50)	NC score	0.005266 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	1104	Shared Neighborhood Hits	11
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

SYMM_MOUSE
θ value	2.36792 (rank : 51)	NC score	0.029349 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

CHIC2_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.035177 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKJ5	Gene names	CHIC2, BTL
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia).

CHIC2_MOUSE
θ value	3.0926 (rank : 53)	NC score	0.035216 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D9G3, Q3T9U2, Q80ZT7	Gene names	Chic2
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 2 protein.

GP101_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.001771 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	Q80T62, Q3UUI9	Gene names	Gpr101
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 101.

T2FA_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.037857 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

BLM_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.009390 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

FANCM_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.014410 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

UBP34_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.016941 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

ZBT24_HUMAN
θ value	4.03905 (rank : 59)	NC score	-0.000996 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	870	Shared Neighborhood Hits	8
SwissProt Accessions	O43167, Q5TED5, Q8N455	Gene names	ZBTB24, KIAA0441, ZNF450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450).

BEGIN_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.010907 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	454	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BUH8, Q9NPU3, Q9P282	Gene names	BEGAIN, KIAA1446
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

CIR_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.024643 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

DCX_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.010211 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

KIFC1_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.003201 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	545	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BW19, O60887, Q14834, Q9UQP7	Gene names	KIFC1, HSET, KNSL2
Domain Architecture
Description	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET).

NUCL_MOUSE
θ value	5.27518 (rank : 64)	NC score	0.009288 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	425	Shared Neighborhood Hits	9
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

RPGR_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.016352 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	279	Shared Neighborhood Hits	13
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

TCOF_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.022850 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TYRO_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.015079 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	P11344	Gene names	Tyr
Domain Architecture
Description	Tyrosinase precursor (EC 1.14.18.1) (Monophenol monooxygenase) (Albino locus protein).

CEP35_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.015323 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	811	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

GRIN1_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.025857 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	681	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

ITPR3_MOUSE
θ value	6.88961 (rank : 70)	NC score	0.005852 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

OPTN_HUMAN
θ value	6.88961 (rank : 71)	NC score	0.004467 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	827	Shared Neighborhood Hits	15
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

PPIG_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.015186 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	670	Shared Neighborhood Hits	20
SwissProt Accessions	Q13427, O00706, Q96DG9	Gene names	PPIG
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase G (EC 5.2.1.8) (Peptidyl-prolyl isomerase G) (PPIase G) (Rotamase G) (Cyclophilin G) (Clk-associating RS-cyclophilin) (CARS-cyclophilin) (CARS-Cyp) (SR-cyclophilin) (SRcyp) (SR-cyp) (CASP10).

RMP_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.024725 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	O94763	Gene names	RMP, C19orf2
Domain Architecture
Description	RNA polymerase II subunit 5-mediating protein (RPB5-mediating protein).

ANXA6_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.003707 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P08133, Q6ZT79	Gene names	ANXA6, ANX6
Domain Architecture
Description	Annexin A6 (Annexin VI) (Lipocortin VI) (P68) (P70) (Protein III) (Chromobindin-20) (67 kDa calelectrin) (Calphobindin-II) (CPB-II).

BRWD1_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.005337 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	448	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

K0056_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.010051 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

LEO1_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.021668 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	958	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MBD5_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.024450 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

SYSM_HUMAN
θ value	8.99809 (rank : 79)	NC score	0.009195 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NP81, Q9BVP3	Gene names	SARS2, SARSM
Domain Architecture
Description	Seryl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.11) (Serine-- tRNA ligase) (SerRSmt).

TALDO_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.011279 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P37837, O00751	Gene names	TALDO1, TAL, TALDO, TALDOR
Domain Architecture
Description	Transaldolase (EC 2.2.1.2).

ZN398_HUMAN
θ value	8.99809 (rank : 81)	NC score	-0.001943 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	765	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TD17, Q8TD18, Q9P2K7, Q9UDV8	Gene names	ZNF398, KIAA1339, ZER6
Domain Architecture
Description	Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71).

