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Network neighborhood for query Sequence : CD5L_HUMAN

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CD5L_HUMAN
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CD5L_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

CD5L_MOUSE
θ value	8.33966e-147 (rank : 2)	NC score	0.995486 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

DMBT1_HUMAN
θ value	3.23591e-74 (rank : 3)	NC score	0.772569 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	152	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

C163A_MOUSE
θ value	6.10265e-73 (rank : 4)	NC score	0.953500 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q2VLH6, Q2VLH5, Q99MX8	Gene names	Cd163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) [Contains: Soluble CD163 (sCD163)].

C163B_HUMAN
θ value	1.27248e-70 (rank : 5)	NC score	0.950819 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	64	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

DMBT1_MOUSE
θ value	1.83746e-69 (rank : 6)	NC score	0.702619 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	134	Shared Neighborhood Hits	36
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

C163A_HUMAN
θ value	2.3998e-69 (rank : 7)	NC score	0.951535 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	34
SwissProt Accessions	Q86VB7, Q07898, Q07899, Q07900, Q07901, Q2VLH7	Gene names	CD163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)].

NETR_HUMAN
θ value	5.17823e-64 (rank : 8)	NC score	0.469437 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	218	Shared Neighborhood Hits	36
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
θ value	7.47731e-63 (rank : 9)	NC score	0.456305 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	216	Shared Neighborhood Hits	36
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

CD6_HUMAN
θ value	6.14528e-49 (rank : 10)	NC score	0.936369 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CD6_MOUSE
θ value	1.73182e-43 (rank : 11)	NC score	0.933170 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	62	Shared Neighborhood Hits	32
SwissProt Accessions	Q61003, Q60679, Q61004	Gene names	Cd6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor.

LOXL3_HUMAN
θ value	9.50281e-42 (rank : 12)	NC score	0.840216 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	P58215, Q96RS1	Gene names	LOXL3, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3).

LOXL2_MOUSE
θ value	8.04462e-41 (rank : 13)	NC score	0.842604 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

LOXL3_MOUSE
θ value	2.34062e-40 (rank : 14)	NC score	0.841043 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z175, Q9JJ39	Gene names	Loxl3, Lor2
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3) (Lysyl oxidase-related protein 2).

LOXL4_HUMAN
θ value	2.34062e-40 (rank : 15)	NC score	0.842960 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q96JB6, Q96DY1, Q96PC0, Q9H6T5	Gene names	LOXL4, LOXC
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL2_HUMAN
θ value	1.51715e-39 (rank : 16)	NC score	0.840067 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y4K0, Q9BW70, Q9Y5Y8	Gene names	LOXL2
Domain Architecture
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14).

LOXL4_MOUSE
θ value	4.88048e-38 (rank : 17)	NC score	0.842028 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	Q924C6	Gene names	Loxl4, Loxc
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

MSRE_MOUSE
θ value	1.42661e-21 (rank : 18)	NC score	0.685331 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P30204, Q923G0, Q9QZ56	Gene names	Msr1, Scvr
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A).

MARCO_HUMAN
θ value	5.42112e-21 (rank : 19)	NC score	0.535981 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	199	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UEW3, Q9Y5S3	Gene names	MARCO, SCARA2
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2).

MSRE_HUMAN
θ value	1.5773e-20 (rank : 20)	NC score	0.624542 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	298	Shared Neighborhood Hits	30
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

MARCO_MOUSE
θ value	4.58923e-20 (rank : 21)	NC score	0.429375 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	242	Shared Neighborhood Hits	30
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

LG3BP_HUMAN
θ value	2.35696e-16 (rank : 22)	NC score	0.851096 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q08380	Gene names	LGALS3BP, M2BP
Domain Architecture
Description	Galectin-3-binding protein precursor (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (Mac-2 BP) (MAC2BP) (Tumor-associated antigen 90K).

CD5_MOUSE
θ value	1.58096e-12 (rank : 23)	NC score	0.617108 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	33	Shared Neighborhood Hits	24
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

CD5_HUMAN
θ value	2.61198e-07 (rank : 24)	NC score	0.569783 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P06127	Gene names	CD5, LEU1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu- 1).

CFAI_HUMAN
θ value	0.000461057 (rank : 25)	NC score	0.137234 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	289	Shared Neighborhood Hits	35
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CORIN_MOUSE
θ value	0.00390308 (rank : 26)	NC score	0.084231 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	451	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

ENTK_MOUSE
θ value	0.0113563 (rank : 27)	NC score	0.130321 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	338	Shared Neighborhood Hits	35
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TMPS5_MOUSE
θ value	0.0193708 (rank : 28)	NC score	0.080844 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

ENTK_HUMAN
θ value	0.0736092 (rank : 29)	NC score	0.117093 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

CORIN_HUMAN
θ value	0.163984 (rank : 30)	NC score	0.070583 (rank : 52)
Query Neighborhood Hits	45	Target Neighborhood Hits	453	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

TMPS5_HUMAN
θ value	0.365318 (rank : 31)	NC score	0.074777 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS3_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.101729 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS2_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.075744 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	252	Shared Neighborhood Hits	25
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

CFAI_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.132386 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	290	Shared Neighborhood Hits	34
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

TLL2_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.065989 (rank : 64)
Query Neighborhood Hits	45	Target Neighborhood Hits	240	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TMPS4_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.079623 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

LTB1L_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.007019 (rank : 181)
Query Neighborhood Hits	45	Target Neighborhood Hits	514	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.007031 (rank : 180)
Query Neighborhood Hits	45	Target Neighborhood Hits	479	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

TLL1_MOUSE
θ value	4.03905 (rank : 39)	NC score	0.068050 (rank : 58)
Query Neighborhood Hits	45	Target Neighborhood Hits	237	Shared Neighborhood Hits	12
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

TMPS3_MOUSE
θ value	5.27518 (rank : 40)	NC score	0.098104 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

XLKD1_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.010747 (rank : 179)
Query Neighborhood Hits	45	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BHC0, Q3TUC1, Q99NE4	Gene names	Xlkd1, Crsbp1
Domain Architecture	No domain graphic available
Description	Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1).

