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Network neighborhood for query Sequence : NEIL3_MOUSE

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NEIL3_MOUSE
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NEIL3_HUMAN
θ value	0 (rank : 1)	NC score	0.982026 (rank : 2)
Query Neighborhood Hits	39	Target Neighborhood Hits	41	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	39	Target Neighborhood Hits	39	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL2_HUMAN
θ value	7.09661e-13 (rank : 3)	NC score	0.469283 (rank : 3)
Query Neighborhood Hits	39	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q969S2, Q7Z3Q7, Q8N842, Q8NG52	Gene names	NEIL2
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 2) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (NEH2).

TOP3A_HUMAN
θ value	3.29651e-10 (rank : 4)	NC score	0.336945 (rank : 7)
Query Neighborhood Hits	39	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_MOUSE
θ value	4.30538e-10 (rank : 5)	NC score	0.338531 (rank : 6)
Query Neighborhood Hits	39	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

NEIL2_MOUSE
θ value	2.13673e-09 (rank : 6)	NC score	0.430401 (rank : 4)
Query Neighborhood Hits	39	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R2P8	Gene names	Neil2
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 2) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (NEH2).

APEX2_MOUSE
θ value	1.17247e-07 (rank : 7)	NC score	0.341699 (rank : 5)
Query Neighborhood Hits	39	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
θ value	7.59969e-07 (rank : 8)	NC score	0.329214 (rank : 8)
Query Neighborhood Hits	39	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

NEIL1_HUMAN
θ value	0.00175202 (rank : 9)	NC score	0.169489 (rank : 9)
Query Neighborhood Hits	39	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q96FI4, Q6ZRA7, Q86XW7, Q9H6C3	Gene names	NEIL1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1) (FPG1).

TTF2_MOUSE
θ value	0.00228821 (rank : 10)	NC score	0.109859 (rank : 16)
Query Neighborhood Hits	39	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

RBP2_MOUSE
θ value	0.00390308 (rank : 11)	NC score	0.086484 (rank : 20)
Query Neighborhood Hits	39	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

RBP2_HUMAN
θ value	0.00869519 (rank : 12)	NC score	0.090181 (rank : 19)
Query Neighborhood Hits	39	Target Neighborhood Hits	249	Shared Neighborhood Hits	10
SwissProt Accessions	P49792, Q13074, Q15280, Q53TE2, Q59FH7	Gene names	RANBP2, NUP358
Domain Architecture
Description	Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (358 kDa nucleoporin) (P270).

TTF2_HUMAN
θ value	0.00869519 (rank : 13)	NC score	0.098608 (rank : 17)
Query Neighborhood Hits	39	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

ZRAN1_HUMAN
θ value	0.00869519 (rank : 14)	NC score	0.150177 (rank : 10)
Query Neighborhood Hits	39	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UGI0	Gene names	ZRANB1, TRABID
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 1 (Protein TRABID).

ZCHC4_MOUSE
θ value	0.0193708 (rank : 15)	NC score	0.141107 (rank : 12)
Query Neighborhood Hits	39	Target Neighborhood Hits	63	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BKW4, Q3UTX6, Q9D2I1	Gene names	Zcchc4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

NEIL1_MOUSE
θ value	0.125558 (rank : 16)	NC score	0.146027 (rank : 11)
Query Neighborhood Hits	39	Target Neighborhood Hits	52	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

UB7I3_HUMAN
θ value	0.21417 (rank : 17)	NC score	0.092553 (rank : 18)
Query Neighborhood Hits	39	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

ZCHC4_HUMAN
θ value	0.21417 (rank : 18)	NC score	0.120720 (rank : 13)
Query Neighborhood Hits	39	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H5U6, Q5IW78, Q96AN7	Gene names	ZCCHC4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

TAB2_HUMAN
θ value	0.279714 (rank : 19)	NC score	0.062671 (rank : 23)
Query Neighborhood Hits	39	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

UB7I3_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.085922 (rank : 21)
Query Neighborhood Hits	39	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

EHMT2_MOUSE
θ value	0.62314 (rank : 21)	NC score	0.017405 (rank : 34)
Query Neighborhood Hits	39	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

FA44A_HUMAN
θ value	1.06291 (rank : 22)	NC score	0.034492 (rank : 30)
Query Neighborhood Hits	39	Target Neighborhood Hits	280	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

BRPF3_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.020826 (rank : 33)
Query Neighborhood Hits	39	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

TAB2_MOUSE
θ value	2.36792 (rank : 24)	NC score	0.051399 (rank : 26)
Query Neighborhood Hits	39	Target Neighborhood Hits	245	Shared Neighborhood Hits	10
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

GBRA4_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.007351 (rank : 41)
Query Neighborhood Hits	39	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D6F4	Gene names	Gabra4
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit alpha-4 precursor (GABA(A) receptor subunit alpha-4).

