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Network neighborhood for query Sequence : ELA2A_MOUSE

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ELA2A_MOUSE
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ELA2A_MOUSE
θ value	1.73892e-144 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	178
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

ELA2A_HUMAN
θ value	5.63297e-119 (rank : 2)	NC score	0.998766 (rank : 2)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	177
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

ELA2B_HUMAN
θ value	7.87842e-113 (rank : 3)	NC score	0.998102 (rank : 3)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	177
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

CLCR_HUMAN
θ value	7.19216e-82 (rank : 4)	NC score	0.996747 (rank : 4)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	176
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

ELA1_HUMAN
θ value	1.65806e-78 (rank : 5)	NC score	0.995440 (rank : 5)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	175
SwissProt Accessions	Q9UNI1, Q5MLF0, Q6DJT0, Q6ISM6	Gene names	ELA1
Domain Architecture
Description	Elastase-1 precursor (EC 3.4.21.36).

ELA3A_HUMAN
θ value	7.97034e-73 (rank : 6)	NC score	0.994376 (rank : 6)
Query Neighborhood Hits	178	Target Neighborhood Hits	173	Shared Neighborhood Hits	173
SwissProt Accessions	P09093, Q9BRW4	Gene names	ELA3A, ELA3
Domain Architecture
Description	Elastase-3A precursor (EC 3.4.21.70) (Elastase IIIA) (Protease E).

ELA3B_HUMAN
θ value	1.35953e-72 (rank : 7)	NC score	0.993766 (rank : 7)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

PLMN_MOUSE
θ value	1.15895e-47 (rank : 8)	NC score	0.961440 (rank : 77)
Query Neighborhood Hits	178	Target Neighborhood Hits	208	Shared Neighborhood Hits	176
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

CTRB1_HUMAN
θ value	7.77379e-44 (rank : 9)	NC score	0.989267 (rank : 9)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	176
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

TM11D_MOUSE
θ value	2.26182e-43 (rank : 10)	NC score	0.981535 (rank : 29)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	176
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11D_HUMAN
θ value	3.85808e-43 (rank : 11)	NC score	0.981950 (rank : 28)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

PLMN_HUMAN
θ value	6.58091e-43 (rank : 12)	NC score	0.961259 (rank : 78)
Query Neighborhood Hits	178	Target Neighborhood Hits	204	Shared Neighborhood Hits	176
SwissProt Accessions	P00747, Q15146, Q6PA00	Gene names	PLG
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

CTRL_HUMAN
θ value	1.46607e-42 (rank : 13)	NC score	0.989827 (rank : 8)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	176
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

ACRO_MOUSE
θ value	3.26607e-42 (rank : 14)	NC score	0.985209 (rank : 12)
Query Neighborhood Hits	178	Target Neighborhood Hits	185	Shared Neighborhood Hits	174
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

HEPS_HUMAN
θ value	3.26607e-42 (rank : 15)	NC score	0.982586 (rank : 22)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

DESC4_MOUSE
θ value	7.27602e-42 (rank : 16)	NC score	0.980788 (rank : 32)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

HEPS_MOUSE
θ value	7.27602e-42 (rank : 17)	NC score	0.982766 (rank : 20)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

TRYG1_MOUSE
θ value	1.2411e-41 (rank : 18)	NC score	0.985319 (rank : 10)
Query Neighborhood Hits	178	Target Neighborhood Hits	181	Shared Neighborhood Hits	174
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

ACRO_HUMAN
θ value	3.61106e-41 (rank : 19)	NC score	0.982542 (rank : 24)
Query Neighborhood Hits	178	Target Neighborhood Hits	291	Shared Neighborhood Hits	174
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

TMPS6_MOUSE
θ value	6.15952e-41 (rank : 20)	NC score	0.945784 (rank : 98)
Query Neighborhood Hits	178	Target Neighborhood Hits	341	Shared Neighborhood Hits	176
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS9_HUMAN
θ value	1.79215e-40 (rank : 21)	NC score	0.967835 (rank : 63)
Query Neighborhood Hits	178	Target Neighborhood Hits	276	Shared Neighborhood Hits	176
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

TRYB1_HUMAN
θ value	1.79215e-40 (rank : 22)	NC score	0.982503 (rank : 25)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB2_HUMAN
θ value	1.79215e-40 (rank : 23)	NC score	0.982503 (rank : 26)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

FA11_MOUSE
θ value	3.99248e-40 (rank : 24)	NC score	0.975427 (rank : 49)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	175
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TMPS3_MOUSE
θ value	3.99248e-40 (rank : 25)	NC score	0.978367 (rank : 37)
Query Neighborhood Hits	178	Target Neighborhood Hits	239	Shared Neighborhood Hits	174
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

KLKB1_MOUSE
θ value	5.21438e-40 (rank : 26)	NC score	0.974875 (rank : 50)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

TMPS3_HUMAN
θ value	5.21438e-40 (rank : 27)	NC score	0.977263 (rank : 43)
Query Neighborhood Hits	178	Target Neighborhood Hits	245	Shared Neighborhood Hits	176
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMSP8_MOUSE
θ value	6.81017e-40 (rank : 28)	NC score	0.985228 (rank : 11)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

BSSP4_HUMAN
θ value	8.89434e-40 (rank : 29)	NC score	0.984151 (rank : 14)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	175
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

TRYA1_HUMAN
θ value	8.89434e-40 (rank : 30)	NC score	0.982785 (rank : 19)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

TMPS6_HUMAN
θ value	1.16164e-39 (rank : 31)	NC score	0.941294 (rank : 114)
Query Neighborhood Hits	178	Target Neighborhood Hits	338	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

PRSS8_MOUSE
θ value	1.98146e-39 (rank : 32)	NC score	0.982922 (rank : 17)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

TMPS7_MOUSE
θ value	1.98146e-39 (rank : 33)	NC score	0.939739 (rank : 118)
Query Neighborhood Hits	178	Target Neighborhood Hits	275	Shared Neighborhood Hits	173
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

KLKB1_HUMAN
θ value	2.58786e-39 (rank : 34)	NC score	0.975782 (rank : 47)
Query Neighborhood Hits	178	Target Neighborhood Hits	183	Shared Neighborhood Hits	174
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

TMPS9_MOUSE
θ value	2.58786e-39 (rank : 35)	NC score	0.968257 (rank : 61)
Query Neighborhood Hits	178	Target Neighborhood Hits	296	Shared Neighborhood Hits	176
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

APOA_HUMAN
θ value	3.37985e-39 (rank : 36)	NC score	0.952064 (rank : 91)
Query Neighborhood Hits	178	Target Neighborhood Hits	221	Shared Neighborhood Hits	176
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

TMPS5_MOUSE
θ value	3.37985e-39 (rank : 37)	NC score	0.980601 (rank : 33)
Query Neighborhood Hits	178	Target Neighborhood Hits	185	Shared Neighborhood Hits	175
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

MCPT6_MOUSE
θ value	9.83387e-39 (rank : 38)	NC score	0.983314 (rank : 16)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

TRYB1_MOUSE
θ value	1.28434e-38 (rank : 39)	NC score	0.983403 (rank : 15)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

TRYG1_HUMAN
θ value	1.28434e-38 (rank : 40)	NC score	0.984278 (rank : 13)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

POLS2_MOUSE
θ value	2.86122e-38 (rank : 41)	NC score	0.978177 (rank : 38)
Query Neighborhood Hits	178	Target Neighborhood Hits	188	Shared Neighborhood Hits	174
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

PRS27_MOUSE
θ value	3.73686e-38 (rank : 42)	NC score	0.982765 (rank : 21)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

TMPS2_HUMAN
θ value	3.73686e-38 (rank : 43)	NC score	0.976623 (rank : 44)
Query Neighborhood Hits	178	Target Neighborhood Hits	252	Shared Neighborhood Hits	174
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS7_HUMAN
θ value	4.88048e-38 (rank : 44)	NC score	0.938673 (rank : 121)
Query Neighborhood Hits	178	Target Neighborhood Hits	275	Shared Neighborhood Hits	173
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TM11E_HUMAN
θ value	8.32485e-38 (rank : 45)	NC score	0.974522 (rank : 54)
Query Neighborhood Hits	178	Target Neighborhood Hits	181	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TMPS4_MOUSE
θ value	1.42001e-37 (rank : 46)	NC score	0.978705 (rank : 36)
Query Neighborhood Hits	178	Target Neighborhood Hits	210	Shared Neighborhood Hits	174
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

FA11_HUMAN
θ value	2.42216e-37 (rank : 47)	NC score	0.974620 (rank : 53)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	175
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TMPS2_MOUSE
θ value	2.42216e-37 (rank : 48)	NC score	0.974711 (rank : 51)
Query Neighborhood Hits	178	Target Neighborhood Hits	243	Shared Neighborhood Hits	174
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS5_HUMAN
θ value	2.42216e-37 (rank : 49)	NC score	0.981387 (rank : 31)
Query Neighborhood Hits	178	Target Neighborhood Hits	181	Shared Neighborhood Hits	176
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

PRS27_HUMAN
θ value	4.13158e-37 (rank : 50)	NC score	0.982205 (rank : 27)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

TEST_HUMAN
θ value	4.13158e-37 (rank : 51)	NC score	0.978161 (rank : 39)
Query Neighborhood Hits	178	Target Neighborhood Hits	172	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

BSSP4_MOUSE
θ value	5.39604e-37 (rank : 52)	NC score	0.982881 (rank : 18)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

TMPSD_MOUSE
θ value	7.04741e-37 (rank : 53)	NC score	0.973876 (rank : 56)
Query Neighborhood Hits	178	Target Neighborhood Hits	334	Shared Neighborhood Hits	176
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TRY2_MOUSE
θ value	7.04741e-37 (rank : 54)	NC score	0.976564 (rank : 45)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P07146	Gene names	Prss2, Try2
Domain Architecture
Description	Anionic trypsin-2 precursor (EC 3.4.21.4) (Anionic trypsin II) (Pretrypsinogen II).

TMPSD_HUMAN
θ value	9.20422e-37 (rank : 55)	NC score	0.973816 (rank : 58)
Query Neighborhood Hits	178	Target Neighborhood Hits	333	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

POLS2_HUMAN
θ value	3.4976e-36 (rank : 56)	NC score	0.975768 (rank : 48)
Query Neighborhood Hits	178	Target Neighborhood Hits	192	Shared Neighborhood Hits	174
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

PRSS8_HUMAN
θ value	3.4976e-36 (rank : 57)	NC score	0.982579 (rank : 23)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

ST14_HUMAN
θ value	7.79185e-36 (rank : 58)	NC score	0.873395 (rank : 155)
Query Neighborhood Hits	178	Target Neighborhood Hits	409	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

TMPS4_HUMAN
θ value	1.32909e-35 (rank : 59)	NC score	0.977910 (rank : 41)
Query Neighborhood Hits	178	Target Neighborhood Hits	203	Shared Neighborhood Hits	174
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

CORIN_HUMAN
θ value	2.26708e-35 (rank : 60)	NC score	0.855691 (rank : 160)
Query Neighborhood Hits	178	Target Neighborhood Hits	453	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

TEST_MOUSE
θ value	2.96089e-35 (rank : 61)	NC score	0.980599 (rank : 34)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

HABP2_MOUSE
θ value	5.0505e-35 (rank : 62)	NC score	0.883051 (rank : 154)
Query Neighborhood Hits	178	Target Neighborhood Hits	445	Shared Neighborhood Hits	174
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

CORIN_MOUSE
θ value	8.61488e-35 (rank : 63)	NC score	0.858430 (rank : 159)
Query Neighborhood Hits	178	Target Neighborhood Hits	451	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

ST14_MOUSE
θ value	1.9192e-34 (rank : 64)	NC score	0.873214 (rank : 156)
Query Neighborhood Hits	178	Target Neighborhood Hits	419	Shared Neighborhood Hits	176
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

KLK15_HUMAN
θ value	4.27553e-34 (rank : 65)	NC score	0.967782 (rank : 64)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	175
SwissProt Accessions	Q9H2R5, Q15358, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9	Gene names	KLK15
Domain Architecture
Description	Kallikrein-15 precursor (EC 3.4.21.-) (ACO protease).

HGFA_MOUSE
θ value	5.584e-34 (rank : 66)	NC score	0.912286 (rank : 140)
Query Neighborhood Hits	178	Target Neighborhood Hits	419	Shared Neighborhood Hits	174
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

TRY3_HUMAN
θ value	5.584e-34 (rank : 67)	NC score	0.973276 (rank : 60)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

HGFA_HUMAN
θ value	1.24399e-33 (rank : 68)	NC score	0.911210 (rank : 142)
Query Neighborhood Hits	178	Target Neighborhood Hits	436	Shared Neighborhood Hits	174
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

CFAD_HUMAN
θ value	4.72714e-33 (rank : 69)	NC score	0.977444 (rank : 42)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	175
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

TM11E_MOUSE
θ value	6.17384e-33 (rank : 70)	NC score	0.974381 (rank : 55)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

NETR_HUMAN
θ value	1.37539e-32 (rank : 71)	NC score	0.891193 (rank : 148)
Query Neighborhood Hits	178	Target Neighborhood Hits	218	Shared Neighborhood Hits	176
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

GRAM_HUMAN
θ value	2.34606e-32 (rank : 72)	NC score	0.981465 (rank : 30)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P51124	Gene names	GZMM, MET1
Domain Architecture
Description	Granzyme M precursor (EC 3.4.21.-) (Met-ase) (Natural killer cell granular protease) (HU-Met-1) (Met-1 serine protease).

UROK_MOUSE
θ value	2.34606e-32 (rank : 73)	NC score	0.963347 (rank : 70)
Query Neighborhood Hits	178	Target Neighborhood Hits	273	Shared Neighborhood Hits	172
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

NETR_MOUSE
θ value	3.06405e-32 (rank : 74)	NC score	0.897032 (rank : 147)
Query Neighborhood Hits	178	Target Neighborhood Hits	216	Shared Neighborhood Hits	174
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

HABP2_HUMAN
θ value	8.91499e-32 (rank : 75)	NC score	0.884082 (rank : 153)
Query Neighborhood Hits	178	Target Neighborhood Hits	431	Shared Neighborhood Hits	174
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

ENTK_HUMAN
θ value	1.16434e-31 (rank : 76)	NC score	0.932987 (rank : 133)
Query Neighborhood Hits	178	Target Neighborhood Hits	310	Shared Neighborhood Hits	174
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TRY2_HUMAN
θ value	3.3877e-31 (rank : 77)	NC score	0.973318 (rank : 59)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	P07478	Gene names	PRSS2, TRY2, TRYP2
Domain Architecture
Description	Trypsin-2 precursor (EC 3.4.21.4) (Trypsin II) (Anionic trypsinogen).

CFAD_MOUSE
θ value	4.42448e-31 (rank : 78)	NC score	0.979380 (rank : 35)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	175
SwissProt Accessions	P03953, Q61280	Gene names	Cfd, Adn, Df
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin) (28 kDa adipocyte protein).

TRY1_HUMAN
θ value	5.77852e-31 (rank : 79)	NC score	0.973817 (rank : 57)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	P07477, Q92955, Q9HAN4, Q9HAN5, Q9HAN6, Q9HAN7	Gene names	PRSS1, TRP1, TRY1, TRYP1
Domain Architecture
Description	Trypsin-1 precursor (EC 3.4.21.4) (Trypsin I) (Cationic trypsinogen).