FBLN5_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.003909 (rank : 182)
Query Neighborhood Hits	45	Target Neighborhood Hits	317	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

TLL1_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.066839 (rank : 62)
Query Neighborhood Hits	45	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

UROM_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.035621 (rank : 178)
Query Neighborhood Hits	45	Target Neighborhood Hits	284	Shared Neighborhood Hits	13
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

ZBTB6_HUMAN
θ value	8.99809 (rank : 45)	NC score	-0.003620 (rank : 183)
Query Neighborhood Hits	45	Target Neighborhood Hits	805	Shared Neighborhood Hits	2
SwissProt Accessions	Q15916	Gene names	ZBTB6, ZID, ZNF482
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain).

ACRO_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.060981 (rank : 77)
Query Neighborhood Hits	45	Target Neighborhood Hits	291	Shared Neighborhood Hits	14
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

ACRO_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.062125 (rank : 71)
Query Neighborhood Hits	45	Target Neighborhood Hits	185	Shared Neighborhood Hits	14
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

APOA_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.052453 (rank : 165)
Query Neighborhood Hits	45	Target Neighborhood Hits	221	Shared Neighborhood Hits	16
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

BMP1_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.062145 (rank : 70)
Query Neighborhood Hits	45	Target Neighborhood Hits	233	Shared Neighborhood Hits	11
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BMP1_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.062295 (rank : 69)
Query Neighborhood Hits	45	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BSSP4_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.057748 (rank : 108)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

BSSP4_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.057956 (rank : 106)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

C1RA_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.068173 (rank : 56)
Query Neighborhood Hits	45	Target Neighborhood Hits	379	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.069367 (rank : 55)
Query Neighborhood Hits	45	Target Neighborhood Hits	380	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

C1R_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.069662 (rank : 54)
Query Neighborhood Hits	45	Target Neighborhood Hits	364	Shared Neighborhood Hits	23
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

C1S_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.071139 (rank : 51)
Query Neighborhood Hits	45	Target Neighborhood Hits	359	Shared Neighborhood Hits	22
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

CFAD_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.053562 (rank : 150)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

CFAD_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.054321 (rank : 141)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P03953, Q61280	Gene names	Cfd, Adn, Df
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin) (28 kDa adipocyte protein).

CLCR_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.057734 (rank : 110)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

CS1A_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.071495 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	360	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

CS1B_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.072475 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	361	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CSMD2_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.051316 (rank : 169)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

CTRB1_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.056748 (rank : 118)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

CTRL_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.057047 (rank : 116)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

CUZD1_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.116706 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	89	Shared Neighborhood Hits	8
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

CUZD1_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.120423 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

DESC4_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.059614 (rank : 91)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

ELA1_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.056249 (rank : 123)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UNI1, Q5MLF0, Q6DJT0, Q6ISM6	Gene names	ELA1
Domain Architecture
Description	Elastase-1 precursor (EC 3.4.21.36).

ELA2A_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.055664 (rank : 128)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

ELA2A_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.055388 (rank : 133)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

ELA2B_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.055407 (rank : 132)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

ELA3A_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.055829 (rank : 126)
Query Neighborhood Hits	45	Target Neighborhood Hits	173	Shared Neighborhood Hits	14
SwissProt Accessions	P09093, Q9BRW4	Gene names	ELA3A, ELA3
Domain Architecture
Description	Elastase-3A precursor (EC 3.4.21.70) (Elastase IIIA) (Protease E).

ELA3B_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.055240 (rank : 134)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

ELNE_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.050543 (rank : 176)
Query Neighborhood Hits	45	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q3UP87, Q61515	Gene names	Ela2
Domain Architecture	No domain graphic available
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase).

FA10_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.054152 (rank : 143)
Query Neighborhood Hits	45	Target Neighborhood Hits	431	Shared Neighborhood Hits	21
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA10_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.053722 (rank : 146)
Query Neighborhood Hits	45	Target Neighborhood Hits	435	Shared Neighborhood Hits	21
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA11_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.060088 (rank : 86)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

FA11_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.058864 (rank : 102)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

FA12_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.054402 (rank : 140)
Query Neighborhood Hits	45	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

FA7_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.052904 (rank : 161)
Query Neighborhood Hits	45	Target Neighborhood Hits	404	Shared Neighborhood Hits	21
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

FA7_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.053722 (rank : 147)
Query Neighborhood Hits	45	Target Neighborhood Hits	374	Shared Neighborhood Hits	20
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

GRAK_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.051277 (rank : 171)
Query Neighborhood Hits	45	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	O35205	Gene names	Gzmk
Domain Architecture
Description	Granzyme K precursor (EC 3.4.21.-).

HABP2_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.053416 (rank : 152)
Query Neighborhood Hits	45	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

HABP2_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.053048 (rank : 158)
Query Neighborhood Hits	45	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

HEPS_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.061230 (rank : 75)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HEPS_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.060710 (rank : 78)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HGFA_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.054897 (rank : 137)
Query Neighborhood Hits	45	Target Neighborhood Hits	436	Shared Neighborhood Hits	18
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

HGFA_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.053586 (rank : 149)
Query Neighborhood Hits	45	Target Neighborhood Hits	419	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

HPTR_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.051294 (rank : 170)
Query Neighborhood Hits	45	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	P00739, Q7LE20, Q92658, Q92659, Q9ULB0	Gene names	HPR
Domain Architecture
Description	Haptoglobin-related protein precursor.

HPT_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.051409 (rank : 168)
Query Neighborhood Hits	45	Target Neighborhood Hits	184	Shared Neighborhood Hits	14
SwissProt Accessions	P00738, P00737, Q2PP15, Q3B7J0, Q6LBY9	Gene names	HP
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

HPT_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.051242 (rank : 172)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

KLK10_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.053703 (rank : 148)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	O43240, Q99920, Q9GZW9	Gene names	KLK10, NES1, PRRSL1
Domain Architecture
Description	Kallikrein-10 precursor (EC 3.4.21.-) (Protease serine-like 1) (Normal epithelial cell-specific 1).