MDM4_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.041656 (rank : 28)
Query Neighborhood Hits	39	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

STAB2_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.008581 (rank : 39)
Query Neighborhood Hits	39	Target Neighborhood Hits	534	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

EHMT2_HUMAN
θ value	4.03905 (rank : 28)	NC score	0.014336 (rank : 35)
Query Neighborhood Hits	39	Target Neighborhood Hits	498	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

MDM4_HUMAN
θ value	4.03905 (rank : 29)	NC score	0.038966 (rank : 29)
Query Neighborhood Hits	39	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

ATS3_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.005645 (rank : 43)
Query Neighborhood Hits	39	Target Neighborhood Hits	179	Shared Neighborhood Hits	2
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

BIN3_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.029829 (rank : 31)
Query Neighborhood Hits	39	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQY0, Q9BVG2, Q9NVY9	Gene names	BIN3
Domain Architecture
Description	Bridging integrator 3.

BIN3_MOUSE
θ value	5.27518 (rank : 32)	NC score	0.027734 (rank : 32)
Query Neighborhood Hits	39	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JI08	Gene names	Bin3
Domain Architecture	No domain graphic available
Description	Bridging integrator 3.

NU153_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.076212 (rank : 22)
Query Neighborhood Hits	39	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

ITB8_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.007765 (rank : 40)
Query Neighborhood Hits	39	Target Neighborhood Hits	280	Shared Neighborhood Hits	3
SwissProt Accessions	P26012	Gene names	ITGB8
Domain Architecture
Description	Integrin beta-8 precursor.

KR101_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.010037 (rank : 37)
Query Neighborhood Hits	39	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

RNF31_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.043724 (rank : 27)
Query Neighborhood Hits	39	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

BARD1_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.007042 (rank : 42)
Query Neighborhood Hits	39	Target Neighborhood Hits	427	Shared Neighborhood Hits	4
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

CCNL1_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.010508 (rank : 36)
Query Neighborhood Hits	39	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UK58, Q6NVY9, Q6UWS7, Q8NI48, Q96QT0, Q9NZF3	Gene names	CCNL1
Domain Architecture	No domain graphic available
Description	Cyclin-L1 (Cyclin-L).

KR109_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.009634 (rank : 38)
Query Neighborhood Hits	39	Target Neighborhood Hits	226	Shared Neighborhood Hits	4
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

APEX1_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.056055 (rank : 24)
Query Neighborhood Hits	39	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.055370 (rank : 25)
Query Neighborhood Hits	39	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

TOP3B_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.112883 (rank : 15)
Query Neighborhood Hits	39	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.113250 (rank : 14)
Query Neighborhood Hits	39	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

Hits sorted by NC score

NEIL3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	39	Target Neighborhood Hits	39	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
NC score	0.982026 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	39	Target Neighborhood Hits	41	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL2_HUMAN
NC score	0.469283 (rank : 3)	θ value	7.09661e-13 (rank : 3)
Query Neighborhood Hits	39	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q969S2, Q7Z3Q7, Q8N842, Q8NG52	Gene names	NEIL2
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 2) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (NEH2).

NEIL2_MOUSE
NC score	0.430401 (rank : 4)	θ value	2.13673e-09 (rank : 6)
Query Neighborhood Hits	39	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R2P8	Gene names	Neil2
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 2) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (NEH2).

APEX2_MOUSE
NC score	0.341699 (rank : 5)	θ value	1.17247e-07 (rank : 7)
Query Neighborhood Hits	39	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

TOP3A_MOUSE
NC score	0.338531 (rank : 6)	θ value	4.30538e-10 (rank : 5)
Query Neighborhood Hits	39	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_HUMAN
NC score	0.336945 (rank : 7)	θ value	3.29651e-10 (rank : 4)
Query Neighborhood Hits	39	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

APEX2_HUMAN
NC score	0.329214 (rank : 8)	θ value	7.59969e-07 (rank : 8)
Query Neighborhood Hits	39	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

NEIL1_HUMAN
NC score	0.169489 (rank : 9)	θ value	0.00175202 (rank : 9)
Query Neighborhood Hits	39	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q96FI4, Q6ZRA7, Q86XW7, Q9H6C3	Gene names	NEIL1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1) (FPG1).

ZRAN1_HUMAN
NC score	0.150177 (rank : 10)	θ value	0.00869519 (rank : 14)
Query Neighborhood Hits	39	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UGI0	Gene names	ZRANB1, TRABID
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 1 (Protein TRABID).