TRYD_HUMAN
θ value	1.28732e-30 (rank : 80)	NC score	0.977945 (rank : 40)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

UROK_HUMAN
θ value	1.28732e-30 (rank : 81)	NC score	0.961746 (rank : 74)
Query Neighborhood Hits	178	Target Neighborhood Hits	272	Shared Neighborhood Hits	172
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

NRPN_MOUSE
θ value	1.6813e-30 (rank : 82)	NC score	0.960144 (rank : 79)
Query Neighborhood Hits	178	Target Neighborhood Hits	186	Shared Neighborhood Hits	175
SwissProt Accessions	Q61955	Gene names	Klk8, Nrpn, Prss19
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8).

ENTK_MOUSE
θ value	2.86786e-30 (rank : 83)	NC score	0.922226 (rank : 137)
Query Neighborhood Hits	178	Target Neighborhood Hits	338	Shared Neighborhood Hits	174
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

FA9_HUMAN
θ value	4.89182e-30 (rank : 84)	NC score	0.903681 (rank : 143)
Query Neighborhood Hits	178	Target Neighborhood Hits	421	Shared Neighborhood Hits	176
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

KLK11_HUMAN
θ value	4.89182e-30 (rank : 85)	NC score	0.962394 (rank : 72)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UBX7, O75837, Q9NS65	Gene names	KLK11, PRSS20, TLSP
Domain Architecture
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin) (Trypsin-like protease).

MCPT1_MOUSE
θ value	8.3442e-30 (rank : 86)	NC score	0.955158 (rank : 86)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P11034	Gene names	Mcpt1
Domain Architecture
Description	Mast cell protease 1 precursor (EC 3.4.21.-) (MMCP-1).

KLK13_HUMAN
θ value	1.08979e-29 (rank : 87)	NC score	0.966438 (rank : 65)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UKR3, Q9Y433	Gene names	KLK13, KLKL4
Domain Architecture
Description	Kallikrein-13 precursor (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4).

KLK11_MOUSE
θ value	1.85889e-29 (rank : 88)	NC score	0.961708 (rank : 75)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q9QYN3, Q9QYN4	Gene names	Klk11, Prss20
Domain Architecture	No domain graphic available
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin).

KLK3_HUMAN
θ value	1.85889e-29 (rank : 89)	NC score	0.953938 (rank : 89)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	176
SwissProt Accessions	P07288, Q16272, Q86TG8	Gene names	KLK3, APS
Domain Architecture
Description	Prostate-specific antigen precursor (EC 3.4.21.77) (PSA) (Kallikrein- 3) (Semenogelase) (Gamma-seminoprotein) (Seminin) (P-30 antigen).

CFAI_MOUSE
θ value	2.42779e-29 (rank : 90)	NC score	0.939838 (rank : 117)
Query Neighborhood Hits	178	Target Neighborhood Hits	290	Shared Neighborhood Hits	175
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

GRAK_MOUSE
θ value	2.42779e-29 (rank : 91)	NC score	0.975846 (rank : 46)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	173
SwissProt Accessions	O35205	Gene names	Gzmk
Domain Architecture
Description	Granzyme K precursor (EC 3.4.21.-).

KLK12_HUMAN
θ value	3.17079e-29 (rank : 92)	NC score	0.965192 (rank : 67)
Query Neighborhood Hits	178	Target Neighborhood Hits	197	Shared Neighborhood Hits	175
SwissProt Accessions	Q9UKR0, Q9UKR1	Gene names	KLK12, KLKL5
Domain Architecture
Description	Kallikrein-12 precursor (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5).

NRPN_HUMAN
θ value	9.2256e-29 (rank : 93)	NC score	0.963695 (rank : 68)
Query Neighborhood Hits	178	Target Neighborhood Hits	182	Shared Neighborhood Hits	175
SwissProt Accessions	O60259, Q9HCB3, Q9UIL9, Q9UQ47	Gene names	KLK8, NRPN, PRSS19, TADG14
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein).

TPA_MOUSE
θ value	1.57365e-28 (rank : 94)	NC score	0.942426 (rank : 110)
Query Neighborhood Hits	178	Target Neighborhood Hits	335	Shared Neighborhood Hits	174
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

FA12_HUMAN
θ value	4.57862e-28 (rank : 95)	NC score	0.916031 (rank : 138)
Query Neighborhood Hits	178	Target Neighborhood Hits	425	Shared Neighborhood Hits	176
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

MCPT4_MOUSE
θ value	4.57862e-28 (rank : 96)	NC score	0.953780 (rank : 90)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P21812, Q9EPQ9, Q9EQT2	Gene names	Mcpt4
Domain Architecture
Description	Mast cell protease 4 precursor (EC 3.4.21.-) (MMCP-4) (Serosal mast cell protease) (MSMCP) (Myonase).

MCPT1_HUMAN
θ value	5.97985e-28 (rank : 97)	NC score	0.945765 (rank : 99)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	P23946, Q16018	Gene names	CMA1, CYH, CYM
Domain Architecture
Description	Chymase precursor (EC 3.4.21.39) (Mast cell protease I).

ELNE_HUMAN
θ value	2.96777e-27 (rank : 98)	NC score	0.944977 (rank : 103)
Query Neighborhood Hits	178	Target Neighborhood Hits	164	Shared Neighborhood Hits	164
SwissProt Accessions	P08246, P09649, Q6B0D9, Q6LDP5	Gene names	ELA2
Domain Architecture
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase) (PMN elastase) (Bone marrow serine protease) (Medullasin) (Human leukocyte elastase) (HLE).

HGFL_HUMAN
θ value	2.96777e-27 (rank : 99)	NC score	0.933411 (rank : 132)
Query Neighborhood Hits	178	Target Neighborhood Hits	190	Shared Neighborhood Hits	173
SwissProt Accessions	P26927, Q13350, Q14870	Gene names	MST1, HGFL
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) (Macrophage-stimulating protein) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

TPA_HUMAN
θ value	2.96777e-27 (rank : 100)	NC score	0.941533 (rank : 113)
Query Neighborhood Hits	178	Target Neighborhood Hits	324	Shared Neighborhood Hits	174
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

HGFL_MOUSE
θ value	3.87602e-27 (rank : 101)	NC score	0.933472 (rank : 131)
Query Neighborhood Hits	178	Target Neighborhood Hits	188	Shared Neighborhood Hits	172
SwissProt Accessions	P26928	Gene names	Mst1, Hgfl
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

PROC_HUMAN
θ value	3.87602e-27 (rank : 102)	NC score	0.915730 (rank : 139)
Query Neighborhood Hits	178	Target Neighborhood Hits	406	Shared Neighborhood Hits	174
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

TSP50_HUMAN
θ value	3.87602e-27 (rank : 103)	NC score	0.974693 (rank : 52)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

GRAC_MOUSE
θ value	5.06226e-27 (rank : 104)	NC score	0.948292 (rank : 94)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P08882, Q61389	Gene names	Gzmc, Ctla-5, Ctla5
Domain Architecture
Description	Granzyme C precursor (EC 3.4.21.-) (Cytotoxic cell protease 2) (CCP2) (B10).

MCPT2_MOUSE
θ value	5.06226e-27 (rank : 105)	NC score	0.956949 (rank : 82)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P15119	Gene names	Mcpt2
Domain Architecture
Description	Mast cell protease 2 precursor (EC 3.4.21.-) (MMCP-2).

KLK4_HUMAN
θ value	6.61148e-27 (rank : 106)	NC score	0.965254 (rank : 66)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y5K2, Q4VB16, Q9GZL6, Q9UBJ6	Gene names	KLK4, EMSP1, PRSS17, PSTS
Domain Architecture
Description	Kallikrein-4 precursor (EC 3.4.21.-) (Prostase) (Kallikrein-like protein 1) (KLK-L1) (Enamel matrix serine proteinase 1).

FA10_MOUSE
θ value	1.12775e-26 (rank : 107)	NC score	0.884252 (rank : 152)
Query Neighborhood Hits	178	Target Neighborhood Hits	435	Shared Neighborhood Hits	176
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

KLK14_HUMAN
θ value	1.92365e-26 (rank : 108)	NC score	0.963572 (rank : 69)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q9P0G3	Gene names	KLK14, KLKL6
Domain Architecture
Description	Kallikrein-14 precursor (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6).

CATG_MOUSE
θ value	2.51237e-26 (rank : 109)	NC score	0.958321 (rank : 81)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P28293	Gene names	Ctsg
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (Vimentin-specific protease) (VSP).

KLK1_HUMAN
θ value	2.51237e-26 (rank : 110)	NC score	0.945160 (rank : 102)
Query Neighborhood Hits	178	Target Neighborhood Hits	183	Shared Neighborhood Hits	173
SwissProt Accessions	P06870, Q8TCV8, Q9BS53, Q9NQU4, Q9UMJ1	Gene names	KLK1
Domain Architecture
Description	Kallikrein-1 precursor (EC 3.4.21.35) (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein).

KLK9_HUMAN
θ value	3.28125e-26 (rank : 111)	NC score	0.962212 (rank : 73)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UKQ9	Gene names	KLK9
Domain Architecture
Description	Kallikrein-9 precursor (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK- L3).

KLK2_HUMAN
θ value	5.59698e-26 (rank : 112)	NC score	0.955175 (rank : 85)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	P20151, Q15946, Q9UJZ9	Gene names	KLK2
Domain Architecture
Description	Kallikrein-2 precursor (EC 3.4.21.35) (Tissue kallikrein-2) (Glandular kallikrein-1) (hGK-1).

ELNE_MOUSE
θ value	7.30988e-26 (rank : 113)	NC score	0.945695 (rank : 101)
Query Neighborhood Hits	178	Target Neighborhood Hits	167	Shared Neighborhood Hits	164
SwissProt Accessions	Q3UP87, Q61515	Gene names	Ela2
Domain Architecture	No domain graphic available
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase).

PROC_MOUSE
θ value	7.30988e-26 (rank : 114)	NC score	0.901370 (rank : 145)
Query Neighborhood Hits	178	Target Neighborhood Hits	426	Shared Neighborhood Hits	176
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

GRAF_MOUSE
θ value	9.54697e-26 (rank : 115)	NC score	0.947748 (rank : 95)
Query Neighborhood Hits	178	Target Neighborhood Hits	172	Shared Neighborhood Hits	172
SwissProt Accessions	P08883	Gene names	Gzmf, Ccp4, Ctla-7, Ctla7
Domain Architecture
Description	Granzyme F precursor (EC 3.4.21.-) (Cytotoxic cell protease 4) (CCP4) (CTL serine protease 3) (C134) (Cytotoxic serine protease 3) (MCSP3).

KLK1_MOUSE
θ value	9.54697e-26 (rank : 116)	NC score	0.944468 (rank : 105)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	P15947, Q61855	Gene names	Klk1, Klk-6, Klk6
Domain Architecture
Description	Glandular kallikrein K1 precursor (EC 3.4.21.35) (Tissue kallikrein-6) (mGK-6) (Renal kallikrein) (KAL-B).

CFAI_HUMAN
θ value	1.24688e-25 (rank : 117)	NC score	0.935477 (rank : 126)
Query Neighborhood Hits	178	Target Neighborhood Hits	289	Shared Neighborhood Hits	175
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CATG_HUMAN
θ value	2.12685e-25 (rank : 118)	NC score	0.953976 (rank : 88)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P08311	Gene names	CTSG
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (CG).

KLK7_HUMAN
θ value	2.77775e-25 (rank : 119)	NC score	0.961576 (rank : 76)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P49862, Q8N5N9, Q8NFV7	Gene names	KLK7, PRSS6, SCCE
Domain Architecture
Description	Kallikrein-7 precursor (EC 3.4.21.-) (hK7) (Stratum corneum chymotryptic enzyme) (hSCCE).

FA7_HUMAN
θ value	4.73814e-25 (rank : 120)	NC score	0.899181 (rank : 146)
Query Neighborhood Hits	178	Target Neighborhood Hits	404	Shared Neighborhood Hits	174
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

HGF_MOUSE
θ value	4.73814e-25 (rank : 121)	NC score	0.924989 (rank : 135)
Query Neighborhood Hits	178	Target Neighborhood Hits	192	Shared Neighborhood Hits	171
SwissProt Accessions	Q08048, Q61662, Q64007, Q6LBE6	Gene names	Hgf
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

FA10_HUMAN
θ value	8.08199e-25 (rank : 122)	NC score	0.885793 (rank : 151)
Query Neighborhood Hits	178	Target Neighborhood Hits	431	Shared Neighborhood Hits	176
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

PRTN3_MOUSE
θ value	8.08199e-25 (rank : 123)	NC score	0.955050 (rank : 87)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	Q61096, O08809	Gene names	Prtn3
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Proteinase 3) (PR-3).

K1B11_MOUSE
θ value	1.05554e-24 (rank : 124)	NC score	0.945702 (rank : 100)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	174
SwissProt Accessions	P15946	Gene names	Klk1b11, Klk-11, Klk11
Domain Architecture
Description	Kallikrein 1-related peptidase b11 precursor (EC 3.4.21.35) (Tissue kallikrein-11) (Glandular kallikrein K11) (mGK-11).

K1KB3_MOUSE
θ value	1.05554e-24 (rank : 125)	NC score	0.944071 (rank : 106)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	P00756	Gene names	Klk1b3, Klk-3, Klk3, Ngfg
Domain Architecture
Description	Kallikrein 1-related peptidase b3 precursor (EC 3.4.21.35) (Glandular kallikrein K3) (Tissue kallikrein-3) (mGK-3) (7S nerve growth factor gamma chain) (Gamma-NGF) [Contains: Nerve growth factor gamma chain 1; Nerve growth factor gamma chain 2].

C1RB_MOUSE
θ value	1.37858e-24 (rank : 126)	NC score	0.833273 (rank : 166)
Query Neighborhood Hits	178	Target Neighborhood Hits	380	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

KLK7_MOUSE
θ value	1.37858e-24 (rank : 127)	NC score	0.962458 (rank : 71)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q91VE3, Q9R048	Gene names	Klk7, Prss6, Scce
Domain Architecture	No domain graphic available
Description	Kallikrein-7 precursor (EC 3.4.21.-) (Stratum corneum chymotryptic enzyme) (Thymopsin).

GRAG_MOUSE
θ value	1.80048e-24 (rank : 128)	NC score	0.942144 (rank : 111)
Query Neighborhood Hits	178	Target Neighborhood Hits	173	Shared Neighborhood Hits	172
SwissProt Accessions	P13366, P97388	Gene names	Gzmg
Domain Architecture
Description	Granzyme G precursor (EC 3.4.21.-) (CTL serine protease 1) (MCSP-1).

K1B21_MOUSE
θ value	1.80048e-24 (rank : 129)	NC score	0.941293 (rank : 115)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q61759, Q61760, Q9JM70	Gene names	Klk1b21, Klk-21, Klk21
Domain Architecture
Description	Kallikrein 1-related peptidase b21 precursor (EC 3.4.21.35) (Tissue kallikrein 21) (Glandular kallikrein K21) (mGK-21).