KLK12_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.050020 (rank : 177)
Query Neighborhood Hits	45	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKR0, Q9UKR1	Gene names	KLK12, KLKL5
Domain Architecture
Description	Kallikrein-12 precursor (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5).

KLK13_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.053378 (rank : 154)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKR3, Q9Y433	Gene names	KLK13, KLKL4
Domain Architecture
Description	Kallikrein-13 precursor (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4).

KLK15_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.050814 (rank : 174)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2R5, Q15358, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9	Gene names	KLK15
Domain Architecture
Description	Kallikrein-15 precursor (EC 3.4.21.-) (ACO protease).

KLK6_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.053386 (rank : 153)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q92876	Gene names	KLK6, PRSS18, PRSS9
Domain Architecture
Description	Kallikrein-6 precursor (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59).

KLK7_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.050642 (rank : 175)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q91VE3, Q9R048	Gene names	Klk7, Prss6, Scce
Domain Architecture	No domain graphic available
Description	Kallikrein-7 precursor (EC 3.4.21.-) (Stratum corneum chymotryptic enzyme) (Thymopsin).

KLKB1_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.057873 (rank : 107)
Query Neighborhood Hits	45	Target Neighborhood Hits	183	Shared Neighborhood Hits	14
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

KLKB1_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.059126 (rank : 98)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

KREM1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.055186 (rank : 135)
Query Neighborhood Hits	45	Target Neighborhood Hits	90	Shared Neighborhood Hits	9
SwissProt Accessions	Q96MU8, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1	Gene names	KREMEN1, KREMEN, KRM1
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

KREM1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.057732 (rank : 111)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

LOXL1_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.287334 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

LOXL1_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.286341 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

LRP12_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.061332 (rank : 74)
Query Neighborhood Hits	45	Target Neighborhood Hits	205	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP12_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.061409 (rank : 73)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LYOX_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.302025 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P28300, Q5FWF0	Gene names	LOX
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase).

LYOX_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.299729 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P28301	Gene names	Lox, Rrg
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase) (RAS excision protein).

MASP1_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.073044 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	369	Shared Neighborhood Hits	23
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

MASP1_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.072574 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	364	Shared Neighborhood Hits	23
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP2_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.071373 (rank : 50)
Query Neighborhood Hits	45	Target Neighborhood Hits	364	Shared Neighborhood Hits	22
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MASP2_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.068031 (rank : 59)
Query Neighborhood Hits	45	Target Neighborhood Hits	382	Shared Neighborhood Hits	22
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MCPT6_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.056156 (rank : 124)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

MFRP_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.061752 (rank : 72)
Query Neighborhood Hits	45	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

MFRP_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.062401 (rank : 68)
Query Neighborhood Hits	45	Target Neighborhood Hits	166	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

NETO1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.058017 (rank : 105)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.057308 (rank : 115)
Query Neighborhood Hits	45	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO2_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.059128 (rank : 97)
Query Neighborhood Hits	45	Target Neighborhood Hits	109	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO2_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.059454 (rank : 94)
Query Neighborhood Hits	45	Target Neighborhood Hits	113	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NRPN_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.051561 (rank : 167)
Query Neighborhood Hits	45	Target Neighborhood Hits	182	Shared Neighborhood Hits	14
SwissProt Accessions	O60259, Q9HCB3, Q9UIL9, Q9UQ47	Gene names	KLK8, NRPN, PRSS19, TADG14
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein).

NRPN_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.052563 (rank : 163)
Query Neighborhood Hits	45	Target Neighborhood Hits	186	Shared Neighborhood Hits	14
SwissProt Accessions	Q61955	Gene names	Klk8, Nrpn, Prss19
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8).

PCOC1_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.060104 (rank : 85)
Query Neighborhood Hits	45	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

PCOC1_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.061072 (rank : 76)
Query Neighborhood Hits	45	Target Neighborhood Hits	100	Shared Neighborhood Hits	7
SwissProt Accessions	Q61398, O35113	Gene names	Pcolce, Pcpe1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein) (P14).

PCOC2_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.066261 (rank : 63)
Query Neighborhood Hits	45	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKZ9, Q9BRH3	Gene names	PCOLCE2, PCPE2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

PCOC2_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.067081 (rank : 61)
Query Neighborhood Hits	45	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4W6, Q3V1K6, Q9CX06	Gene names	Pcolce2, Pcpe2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

PLMN_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.053101 (rank : 157)
Query Neighborhood Hits	45	Target Neighborhood Hits	204	Shared Neighborhood Hits	14
SwissProt Accessions	P00747, Q15146, Q6PA00	Gene names	PLG
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

PLMN_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.052940 (rank : 159)
Query Neighborhood Hits	45	Target Neighborhood Hits	208	Shared Neighborhood Hits	14
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

POLS2_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.056547 (rank : 120)
Query Neighborhood Hits	45	Target Neighborhood Hits	192	Shared Neighborhood Hits	14
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

POLS2_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.054944 (rank : 136)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

PROC_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.054876 (rank : 138)
Query Neighborhood Hits	45	Target Neighborhood Hits	406	Shared Neighborhood Hits	21
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

PROC_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.053376 (rank : 155)
Query Neighborhood Hits	45	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

PRS27_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.057436 (rank : 114)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

PRS27_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.057626 (rank : 112)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

PRSS8_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.055706 (rank : 127)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

PRSS8_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.056619 (rank : 119)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

ST14_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.077269 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	409	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

ST14_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.079467 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	419	Shared Neighborhood Hits	22
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

TECTB_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.056518 (rank : 122)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PL2	Gene names	TECTB
Domain Architecture
Description	Beta-tectorin precursor.

TECTB_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.056545 (rank : 121)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O08524	Gene names	Tectb
Domain Architecture
Description	Beta-tectorin precursor.