NSD1_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.052279 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	472	Shared Neighborhood Hits	27
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

Hits sorted by NC score

MSH6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	P52701, O43706, O43917, Q8TCX4, Q9BTB5	Gene names	MSH6, GTBP
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

MSH6_MOUSE
NC score	0.991263 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	P54276, O54710	Gene names	Msh6, Gtmbp
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

MSH3_MOUSE
NC score	0.855877 (rank : 3)	θ value	1.65806e-78 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	P13705	Gene names	Msh3, Rep-3
Domain Architecture
Description	DNA mismatch repair protein Msh3 (Repair-3 protein) (REP-1).

MSH3_HUMAN
NC score	0.853283 (rank : 4)	θ value	2.1655e-78 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	P20585, Q6PJT5, Q86UQ6, Q92867	Gene names	MSH3, DUC1, DUG
Domain Architecture
Description	DNA mismatch repair protein Msh3 (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1).

MSH2_HUMAN
NC score	0.822710 (rank : 5)	θ value	3.0428e-56 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P43246, O75488	Gene names	MSH2
Domain Architecture
Description	DNA mismatch repair protein Msh2 (MutS protein homolog 2).

MSH2_MOUSE
NC score	0.821127 (rank : 6)	θ value	3.36421e-55 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P43247	Gene names	Msh2
Domain Architecture
Description	DNA mismatch repair protein Msh2 (MutS protein homolog 2).

MSH4_HUMAN
NC score	0.755530 (rank : 7)	θ value	8.3442e-30 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	O15457, Q8NEB3, Q9UNP8	Gene names	MSH4
Domain Architecture
Description	MutS protein homolog 4.

MSH5_HUMAN
NC score	0.754730 (rank : 8)	θ value	1.16434e-31 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	O43196, O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7	Gene names	MSH5
Domain Architecture
Description	MutS protein homolog 5.

MSH5_MOUSE
NC score	0.753003 (rank : 9)	θ value	2.59387e-31 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QUM7, Q9Z1Q6	Gene names	Msh5
Domain Architecture	No domain graphic available
Description	MutS protein homolog 5.

MSH4_MOUSE
NC score	0.751674 (rank : 10)	θ value	1.4233e-29 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MT2, Q920J1	Gene names	Msh4
Domain Architecture
Description	MutS protein homolog 4 (mMsh4).

ZCPW1_HUMAN
NC score	0.252764 (rank : 11)	θ value	7.59969e-07 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	116	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

ZCPW1_MOUSE
NC score	0.227892 (rank : 12)	θ value	9.92553e-07 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

PWWP2_HUMAN
NC score	0.195746 (rank : 13)	θ value	0.0113563 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

PSIP1_MOUSE
NC score	0.192523 (rank : 14)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	313	Shared Neighborhood Hits	28
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

PSIP1_HUMAN
NC score	0.182423 (rank : 15)	θ value	0.000461057 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

HDGF_HUMAN
NC score	0.177498 (rank : 16)	θ value	0.0252991 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	P51858, Q5SZ09	Gene names	HDGF, HMG1L2
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF) (High-mobility group protein 1- like 2) (HMG-1L2).

HDGF_MOUSE
NC score	0.173942 (rank : 17)	θ value	0.0252991 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	P51859, Q8BPG7, Q9CYA4, Q9JK87	Gene names	Hdgf, Tdrm1
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF).

HDGR3_HUMAN
NC score	0.169029 (rank : 18)	θ value	0.0563607 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

HDGR3_MOUSE
NC score	0.167971 (rank : 19)	θ value	0.0736092 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JMG7, Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7	Gene names	Hdgfrp3
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3).

NSD1_HUMAN
NC score	0.119524 (rank : 20)	θ value	9.92553e-07 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	427	Shared Neighborhood Hits	28
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

DNM3B_HUMAN
NC score	0.112596 (rank : 21)	θ value	0.0148317 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	59	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBC3, Q9UBD4, Q9UJQ5, Q9UKA6, Q9UNE5, Q9Y5R9, Q9Y5S0	Gene names	DNMT3B
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB).