NEIL1_MOUSE
NC score	0.146027 (rank : 11)	θ value	0.125558 (rank : 16)
Query Neighborhood Hits	39	Target Neighborhood Hits	52	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

ZCHC4_MOUSE
NC score	0.141107 (rank : 12)	θ value	0.0193708 (rank : 15)
Query Neighborhood Hits	39	Target Neighborhood Hits	63	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BKW4, Q3UTX6, Q9D2I1	Gene names	Zcchc4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

ZCHC4_HUMAN
NC score	0.120720 (rank : 13)	θ value	0.21417 (rank : 18)
Query Neighborhood Hits	39	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H5U6, Q5IW78, Q96AN7	Gene names	ZCCHC4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

TOP3B_MOUSE
NC score	0.113250 (rank : 14)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	39	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_HUMAN
NC score	0.112883 (rank : 15)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	39	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TTF2_MOUSE
NC score	0.109859 (rank : 16)	θ value	0.00228821 (rank : 10)
Query Neighborhood Hits	39	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TTF2_HUMAN
NC score	0.098608 (rank : 17)	θ value	0.00869519 (rank : 13)
Query Neighborhood Hits	39	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

UB7I3_HUMAN
NC score	0.092553 (rank : 18)	θ value	0.21417 (rank : 17)
Query Neighborhood Hits	39	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

RBP2_HUMAN
NC score	0.090181 (rank : 19)	θ value	0.00869519 (rank : 12)
Query Neighborhood Hits	39	Target Neighborhood Hits	249	Shared Neighborhood Hits	10
SwissProt Accessions	P49792, Q13074, Q15280, Q53TE2, Q59FH7	Gene names	RANBP2, NUP358
Domain Architecture
Description	Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (358 kDa nucleoporin) (P270).

RBP2_MOUSE
NC score	0.086484 (rank : 20)	θ value	0.00390308 (rank : 11)
Query Neighborhood Hits	39	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

UB7I3_MOUSE
NC score	0.085922 (rank : 21)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	39	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

NU153_HUMAN
NC score	0.076212 (rank : 22)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	39	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

TAB2_HUMAN
NC score	0.062671 (rank : 23)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	39	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

APEX1_HUMAN
NC score	0.056055 (rank : 24)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	39	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
NC score	0.055370 (rank : 25)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	39	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

TAB2_MOUSE
NC score	0.051399 (rank : 26)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	39	Target Neighborhood Hits	245	Shared Neighborhood Hits	10
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

RNF31_HUMAN
NC score	0.043724 (rank : 27)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	39	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

MDM4_MOUSE
NC score	0.041656 (rank : 28)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	39	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MDM4_HUMAN
NC score	0.038966 (rank : 29)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	39	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

FA44A_HUMAN
NC score	0.034492 (rank : 30)	θ value	1.06291 (rank : 22)
Query Neighborhood Hits	39	Target Neighborhood Hits	280	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

BIN3_HUMAN
NC score	0.029829 (rank : 31)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	39	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQY0, Q9BVG2, Q9NVY9	Gene names	BIN3
Domain Architecture
Description	Bridging integrator 3.

BIN3_MOUSE
NC score	0.027734 (rank : 32)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	39	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JI08	Gene names	Bin3
Domain Architecture	No domain graphic available
Description	Bridging integrator 3.

BRPF3_HUMAN
NC score	0.020826 (rank : 33)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	39	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

EHMT2_MOUSE
NC score	0.017405 (rank : 34)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	39	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT2_HUMAN
NC score	0.014336 (rank : 35)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	39	Target Neighborhood Hits	498	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

CCNL1_HUMAN
NC score	0.010508 (rank : 36)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	39	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UK58, Q6NVY9, Q6UWS7, Q8NI48, Q96QT0, Q9NZF3	Gene names	CCNL1
Domain Architecture	No domain graphic available
Description	Cyclin-L1 (Cyclin-L).

KR101_HUMAN
NC score	0.010037 (rank : 37)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	39	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR109_HUMAN
NC score	0.009634 (rank : 38)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	39	Target Neighborhood Hits	226	Shared Neighborhood Hits	4
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

STAB2_HUMAN
NC score	0.008581 (rank : 39)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	39	Target Neighborhood Hits	534	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

ITB8_HUMAN
NC score	0.007765 (rank : 40)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	39	Target Neighborhood Hits	280	Shared Neighborhood Hits	3
SwissProt Accessions	P26012	Gene names	ITGB8
Domain Architecture
Description	Integrin beta-8 precursor.

GBRA4_MOUSE
NC score	0.007351 (rank : 41)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	39	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D6F4	Gene names	Gabra4
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit alpha-4 precursor (GABA(A) receptor subunit alpha-4).

BARD1_HUMAN
NC score	0.007042 (rank : 42)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	39	Target Neighborhood Hits	427	Shared Neighborhood Hits	4
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ATS3_HUMAN
NC score	0.005645 (rank : 43)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	39	Target Neighborhood Hits	179	Shared Neighborhood Hits	2
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).