HGF_HUMAN
θ value	2.35151e-24 (rank : 130)	NC score	0.925492 (rank : 134)
Query Neighborhood Hits	178	Target Neighborhood Hits	191	Shared Neighborhood Hits	171
SwissProt Accessions	P14210, Q02935, Q13494, Q14519, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6	Gene names	HGF, HPTA
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

MCPT9_MOUSE
θ value	2.35151e-24 (rank : 131)	NC score	0.946306 (rank : 96)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	O35164	Gene names	Mcpt9
Domain Architecture
Description	Mast cell protease 9 precursor (EC 3.4.21.-) (MMCP-9).

K1B24_MOUSE
θ value	3.07116e-24 (rank : 132)	NC score	0.943350 (rank : 107)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	174
SwissProt Accessions	Q61754, Q61755, Q9JM69	Gene names	Klk1b24, Klk-24, Klk24
Domain Architecture
Description	Kallikrein 1-related peptidase b24 precursor (EC 3.4.21.35) (Glandular kallikrein K24) (Tissue kallikrein 24) (mGK-24).

MASP2_HUMAN
θ value	4.01107e-24 (rank : 133)	NC score	0.849503 (rank : 162)
Query Neighborhood Hits	178	Target Neighborhood Hits	364	Shared Neighborhood Hits	176
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

FA7_MOUSE
θ value	5.23862e-24 (rank : 134)	NC score	0.911296 (rank : 141)
Query Neighborhood Hits	178	Target Neighborhood Hits	374	Shared Neighborhood Hits	174
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

K1B22_MOUSE
θ value	5.23862e-24 (rank : 135)	NC score	0.942121 (rank : 112)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P15948	Gene names	Klk1b22, Klk-22, Klk22
Domain Architecture
Description	Kallikrein 1-related peptidase b22 precursor (EC 3.4.21.35) (Glandular kallikrein K22) (Tissue kallikrein 22) (mGK-22) (Epidermal growth factor-binding protein type A) (EGF-BP A) (Nerve growth factor beta chain endopeptidase) (Beta-NGF-endopeptidase).

K1KB9_MOUSE
θ value	5.23862e-24 (rank : 136)	NC score	0.944741 (rank : 104)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	P15949	Gene names	Klk1b9, Egfbp3, Klk-9, Klk9
Domain Architecture
Description	Kallikrein 1-related peptidase b9 precursor (EC 3.4.21.35) (Tissue kallikrein-9) (Glandular kallikrein K9) (mGK-9) (Epidermal growth factor-binding protein type C) (EGF-BP C).

MASP2_MOUSE
θ value	5.23862e-24 (rank : 137)	NC score	0.852135 (rank : 161)
Query Neighborhood Hits	178	Target Neighborhood Hits	382	Shared Neighborhood Hits	176
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MCPT5_MOUSE
θ value	1.5242e-23 (rank : 138)	NC score	0.934403 (rank : 128)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	175
SwissProt Accessions	P21844, Q9R1F0	Gene names	Mcpt5
Domain Architecture
Description	Mast cell protease 5 precursor (EC 3.4.21.-) (MMCP-5) (Mast cell chymase 1).

MASP1_MOUSE
θ value	1.99067e-23 (rank : 139)	NC score	0.865936 (rank : 157)
Query Neighborhood Hits	178	Target Neighborhood Hits	364	Shared Neighborhood Hits	176
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

K1KB1_MOUSE
θ value	2.59989e-23 (rank : 140)	NC score	0.943316 (rank : 108)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	174
SwissProt Accessions	P00755	Gene names	Klk1b1, Klk-1, Klk1
Domain Architecture
Description	Kallikrein 1-related peptidase b1 precursor (EC 3.4.21.35) (Glandular kallikrein K1) (Tissue kallikrein-1) (mGK-1).

PRTN3_HUMAN
θ value	5.79196e-23 (rank : 141)	NC score	0.956164 (rank : 84)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	P24158, P15637, P18078, Q6LBM7, Q9UQD8	Gene names	PRTN3, MBN
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Leukocyte proteinase 3) (PR-3) (PR3) (AGP7) (Wegener autoantigen) (P29) (C-ANCA antigen) (Neutrophil proteinase 4) (NP-4).

THRB_HUMAN
θ value	5.79196e-23 (rank : 142)	NC score	0.938039 (rank : 122)
Query Neighborhood Hits	178	Target Neighborhood Hits	196	Shared Neighborhood Hits	175
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

THRB_MOUSE
θ value	5.79196e-23 (rank : 143)	NC score	0.939885 (rank : 116)
Query Neighborhood Hits	178	Target Neighborhood Hits	195	Shared Neighborhood Hits	175
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

K1KB5_MOUSE
θ value	7.56453e-23 (rank : 144)	NC score	0.939266 (rank : 119)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P15945, Q52KM1, Q565D7	Gene names	Klk1b5, Klk-5, Klk5
Domain Architecture
Description	Kallikrein 1-related peptidase b5 precursor (EC 3.4.21.35) (Glandular kallikrein K5) (Tissue kallikrein-5) (mGK-5).

MASP1_HUMAN
θ value	9.87957e-23 (rank : 145)	NC score	0.861198 (rank : 158)
Query Neighborhood Hits	178	Target Neighborhood Hits	369	Shared Neighborhood Hits	174
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

C1S_HUMAN
θ value	1.29031e-22 (rank : 146)	NC score	0.836464 (rank : 164)
Query Neighborhood Hits	178	Target Neighborhood Hits	359	Shared Neighborhood Hits	172
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

GRAH_HUMAN
θ value	1.6852e-22 (rank : 147)	NC score	0.950267 (rank : 92)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P20718	Gene names	GZMH, CGL2, CTSGL2
Domain Architecture
Description	Granzyme H precursor (EC 3.4.21.-) (Cytotoxic T-lymphocyte proteinase) (Cathepsin G-like 2) (CTSGL2) (CCP-X) (Cytotoxic serine protease C) (CSP-C).

KLK6_HUMAN
θ value	1.6852e-22 (rank : 148)	NC score	0.968253 (rank : 62)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q92876	Gene names	KLK6, PRSS18, PRSS9
Domain Architecture
Description	Kallikrein-6 precursor (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59).

K1B27_MOUSE
θ value	2.20094e-22 (rank : 149)	NC score	0.942685 (rank : 109)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	Q9JM71	Gene names	Klk1b27, Klk-27, Klk27
Domain Architecture
Description	Kallikrein 1-related peptidase b27 precursor (EC 3.4.21.-) (Tissue kallikrein 27) (Glandular kallikrein K27) (mGK-27) (mKlk27).

K1KB8_MOUSE
θ value	2.20094e-22 (rank : 150)	NC score	0.937873 (rank : 124)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P07628	Gene names	Klk1b8, Klk-8, Klk8
Domain Architecture
Description	Kallikrein 1-related peptidase b8 precursor (EC 3.4.21.35) (Tissue kallikrein-8) (Glandular kallikrein K8) (mGK-8).

KLK5_HUMAN
θ value	3.75424e-22 (rank : 151)	NC score	0.958580 (rank : 80)
Query Neighborhood Hits	178	Target Neighborhood Hits	182	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y337, Q9HBG8	Gene names	KLK5, SCTE
Domain Architecture
Description	Kallikrein-5 precursor (EC 3.4.21.-) (Stratum corneum tryptic enzyme) (Kallikrein-like protein 2) (KLK-L2).

C1R_HUMAN
θ value	4.9032e-22 (rank : 152)	NC score	0.828721 (rank : 167)
Query Neighborhood Hits	178	Target Neighborhood Hits	364	Shared Neighborhood Hits	172
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

EGFB2_MOUSE
θ value	8.36355e-22 (rank : 153)	NC score	0.937926 (rank : 123)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	P36368, P00754	Gene names	Egfbp2, Egfbp-2, Klk-13, Klk13
Domain Architecture
Description	Epidermal growth factor-binding protein type B precursor (EC 3.4.21.35) (EGF-BP B) (Glandular kallikrein K13) (Tissue kallikrein 13) (mGK-13) (Prorenin-converting enzyme) (PRECE).

MCPTX_MOUSE
θ value	1.09232e-21 (rank : 154)	NC score	0.946171 (rank : 97)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q00356	Gene names	Mcptl
Domain Architecture
Description	Mast cell protease-like protein precursor (EC 3.4.21.-).

CS1A_MOUSE
θ value	1.42661e-21 (rank : 155)	NC score	0.836074 (rank : 165)
Query Neighborhood Hits	178	Target Neighborhood Hits	360	Shared Neighborhood Hits	171
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

MCPT8_MOUSE
θ value	1.42661e-21 (rank : 156)	NC score	0.939128 (rank : 120)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P43430, Q9R1F1	Gene names	Mcpt8
Domain Architecture
Description	Mast cell protease 8 precursor (EC 3.4.21.-) (MMCP-8).

K1KB4_MOUSE
θ value	2.43343e-21 (rank : 157)	NC score	0.933581 (rank : 130)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P00757	Gene names	Klk1b4, Klk-4, Klk4, Ngfa
Domain Architecture
Description	Kallikrein 1-related peptidase-like b4 precursor (7S nerve growth factor alpha chain) (Alpha-NGF).

C1RA_MOUSE
θ value	7.0802e-21 (rank : 158)	NC score	0.825507 (rank : 168)
Query Neighborhood Hits	178	Target Neighborhood Hits	379	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

K1B26_MOUSE
θ value	9.24701e-21 (rank : 159)	NC score	0.937835 (rank : 125)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P36369, P00753, P00754	Gene names	Klk1b26, Klk-26, Klk26
Domain Architecture
Description	Kallikrein 1-related peptidase b26 precursor (EC 3.4.21.35) (Glandular kallikrein K26) (Tissue kallikrein 26) (mGK-26) (Prorenin-converting enzyme 2) (PRECE-2).

CS1B_MOUSE
θ value	1.5773e-20 (rank : 160)	NC score	0.840119 (rank : 163)
Query Neighborhood Hits	178	Target Neighborhood Hits	361	Shared Neighborhood Hits	172
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

GRAE_MOUSE
θ value	2.97466e-19 (rank : 161)	NC score	0.935017 (rank : 127)
Query Neighborhood Hits	178	Target Neighborhood Hits	172	Shared Neighborhood Hits	171
SwissProt Accessions	P08884, P97389	Gene names	Gzme, Ccp3, Ctla-6, Ctla6
Domain Architecture
Description	Granzyme E precursor (EC 3.4.21.-) (Cytotoxic cell protease 3) (CCP3) (CTL serine protease 2) (D12) (Cytotoxic serine protease 2) (MCSP2).

K1B16_MOUSE
θ value	1.92812e-18 (rank : 162)	NC score	0.923274 (rank : 136)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	P04071	Gene names	Klk1b16, Klk-16, Klk16
Domain Architecture
Description	Kallikrein 1-related peptidase b16 precursor (EC 3.4.21.54) (Gamma- renin, submandibular gland) (mGK-16).

GRAD_MOUSE
θ value	2.5182e-18 (rank : 163)	NC score	0.933847 (rank : 129)
Query Neighborhood Hits	178	Target Neighborhood Hits	173	Shared Neighborhood Hits	171
SwissProt Accessions	P11033, P97387	Gene names	Gzmd
Domain Architecture
Description	Granzyme D precursor (EC 3.4.21.-).

KLK10_HUMAN
θ value	2.13179e-17 (rank : 164)	NC score	0.956218 (rank : 83)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	175
SwissProt Accessions	O43240, Q99920, Q9GZW9	Gene names	KLK10, NES1, PRRSL1
Domain Architecture
Description	Kallikrein-10 precursor (EC 3.4.21.-) (Protease serine-like 1) (Normal epithelial cell-specific 1).

CAP7_HUMAN
θ value	1.52774e-15 (rank : 165)	NC score	0.949768 (rank : 93)
Query Neighborhood Hits	178	Target Neighborhood Hits	169	Shared Neighborhood Hits	169
SwissProt Accessions	P20160, P80014, Q52LG4	Gene names	AZU1
Domain Architecture
Description	Azurocidin precursor (Cationic antimicrobial protein CAP37) (Heparin- binding protein) (HBP).

HPT_MOUSE
θ value	1.09485e-13 (rank : 166)	NC score	0.901695 (rank : 144)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	169
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

HPT_HUMAN
θ value	1.9326e-10 (rank : 167)	NC score	0.887474 (rank : 149)
Query Neighborhood Hits	178	Target Neighborhood Hits	184	Shared Neighborhood Hits	164
SwissProt Accessions	P00738, P00737, Q2PP15, Q3B7J0, Q6LBY9	Gene names	HP
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

HPTR_HUMAN
θ value	3.29651e-10 (rank : 168)	NC score	0.886959 (rank : 150)
Query Neighborhood Hits	178	Target Neighborhood Hits	166	Shared Neighborhood Hits	164
SwissProt Accessions	P00739, Q7LE20, Q92658, Q92659, Q9ULB0	Gene names	HPR
Domain Architecture
Description	Haptoglobin-related protein precursor.

CFAB_MOUSE
θ value	6.87365e-08 (rank : 169)	NC score	0.710717 (rank : 172)
Query Neighborhood Hits	178	Target Neighborhood Hits	262	Shared Neighborhood Hits	168
SwissProt Accessions	P04186	Gene names	Cfb, Bf, H2-Bf
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CO2_MOUSE
θ value	1.29631e-06 (rank : 170)	NC score	0.755128 (rank : 169)
Query Neighborhood Hits	178	Target Neighborhood Hits	250	Shared Neighborhood Hits	171
SwissProt Accessions	P21180	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CFAB_HUMAN
θ value	1.69304e-06 (rank : 171)	NC score	0.720563 (rank : 170)
Query Neighborhood Hits	178	Target Neighborhood Hits	251	Shared Neighborhood Hits	168
SwissProt Accessions	P00751, O15006, Q29944, Q96HX6, Q9BTF5, Q9BX92	Gene names	CFB, BF
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Glycine-rich beta glycoprotein) (GBG) (PBF2) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CO2_HUMAN
θ value	2.88788e-06 (rank : 172)	NC score	0.717735 (rank : 171)
Query Neighborhood Hits	178	Target Neighborhood Hits	258	Shared Neighborhood Hits	173
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

PROZ_HUMAN
θ value	0.00298849 (rank : 173)	NC score	0.542500 (rank : 173)
Query Neighborhood Hits	178	Target Neighborhood Hits	422	Shared Neighborhood Hits	161
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PRS23_HUMAN
θ value	0.00665767 (rank : 174)	NC score	0.159396 (rank : 180)
Query Neighborhood Hits	178	Target Neighborhood Hits	56	Shared Neighborhood Hits	49
SwissProt Accessions	O95084	Gene names	PRSS23, ZSIG13
Domain Architecture
Description	Serine protease 23 precursor (EC 3.4.21.-) (Putative secreted protein ZSIG13).

PRS23_MOUSE
θ value	0.00665767 (rank : 175)	NC score	0.161713 (rank : 179)
Query Neighborhood Hits	178	Target Neighborhood Hits	61	Shared Neighborhood Hits	53
SwissProt Accessions	Q9D6X6, Q544M8, Q8VEG1	Gene names	Prss23
Domain Architecture
Description	Serine protease 23 precursor (EC 3.4.21.-).

