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Network neighborhood for query Sequence : APEX2_MOUSE

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APEX2_MOUSE
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APEX2_HUMAN
θ value	0 (rank : 1)	NC score	0.994768 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

APEX2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX1_HUMAN
θ value	2.7842e-17 (rank : 3)	NC score	0.606003 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
θ value	8.10077e-17 (rank : 4)	NC score	0.603800 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

NEIL3_MOUSE
θ value	1.17247e-07 (rank : 5)	NC score	0.341699 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
θ value	6.43352e-06 (rank : 6)	NC score	0.319748 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

TOP3A_MOUSE
θ value	1.09739e-05 (rank : 7)	NC score	0.246789 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

LIN1_HUMAN
θ value	2.44474e-05 (rank : 8)	NC score	0.245106 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

TOP3A_HUMAN
θ value	5.44631e-05 (rank : 9)	NC score	0.238441 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

POL2_MOUSE
θ value	0.125558 (rank : 10)	NC score	0.150866 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

MAP9_MOUSE
θ value	1.06291 (rank : 11)	NC score	0.029157 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	529	Shared Neighborhood Hits	3
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

TTF2_MOUSE
θ value	1.38821 (rank : 12)	NC score	0.046207 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TNKS1_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.007576 (rank : 16)
Query Neighborhood Hits	15	Target Neighborhood Hits	477	Shared Neighborhood Hits	3
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

NOTC1_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.002700 (rank : 17)
Query Neighborhood Hits	15	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

TTF2_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.033234 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

TOP3B_HUMAN
θ value	θ > 10 (rank : 16)	NC score	0.078219 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_MOUSE
θ value	θ > 10 (rank : 17)	NC score	0.078473 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

Hits sorted by NC score

APEX2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
NC score	0.994768 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

APEX1_HUMAN
NC score	0.606003 (rank : 3)	θ value	2.7842e-17 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
NC score	0.603800 (rank : 4)	θ value	8.10077e-17 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

NEIL3_MOUSE
NC score	0.341699 (rank : 5)	θ value	1.17247e-07 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
NC score	0.319748 (rank : 6)	θ value	6.43352e-06 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

TOP3A_MOUSE
NC score	0.246789 (rank : 7)	θ value	1.09739e-05 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

LIN1_HUMAN
NC score	0.245106 (rank : 8)	θ value	2.44474e-05 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

TOP3A_HUMAN
NC score	0.238441 (rank : 9)	θ value	5.44631e-05 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

POL2_MOUSE
NC score	0.150866 (rank : 10)	θ value	0.125558 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

TOP3B_MOUSE
NC score	0.078473 (rank : 11)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_HUMAN
NC score	0.078219 (rank : 12)	θ value	θ > 10 (rank : 16)
Query Neighborhood Hits	15	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TTF2_MOUSE
NC score	0.046207 (rank : 13)	θ value	1.38821 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TTF2_HUMAN
NC score	0.033234 (rank : 14)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

MAP9_MOUSE
NC score	0.029157 (rank : 15)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	529	Shared Neighborhood Hits	3
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

TNKS1_HUMAN
NC score	0.007576 (rank : 16)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	477	Shared Neighborhood Hits	3
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

NOTC1_HUMAN
NC score	0.002700 (rank : 17)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].