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Network neighborhood for query Sequence : TOP3A_MOUSE

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TOP3A_MOUSE
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TOP3A_HUMAN
θ value	0 (rank : 1)	NC score	0.997424 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3B_MOUSE
θ value	1.02895e-112 (rank : 3)	NC score	0.890109 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_HUMAN
θ value	4.32305e-111 (rank : 4)	NC score	0.889161 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

NEIL3_MOUSE
θ value	4.30538e-10 (rank : 5)	NC score	0.338531 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	39	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
θ value	8.11959e-09 (rank : 6)	NC score	0.324858 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

APEX2_MOUSE
θ value	1.09739e-05 (rank : 7)	NC score	0.246789 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
θ value	2.44474e-05 (rank : 8)	NC score	0.239307 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

ZCHC4_MOUSE
θ value	0.0961366 (rank : 9)	NC score	0.094027 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BKW4, Q3UTX6, Q9D2I1	Gene names	Zcchc4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

TTF2_MOUSE
θ value	0.21417 (rank : 10)	NC score	0.049193 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

ZCHC4_HUMAN
θ value	0.813845 (rank : 11)	NC score	0.075894 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H5U6, Q5IW78, Q96AN7	Gene names	ZCCHC4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

UBP47_HUMAN
θ value	1.38821 (rank : 12)	NC score	0.016057 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	149	Shared Neighborhood Hits	2
SwissProt Accessions	Q96K76, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1	Gene names	USP47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

R113A_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.024197 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

RUFY2_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.008238 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	820	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

EDEM1_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.013265 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

NUCB2_HUMAN
θ value	4.03905 (rank : 16)	NC score	0.012565 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	321	Shared Neighborhood Hits	2
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

SORL_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.009157 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	440	Shared Neighborhood Hits	3
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

PCLO_MOUSE
θ value	5.27518 (rank : 18)	NC score	0.004469 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	2275	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RAD21_MOUSE
θ value	5.27518 (rank : 19)	NC score	0.016708 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q61550, P70219, Q91VB9, Q9DBU4	Gene names	Rad21, Hr21
Domain Architecture
Description	Double-strand-break repair protein rad21 homolog (Pokeweed agglutinin- binding protein 29) (PW29) (SCC1 homolog).

SORL_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.008773 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	439	Shared Neighborhood Hits	3
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

IGFL_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.019075 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q6B9Z0	Gene names	Igfl, Gm580
Domain Architecture	No domain graphic available
Description	Insulin growth factor-like family member precursor.

TTF2_HUMAN
θ value	6.88961 (rank : 22)	NC score	0.034838 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

BRD9_MOUSE
θ value	8.99809 (rank : 23)	NC score	0.015665 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UQU0, Q5FWH1, Q811F7	Gene names	Brd9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9.

RUFY1_HUMAN
θ value	8.99809 (rank : 24)	NC score	0.009848 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	848	Shared Neighborhood Hits	5
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

Hits sorted by NC score

TOP3A_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_HUMAN
NC score	0.997424 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3B_MOUSE
NC score	0.890109 (rank : 3)	θ value	1.02895e-112 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_HUMAN
NC score	0.889161 (rank : 4)	θ value	4.32305e-111 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

NEIL3_MOUSE
NC score	0.338531 (rank : 5)	θ value	4.30538e-10 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	39	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
NC score	0.324858 (rank : 6)	θ value	8.11959e-09 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

APEX2_MOUSE
NC score	0.246789 (rank : 7)	θ value	1.09739e-05 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
NC score	0.239307 (rank : 8)	θ value	2.44474e-05 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

ZCHC4_MOUSE
NC score	0.094027 (rank : 9)	θ value	0.0961366 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BKW4, Q3UTX6, Q9D2I1	Gene names	Zcchc4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

ZCHC4_HUMAN
NC score	0.075894 (rank : 10)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H5U6, Q5IW78, Q96AN7	Gene names	ZCCHC4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

TTF2_MOUSE
NC score	0.049193 (rank : 11)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TTF2_HUMAN
NC score	0.034838 (rank : 12)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

R113A_HUMAN
NC score	0.024197 (rank : 13)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

IGFL_MOUSE
NC score	0.019075 (rank : 14)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q6B9Z0	Gene names	Igfl, Gm580
Domain Architecture	No domain graphic available
Description	Insulin growth factor-like family member precursor.

RAD21_MOUSE
NC score	0.016708 (rank : 15)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q61550, P70219, Q91VB9, Q9DBU4	Gene names	Rad21, Hr21
Domain Architecture
Description	Double-strand-break repair protein rad21 homolog (Pokeweed agglutinin- binding protein 29) (PW29) (SCC1 homolog).

UBP47_HUMAN
NC score	0.016057 (rank : 16)	θ value	1.38821 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	149	Shared Neighborhood Hits	2
SwissProt Accessions	Q96K76, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1	Gene names	USP47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

BRD9_MOUSE
NC score	0.015665 (rank : 17)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UQU0, Q5FWH1, Q811F7	Gene names	Brd9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9.

EDEM1_HUMAN
NC score	0.013265 (rank : 18)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

NUCB2_HUMAN
NC score	0.012565 (rank : 19)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	321	Shared Neighborhood Hits	2
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

RUFY1_HUMAN
NC score	0.009848 (rank : 20)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	848	Shared Neighborhood Hits	5
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

SORL_HUMAN
NC score	0.009157 (rank : 21)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	440	Shared Neighborhood Hits	3
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
NC score	0.008773 (rank : 22)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	439	Shared Neighborhood Hits	3
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

RUFY2_MOUSE
NC score	0.008238 (rank : 23)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	820	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PCLO_MOUSE
NC score	0.004469 (rank : 24)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	2275	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).