TEST_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.060607 (rank : 82)
Query Neighborhood Hits	45	Target Neighborhood Hits	172	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

TEST_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.057476 (rank : 113)
Query Neighborhood Hits	45	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

TGBR3_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.056111 (rank : 125)
Query Neighborhood Hits	45	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q03167, Q5T2T4, Q5U731, Q9UGI2	Gene names	TGFBR3
Domain Architecture
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

TGBR3_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.054706 (rank : 139)
Query Neighborhood Hits	45	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O88393, Q6NS72	Gene names	Tgfbr3
Domain Architecture	No domain graphic available
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

THRB_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.053527 (rank : 151)
Query Neighborhood Hits	45	Target Neighborhood Hits	196	Shared Neighborhood Hits	14
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

THRB_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.052769 (rank : 162)
Query Neighborhood Hits	45	Target Neighborhood Hits	195	Shared Neighborhood Hits	14
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

TLL2_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.064153 (rank : 67)
Query Neighborhood Hits	45	Target Neighborhood Hits	241	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TM11D_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.059566 (rank : 92)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11D_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.060062 (rank : 87)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11E_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.060393 (rank : 84)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TM11E_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.059040 (rank : 99)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TMPS2_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.065762 (rank : 65)
Query Neighborhood Hits	45	Target Neighborhood Hits	243	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS4_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.067399 (rank : 60)
Query Neighborhood Hits	45	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

TMPS6_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.059919 (rank : 89)
Query Neighborhood Hits	45	Target Neighborhood Hits	338	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS6_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.059347 (rank : 96)
Query Neighborhood Hits	45	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS7_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.070577 (rank : 53)
Query Neighborhood Hits	45	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TMPS7_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.068053 (rank : 57)
Query Neighborhood Hits	45	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TMPS9_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.058930 (rank : 101)
Query Neighborhood Hits	45	Target Neighborhood Hits	276	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

TMPS9_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.058561 (rank : 103)
Query Neighborhood Hits	45	Target Neighborhood Hits	296	Shared Neighborhood Hits	14
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

TMPSD_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.073205 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPSD_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.091757 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	334	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMSP8_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.059958 (rank : 88)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

TPA_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.059481 (rank : 93)
Query Neighborhood Hits	45	Target Neighborhood Hits	324	Shared Neighborhood Hits	16
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TPA_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.060688 (rank : 80)
Query Neighborhood Hits	45	Target Neighborhood Hits	335	Shared Neighborhood Hits	16
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TRY1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.052558 (rank : 164)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	P07477, Q92955, Q9HAN4, Q9HAN5, Q9HAN6, Q9HAN7	Gene names	PRSS1, TRP1, TRY1, TRYP1
Domain Architecture
Description	Trypsin-1 precursor (EC 3.4.21.4) (Trypsin I) (Cationic trypsinogen).

TRY2_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.052297 (rank : 166)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P07478	Gene names	PRSS2, TRY2, TRYP2
Domain Architecture
Description	Trypsin-2 precursor (EC 3.4.21.4) (Trypsin II) (Anionic trypsinogen).

TRY2_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.052908 (rank : 160)
Query Neighborhood Hits	45	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	P07146	Gene names	Prss2, Try2
Domain Architecture
Description	Anionic trypsin-2 precursor (EC 3.4.21.4) (Anionic trypsin II) (Pretrypsinogen II).

TRY3_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.053194 (rank : 156)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

TRYA1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.055606 (rank : 129)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

TRYB1_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.055496 (rank : 130)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB1_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.054200 (rank : 142)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

TRYB2_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.055496 (rank : 131)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

TRYD_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.053994 (rank : 145)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

TRYG1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.058189 (rank : 104)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TRYG1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.059007 (rank : 100)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TSG6_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.060704 (rank : 79)
Query Neighborhood Hits	45	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	P98066, Q8WWI9	Gene names	TNFAIP6, TSG6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein) (Hyaluronate-binding protein).

TSG6_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.060605 (rank : 83)
Query Neighborhood Hits	45	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	O08859	Gene names	Tnfaip6, Tnfip6, Tsg6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein).

TSP50_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.060670 (rank : 81)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

UROK_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.059698 (rank : 90)
Query Neighborhood Hits	45	Target Neighborhood Hits	272	Shared Neighborhood Hits	16
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

UROK_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.056986 (rank : 117)
Query Neighborhood Hits	45	Target Neighborhood Hits	273	Shared Neighborhood Hits	16
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

ZP2_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.065102 (rank : 66)
Query Neighborhood Hits	45	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q05996	Gene names	ZP2, ZPA
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

ZP2_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.059358 (rank : 95)
Query Neighborhood Hits	45	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P20239	Gene names	Zp2, Zp-2, Zpa
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

ZP3_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.050938 (rank : 173)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P21754, Q06633	Gene names	ZP3, ZP3A, ZPC
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Zona pellucida protein C) (Sperm receptor) (ZP3A/ZP3B).

ZP3_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.054065 (rank : 144)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P10761	Gene names	Zp3, Zp-3, Zpc
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Sperm receptor) (Zona pellucida protein C).

ZP4_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.057747 (rank : 109)
Query Neighborhood Hits	45	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q12836	Gene names	ZP4, ZPB
Domain Architecture
Description	Zona pellucida sperm-binding protein 4 precursor (Zona pellucida sperm-binding protein B).

Hits sorted by NC score

CD5L_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

CD5L_MOUSE
NC score	0.995486 (rank : 2)	θ value	8.33966e-147 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

C163A_MOUSE
NC score	0.953500 (rank : 3)	θ value	6.10265e-73 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q2VLH6, Q2VLH5, Q99MX8	Gene names	Cd163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) [Contains: Soluble CD163 (sCD163)].

C163A_HUMAN
NC score	0.951535 (rank : 4)	θ value	2.3998e-69 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	34
SwissProt Accessions	Q86VB7, Q07898, Q07899, Q07900, Q07901, Q2VLH7	Gene names	CD163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)].