DLP1_HUMAN
θ value	0.125558 (rank : 176)	NC score	0.014213 (rank : 272)
Query Neighborhood Hits	178	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YH6, Q33DR4, Q4G158, Q5VU38, Q5VU39, Q9NR58	Gene names	PDSS2, C6orf210, DLP1
Domain Architecture	No domain graphic available
Description	Decaprenyl-diphosphate synthase subunit 2 (EC 2.5.1.-) (Decaprenyl pyrophosphate synthetase subunit 2) (Candidate tumor suppressor protein).

PROZ_MOUSE
θ value	0.125558 (rank : 177)	NC score	0.517080 (rank : 174)
Query Neighborhood Hits	178	Target Neighborhood Hits	410	Shared Neighborhood Hits	159
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

KRA54_HUMAN
θ value	5.27518 (rank : 178)	NC score	0.009174 (rank : 273)
Query Neighborhood Hits	178	Target Neighborhood Hits	270	Shared Neighborhood Hits	9
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

BMP1_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.092970 (rank : 200)
Query Neighborhood Hits	178	Target Neighborhood Hits	233	Shared Neighborhood Hits	27
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BMP1_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.093509 (rank : 198)
Query Neighborhood Hits	178	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

C163B_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.060724 (rank : 257)
Query Neighborhood Hits	178	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

CD320_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.121676 (rank : 184)
Query Neighborhood Hits	178	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

CD5L_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.055388 (rank : 266)
Query Neighborhood Hits	178	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

CD5L_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.057153 (rank : 263)
Query Neighborhood Hits	178	Target Neighborhood Hits	49	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

CO6_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.064499 (rank : 253)
Query Neighborhood Hits	178	Target Neighborhood Hits	331	Shared Neighborhood Hits	37
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CO9_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.064659 (rank : 252)
Query Neighborhood Hits	178	Target Neighborhood Hits	147	Shared Neighborhood Hits	25
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

CO9_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.059217 (rank : 261)
Query Neighborhood Hits	178	Target Neighborhood Hits	153	Shared Neighborhood Hits	21
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

CSMD1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.073370 (rank : 235)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	24
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

CSMD1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.073460 (rank : 234)
Query Neighborhood Hits	178	Target Neighborhood Hits	193	Shared Neighborhood Hits	22
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

CSMD2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.072635 (rank : 237)
Query Neighborhood Hits	178	Target Neighborhood Hits	188	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

CSMD3_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.074758 (rank : 230)
Query Neighborhood Hits	178	Target Neighborhood Hits	199	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

CUBN_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.073967 (rank : 232)
Query Neighborhood Hits	178	Target Neighborhood Hits	482	Shared Neighborhood Hits	37
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

CUBN_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.078696 (rank : 225)
Query Neighborhood Hits	178	Target Neighborhood Hits	477	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

CUZD1_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.080405 (rank : 223)
Query Neighborhood Hits	178	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

CUZD1_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.075685 (rank : 227)
Query Neighborhood Hits	178	Target Neighborhood Hits	91	Shared Neighborhood Hits	17
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

DCBD1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.059000 (rank : 262)
Query Neighborhood Hits	178	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

DCBD1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.081264 (rank : 220)
Query Neighborhood Hits	178	Target Neighborhood Hits	89	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D4J3, Q8R327, Q9D696	Gene names	Dcbld1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

DCBD2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.056335 (rank : 265)
Query Neighborhood Hits	178	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PD2, Q8N6M4, Q8TDX2	Gene names	DCBLD2, CLCP1, ESDN
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein) (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1).

DCBD2_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.052810 (rank : 268)
Query Neighborhood Hits	178	Target Neighborhood Hits	113	Shared Neighborhood Hits	14
SwissProt Accessions	Q91ZV3, Q8BKI4	Gene names	Dcbld2, Esdn
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein).

DMBT1_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.089779 (rank : 204)
Query Neighborhood Hits	178	Target Neighborhood Hits	152	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

DMBT1_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.096759 (rank : 192)
Query Neighborhood Hits	178	Target Neighborhood Hits	134	Shared Neighborhood Hits	28
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

EGFL8_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.059936 (rank : 259)
Query Neighborhood Hits	178	Target Neighborhood Hits	270	Shared Neighborhood Hits	28
SwissProt Accessions	Q99944, Q8IV30	Gene names	EGFL8, C6orf8, NG3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8) (Vascular endothelial-statin 2) (VE-statin-2).

EGFL8_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.059905 (rank : 260)
Query Neighborhood Hits	178	Target Neighborhood Hits	266	Shared Neighborhood Hits	28
SwissProt Accessions	Q6GUQ1, O35447	Gene names	Egfl8, Ng3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8).

GAS6_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.072373 (rank : 238)
Query Neighborhood Hits	178	Target Neighborhood Hits	348	Shared Neighborhood Hits	35
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

GAS6_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.068279 (rank : 248)
Query Neighborhood Hits	178	Target Neighborhood Hits	343	Shared Neighborhood Hits	32
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

GP126_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.052994 (rank : 267)
Query Neighborhood Hits	178	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

IDD_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.057105 (rank : 264)
Query Neighborhood Hits	178	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

KREM1_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.193087 (rank : 178)
Query Neighborhood Hits	178	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q96MU8, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1	Gene names	KREMEN1, KREMEN, KRM1
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

KREM1_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.197346 (rank : 176)
Query Neighborhood Hits	178	Target Neighborhood Hits	92	Shared Neighborhood Hits	34
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

KREM2_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.198966 (rank : 175)
Query Neighborhood Hits	178	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NCW0, Q8N2J4, Q8NCW1, Q96GL8, Q9BTP9	Gene names	KREMEN2, KRM2
Domain Architecture
Description	Kremen protein 2 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 2) (Dickkopf receptor 2).

KREM2_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.193167 (rank : 177)
Query Neighborhood Hits	178	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K1S7	Gene names	Kremen2
Domain Architecture
Description	Kremen protein 2 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 2) (Dickkopf receptor 2).

LDLR_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.082282 (rank : 218)
Query Neighborhood Hits	178	Target Neighborhood Hits	375	Shared Neighborhood Hits	41
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LDLR_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.082585 (rank : 217)
Query Neighborhood Hits	178	Target Neighborhood Hits	382	Shared Neighborhood Hits	41
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP10_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.088950 (rank : 206)
Query Neighborhood Hits	178	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LRP10_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.088822 (rank : 207)
Query Neighborhood Hits	178	Target Neighborhood Hits	169	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LRP11_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.060506 (rank : 258)
Query Neighborhood Hits	178	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

LRP11_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.061644 (rank : 255)
Query Neighborhood Hits	178	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

LRP12_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.122425 (rank : 183)
Query Neighborhood Hits	178	Target Neighborhood Hits	205	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP12_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.123841 (rank : 182)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP1B_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.088528 (rank : 208)
Query Neighborhood Hits	178	Target Neighborhood Hits	602	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.090362 (rank : 203)
Query Neighborhood Hits	178	Target Neighborhood Hits	606	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.084837 (rank : 213)
Query Neighborhood Hits	178	Target Neighborhood Hits	617	Shared Neighborhood Hits	50
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.096595 (rank : 193)
Query Neighborhood Hits	178	Target Neighborhood Hits	573	Shared Neighborhood Hits	52
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP3_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.121430 (rank : 185)
Query Neighborhood Hits	178	Target Neighborhood Hits	280	Shared Neighborhood Hits	29
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP4_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.082921 (rank : 216)
Query Neighborhood Hits	178	Target Neighborhood Hits	355	Shared Neighborhood Hits	40
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LRP4_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.082087 (rank : 219)
Query Neighborhood Hits	178	Target Neighborhood Hits	351	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

LRP5_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.069446 (rank : 245)
Query Neighborhood Hits	178	Target Neighborhood Hits	224	Shared Neighborhood Hits	33
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP5_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.068316 (rank : 247)
Query Neighborhood Hits	178	Target Neighborhood Hits	236	Shared Neighborhood Hits	29
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

LRP6_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.080871 (rank : 221)
Query Neighborhood Hits	178	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.080243 (rank : 224)
Query Neighborhood Hits	178	Target Neighborhood Hits	232	Shared Neighborhood Hits	38
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.080696 (rank : 222)
Query Neighborhood Hits	178	Target Neighborhood Hits	346	Shared Neighborhood Hits	36
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.084169 (rank : 214)
Query Neighborhood Hits	178	Target Neighborhood Hits	385	Shared Neighborhood Hits	39
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LYAM2_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.051007 (rank : 271)
Query Neighborhood Hits	178	Target Neighborhood Hits	394	Shared Neighborhood Hits	30
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

MFRP_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.110256 (rank : 189)
Query Neighborhood Hits	178	Target Neighborhood Hits	165	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

MFRP_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.116772 (rank : 186)
Query Neighborhood Hits	178	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

NETO1_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.073839 (rank : 233)
Query Neighborhood Hits	178	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO1_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.074634 (rank : 231)
Query Neighborhood Hits	178	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.072129 (rank : 239)
Query Neighborhood Hits	178	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO2_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.071831 (rank : 240)
Query Neighborhood Hits	178	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NRP1_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.070942 (rank : 242)
Query Neighborhood Hits	178	Target Neighborhood Hits	119	Shared Neighborhood Hits	18
SwissProt Accessions	O14786, O60461, Q96IH5	Gene names	NRP1, NRP, VEGF165R
Domain Architecture
Description	Neuropilin-1 precursor (Vascular endothelial cell growth factor 165 receptor) (CD304 antigen).

NRP1_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.071289 (rank : 241)
Query Neighborhood Hits	178	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	P97333	Gene names	Nrp1, Nrp
Domain Architecture
Description	Neuropilin-1 precursor (A5 protein).

NRP2_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.070744 (rank : 244)
Query Neighborhood Hits	178	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

NRP2_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.070926 (rank : 243)
Query Neighborhood Hits	178	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O35375, O35373, O35374, O35376, O35377, O35378	Gene names	Nrp2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

PCOC1_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.086013 (rank : 210)
Query Neighborhood Hits	178	Target Neighborhood Hits	146	Shared Neighborhood Hits	17
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

PCOC1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.087625 (rank : 209)
Query Neighborhood Hits	178	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q61398, O35113	Gene names	Pcolce, Pcpe1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein) (P14).

PCOC2_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.089017 (rank : 205)
Query Neighborhood Hits	178	Target Neighborhood Hits	73	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UKZ9, Q9BRH3	Gene names	PCOLCE2, PCPE2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

PCOC2_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.085212 (rank : 212)
Query Neighborhood Hits	178	Target Neighborhood Hits	73	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4W6, Q3V1K6, Q9CX06	Gene names	Pcolce2, Pcpe2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

PDGFD_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.067665 (rank : 250)
Query Neighborhood Hits	178	Target Neighborhood Hits	74	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZP0, Q9BWV5	Gene names	PDGFD, IEGF, SCDGFB
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor D precursor (PDGF D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B).

PDGFD_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.067939 (rank : 249)
Query Neighborhood Hits	178	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q925I7, Q3URF6, Q8K2L3, Q9D1L8	Gene names	Pdgfd, Scdgfb
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor chain precursor (PDGF D) (Spinal cord- derived growth factor B) (SCDGF-B).

PRGB_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.107599 (rank : 190)
Query Neighborhood Hits	178	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q02325	Gene names	PLGL, PRGB
Domain Architecture
Description	Plasminogen-related protein B precursor.

PROS_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.075400 (rank : 228)
Query Neighborhood Hits	178	Target Neighborhood Hits	340	Shared Neighborhood Hits	30
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

PROS_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.069310 (rank : 246)
Query Neighborhood Hits	178	Target Neighborhood Hits	330	Shared Neighborhood Hits	27
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

SEZ6L_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.072897 (rank : 236)
Query Neighborhood Hits	178	Target Neighborhood Hits	289	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

SORL_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.075237 (rank : 229)
Query Neighborhood Hits	178	Target Neighborhood Hits	440	Shared Neighborhood Hits	23
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.078277 (rank : 226)
Query Neighborhood Hits	178	Target Neighborhood Hits	439	Shared Neighborhood Hits	25
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SPIT1_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.052792 (rank : 269)
Query Neighborhood Hits	178	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT1_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.052261 (rank : 270)
Query Neighborhood Hits	178	Target Neighborhood Hits	96	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SSPO_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.061251 (rank : 256)
Query Neighborhood Hits	178	Target Neighborhood Hits	800	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

TLL1_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.094133 (rank : 197)
Query Neighborhood Hits	178	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

TLL1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.093324 (rank : 199)
Query Neighborhood Hits	178	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

TLL2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.094509 (rank : 196)
Query Neighborhood Hits	178	Target Neighborhood Hits	241	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TLL2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.094658 (rank : 195)
Query Neighborhood Hits	178	Target Neighborhood Hits	240	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TMG1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.125412 (rank : 181)
Query Neighborhood Hits	178	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	O14668	Gene names	PRRG1, PRGP1, TMG1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 1 precursor (Proline- rich Gla protein 1) (Proline-rich gamma-carboxyglutamic acid protein 1).

TMG2_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.096139 (rank : 194)
Query Neighborhood Hits	178	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	O14669	Gene names	PRRG2, PRGP2, TMG2
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2).

TMG2_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.091243 (rank : 202)
Query Neighborhood Hits	178	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R182, Q9EQI2	Gene names	Prrg2, N4wbp1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2) (NEDD4 WW domain-binding protein 1).

TMG3_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.113326 (rank : 187)
Query Neighborhood Hits	178	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZD7, Q8N2N6	Gene names	PRRG3, TMG3
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

TMG3_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.111433 (rank : 188)
Query Neighborhood Hits	178	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PAQ9	Gene names	Prrg3, Gm368, Tmg3
Domain Architecture	No domain graphic available
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

TMG4_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.097436 (rank : 191)
Query Neighborhood Hits	178	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZD6	Gene names	PRRG4, TMG4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

TMG4_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.092793 (rank : 201)
Query Neighborhood Hits	178	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BGN6, Q8BM25	Gene names	Prrg4, Tmg4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

TSG6_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.065761 (rank : 251)
Query Neighborhood Hits	178	Target Neighborhood Hits	91	Shared Neighborhood Hits	14
SwissProt Accessions	P98066, Q8WWI9	Gene names	TNFAIP6, TSG6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein) (Hyaluronate-binding protein).

TSG6_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.064445 (rank : 254)
Query Neighborhood Hits	178	Target Neighborhood Hits	91	Shared Neighborhood Hits	14
SwissProt Accessions	O08859	Gene names	Tnfaip6, Tnfip6, Tsg6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein).

VLDLR_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.083898 (rank : 215)
Query Neighborhood Hits	178	Target Neighborhood Hits	383	Shared Neighborhood Hits	40
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.085408 (rank : 211)
Query Neighborhood Hits	178	Target Neighborhood Hits	360	Shared Neighborhood Hits	39
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

Hits sorted by NC score

ELA2A_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.73892e-144 (rank : 1)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	178
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

ELA2A_HUMAN
NC score	0.998766 (rank : 2)	θ value	5.63297e-119 (rank : 2)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	177
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

ELA2B_HUMAN
NC score	0.998102 (rank : 3)	θ value	7.87842e-113 (rank : 3)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	177
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

CLCR_HUMAN
NC score	0.996747 (rank : 4)	θ value	7.19216e-82 (rank : 4)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	176
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

ELA1_HUMAN
NC score	0.995440 (rank : 5)	θ value	1.65806e-78 (rank : 5)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	175
SwissProt Accessions	Q9UNI1, Q5MLF0, Q6DJT0, Q6ISM6	Gene names	ELA1
Domain Architecture
Description	Elastase-1 precursor (EC 3.4.21.36).