DNM3B_MOUSE
NC score	0.110759 (rank : 22)	θ value	0.0193708 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	61	Shared Neighborhood Hits	22
SwissProt Accessions	O88509, O88510, O88511	Gene names	Dnmt3b
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase MmuIIIB) (DNA MTase MmuIIIB) (M.MmuIIIB).

DNM3A_HUMAN
NC score	0.094313 (rank : 23)	θ value	0.21417 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

DNM3A_MOUSE
NC score	0.094091 (rank : 24)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	91	Shared Neighborhood Hits	19
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

ZMY11_MOUSE
NC score	0.082063 (rank : 25)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R5C8, Q8C155	Gene names	Zmynd11
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11.

ZMY11_HUMAN
NC score	0.081592 (rank : 26)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	201	Shared Neighborhood Hits	24
SwissProt Accessions	Q15326	Gene names	ZMYND11, BS69
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A- binding protein) (BS69 protein).

PKCB1_HUMAN
NC score	0.070009 (rank : 27)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	488	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

NSD1_MOUSE
NC score	0.052279 (rank : 28)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	472	Shared Neighborhood Hits	27
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

ZCH10_MOUSE
NC score	0.049870 (rank : 29)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

PHF20_MOUSE
NC score	0.045583 (rank : 30)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	513	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

SRRM2_HUMAN
NC score	0.044096 (rank : 31)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	1296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SVIL_MOUSE
NC score	0.042336 (rank : 32)	θ value	0.0113563 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	439	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

SRRM2_MOUSE
NC score	0.039255 (rank : 33)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	1470	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

BRPF1_HUMAN
NC score	0.038752 (rank : 34)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	259	Shared Neighborhood Hits	9
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

IWS1_MOUSE
NC score	0.038593 (rank : 35)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	1258	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

T2FA_HUMAN
NC score	0.037857 (rank : 36)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

ATRX_MOUSE
NC score	0.037751 (rank : 37)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	682	Shared Neighborhood Hits	38
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

CHIC2_MOUSE
NC score	0.035216 (rank : 38)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D9G3, Q3T9U2, Q80ZT7	Gene names	Chic2
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 2 protein.

CHIC2_HUMAN
NC score	0.035177 (rank : 39)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKJ5	Gene names	CHIC2, BTL
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia).

AFF4_HUMAN
NC score	0.032513 (rank : 40)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	611	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

TXND2_MOUSE
NC score	0.032145 (rank : 41)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	828	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

BRPF3_HUMAN
NC score	0.030803 (rank : 42)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	217	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

SYMM_HUMAN
NC score	0.030738 (rank : 43)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GW9, Q76E79, Q8IW62, Q8N7N4	Gene names	MARS2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

CLSPN_HUMAN
NC score	0.030330 (rank : 44)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	433	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

SYMM_MOUSE
NC score	0.029349 (rank : 45)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

NKTR_HUMAN
NC score	0.029255 (rank : 46)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	658	Shared Neighborhood Hits	25
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

ZN318_HUMAN
NC score	0.026562 (rank : 47)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	497	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

GRIN1_HUMAN
NC score	0.025857 (rank : 48)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	681	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

AP3B1_MOUSE
NC score	0.025356 (rank : 49)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	302	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

RMP_HUMAN
NC score	0.024725 (rank : 50)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	O94763	Gene names	RMP, C19orf2
Domain Architecture
Description	RNA polymerase II subunit 5-mediating protein (RPB5-mediating protein).

CIR_HUMAN
NC score	0.024643 (rank : 51)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

TRPS1_MOUSE
NC score	0.024630 (rank : 52)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	609	Shared Neighborhood Hits	11
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

MBD5_HUMAN
NC score	0.024450 (rank : 53)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

TCOF_HUMAN
NC score	0.022850 (rank : 54)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

LEO1_HUMAN
NC score	0.021668 (rank : 55)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	958	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

HORN_MOUSE
NC score	0.021639 (rank : 56)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHD8	Gene names	Hrnr
Domain Architecture
Description	Hornerin.