C163B_HUMAN
NC score	0.950819 (rank : 5)	θ value	1.27248e-70 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	64	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

CD6_HUMAN
NC score	0.936369 (rank : 6)	θ value	6.14528e-49 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CD6_MOUSE
NC score	0.933170 (rank : 7)	θ value	1.73182e-43 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	62	Shared Neighborhood Hits	32
SwissProt Accessions	Q61003, Q60679, Q61004	Gene names	Cd6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor.

LG3BP_HUMAN
NC score	0.851096 (rank : 8)	θ value	2.35696e-16 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q08380	Gene names	LGALS3BP, M2BP
Domain Architecture
Description	Galectin-3-binding protein precursor (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (Mac-2 BP) (MAC2BP) (Tumor-associated antigen 90K).

LOXL4_HUMAN
NC score	0.842960 (rank : 9)	θ value	2.34062e-40 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q96JB6, Q96DY1, Q96PC0, Q9H6T5	Gene names	LOXL4, LOXC
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL2_MOUSE
NC score	0.842604 (rank : 10)	θ value	8.04462e-41 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

LOXL4_MOUSE
NC score	0.842028 (rank : 11)	θ value	4.88048e-38 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	Q924C6	Gene names	Loxl4, Loxc
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL3_MOUSE
NC score	0.841043 (rank : 12)	θ value	2.34062e-40 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z175, Q9JJ39	Gene names	Loxl3, Lor2
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3) (Lysyl oxidase-related protein 2).

LOXL3_HUMAN
NC score	0.840216 (rank : 13)	θ value	9.50281e-42 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	P58215, Q96RS1	Gene names	LOXL3, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3).

LOXL2_HUMAN
NC score	0.840067 (rank : 14)	θ value	1.51715e-39 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y4K0, Q9BW70, Q9Y5Y8	Gene names	LOXL2
Domain Architecture
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14).

DMBT1_HUMAN
NC score	0.772569 (rank : 15)	θ value	3.23591e-74 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	152	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

DMBT1_MOUSE
NC score	0.702619 (rank : 16)	θ value	1.83746e-69 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	134	Shared Neighborhood Hits	36
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

MSRE_MOUSE
NC score	0.685331 (rank : 17)	θ value	1.42661e-21 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P30204, Q923G0, Q9QZ56	Gene names	Msr1, Scvr
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A).

MSRE_HUMAN
NC score	0.624542 (rank : 18)	θ value	1.5773e-20 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	298	Shared Neighborhood Hits	30
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

CD5_MOUSE
NC score	0.617108 (rank : 19)	θ value	1.58096e-12 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	33	Shared Neighborhood Hits	24
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

CD5_HUMAN
NC score	0.569783 (rank : 20)	θ value	2.61198e-07 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P06127	Gene names	CD5, LEU1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu- 1).

MARCO_HUMAN
NC score	0.535981 (rank : 21)	θ value	5.42112e-21 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	199	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UEW3, Q9Y5S3	Gene names	MARCO, SCARA2
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2).

NETR_HUMAN
NC score	0.469437 (rank : 22)	θ value	5.17823e-64 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	218	Shared Neighborhood Hits	36
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
NC score	0.456305 (rank : 23)	θ value	7.47731e-63 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	216	Shared Neighborhood Hits	36
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

MARCO_MOUSE
NC score	0.429375 (rank : 24)	θ value	4.58923e-20 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	242	Shared Neighborhood Hits	30
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

LYOX_HUMAN
NC score	0.302025 (rank : 25)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P28300, Q5FWF0	Gene names	LOX
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase).

LYOX_MOUSE
NC score	0.299729 (rank : 26)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P28301	Gene names	Lox, Rrg
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase) (RAS excision protein).

LOXL1_HUMAN
NC score	0.287334 (rank : 27)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	45	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

LOXL1_MOUSE
NC score	0.286341 (rank : 28)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	45	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

CFAI_HUMAN
NC score	0.137234 (rank : 29)	θ value	0.000461057 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	289	Shared Neighborhood Hits	35
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CFAI_MOUSE
NC score	0.132386 (rank : 30)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	290	Shared Neighborhood Hits	34
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

ENTK_MOUSE
NC score	0.130321 (rank : 31)	θ value	0.0113563 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	338	Shared Neighborhood Hits	35
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

CUZD1_MOUSE
NC score	0.120423 (rank : 32)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	45	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

ENTK_HUMAN
NC score	0.117093 (rank : 33)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

CUZD1_HUMAN
NC score	0.116706 (rank : 34)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	45	Target Neighborhood Hits	89	Shared Neighborhood Hits	8
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

TMPS3_HUMAN
NC score	0.101729 (rank : 35)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS3_MOUSE
NC score	0.098104 (rank : 36)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPSD_MOUSE
NC score	0.091757 (rank : 37)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	45	Target Neighborhood Hits	334	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

CORIN_MOUSE
NC score	0.084231 (rank : 38)	θ value	0.00390308 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	451	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

TMPS5_MOUSE
NC score	0.080844 (rank : 39)	θ value	0.0193708 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS4_MOUSE
NC score	0.079623 (rank : 40)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

ST14_MOUSE
NC score	0.079467 (rank : 41)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	45	Target Neighborhood Hits	419	Shared Neighborhood Hits	22
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

ST14_HUMAN
NC score	0.077269 (rank : 42)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	45	Target Neighborhood Hits	409	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

TMPS2_HUMAN
NC score	0.075744 (rank : 43)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	252	Shared Neighborhood Hits	25
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS5_HUMAN
NC score	0.074777 (rank : 44)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPSD_HUMAN
NC score	0.073205 (rank : 45)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	45	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

MASP1_HUMAN
NC score	0.073044 (rank : 46)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	45	Target Neighborhood Hits	369	Shared Neighborhood Hits	23
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

MASP1_MOUSE
NC score	0.072574 (rank : 47)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	45	Target Neighborhood Hits	364	Shared Neighborhood Hits	23
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

CS1B_MOUSE
NC score	0.072475 (rank : 48)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	45	Target Neighborhood Hits	361	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CS1A_MOUSE
NC score	0.071495 (rank : 49)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	45	Target Neighborhood Hits	360	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