ELA3A_HUMAN
NC score	0.994376 (rank : 6)	θ value	7.97034e-73 (rank : 6)
Query Neighborhood Hits	178	Target Neighborhood Hits	173	Shared Neighborhood Hits	173
SwissProt Accessions	P09093, Q9BRW4	Gene names	ELA3A, ELA3
Domain Architecture
Description	Elastase-3A precursor (EC 3.4.21.70) (Elastase IIIA) (Protease E).

ELA3B_HUMAN
NC score	0.993766 (rank : 7)	θ value	1.35953e-72 (rank : 7)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

CTRL_HUMAN
NC score	0.989827 (rank : 8)	θ value	1.46607e-42 (rank : 13)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	176
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

CTRB1_HUMAN
NC score	0.989267 (rank : 9)	θ value	7.77379e-44 (rank : 9)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	176
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

TRYG1_MOUSE
NC score	0.985319 (rank : 10)	θ value	1.2411e-41 (rank : 18)
Query Neighborhood Hits	178	Target Neighborhood Hits	181	Shared Neighborhood Hits	174
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TMSP8_MOUSE
NC score	0.985228 (rank : 11)	θ value	6.81017e-40 (rank : 28)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

ACRO_MOUSE
NC score	0.985209 (rank : 12)	θ value	3.26607e-42 (rank : 14)
Query Neighborhood Hits	178	Target Neighborhood Hits	185	Shared Neighborhood Hits	174
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

TRYG1_HUMAN
NC score	0.984278 (rank : 13)	θ value	1.28434e-38 (rank : 40)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

BSSP4_HUMAN
NC score	0.984151 (rank : 14)	θ value	8.89434e-40 (rank : 29)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	175
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

TRYB1_MOUSE
NC score	0.983403 (rank : 15)	θ value	1.28434e-38 (rank : 39)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

MCPT6_MOUSE
NC score	0.983314 (rank : 16)	θ value	9.83387e-39 (rank : 38)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

PRSS8_MOUSE
NC score	0.982922 (rank : 17)	θ value	1.98146e-39 (rank : 32)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

BSSP4_MOUSE
NC score	0.982881 (rank : 18)	θ value	5.39604e-37 (rank : 52)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

TRYA1_HUMAN
NC score	0.982785 (rank : 19)	θ value	8.89434e-40 (rank : 30)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

HEPS_MOUSE
NC score	0.982766 (rank : 20)	θ value	7.27602e-42 (rank : 17)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

PRS27_MOUSE
NC score	0.982765 (rank : 21)	θ value	3.73686e-38 (rank : 42)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

HEPS_HUMAN
NC score	0.982586 (rank : 22)	θ value	3.26607e-42 (rank : 15)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

PRSS8_HUMAN
NC score	0.982579 (rank : 23)	θ value	3.4976e-36 (rank : 57)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

ACRO_HUMAN
NC score	0.982542 (rank : 24)	θ value	3.61106e-41 (rank : 19)
Query Neighborhood Hits	178	Target Neighborhood Hits	291	Shared Neighborhood Hits	174
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

TRYB1_HUMAN
NC score	0.982503 (rank : 25)	θ value	1.79215e-40 (rank : 22)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB2_HUMAN
NC score	0.982503 (rank : 26)	θ value	1.79215e-40 (rank : 23)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

PRS27_HUMAN
NC score	0.982205 (rank : 27)	θ value	4.13158e-37 (rank : 50)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

TM11D_HUMAN
NC score	0.981950 (rank : 28)	θ value	3.85808e-43 (rank : 11)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11D_MOUSE
NC score	0.981535 (rank : 29)	θ value	2.26182e-43 (rank : 10)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	176
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

GRAM_HUMAN
NC score	0.981465 (rank : 30)	θ value	2.34606e-32 (rank : 72)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P51124	Gene names	GZMM, MET1
Domain Architecture
Description	Granzyme M precursor (EC 3.4.21.-) (Met-ase) (Natural killer cell granular protease) (HU-Met-1) (Met-1 serine protease).

TMPS5_HUMAN
NC score	0.981387 (rank : 31)	θ value	2.42216e-37 (rank : 49)
Query Neighborhood Hits	178	Target Neighborhood Hits	181	Shared Neighborhood Hits	176
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

DESC4_MOUSE
NC score	0.980788 (rank : 32)	θ value	7.27602e-42 (rank : 16)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

TMPS5_MOUSE
NC score	0.980601 (rank : 33)	θ value	3.37985e-39 (rank : 37)
Query Neighborhood Hits	178	Target Neighborhood Hits	185	Shared Neighborhood Hits	175
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TEST_MOUSE
NC score	0.980599 (rank : 34)	θ value	2.96089e-35 (rank : 61)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

CFAD_MOUSE
NC score	0.979380 (rank : 35)	θ value	4.42448e-31 (rank : 78)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	175
SwissProt Accessions	P03953, Q61280	Gene names	Cfd, Adn, Df
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin) (28 kDa adipocyte protein).

TMPS4_MOUSE
NC score	0.978705 (rank : 36)	θ value	1.42001e-37 (rank : 46)
Query Neighborhood Hits	178	Target Neighborhood Hits	210	Shared Neighborhood Hits	174
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

TMPS3_MOUSE
NC score	0.978367 (rank : 37)	θ value	3.99248e-40 (rank : 25)
Query Neighborhood Hits	178	Target Neighborhood Hits	239	Shared Neighborhood Hits	174
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

POLS2_MOUSE
NC score	0.978177 (rank : 38)	θ value	2.86122e-38 (rank : 41)
Query Neighborhood Hits	178	Target Neighborhood Hits	188	Shared Neighborhood Hits	174
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

TEST_HUMAN
NC score	0.978161 (rank : 39)	θ value	4.13158e-37 (rank : 51)
Query Neighborhood Hits	178	Target Neighborhood Hits	172	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

TRYD_HUMAN
NC score	0.977945 (rank : 40)	θ value	1.28732e-30 (rank : 80)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

TMPS4_HUMAN
NC score	0.977910 (rank : 41)	θ value	1.32909e-35 (rank : 59)
Query Neighborhood Hits	178	Target Neighborhood Hits	203	Shared Neighborhood Hits	174
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

CFAD_HUMAN
NC score	0.977444 (rank : 42)	θ value	4.72714e-33 (rank : 69)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	175
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

TMPS3_HUMAN
NC score	0.977263 (rank : 43)	θ value	5.21438e-40 (rank : 27)
Query Neighborhood Hits	178	Target Neighborhood Hits	245	Shared Neighborhood Hits	176
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS2_HUMAN
NC score	0.976623 (rank : 44)	θ value	3.73686e-38 (rank : 43)
Query Neighborhood Hits	178	Target Neighborhood Hits	252	Shared Neighborhood Hits	174
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TRY2_MOUSE
NC score	0.976564 (rank : 45)	θ value	7.04741e-37 (rank : 54)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P07146	Gene names	Prss2, Try2
Domain Architecture
Description	Anionic trypsin-2 precursor (EC 3.4.21.4) (Anionic trypsin II) (Pretrypsinogen II).

GRAK_MOUSE
NC score	0.975846 (rank : 46)	θ value	2.42779e-29 (rank : 91)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	173
SwissProt Accessions	O35205	Gene names	Gzmk
Domain Architecture
Description	Granzyme K precursor (EC 3.4.21.-).

KLKB1_HUMAN
NC score	0.975782 (rank : 47)	θ value	2.58786e-39 (rank : 34)
Query Neighborhood Hits	178	Target Neighborhood Hits	183	Shared Neighborhood Hits	174
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

POLS2_HUMAN
NC score	0.975768 (rank : 48)	θ value	3.4976e-36 (rank : 56)
Query Neighborhood Hits	178	Target Neighborhood Hits	192	Shared Neighborhood Hits	174
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

FA11_MOUSE
NC score	0.975427 (rank : 49)	θ value	3.99248e-40 (rank : 24)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	175
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

KLKB1_MOUSE
NC score	0.974875 (rank : 50)	θ value	5.21438e-40 (rank : 26)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

TMPS2_MOUSE
NC score	0.974711 (rank : 51)	θ value	2.42216e-37 (rank : 48)
Query Neighborhood Hits	178	Target Neighborhood Hits	243	Shared Neighborhood Hits	174
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TSP50_HUMAN
NC score	0.974693 (rank : 52)	θ value	3.87602e-27 (rank : 103)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

FA11_HUMAN
NC score	0.974620 (rank : 53)	θ value	2.42216e-37 (rank : 47)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	175
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TM11E_HUMAN
NC score	0.974522 (rank : 54)	θ value	8.32485e-38 (rank : 45)
Query Neighborhood Hits	178	Target Neighborhood Hits	181	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TM11E_MOUSE
NC score	0.974381 (rank : 55)	θ value	6.17384e-33 (rank : 70)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TMPSD_MOUSE
NC score	0.973876 (rank : 56)	θ value	7.04741e-37 (rank : 53)
Query Neighborhood Hits	178	Target Neighborhood Hits	334	Shared Neighborhood Hits	176
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TRY1_HUMAN
NC score	0.973817 (rank : 57)	θ value	5.77852e-31 (rank : 79)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	P07477, Q92955, Q9HAN4, Q9HAN5, Q9HAN6, Q9HAN7	Gene names	PRSS1, TRP1, TRY1, TRYP1
Domain Architecture
Description	Trypsin-1 precursor (EC 3.4.21.4) (Trypsin I) (Cationic trypsinogen).

TMPSD_HUMAN
NC score	0.973816 (rank : 58)	θ value	9.20422e-37 (rank : 55)
Query Neighborhood Hits	178	Target Neighborhood Hits	333	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TRY2_HUMAN
NC score	0.973318 (rank : 59)	θ value	3.3877e-31 (rank : 77)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	P07478	Gene names	PRSS2, TRY2, TRYP2
Domain Architecture
Description	Trypsin-2 precursor (EC 3.4.21.4) (Trypsin II) (Anionic trypsinogen).

TRY3_HUMAN
NC score	0.973276 (rank : 60)	θ value	5.584e-34 (rank : 67)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

TMPS9_MOUSE
NC score	0.968257 (rank : 61)	θ value	2.58786e-39 (rank : 35)
Query Neighborhood Hits	178	Target Neighborhood Hits	296	Shared Neighborhood Hits	176
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

KLK6_HUMAN
NC score	0.968253 (rank : 62)	θ value	1.6852e-22 (rank : 148)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q92876	Gene names	KLK6, PRSS18, PRSS9
Domain Architecture
Description	Kallikrein-6 precursor (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59).

TMPS9_HUMAN
NC score	0.967835 (rank : 63)	θ value	1.79215e-40 (rank : 21)
Query Neighborhood Hits	178	Target Neighborhood Hits	276	Shared Neighborhood Hits	176
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

KLK15_HUMAN
NC score	0.967782 (rank : 64)	θ value	4.27553e-34 (rank : 65)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	175
SwissProt Accessions	Q9H2R5, Q15358, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9	Gene names	KLK15
Domain Architecture
Description	Kallikrein-15 precursor (EC 3.4.21.-) (ACO protease).

KLK13_HUMAN
NC score	0.966438 (rank : 65)	θ value	1.08979e-29 (rank : 87)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UKR3, Q9Y433	Gene names	KLK13, KLKL4
Domain Architecture
Description	Kallikrein-13 precursor (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4).

KLK4_HUMAN
NC score	0.965254 (rank : 66)	θ value	6.61148e-27 (rank : 106)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y5K2, Q4VB16, Q9GZL6, Q9UBJ6	Gene names	KLK4, EMSP1, PRSS17, PSTS
Domain Architecture
Description	Kallikrein-4 precursor (EC 3.4.21.-) (Prostase) (Kallikrein-like protein 1) (KLK-L1) (Enamel matrix serine proteinase 1).

KLK12_HUMAN
NC score	0.965192 (rank : 67)	θ value	3.17079e-29 (rank : 92)
Query Neighborhood Hits	178	Target Neighborhood Hits	197	Shared Neighborhood Hits	175
SwissProt Accessions	Q9UKR0, Q9UKR1	Gene names	KLK12, KLKL5
Domain Architecture
Description	Kallikrein-12 precursor (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5).

NRPN_HUMAN
NC score	0.963695 (rank : 68)	θ value	9.2256e-29 (rank : 93)
Query Neighborhood Hits	178	Target Neighborhood Hits	182	Shared Neighborhood Hits	175
SwissProt Accessions	O60259, Q9HCB3, Q9UIL9, Q9UQ47	Gene names	KLK8, NRPN, PRSS19, TADG14
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein).

KLK14_HUMAN
NC score	0.963572 (rank : 69)	θ value	1.92365e-26 (rank : 108)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q9P0G3	Gene names	KLK14, KLKL6
Domain Architecture
Description	Kallikrein-14 precursor (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6).

UROK_MOUSE
NC score	0.963347 (rank : 70)	θ value	2.34606e-32 (rank : 73)
Query Neighborhood Hits	178	Target Neighborhood Hits	273	Shared Neighborhood Hits	172
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

KLK7_MOUSE
NC score	0.962458 (rank : 71)	θ value	1.37858e-24 (rank : 127)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	Q91VE3, Q9R048	Gene names	Klk7, Prss6, Scce
Domain Architecture	No domain graphic available
Description	Kallikrein-7 precursor (EC 3.4.21.-) (Stratum corneum chymotryptic enzyme) (Thymopsin).

KLK11_HUMAN
NC score	0.962394 (rank : 72)	θ value	4.89182e-30 (rank : 85)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UBX7, O75837, Q9NS65	Gene names	KLK11, PRSS20, TLSP
Domain Architecture
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin) (Trypsin-like protease).

KLK9_HUMAN
NC score	0.962212 (rank : 73)	θ value	3.28125e-26 (rank : 111)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UKQ9	Gene names	KLK9
Domain Architecture
Description	Kallikrein-9 precursor (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK- L3).

UROK_HUMAN
NC score	0.961746 (rank : 74)	θ value	1.28732e-30 (rank : 81)
Query Neighborhood Hits	178	Target Neighborhood Hits	272	Shared Neighborhood Hits	172
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

KLK11_MOUSE
NC score	0.961708 (rank : 75)	θ value	1.85889e-29 (rank : 88)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q9QYN3, Q9QYN4	Gene names	Klk11, Prss20
Domain Architecture	No domain graphic available
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin).

KLK7_HUMAN
NC score	0.961576 (rank : 76)	θ value	2.77775e-25 (rank : 119)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P49862, Q8N5N9, Q8NFV7	Gene names	KLK7, PRSS6, SCCE
Domain Architecture
Description	Kallikrein-7 precursor (EC 3.4.21.-) (hK7) (Stratum corneum chymotryptic enzyme) (hSCCE).