NU214_HUMAN
NC score	0.019720 (rank : 57)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	657	Shared Neighborhood Hits	8
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

UBP34_MOUSE
NC score	0.018867 (rank : 58)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

SPAG5_MOUSE
NC score	0.017392 (rank : 59)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	612	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

UBP34_HUMAN
NC score	0.016941 (rank : 60)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

RPGR_HUMAN
NC score	0.016352 (rank : 61)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	279	Shared Neighborhood Hits	13
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

CEP35_HUMAN
NC score	0.015323 (rank : 62)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	811	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

PPIG_HUMAN
NC score	0.015186 (rank : 63)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	670	Shared Neighborhood Hits	20
SwissProt Accessions	Q13427, O00706, Q96DG9	Gene names	PPIG
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase G (EC 5.2.1.8) (Peptidyl-prolyl isomerase G) (PPIase G) (Rotamase G) (Cyclophilin G) (Clk-associating RS-cyclophilin) (CARS-cyclophilin) (CARS-Cyp) (SR-cyclophilin) (SRcyp) (SR-cyp) (CASP10).

TYRO_MOUSE
NC score	0.015079 (rank : 64)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	P11344	Gene names	Tyr
Domain Architecture
Description	Tyrosinase precursor (EC 1.14.18.1) (Monophenol monooxygenase) (Albino locus protein).

FANCM_HUMAN
NC score	0.014410 (rank : 65)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

TALDO_HUMAN
NC score	0.011279 (rank : 66)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P37837, O00751	Gene names	TALDO1, TAL, TALDO, TALDOR
Domain Architecture
Description	Transaldolase (EC 2.2.1.2).

BEGIN_HUMAN
NC score	0.010907 (rank : 67)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	454	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BUH8, Q9NPU3, Q9P282	Gene names	BEGAIN, KIAA1446
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

DCX_MOUSE
NC score	0.010211 (rank : 68)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

K0056_MOUSE
NC score	0.010051 (rank : 69)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQK0, Q9CS21	Gene names	Kiaa0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

BLM_HUMAN
NC score	0.009390 (rank : 70)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

NUCL_MOUSE
NC score	0.009288 (rank : 71)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	425	Shared Neighborhood Hits	9
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

SYSM_HUMAN
NC score	0.009195 (rank : 72)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NP81, Q9BVP3	Gene names	SARS2, SARSM
Domain Architecture
Description	Seryl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.11) (Serine-- tRNA ligase) (SerRSmt).

ITPR3_MOUSE
NC score	0.005852 (rank : 73)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

BRWD1_HUMAN
NC score	0.005337 (rank : 74)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	448	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

RABE1_HUMAN
NC score	0.005266 (rank : 75)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	1104	Shared Neighborhood Hits	11
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

OPTN_HUMAN
NC score	0.004467 (rank : 76)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	827	Shared Neighborhood Hits	15
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

ANXA6_HUMAN
NC score	0.003707 (rank : 77)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P08133, Q6ZT79	Gene names	ANXA6, ANX6
Domain Architecture
Description	Annexin A6 (Annexin VI) (Lipocortin VI) (P68) (P70) (Protein III) (Chromobindin-20) (67 kDa calelectrin) (Calphobindin-II) (CPB-II).

KIFC1_HUMAN
NC score	0.003201 (rank : 78)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	545	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BW19, O60887, Q14834, Q9UQP7	Gene names	KIFC1, HSET, KNSL2
Domain Architecture
Description	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET).

SALL1_HUMAN
NC score	0.002808 (rank : 79)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	821	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

GP101_MOUSE
NC score	0.001771 (rank : 80)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	Q80T62, Q3UUI9	Gene names	Gpr101
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 101.

ZBT24_HUMAN
NC score	-0.000996 (rank : 81)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	870	Shared Neighborhood Hits	8
SwissProt Accessions	O43167, Q5TED5, Q8N455	Gene names	ZBTB24, KIAA0441, ZNF450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450).

ZN398_HUMAN
NC score	-0.001943 (rank : 82)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	765	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TD17, Q8TD18, Q9P2K7, Q9UDV8	Gene names	ZNF398, KIAA1339, ZER6
Domain Architecture
Description	Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71).