MASP2_HUMAN
NC score	0.071373 (rank : 50)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	45	Target Neighborhood Hits	364	Shared Neighborhood Hits	22
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

C1S_HUMAN
NC score	0.071139 (rank : 51)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	45	Target Neighborhood Hits	359	Shared Neighborhood Hits	22
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

CORIN_HUMAN
NC score	0.070583 (rank : 52)	θ value	0.163984 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	453	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

TMPS7_HUMAN
NC score	0.070577 (rank : 53)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	45	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

C1R_HUMAN
NC score	0.069662 (rank : 54)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	45	Target Neighborhood Hits	364	Shared Neighborhood Hits	23
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

C1RB_MOUSE
NC score	0.069367 (rank : 55)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	45	Target Neighborhood Hits	380	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

C1RA_MOUSE
NC score	0.068173 (rank : 56)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	45	Target Neighborhood Hits	379	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

TMPS7_MOUSE
NC score	0.068053 (rank : 57)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	45	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TLL1_MOUSE
NC score	0.068050 (rank : 58)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	237	Shared Neighborhood Hits	12
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

MASP2_MOUSE
NC score	0.068031 (rank : 59)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	45	Target Neighborhood Hits	382	Shared Neighborhood Hits	22
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

TMPS4_HUMAN
NC score	0.067399 (rank : 60)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	45	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

PCOC2_MOUSE
NC score	0.067081 (rank : 61)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	45	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4W6, Q3V1K6, Q9CX06	Gene names	Pcolce2, Pcpe2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

TLL1_HUMAN
NC score	0.066839 (rank : 62)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

PCOC2_HUMAN
NC score	0.066261 (rank : 63)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	45	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKZ9, Q9BRH3	Gene names	PCOLCE2, PCPE2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

TLL2_MOUSE
NC score	0.065989 (rank : 64)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	240	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TMPS2_MOUSE
NC score	0.065762 (rank : 65)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	45	Target Neighborhood Hits	243	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

ZP2_HUMAN
NC score	0.065102 (rank : 66)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	45	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q05996	Gene names	ZP2, ZPA
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

TLL2_HUMAN
NC score	0.064153 (rank : 67)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	45	Target Neighborhood Hits	241	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

MFRP_MOUSE
NC score	0.062401 (rank : 68)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	45	Target Neighborhood Hits	166	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

BMP1_MOUSE
NC score	0.062295 (rank : 69)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	45	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BMP1_HUMAN
NC score	0.062145 (rank : 70)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	233	Shared Neighborhood Hits	11
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

ACRO_MOUSE
NC score	0.062125 (rank : 71)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	185	Shared Neighborhood Hits	14
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

MFRP_HUMAN
NC score	0.061752 (rank : 72)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	45	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

LRP12_MOUSE
NC score	0.061409 (rank : 73)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP12_HUMAN
NC score	0.061332 (rank : 74)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	45	Target Neighborhood Hits	205	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

HEPS_HUMAN
NC score	0.061230 (rank : 75)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

PCOC1_MOUSE
NC score	0.061072 (rank : 76)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	45	Target Neighborhood Hits	100	Shared Neighborhood Hits	7
SwissProt Accessions	Q61398, O35113	Gene names	Pcolce, Pcpe1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein) (P14).

ACRO_HUMAN
NC score	0.060981 (rank : 77)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	291	Shared Neighborhood Hits	14
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

HEPS_MOUSE
NC score	0.060710 (rank : 78)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

TSG6_HUMAN
NC score	0.060704 (rank : 79)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	45	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	P98066, Q8WWI9	Gene names	TNFAIP6, TSG6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein) (Hyaluronate-binding protein).

TPA_MOUSE
NC score	0.060688 (rank : 80)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	45	Target Neighborhood Hits	335	Shared Neighborhood Hits	16
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TSP50_HUMAN
NC score	0.060670 (rank : 81)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

TEST_HUMAN
NC score	0.060607 (rank : 82)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	45	Target Neighborhood Hits	172	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

TSG6_MOUSE
NC score	0.060605 (rank : 83)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	45	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	O08859	Gene names	Tnfaip6, Tnfip6, Tsg6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein).

TM11E_HUMAN
NC score	0.060393 (rank : 84)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

PCOC1_HUMAN
NC score	0.060104 (rank : 85)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	45	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

FA11_HUMAN
NC score	0.060088 (rank : 86)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TM11D_MOUSE
NC score	0.060062 (rank : 87)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TMSP8_MOUSE
NC score	0.059958 (rank : 88)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

TMPS6_HUMAN
NC score	0.059919 (rank : 89)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	45	Target Neighborhood Hits	338	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

UROK_HUMAN
NC score	0.059698 (rank : 90)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	45	Target Neighborhood Hits	272	Shared Neighborhood Hits	16
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

DESC4_MOUSE
NC score	0.059614 (rank : 91)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

TM11D_HUMAN
NC score	0.059566 (rank : 92)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TPA_HUMAN
NC score	0.059481 (rank : 93)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	45	Target Neighborhood Hits	324	Shared Neighborhood Hits	16
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

NETO2_MOUSE
NC score	0.059454 (rank : 94)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	45	Target Neighborhood Hits	113	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

ZP2_MOUSE
NC score	0.059358 (rank : 95)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	45	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P20239	Gene names	Zp2, Zp-2, Zpa
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

TMPS6_MOUSE
NC score	0.059347 (rank : 96)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	45	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

NETO2_HUMAN
NC score	0.059128 (rank : 97)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	45	Target Neighborhood Hits	109	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

KLKB1_MOUSE
NC score	0.059126 (rank : 98)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

TM11E_MOUSE
NC score	0.059040 (rank : 99)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TRYG1_MOUSE
NC score	0.059007 (rank : 100)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TMPS9_HUMAN
NC score	0.058930 (rank : 101)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	45	Target Neighborhood Hits	276	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

FA11_MOUSE
NC score	0.058864 (rank : 102)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TMPS9_MOUSE
NC score	0.058561 (rank : 103)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	45	Target Neighborhood Hits	296	Shared Neighborhood Hits	14
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

TRYG1_HUMAN
NC score	0.058189 (rank : 104)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

NETO1_HUMAN
NC score	0.058017 (rank : 105)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

BSSP4_MOUSE
NC score	0.057956 (rank : 106)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

KLKB1_HUMAN
NC score	0.057873 (rank : 107)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	45	Target Neighborhood Hits	183	Shared Neighborhood Hits	14
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

BSSP4_HUMAN
NC score	0.057748 (rank : 108)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

ZP4_HUMAN
NC score	0.057747 (rank : 109)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	45	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q12836	Gene names	ZP4, ZPB
Domain Architecture
Description	Zona pellucida sperm-binding protein 4 precursor (Zona pellucida sperm-binding protein B).