PLMN_MOUSE
NC score	0.961440 (rank : 77)	θ value	1.15895e-47 (rank : 8)
Query Neighborhood Hits	178	Target Neighborhood Hits	208	Shared Neighborhood Hits	176
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

PLMN_HUMAN
NC score	0.961259 (rank : 78)	θ value	6.58091e-43 (rank : 12)
Query Neighborhood Hits	178	Target Neighborhood Hits	204	Shared Neighborhood Hits	176
SwissProt Accessions	P00747, Q15146, Q6PA00	Gene names	PLG
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

NRPN_MOUSE
NC score	0.960144 (rank : 79)	θ value	1.6813e-30 (rank : 82)
Query Neighborhood Hits	178	Target Neighborhood Hits	186	Shared Neighborhood Hits	175
SwissProt Accessions	Q61955	Gene names	Klk8, Nrpn, Prss19
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8).

KLK5_HUMAN
NC score	0.958580 (rank : 80)	θ value	3.75424e-22 (rank : 151)
Query Neighborhood Hits	178	Target Neighborhood Hits	182	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y337, Q9HBG8	Gene names	KLK5, SCTE
Domain Architecture
Description	Kallikrein-5 precursor (EC 3.4.21.-) (Stratum corneum tryptic enzyme) (Kallikrein-like protein 2) (KLK-L2).

CATG_MOUSE
NC score	0.958321 (rank : 81)	θ value	2.51237e-26 (rank : 109)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P28293	Gene names	Ctsg
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (Vimentin-specific protease) (VSP).

MCPT2_MOUSE
NC score	0.956949 (rank : 82)	θ value	5.06226e-27 (rank : 105)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P15119	Gene names	Mcpt2
Domain Architecture
Description	Mast cell protease 2 precursor (EC 3.4.21.-) (MMCP-2).

KLK10_HUMAN
NC score	0.956218 (rank : 83)	θ value	2.13179e-17 (rank : 164)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	175
SwissProt Accessions	O43240, Q99920, Q9GZW9	Gene names	KLK10, NES1, PRRSL1
Domain Architecture
Description	Kallikrein-10 precursor (EC 3.4.21.-) (Protease serine-like 1) (Normal epithelial cell-specific 1).

PRTN3_HUMAN
NC score	0.956164 (rank : 84)	θ value	5.79196e-23 (rank : 141)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	173
SwissProt Accessions	P24158, P15637, P18078, Q6LBM7, Q9UQD8	Gene names	PRTN3, MBN
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Leukocyte proteinase 3) (PR-3) (PR3) (AGP7) (Wegener autoantigen) (P29) (C-ANCA antigen) (Neutrophil proteinase 4) (NP-4).

KLK2_HUMAN
NC score	0.955175 (rank : 85)	θ value	5.59698e-26 (rank : 112)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	P20151, Q15946, Q9UJZ9	Gene names	KLK2
Domain Architecture
Description	Kallikrein-2 precursor (EC 3.4.21.35) (Tissue kallikrein-2) (Glandular kallikrein-1) (hGK-1).

MCPT1_MOUSE
NC score	0.955158 (rank : 86)	θ value	8.3442e-30 (rank : 86)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P11034	Gene names	Mcpt1
Domain Architecture
Description	Mast cell protease 1 precursor (EC 3.4.21.-) (MMCP-1).

PRTN3_MOUSE
NC score	0.955050 (rank : 87)	θ value	8.08199e-25 (rank : 123)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	Q61096, O08809	Gene names	Prtn3
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Proteinase 3) (PR-3).

CATG_HUMAN
NC score	0.953976 (rank : 88)	θ value	2.12685e-25 (rank : 118)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P08311	Gene names	CTSG
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (CG).

KLK3_HUMAN
NC score	0.953938 (rank : 89)	θ value	1.85889e-29 (rank : 89)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	176
SwissProt Accessions	P07288, Q16272, Q86TG8	Gene names	KLK3, APS
Domain Architecture
Description	Prostate-specific antigen precursor (EC 3.4.21.77) (PSA) (Kallikrein- 3) (Semenogelase) (Gamma-seminoprotein) (Seminin) (P-30 antigen).

MCPT4_MOUSE
NC score	0.953780 (rank : 90)	θ value	4.57862e-28 (rank : 96)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P21812, Q9EPQ9, Q9EQT2	Gene names	Mcpt4
Domain Architecture
Description	Mast cell protease 4 precursor (EC 3.4.21.-) (MMCP-4) (Serosal mast cell protease) (MSMCP) (Myonase).

APOA_HUMAN
NC score	0.952064 (rank : 91)	θ value	3.37985e-39 (rank : 36)
Query Neighborhood Hits	178	Target Neighborhood Hits	221	Shared Neighborhood Hits	176
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

GRAH_HUMAN
NC score	0.950267 (rank : 92)	θ value	1.6852e-22 (rank : 147)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P20718	Gene names	GZMH, CGL2, CTSGL2
Domain Architecture
Description	Granzyme H precursor (EC 3.4.21.-) (Cytotoxic T-lymphocyte proteinase) (Cathepsin G-like 2) (CTSGL2) (CCP-X) (Cytotoxic serine protease C) (CSP-C).

CAP7_HUMAN
NC score	0.949768 (rank : 93)	θ value	1.52774e-15 (rank : 165)
Query Neighborhood Hits	178	Target Neighborhood Hits	169	Shared Neighborhood Hits	169
SwissProt Accessions	P20160, P80014, Q52LG4	Gene names	AZU1
Domain Architecture
Description	Azurocidin precursor (Cationic antimicrobial protein CAP37) (Heparin- binding protein) (HBP).

GRAC_MOUSE
NC score	0.948292 (rank : 94)	θ value	5.06226e-27 (rank : 104)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P08882, Q61389	Gene names	Gzmc, Ctla-5, Ctla5
Domain Architecture
Description	Granzyme C precursor (EC 3.4.21.-) (Cytotoxic cell protease 2) (CCP2) (B10).

GRAF_MOUSE
NC score	0.947748 (rank : 95)	θ value	9.54697e-26 (rank : 115)
Query Neighborhood Hits	178	Target Neighborhood Hits	172	Shared Neighborhood Hits	172
SwissProt Accessions	P08883	Gene names	Gzmf, Ccp4, Ctla-7, Ctla7
Domain Architecture
Description	Granzyme F precursor (EC 3.4.21.-) (Cytotoxic cell protease 4) (CCP4) (CTL serine protease 3) (C134) (Cytotoxic serine protease 3) (MCSP3).

MCPT9_MOUSE
NC score	0.946306 (rank : 96)	θ value	2.35151e-24 (rank : 131)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	O35164	Gene names	Mcpt9
Domain Architecture
Description	Mast cell protease 9 precursor (EC 3.4.21.-) (MMCP-9).

MCPTX_MOUSE
NC score	0.946171 (rank : 97)	θ value	1.09232e-21 (rank : 154)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q00356	Gene names	Mcptl
Domain Architecture
Description	Mast cell protease-like protein precursor (EC 3.4.21.-).

TMPS6_MOUSE
NC score	0.945784 (rank : 98)	θ value	6.15952e-41 (rank : 20)
Query Neighborhood Hits	178	Target Neighborhood Hits	341	Shared Neighborhood Hits	176
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

MCPT1_HUMAN
NC score	0.945765 (rank : 99)	θ value	5.97985e-28 (rank : 97)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	173
SwissProt Accessions	P23946, Q16018	Gene names	CMA1, CYH, CYM
Domain Architecture
Description	Chymase precursor (EC 3.4.21.39) (Mast cell protease I).

K1B11_MOUSE
NC score	0.945702 (rank : 100)	θ value	1.05554e-24 (rank : 124)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	174
SwissProt Accessions	P15946	Gene names	Klk1b11, Klk-11, Klk11
Domain Architecture
Description	Kallikrein 1-related peptidase b11 precursor (EC 3.4.21.35) (Tissue kallikrein-11) (Glandular kallikrein K11) (mGK-11).

ELNE_MOUSE
NC score	0.945695 (rank : 101)	θ value	7.30988e-26 (rank : 113)
Query Neighborhood Hits	178	Target Neighborhood Hits	167	Shared Neighborhood Hits	164
SwissProt Accessions	Q3UP87, Q61515	Gene names	Ela2
Domain Architecture	No domain graphic available
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase).

KLK1_HUMAN
NC score	0.945160 (rank : 102)	θ value	2.51237e-26 (rank : 110)
Query Neighborhood Hits	178	Target Neighborhood Hits	183	Shared Neighborhood Hits	173
SwissProt Accessions	P06870, Q8TCV8, Q9BS53, Q9NQU4, Q9UMJ1	Gene names	KLK1
Domain Architecture
Description	Kallikrein-1 precursor (EC 3.4.21.35) (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein).

ELNE_HUMAN
NC score	0.944977 (rank : 103)	θ value	2.96777e-27 (rank : 98)
Query Neighborhood Hits	178	Target Neighborhood Hits	164	Shared Neighborhood Hits	164
SwissProt Accessions	P08246, P09649, Q6B0D9, Q6LDP5	Gene names	ELA2
Domain Architecture
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase) (PMN elastase) (Bone marrow serine protease) (Medullasin) (Human leukocyte elastase) (HLE).

K1KB9_MOUSE
NC score	0.944741 (rank : 104)	θ value	5.23862e-24 (rank : 136)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	P15949	Gene names	Klk1b9, Egfbp3, Klk-9, Klk9
Domain Architecture
Description	Kallikrein 1-related peptidase b9 precursor (EC 3.4.21.35) (Tissue kallikrein-9) (Glandular kallikrein K9) (mGK-9) (Epidermal growth factor-binding protein type C) (EGF-BP C).

KLK1_MOUSE
NC score	0.944468 (rank : 105)	θ value	9.54697e-26 (rank : 116)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	P15947, Q61855	Gene names	Klk1, Klk-6, Klk6
Domain Architecture
Description	Glandular kallikrein K1 precursor (EC 3.4.21.35) (Tissue kallikrein-6) (mGK-6) (Renal kallikrein) (KAL-B).

K1KB3_MOUSE
NC score	0.944071 (rank : 106)	θ value	1.05554e-24 (rank : 125)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	P00756	Gene names	Klk1b3, Klk-3, Klk3, Ngfg
Domain Architecture
Description	Kallikrein 1-related peptidase b3 precursor (EC 3.4.21.35) (Glandular kallikrein K3) (Tissue kallikrein-3) (mGK-3) (7S nerve growth factor gamma chain) (Gamma-NGF) [Contains: Nerve growth factor gamma chain 1; Nerve growth factor gamma chain 2].

K1B24_MOUSE
NC score	0.943350 (rank : 107)	θ value	3.07116e-24 (rank : 132)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	174
SwissProt Accessions	Q61754, Q61755, Q9JM69	Gene names	Klk1b24, Klk-24, Klk24
Domain Architecture
Description	Kallikrein 1-related peptidase b24 precursor (EC 3.4.21.35) (Glandular kallikrein K24) (Tissue kallikrein 24) (mGK-24).

K1KB1_MOUSE
NC score	0.943316 (rank : 108)	θ value	2.59989e-23 (rank : 140)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	174
SwissProt Accessions	P00755	Gene names	Klk1b1, Klk-1, Klk1
Domain Architecture
Description	Kallikrein 1-related peptidase b1 precursor (EC 3.4.21.35) (Glandular kallikrein K1) (Tissue kallikrein-1) (mGK-1).

K1B27_MOUSE
NC score	0.942685 (rank : 109)	θ value	2.20094e-22 (rank : 149)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	Q9JM71	Gene names	Klk1b27, Klk-27, Klk27
Domain Architecture
Description	Kallikrein 1-related peptidase b27 precursor (EC 3.4.21.-) (Tissue kallikrein 27) (Glandular kallikrein K27) (mGK-27) (mKlk27).

TPA_MOUSE
NC score	0.942426 (rank : 110)	θ value	1.57365e-28 (rank : 94)
Query Neighborhood Hits	178	Target Neighborhood Hits	335	Shared Neighborhood Hits	174
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

GRAG_MOUSE
NC score	0.942144 (rank : 111)	θ value	1.80048e-24 (rank : 128)
Query Neighborhood Hits	178	Target Neighborhood Hits	173	Shared Neighborhood Hits	172
SwissProt Accessions	P13366, P97388	Gene names	Gzmg
Domain Architecture
Description	Granzyme G precursor (EC 3.4.21.-) (CTL serine protease 1) (MCSP-1).

K1B22_MOUSE
NC score	0.942121 (rank : 112)	θ value	5.23862e-24 (rank : 135)
Query Neighborhood Hits	178	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	P15948	Gene names	Klk1b22, Klk-22, Klk22
Domain Architecture
Description	Kallikrein 1-related peptidase b22 precursor (EC 3.4.21.35) (Glandular kallikrein K22) (Tissue kallikrein 22) (mGK-22) (Epidermal growth factor-binding protein type A) (EGF-BP A) (Nerve growth factor beta chain endopeptidase) (Beta-NGF-endopeptidase).

TPA_HUMAN
NC score	0.941533 (rank : 113)	θ value	2.96777e-27 (rank : 100)
Query Neighborhood Hits	178	Target Neighborhood Hits	324	Shared Neighborhood Hits	174
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TMPS6_HUMAN
NC score	0.941294 (rank : 114)	θ value	1.16164e-39 (rank : 31)
Query Neighborhood Hits	178	Target Neighborhood Hits	338	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

K1B21_MOUSE
NC score	0.941293 (rank : 115)	θ value	1.80048e-24 (rank : 129)
Query Neighborhood Hits	178	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q61759, Q61760, Q9JM70	Gene names	Klk1b21, Klk-21, Klk21
Domain Architecture
Description	Kallikrein 1-related peptidase b21 precursor (EC 3.4.21.35) (Tissue kallikrein 21) (Glandular kallikrein K21) (mGK-21).

THRB_MOUSE
NC score	0.939885 (rank : 116)	θ value	5.79196e-23 (rank : 143)
Query Neighborhood Hits	178	Target Neighborhood Hits	195	Shared Neighborhood Hits	175
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

CFAI_MOUSE
NC score	0.939838 (rank : 117)	θ value	2.42779e-29 (rank : 90)
Query Neighborhood Hits	178	Target Neighborhood Hits	290	Shared Neighborhood Hits	175
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

TMPS7_MOUSE
NC score	0.939739 (rank : 118)	θ value	1.98146e-39 (rank : 33)
Query Neighborhood Hits	178	Target Neighborhood Hits	275	Shared Neighborhood Hits	173
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

K1KB5_MOUSE
NC score	0.939266 (rank : 119)	θ value	7.56453e-23 (rank : 144)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P15945, Q52KM1, Q565D7	Gene names	Klk1b5, Klk-5, Klk5
Domain Architecture
Description	Kallikrein 1-related peptidase b5 precursor (EC 3.4.21.35) (Glandular kallikrein K5) (Tissue kallikrein-5) (mGK-5).

MCPT8_MOUSE
NC score	0.939128 (rank : 120)	θ value	1.42661e-21 (rank : 156)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	174
SwissProt Accessions	P43430, Q9R1F1	Gene names	Mcpt8
Domain Architecture
Description	Mast cell protease 8 precursor (EC 3.4.21.-) (MMCP-8).

TMPS7_HUMAN
NC score	0.938673 (rank : 121)	θ value	4.88048e-38 (rank : 44)
Query Neighborhood Hits	178	Target Neighborhood Hits	275	Shared Neighborhood Hits	173
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

THRB_HUMAN
NC score	0.938039 (rank : 122)	θ value	5.79196e-23 (rank : 142)
Query Neighborhood Hits	178	Target Neighborhood Hits	196	Shared Neighborhood Hits	175
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

EGFB2_MOUSE
NC score	0.937926 (rank : 123)	θ value	8.36355e-22 (rank : 153)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	174
SwissProt Accessions	P36368, P00754	Gene names	Egfbp2, Egfbp-2, Klk-13, Klk13
Domain Architecture
Description	Epidermal growth factor-binding protein type B precursor (EC 3.4.21.35) (EGF-BP B) (Glandular kallikrein K13) (Tissue kallikrein 13) (mGK-13) (Prorenin-converting enzyme) (PRECE).

K1KB8_MOUSE
NC score	0.937873 (rank : 124)	θ value	2.20094e-22 (rank : 150)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P07628	Gene names	Klk1b8, Klk-8, Klk8
Domain Architecture
Description	Kallikrein 1-related peptidase b8 precursor (EC 3.4.21.35) (Tissue kallikrein-8) (Glandular kallikrein K8) (mGK-8).

K1B26_MOUSE
NC score	0.937835 (rank : 125)	θ value	9.24701e-21 (rank : 159)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P36369, P00753, P00754	Gene names	Klk1b26, Klk-26, Klk26
Domain Architecture
Description	Kallikrein 1-related peptidase b26 precursor (EC 3.4.21.35) (Glandular kallikrein K26) (Tissue kallikrein 26) (mGK-26) (Prorenin-converting enzyme 2) (PRECE-2).

CFAI_HUMAN
NC score	0.935477 (rank : 126)	θ value	1.24688e-25 (rank : 117)
Query Neighborhood Hits	178	Target Neighborhood Hits	289	Shared Neighborhood Hits	175
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

GRAE_MOUSE
NC score	0.935017 (rank : 127)	θ value	2.97466e-19 (rank : 161)
Query Neighborhood Hits	178	Target Neighborhood Hits	172	Shared Neighborhood Hits	171
SwissProt Accessions	P08884, P97389	Gene names	Gzme, Ccp3, Ctla-6, Ctla6
Domain Architecture
Description	Granzyme E precursor (EC 3.4.21.-) (Cytotoxic cell protease 3) (CCP3) (CTL serine protease 2) (D12) (Cytotoxic serine protease 2) (MCSP2).

MCPT5_MOUSE
NC score	0.934403 (rank : 128)	θ value	1.5242e-23 (rank : 138)
Query Neighborhood Hits	178	Target Neighborhood Hits	175	Shared Neighborhood Hits	175
SwissProt Accessions	P21844, Q9R1F0	Gene names	Mcpt5
Domain Architecture
Description	Mast cell protease 5 precursor (EC 3.4.21.-) (MMCP-5) (Mast cell chymase 1).

GRAD_MOUSE
NC score	0.933847 (rank : 129)	θ value	2.5182e-18 (rank : 163)
Query Neighborhood Hits	178	Target Neighborhood Hits	173	Shared Neighborhood Hits	171
SwissProt Accessions	P11033, P97387	Gene names	Gzmd
Domain Architecture
Description	Granzyme D precursor (EC 3.4.21.-).

K1KB4_MOUSE
NC score	0.933581 (rank : 130)	θ value	2.43343e-21 (rank : 157)
Query Neighborhood Hits	178	Target Neighborhood Hits	177	Shared Neighborhood Hits	174
SwissProt Accessions	P00757	Gene names	Klk1b4, Klk-4, Klk4, Ngfa
Domain Architecture
Description	Kallikrein 1-related peptidase-like b4 precursor (7S nerve growth factor alpha chain) (Alpha-NGF).

HGFL_MOUSE
NC score	0.933472 (rank : 131)	θ value	3.87602e-27 (rank : 101)
Query Neighborhood Hits	178	Target Neighborhood Hits	188	Shared Neighborhood Hits	172
SwissProt Accessions	P26928	Gene names	Mst1, Hgfl
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

HGFL_HUMAN
NC score	0.933411 (rank : 132)	θ value	2.96777e-27 (rank : 99)
Query Neighborhood Hits	178	Target Neighborhood Hits	190	Shared Neighborhood Hits	173
SwissProt Accessions	P26927, Q13350, Q14870	Gene names	MST1, HGFL
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) (Macrophage-stimulating protein) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

ENTK_HUMAN
NC score	0.932987 (rank : 133)	θ value	1.16434e-31 (rank : 76)
Query Neighborhood Hits	178	Target Neighborhood Hits	310	Shared Neighborhood Hits	174
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

HGF_HUMAN
NC score	0.925492 (rank : 134)	θ value	2.35151e-24 (rank : 130)
Query Neighborhood Hits	178	Target Neighborhood Hits	191	Shared Neighborhood Hits	171
SwissProt Accessions	P14210, Q02935, Q13494, Q14519, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6	Gene names	HGF, HPTA
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

HGF_MOUSE
NC score	0.924989 (rank : 135)	θ value	4.73814e-25 (rank : 121)
Query Neighborhood Hits	178	Target Neighborhood Hits	192	Shared Neighborhood Hits	171
SwissProt Accessions	Q08048, Q61662, Q64007, Q6LBE6	Gene names	Hgf
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

K1B16_MOUSE
NC score	0.923274 (rank : 136)	θ value	1.92812e-18 (rank : 162)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	174
SwissProt Accessions	P04071	Gene names	Klk1b16, Klk-16, Klk16
Domain Architecture
Description	Kallikrein 1-related peptidase b16 precursor (EC 3.4.21.54) (Gamma- renin, submandibular gland) (mGK-16).

ENTK_MOUSE
NC score	0.922226 (rank : 137)	θ value	2.86786e-30 (rank : 83)
Query Neighborhood Hits	178	Target Neighborhood Hits	338	Shared Neighborhood Hits	174
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

FA12_HUMAN
NC score	0.916031 (rank : 138)	θ value	4.57862e-28 (rank : 95)
Query Neighborhood Hits	178	Target Neighborhood Hits	425	Shared Neighborhood Hits	176
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

PROC_HUMAN
NC score	0.915730 (rank : 139)	θ value	3.87602e-27 (rank : 102)
Query Neighborhood Hits	178	Target Neighborhood Hits	406	Shared Neighborhood Hits	174
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

HGFA_MOUSE
NC score	0.912286 (rank : 140)	θ value	5.584e-34 (rank : 66)
Query Neighborhood Hits	178	Target Neighborhood Hits	419	Shared Neighborhood Hits	174
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

FA7_MOUSE
NC score	0.911296 (rank : 141)	θ value	5.23862e-24 (rank : 134)
Query Neighborhood Hits	178	Target Neighborhood Hits	374	Shared Neighborhood Hits	174
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

HGFA_HUMAN
NC score	0.911210 (rank : 142)	θ value	1.24399e-33 (rank : 68)
Query Neighborhood Hits	178	Target Neighborhood Hits	436	Shared Neighborhood Hits	174
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

FA9_HUMAN
NC score	0.903681 (rank : 143)	θ value	4.89182e-30 (rank : 84)
Query Neighborhood Hits	178	Target Neighborhood Hits	421	Shared Neighborhood Hits	176
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

HPT_MOUSE
NC score	0.901695 (rank : 144)	θ value	1.09485e-13 (rank : 166)
Query Neighborhood Hits	178	Target Neighborhood Hits	178	Shared Neighborhood Hits	169
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

PROC_MOUSE
NC score	0.901370 (rank : 145)	θ value	7.30988e-26 (rank : 114)
Query Neighborhood Hits	178	Target Neighborhood Hits	426	Shared Neighborhood Hits	176
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

FA7_HUMAN
NC score	0.899181 (rank : 146)	θ value	4.73814e-25 (rank : 120)
Query Neighborhood Hits	178	Target Neighborhood Hits	404	Shared Neighborhood Hits	174
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

NETR_MOUSE
NC score	0.897032 (rank : 147)	θ value	3.06405e-32 (rank : 74)
Query Neighborhood Hits	178	Target Neighborhood Hits	216	Shared Neighborhood Hits	174
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

NETR_HUMAN
NC score	0.891193 (rank : 148)	θ value	1.37539e-32 (rank : 71)
Query Neighborhood Hits	178	Target Neighborhood Hits	218	Shared Neighborhood Hits	176
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

HPT_HUMAN
NC score	0.887474 (rank : 149)	θ value	1.9326e-10 (rank : 167)
Query Neighborhood Hits	178	Target Neighborhood Hits	184	Shared Neighborhood Hits	164
SwissProt Accessions	P00738, P00737, Q2PP15, Q3B7J0, Q6LBY9	Gene names	HP
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

HPTR_HUMAN
NC score	0.886959 (rank : 150)	θ value	3.29651e-10 (rank : 168)
Query Neighborhood Hits	178	Target Neighborhood Hits	166	Shared Neighborhood Hits	164
SwissProt Accessions	P00739, Q7LE20, Q92658, Q92659, Q9ULB0	Gene names	HPR
Domain Architecture
Description	Haptoglobin-related protein precursor.

FA10_HUMAN
NC score	0.885793 (rank : 151)	θ value	8.08199e-25 (rank : 122)
Query Neighborhood Hits	178	Target Neighborhood Hits	431	Shared Neighborhood Hits	176
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA10_MOUSE
NC score	0.884252 (rank : 152)	θ value	1.12775e-26 (rank : 107)
Query Neighborhood Hits	178	Target Neighborhood Hits	435	Shared Neighborhood Hits	176
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

HABP2_HUMAN
NC score	0.884082 (rank : 153)	θ value	8.91499e-32 (rank : 75)
Query Neighborhood Hits	178	Target Neighborhood Hits	431	Shared Neighborhood Hits	174
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

HABP2_MOUSE
NC score	0.883051 (rank : 154)	θ value	5.0505e-35 (rank : 62)
Query Neighborhood Hits	178	Target Neighborhood Hits	445	Shared Neighborhood Hits	174
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

ST14_HUMAN
NC score	0.873395 (rank : 155)	θ value	7.79185e-36 (rank : 58)
Query Neighborhood Hits	178	Target Neighborhood Hits	409	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

ST14_MOUSE
NC score	0.873214 (rank : 156)	θ value	1.9192e-34 (rank : 64)
Query Neighborhood Hits	178	Target Neighborhood Hits	419	Shared Neighborhood Hits	176
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

MASP1_MOUSE
NC score	0.865936 (rank : 157)	θ value	1.99067e-23 (rank : 139)
Query Neighborhood Hits	178	Target Neighborhood Hits	364	Shared Neighborhood Hits	176
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP1_HUMAN
NC score	0.861198 (rank : 158)	θ value	9.87957e-23 (rank : 145)
Query Neighborhood Hits	178	Target Neighborhood Hits	369	Shared Neighborhood Hits	174
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

CORIN_MOUSE
NC score	0.858430 (rank : 159)	θ value	8.61488e-35 (rank : 63)
Query Neighborhood Hits	178	Target Neighborhood Hits	451	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

CORIN_HUMAN
NC score	0.855691 (rank : 160)	θ value	2.26708e-35 (rank : 60)
Query Neighborhood Hits	178	Target Neighborhood Hits	453	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

MASP2_MOUSE
NC score	0.852135 (rank : 161)	θ value	5.23862e-24 (rank : 137)
Query Neighborhood Hits	178	Target Neighborhood Hits	382	Shared Neighborhood Hits	176
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MASP2_HUMAN
NC score	0.849503 (rank : 162)	θ value	4.01107e-24 (rank : 133)
Query Neighborhood Hits	178	Target Neighborhood Hits	364	Shared Neighborhood Hits	176
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

CS1B_MOUSE
NC score	0.840119 (rank : 163)	θ value	1.5773e-20 (rank : 160)
Query Neighborhood Hits	178	Target Neighborhood Hits	361	Shared Neighborhood Hits	172
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

C1S_HUMAN
NC score	0.836464 (rank : 164)	θ value	1.29031e-22 (rank : 146)
Query Neighborhood Hits	178	Target Neighborhood Hits	359	Shared Neighborhood Hits	172
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

CS1A_MOUSE
NC score	0.836074 (rank : 165)	θ value	1.42661e-21 (rank : 155)
Query Neighborhood Hits	178	Target Neighborhood Hits	360	Shared Neighborhood Hits	171
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

C1RB_MOUSE
NC score	0.833273 (rank : 166)	θ value	1.37858e-24 (rank : 126)
Query Neighborhood Hits	178	Target Neighborhood Hits	380	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

C1R_HUMAN
NC score	0.828721 (rank : 167)	θ value	4.9032e-22 (rank : 152)
Query Neighborhood Hits	178	Target Neighborhood Hits	364	Shared Neighborhood Hits	172
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

C1RA_MOUSE
NC score	0.825507 (rank : 168)	θ value	7.0802e-21 (rank : 158)
Query Neighborhood Hits	178	Target Neighborhood Hits	379	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

CO2_MOUSE
NC score	0.755128 (rank : 169)	θ value	1.29631e-06 (rank : 170)
Query Neighborhood Hits	178	Target Neighborhood Hits	250	Shared Neighborhood Hits	171
SwissProt Accessions	P21180	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CFAB_HUMAN
NC score	0.720563 (rank : 170)	θ value	1.69304e-06 (rank : 171)
Query Neighborhood Hits	178	Target Neighborhood Hits	251	Shared Neighborhood Hits	168
SwissProt Accessions	P00751, O15006, Q29944, Q96HX6, Q9BTF5, Q9BX92	Gene names	CFB, BF
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Glycine-rich beta glycoprotein) (GBG) (PBF2) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CO2_HUMAN
NC score	0.717735 (rank : 171)	θ value	2.88788e-06 (rank : 172)
Query Neighborhood Hits	178	Target Neighborhood Hits	258	Shared Neighborhood Hits	173
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CFAB_MOUSE
NC score	0.710717 (rank : 172)	θ value	6.87365e-08 (rank : 169)
Query Neighborhood Hits	178	Target Neighborhood Hits	262	Shared Neighborhood Hits	168
SwissProt Accessions	P04186	Gene names	Cfb, Bf, H2-Bf
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

PROZ_HUMAN
NC score	0.542500 (rank : 173)	θ value	0.00298849 (rank : 173)
Query Neighborhood Hits	178	Target Neighborhood Hits	422	Shared Neighborhood Hits	161
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PROZ_MOUSE
NC score	0.517080 (rank : 174)	θ value	0.125558 (rank : 177)
Query Neighborhood Hits	178	Target Neighborhood Hits	410	Shared Neighborhood Hits	159
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

KREM2_HUMAN
NC score	0.198966 (rank : 175)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	178	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NCW0, Q8N2J4, Q8NCW1, Q96GL8, Q9BTP9	Gene names	KREMEN2, KRM2
Domain Architecture
Description	Kremen protein 2 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 2) (Dickkopf receptor 2).

KREM1_MOUSE
NC score	0.197346 (rank : 176)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	178	Target Neighborhood Hits	92	Shared Neighborhood Hits	34
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

KREM2_MOUSE
NC score	0.193167 (rank : 177)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	178	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K1S7	Gene names	Kremen2
Domain Architecture
Description	Kremen protein 2 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 2) (Dickkopf receptor 2).

KREM1_HUMAN
NC score	0.193087 (rank : 178)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	178	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q96MU8, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1	Gene names	KREMEN1, KREMEN, KRM1
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

PRS23_MOUSE
NC score	0.161713 (rank : 179)	θ value	0.00665767 (rank : 175)
Query Neighborhood Hits	178	Target Neighborhood Hits	61	Shared Neighborhood Hits	53
SwissProt Accessions	Q9D6X6, Q544M8, Q8VEG1	Gene names	Prss23
Domain Architecture
Description	Serine protease 23 precursor (EC 3.4.21.-).

PRS23_HUMAN
NC score	0.159396 (rank : 180)	θ value	0.00665767 (rank : 174)
Query Neighborhood Hits	178	Target Neighborhood Hits	56	Shared Neighborhood Hits	49
SwissProt Accessions	O95084	Gene names	PRSS23, ZSIG13
Domain Architecture
Description	Serine protease 23 precursor (EC 3.4.21.-) (Putative secreted protein ZSIG13).

TMG1_HUMAN
NC score	0.125412 (rank : 181)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	178	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	O14668	Gene names	PRRG1, PRGP1, TMG1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 1 precursor (Proline- rich Gla protein 1) (Proline-rich gamma-carboxyglutamic acid protein 1).

LRP12_MOUSE
NC score	0.123841 (rank : 182)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	178	Target Neighborhood Hits	180	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP12_HUMAN
NC score	0.122425 (rank : 183)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	178	Target Neighborhood Hits	205	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

CD320_HUMAN
NC score	0.121676 (rank : 184)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	178	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LRP3_HUMAN
NC score	0.121430 (rank : 185)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	178	Target Neighborhood Hits	280	Shared Neighborhood Hits	29
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

MFRP_MOUSE
NC score	0.116772 (rank : 186)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	178	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

TMG3_HUMAN
NC score	0.113326 (rank : 187)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	178	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZD7, Q8N2N6	Gene names	PRRG3, TMG3
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

TMG3_MOUSE
NC score	0.111433 (rank : 188)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	178	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PAQ9	Gene names	Prrg3, Gm368, Tmg3
Domain Architecture	No domain graphic available
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

MFRP_HUMAN
NC score	0.110256 (rank : 189)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	178	Target Neighborhood Hits	165	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

PRGB_HUMAN
NC score	0.107599 (rank : 190)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	178	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q02325	Gene names	PLGL, PRGB
Domain Architecture
Description	Plasminogen-related protein B precursor.

TMG4_HUMAN
NC score	0.097436 (rank : 191)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	178	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZD6	Gene names	PRRG4, TMG4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

DMBT1_MOUSE
NC score	0.096759 (rank : 192)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	178	Target Neighborhood Hits	134	Shared Neighborhood Hits	28
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

LRP2_HUMAN
NC score	0.096595 (rank : 193)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	178	Target Neighborhood Hits	573	Shared Neighborhood Hits	52
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

TMG2_HUMAN
NC score	0.096139 (rank : 194)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	178	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	O14669	Gene names	PRRG2, PRGP2, TMG2
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2).

TLL2_MOUSE
NC score	0.094658 (rank : 195)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	178	Target Neighborhood Hits	240	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TLL2_HUMAN
NC score	0.094509 (rank : 196)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	178	Target Neighborhood Hits	241	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TLL1_HUMAN
NC score	0.094133 (rank : 197)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	178	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

BMP1_MOUSE
NC score	0.093509 (rank : 198)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	178	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

TLL1_MOUSE
NC score	0.093324 (rank : 199)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	178	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

BMP1_HUMAN
NC score	0.092970 (rank : 200)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	178	Target Neighborhood Hits	233	Shared Neighborhood Hits	27
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

TMG4_MOUSE
NC score	0.092793 (rank : 201)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	178	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BGN6, Q8BM25	Gene names	Prrg4, Tmg4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

TMG2_MOUSE
NC score	0.091243 (rank : 202)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	178	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R182, Q9EQI2	Gene names	Prrg2, N4wbp1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2) (NEDD4 WW domain-binding protein 1).

LRP1B_MOUSE
NC score	0.090362 (rank : 203)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	178	Target Neighborhood Hits	606	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

DMBT1_HUMAN
NC score	0.089779 (rank : 204)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	178	Target Neighborhood Hits	152	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

PCOC2_HUMAN
NC score	0.089017 (rank : 205)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	178	Target Neighborhood Hits	73	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UKZ9, Q9BRH3	Gene names	PCOLCE2, PCPE2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

LRP10_HUMAN
NC score	0.088950 (rank : 206)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	178	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LRP10_MOUSE
NC score	0.088822 (rank : 207)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	178	Target Neighborhood Hits	169	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LRP1B_HUMAN
NC score	0.088528 (rank : 208)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	178	Target Neighborhood Hits	602	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

PCOC1_MOUSE
NC score	0.087625 (rank : 209)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	178	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q61398, O35113	Gene names	Pcolce, Pcpe1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein) (P14).

PCOC1_HUMAN
NC score	0.086013 (rank : 210)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	178	Target Neighborhood Hits	146	Shared Neighborhood Hits	17
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

VLDLR_MOUSE
NC score	0.085408 (rank : 211)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	178	Target Neighborhood Hits	360	Shared Neighborhood Hits	39
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

PCOC2_MOUSE
NC score	0.085212 (rank : 212)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	178	Target Neighborhood Hits	73	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4W6, Q3V1K6, Q9CX06	Gene names	Pcolce2, Pcpe2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

LRP1_HUMAN
NC score	0.084837 (rank : 213)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	178	Target Neighborhood Hits	617	Shared Neighborhood Hits	50
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP8_MOUSE
NC score	0.084169 (rank : 214)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	178	Target Neighborhood Hits	385	Shared Neighborhood Hits	39
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_HUMAN
NC score	0.083898 (rank : 215)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	178	Target Neighborhood Hits	383	Shared Neighborhood Hits	40
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP4_HUMAN
NC score	0.082921 (rank : 216)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	178	Target Neighborhood Hits	355	Shared Neighborhood Hits	40
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LDLR_MOUSE
NC score	0.082585 (rank : 217)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	178	Target Neighborhood Hits	382	Shared Neighborhood Hits	41
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LDLR_HUMAN
NC score	0.082282 (rank : 218)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	178	Target Neighborhood Hits	375	Shared Neighborhood Hits	41
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP4_MOUSE
NC score	0.082087 (rank : 219)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	178	Target Neighborhood Hits	351	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

DCBD1_MOUSE
NC score	0.081264 (rank : 220)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	178	Target Neighborhood Hits	89	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D4J3, Q8R327, Q9D696	Gene names	Dcbld1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

LRP6_HUMAN
NC score	0.080871 (rank : 221)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	178	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
NC score	0.080696 (rank : 222)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	178	Target Neighborhood Hits	346	Shared Neighborhood Hits	36
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

CUZD1_HUMAN
NC score	0.080405 (rank : 223)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	178	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

LRP6_MOUSE
NC score	0.080243 (rank : 224)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	178	Target Neighborhood Hits	232	Shared Neighborhood Hits	38
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

CUBN_MOUSE
NC score	0.078696 (rank : 225)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	178	Target Neighborhood Hits	477	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

SORL_MOUSE
NC score	0.078277 (rank : 226)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	178	Target Neighborhood Hits	439	Shared Neighborhood Hits	25
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

CUZD1_MOUSE
NC score	0.075685 (rank : 227)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	178	Target Neighborhood Hits	91	Shared Neighborhood Hits	17
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

PROS_HUMAN
NC score	0.075400 (rank : 228)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	178	Target Neighborhood Hits	340	Shared Neighborhood Hits	30
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

SORL_HUMAN
NC score	0.075237 (rank : 229)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	178	Target Neighborhood Hits	440	Shared Neighborhood Hits	23
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

CSMD3_HUMAN
NC score	0.074758 (rank : 230)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	178	Target Neighborhood Hits	199	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

NETO1_MOUSE
NC score	0.074634 (rank : 231)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	178	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

CUBN_HUMAN
NC score	0.073967 (rank : 232)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	178	Target Neighborhood Hits	482	Shared Neighborhood Hits	37
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

NETO1_HUMAN
NC score	0.073839 (rank : 233)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	178	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

CSMD1_MOUSE
NC score	0.073460 (rank : 234)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	178	Target Neighborhood Hits	193	Shared Neighborhood Hits	22
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

CSMD1_HUMAN
NC score	0.073370 (rank : 235)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	178	Target Neighborhood Hits	176	Shared Neighborhood Hits	24
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

SEZ6L_HUMAN
NC score	0.072897 (rank : 236)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	178	Target Neighborhood Hits	289	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

CSMD2_HUMAN
NC score	0.072635 (rank : 237)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	178	Target Neighborhood Hits	188	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

GAS6_HUMAN
NC score	0.072373 (rank : 238)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	178	Target Neighborhood Hits	348	Shared Neighborhood Hits	35
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

NETO2_HUMAN
NC score	0.072129 (rank : 239)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	178	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO2_MOUSE
NC score	0.071831 (rank : 240)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	178	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NRP1_MOUSE
NC score	0.071289 (rank : 241)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	178	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	P97333	Gene names	Nrp1, Nrp
Domain Architecture
Description	Neuropilin-1 precursor (A5 protein).

NRP1_HUMAN
NC score	0.070942 (rank : 242)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	178	Target Neighborhood Hits	119	Shared Neighborhood Hits	18
SwissProt Accessions	O14786, O60461, Q96IH5	Gene names	NRP1, NRP, VEGF165R
Domain Architecture
Description	Neuropilin-1 precursor (Vascular endothelial cell growth factor 165 receptor) (CD304 antigen).

NRP2_MOUSE
NC score	0.070926 (rank : 243)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	178	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O35375, O35373, O35374, O35376, O35377, O35378	Gene names	Nrp2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

NRP2_HUMAN
NC score	0.070744 (rank : 244)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	178	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

LRP5_HUMAN
NC score	0.069446 (rank : 245)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	178	Target Neighborhood Hits	224	Shared Neighborhood Hits	33
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

PROS_MOUSE
NC score	0.069310 (rank : 246)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	178	Target Neighborhood Hits	330	Shared Neighborhood Hits	27
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

LRP5_MOUSE
NC score	0.068316 (rank : 247)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	178	Target Neighborhood Hits	236	Shared Neighborhood Hits	29
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

GAS6_MOUSE
NC score	0.068279 (rank : 248)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	178	Target Neighborhood Hits	343	Shared Neighborhood Hits	32
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

PDGFD_MOUSE
NC score	0.067939 (rank : 249)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	178	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q925I7, Q3URF6, Q8K2L3, Q9D1L8	Gene names	Pdgfd, Scdgfb
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor chain precursor (PDGF D) (Spinal cord- derived growth factor B) (SCDGF-B).

PDGFD_HUMAN
NC score	0.067665 (rank : 250)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	178	Target Neighborhood Hits	74	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZP0, Q9BWV5	Gene names	PDGFD, IEGF, SCDGFB
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor D precursor (PDGF D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B).

TSG6_HUMAN
NC score	0.065761 (rank : 251)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	178	Target Neighborhood Hits	91	Shared Neighborhood Hits	14
SwissProt Accessions	P98066, Q8WWI9	Gene names	TNFAIP6, TSG6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein) (Hyaluronate-binding protein).

CO9_HUMAN
NC score	0.064659 (rank : 252)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	178	Target Neighborhood Hits	147	Shared Neighborhood Hits	25
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

CO6_HUMAN
NC score	0.064499 (rank : 253)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	178	Target Neighborhood Hits	331	Shared Neighborhood Hits	37
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

TSG6_MOUSE
NC score	0.064445 (rank : 254)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	178	Target Neighborhood Hits	91	Shared Neighborhood Hits	14
SwissProt Accessions	O08859	Gene names	Tnfaip6, Tnfip6, Tsg6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein).

LRP11_MOUSE
NC score	0.061644 (rank : 255)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	178	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

SSPO_MOUSE
NC score	0.061251 (rank : 256)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	178	Target Neighborhood Hits	800	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

C163B_HUMAN
NC score	0.060724 (rank : 257)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	178	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

LRP11_HUMAN
NC score	0.060506 (rank : 258)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	178	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

EGFL8_HUMAN
NC score	0.059936 (rank : 259)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	178	Target Neighborhood Hits	270	Shared Neighborhood Hits	28
SwissProt Accessions	Q99944, Q8IV30	Gene names	EGFL8, C6orf8, NG3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8) (Vascular endothelial-statin 2) (VE-statin-2).

EGFL8_MOUSE
NC score	0.059905 (rank : 260)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	178	Target Neighborhood Hits	266	Shared Neighborhood Hits	28
SwissProt Accessions	Q6GUQ1, O35447	Gene names	Egfl8, Ng3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8).

CO9_MOUSE
NC score	0.059217 (rank : 261)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	178	Target Neighborhood Hits	153	Shared Neighborhood Hits	21
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

DCBD1_HUMAN
NC score	0.059000 (rank : 262)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	178	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

CD5L_MOUSE
NC score	0.057153 (rank : 263)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	178	Target Neighborhood Hits	49	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

IDD_HUMAN
NC score	0.057105 (rank : 264)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	178	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

DCBD2_HUMAN
NC score	0.056335 (rank : 265)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	178	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PD2, Q8N6M4, Q8TDX2	Gene names	DCBLD2, CLCP1, ESDN
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein) (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1).

CD5L_HUMAN
NC score	0.055388 (rank : 266)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	178	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

GP126_HUMAN
NC score	0.052994 (rank : 267)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	178	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

DCBD2_MOUSE
NC score	0.052810 (rank : 268)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	178	Target Neighborhood Hits	113	Shared Neighborhood Hits	14
SwissProt Accessions	Q91ZV3, Q8BKI4	Gene names	Dcbld2, Esdn
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein).

SPIT1_HUMAN
NC score	0.052792 (rank : 269)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	178	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT1_MOUSE
NC score	0.052261 (rank : 270)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	178	Target Neighborhood Hits	96	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

LYAM2_HUMAN
NC score	0.051007 (rank : 271)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	178	Target Neighborhood Hits	394	Shared Neighborhood Hits	30
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

DLP1_HUMAN
NC score	0.014213 (rank : 272)	θ value	0.125558 (rank : 176)
Query Neighborhood Hits	178	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YH6, Q33DR4, Q4G158, Q5VU38, Q5VU39, Q9NR58	Gene names	PDSS2, C6orf210, DLP1
Domain Architecture	No domain graphic available
Description	Decaprenyl-diphosphate synthase subunit 2 (EC 2.5.1.-) (Decaprenyl pyrophosphate synthetase subunit 2) (Candidate tumor suppressor protein).

KRA54_HUMAN
NC score	0.009174 (rank : 273)	θ value	5.27518 (rank : 178)
Query Neighborhood Hits	178	Target Neighborhood Hits	270	Shared Neighborhood Hits	9
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).