CLCR_HUMAN
NC score	0.057734 (rank : 110)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

KREM1_MOUSE
NC score	0.057732 (rank : 111)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

PRS27_MOUSE
NC score	0.057626 (rank : 112)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

TEST_MOUSE
NC score	0.057476 (rank : 113)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	45	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

PRS27_HUMAN
NC score	0.057436 (rank : 114)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

NETO1_MOUSE
NC score	0.057308 (rank : 115)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	45	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

CTRL_HUMAN
NC score	0.057047 (rank : 116)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

UROK_MOUSE
NC score	0.056986 (rank : 117)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	45	Target Neighborhood Hits	273	Shared Neighborhood Hits	16
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

CTRB1_HUMAN
NC score	0.056748 (rank : 118)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

PRSS8_MOUSE
NC score	0.056619 (rank : 119)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

POLS2_HUMAN
NC score	0.056547 (rank : 120)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	45	Target Neighborhood Hits	192	Shared Neighborhood Hits	14
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

TECTB_MOUSE
NC score	0.056545 (rank : 121)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O08524	Gene names	Tectb
Domain Architecture
Description	Beta-tectorin precursor.

TECTB_HUMAN
NC score	0.056518 (rank : 122)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PL2	Gene names	TECTB
Domain Architecture
Description	Beta-tectorin precursor.

ELA1_HUMAN
NC score	0.056249 (rank : 123)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UNI1, Q5MLF0, Q6DJT0, Q6ISM6	Gene names	ELA1
Domain Architecture
Description	Elastase-1 precursor (EC 3.4.21.36).

MCPT6_MOUSE
NC score	0.056156 (rank : 124)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

TGBR3_HUMAN
NC score	0.056111 (rank : 125)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	45	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q03167, Q5T2T4, Q5U731, Q9UGI2	Gene names	TGFBR3
Domain Architecture
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

ELA3A_HUMAN
NC score	0.055829 (rank : 126)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	45	Target Neighborhood Hits	173	Shared Neighborhood Hits	14
SwissProt Accessions	P09093, Q9BRW4	Gene names	ELA3A, ELA3
Domain Architecture
Description	Elastase-3A precursor (EC 3.4.21.70) (Elastase IIIA) (Protease E).

PRSS8_HUMAN
NC score	0.055706 (rank : 127)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

ELA2A_HUMAN
NC score	0.055664 (rank : 128)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

TRYA1_HUMAN
NC score	0.055606 (rank : 129)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

TRYB1_HUMAN
NC score	0.055496 (rank : 130)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB2_HUMAN
NC score	0.055496 (rank : 131)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

ELA2B_HUMAN
NC score	0.055407 (rank : 132)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

ELA2A_MOUSE
NC score	0.055388 (rank : 133)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

ELA3B_HUMAN
NC score	0.055240 (rank : 134)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

KREM1_HUMAN
NC score	0.055186 (rank : 135)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	45	Target Neighborhood Hits	90	Shared Neighborhood Hits	9
SwissProt Accessions	Q96MU8, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1	Gene names	KREMEN1, KREMEN, KRM1
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

POLS2_MOUSE
NC score	0.054944 (rank : 136)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

HGFA_HUMAN
NC score	0.054897 (rank : 137)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	45	Target Neighborhood Hits	436	Shared Neighborhood Hits	18
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

PROC_HUMAN
NC score	0.054876 (rank : 138)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	45	Target Neighborhood Hits	406	Shared Neighborhood Hits	21
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

TGBR3_MOUSE
NC score	0.054706 (rank : 139)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	45	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O88393, Q6NS72	Gene names	Tgfbr3
Domain Architecture	No domain graphic available
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

FA12_HUMAN
NC score	0.054402 (rank : 140)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	45	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

CFAD_MOUSE
NC score	0.054321 (rank : 141)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P03953, Q61280	Gene names	Cfd, Adn, Df
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin) (28 kDa adipocyte protein).

TRYB1_MOUSE
NC score	0.054200 (rank : 142)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

FA10_HUMAN
NC score	0.054152 (rank : 143)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	45	Target Neighborhood Hits	431	Shared Neighborhood Hits	21
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

ZP3_MOUSE
NC score	0.054065 (rank : 144)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P10761	Gene names	Zp3, Zp-3, Zpc
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Sperm receptor) (Zona pellucida protein C).

TRYD_HUMAN
NC score	0.053994 (rank : 145)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

FA10_MOUSE
NC score	0.053722 (rank : 146)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	45	Target Neighborhood Hits	435	Shared Neighborhood Hits	21
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA7_MOUSE
NC score	0.053722 (rank : 147)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	45	Target Neighborhood Hits	374	Shared Neighborhood Hits	20
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

KLK10_HUMAN
NC score	0.053703 (rank : 148)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	O43240, Q99920, Q9GZW9	Gene names	KLK10, NES1, PRRSL1
Domain Architecture
Description	Kallikrein-10 precursor (EC 3.4.21.-) (Protease serine-like 1) (Normal epithelial cell-specific 1).

HGFA_MOUSE
NC score	0.053586 (rank : 149)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	45	Target Neighborhood Hits	419	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

CFAD_HUMAN
NC score	0.053562 (rank : 150)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

THRB_HUMAN
NC score	0.053527 (rank : 151)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	45	Target Neighborhood Hits	196	Shared Neighborhood Hits	14
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

HABP2_HUMAN
NC score	0.053416 (rank : 152)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	45	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

KLK6_HUMAN
NC score	0.053386 (rank : 153)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q92876	Gene names	KLK6, PRSS18, PRSS9
Domain Architecture
Description	Kallikrein-6 precursor (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59).

KLK13_HUMAN
NC score	0.053378 (rank : 154)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	45	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKR3, Q9Y433	Gene names	KLK13, KLKL4
Domain Architecture
Description	Kallikrein-13 precursor (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4).

PROC_MOUSE
NC score	0.053376 (rank : 155)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	45	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

TRY3_HUMAN
NC score	0.053194 (rank : 156)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

PLMN_HUMAN
NC score	0.053101 (rank : 157)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	45	Target Neighborhood Hits	204	Shared Neighborhood Hits	14
SwissProt Accessions	P00747, Q15146, Q6PA00	Gene names	PLG
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

HABP2_MOUSE
NC score	0.053048 (rank : 158)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	45	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

PLMN_MOUSE
NC score	0.052940 (rank : 159)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	45	Target Neighborhood Hits	208	Shared Neighborhood Hits	14
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

TRY2_MOUSE
NC score	0.052908 (rank : 160)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	45	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	P07146	Gene names	Prss2, Try2
Domain Architecture
Description	Anionic trypsin-2 precursor (EC 3.4.21.4) (Anionic trypsin II) (Pretrypsinogen II).

FA7_HUMAN
NC score	0.052904 (rank : 161)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	45	Target Neighborhood Hits	404	Shared Neighborhood Hits	21
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

THRB_MOUSE
NC score	0.052769 (rank : 162)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	45	Target Neighborhood Hits	195	Shared Neighborhood Hits	14
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

NRPN_MOUSE
NC score	0.052563 (rank : 163)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	45	Target Neighborhood Hits	186	Shared Neighborhood Hits	14
SwissProt Accessions	Q61955	Gene names	Klk8, Nrpn, Prss19
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8).

TRY1_HUMAN
NC score	0.052558 (rank : 164)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	P07477, Q92955, Q9HAN4, Q9HAN5, Q9HAN6, Q9HAN7	Gene names	PRSS1, TRP1, TRY1, TRYP1
Domain Architecture
Description	Trypsin-1 precursor (EC 3.4.21.4) (Trypsin I) (Cationic trypsinogen).

APOA_HUMAN
NC score	0.052453 (rank : 165)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	221	Shared Neighborhood Hits	16
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

TRY2_HUMAN
NC score	0.052297 (rank : 166)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	P07478	Gene names	PRSS2, TRY2, TRYP2
Domain Architecture
Description	Trypsin-2 precursor (EC 3.4.21.4) (Trypsin II) (Anionic trypsinogen).

NRPN_HUMAN
NC score	0.051561 (rank : 167)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	45	Target Neighborhood Hits	182	Shared Neighborhood Hits	14
SwissProt Accessions	O60259, Q9HCB3, Q9UIL9, Q9UQ47	Gene names	KLK8, NRPN, PRSS19, TADG14
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein).

HPT_HUMAN
NC score	0.051409 (rank : 168)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	45	Target Neighborhood Hits	184	Shared Neighborhood Hits	14
SwissProt Accessions	P00738, P00737, Q2PP15, Q3B7J0, Q6LBY9	Gene names	HP
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

CSMD2_HUMAN
NC score	0.051316 (rank : 169)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

HPTR_HUMAN
NC score	0.051294 (rank : 170)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	45	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	P00739, Q7LE20, Q92658, Q92659, Q9ULB0	Gene names	HPR
Domain Architecture
Description	Haptoglobin-related protein precursor.

GRAK_MOUSE
NC score	0.051277 (rank : 171)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	45	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	O35205	Gene names	Gzmk
Domain Architecture
Description	Granzyme K precursor (EC 3.4.21.-).

HPT_MOUSE
NC score	0.051242 (rank : 172)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

ZP3_HUMAN
NC score	0.050938 (rank : 173)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P21754, Q06633	Gene names	ZP3, ZP3A, ZPC
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Zona pellucida protein C) (Sperm receptor) (ZP3A/ZP3B).

KLK15_HUMAN
NC score	0.050814 (rank : 174)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	45	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2R5, Q15358, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9	Gene names	KLK15
Domain Architecture
Description	Kallikrein-15 precursor (EC 3.4.21.-) (ACO protease).

KLK7_MOUSE
NC score	0.050642 (rank : 175)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	14
SwissProt Accessions	Q91VE3, Q9R048	Gene names	Klk7, Prss6, Scce
Domain Architecture	No domain graphic available
Description	Kallikrein-7 precursor (EC 3.4.21.-) (Stratum corneum chymotryptic enzyme) (Thymopsin).

ELNE_MOUSE
NC score	0.050543 (rank : 176)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	45	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q3UP87, Q61515	Gene names	Ela2
Domain Architecture	No domain graphic available
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase).

KLK12_HUMAN
NC score	0.050020 (rank : 177)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	45	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKR0, Q9UKR1	Gene names	KLK12, KLKL5
Domain Architecture
Description	Kallikrein-12 precursor (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5).

UROM_HUMAN
NC score	0.035621 (rank : 178)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	284	Shared Neighborhood Hits	13
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

XLKD1_MOUSE
NC score	0.010747 (rank : 179)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BHC0, Q3TUC1, Q99NE4	Gene names	Xlkd1, Crsbp1
Domain Architecture	No domain graphic available
Description	Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1).

LTB1S_MOUSE
NC score	0.007031 (rank : 180)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	479	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1L_MOUSE
NC score	0.007019 (rank : 181)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	514	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

FBLN5_MOUSE
NC score	0.003909 (rank : 182)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	317	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

ZBTB6_HUMAN
NC score	-0.003620 (rank : 183)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	805	Shared Neighborhood Hits	2
SwissProt Accessions	Q15916	Gene names	ZBTB6, ZID, ZNF482
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain).