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Network neighborhood for query Sequence : LOXL4_HUMAN

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LOXL4_HUMAN
SwissProt Accessions	Q96JB6, Q96DY1, Q96PC0, Q9H6T5	Gene names	LOXL4, LOXC
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LOXL2_HUMAN
θ value	0 (rank : 1)	NC score	0.994586 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y4K0, Q9BW70, Q9Y5Y8	Gene names	LOXL2
Domain Architecture
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14).

LOXL2_MOUSE
θ value	0 (rank : 2)	NC score	0.994620 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	44	Shared Neighborhood Hits	37
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

LOXL3_HUMAN
θ value	0 (rank : 3)	NC score	0.994391 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	P58215, Q96RS1	Gene names	LOXL3, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3).

LOXL3_MOUSE
θ value	0 (rank : 4)	NC score	0.993675 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	48	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z175, Q9JJ39	Gene names	Loxl3, Lor2
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3) (Lysyl oxidase-related protein 2).

LOXL4_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JB6, Q96DY1, Q96PC0, Q9H6T5	Gene names	LOXL4, LOXC
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL4_MOUSE
θ value	0 (rank : 6)	NC score	0.999033 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	40
SwissProt Accessions	Q924C6	Gene names	Loxl4, Loxc
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

DMBT1_HUMAN
θ value	1.7756e-72 (rank : 7)	NC score	0.671503 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

DMBT1_MOUSE
θ value	2.74572e-65 (rank : 8)	NC score	0.612329 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

NETR_HUMAN
θ value	1.01059e-59 (rank : 9)	NC score	0.414126 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	218	Shared Neighborhood Hits	36
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
θ value	5.54529e-58 (rank : 10)	NC score	0.406020 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	36
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

LYOX_MOUSE
θ value	7.24236e-58 (rank : 11)	NC score	0.730445 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	P28301	Gene names	Lox, Rrg
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase) (RAS excision protein).

LYOX_HUMAN
θ value	1.23536e-57 (rank : 12)	NC score	0.733322 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P28300, Q5FWF0	Gene names	LOX
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase).

C163B_HUMAN
θ value	2.7521e-57 (rank : 13)	NC score	0.822786 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

C163A_MOUSE
θ value	5.19021e-56 (rank : 14)	NC score	0.824971 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	Q2VLH6, Q2VLH5, Q99MX8	Gene names	Cd163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) [Contains: Soluble CD163 (sCD163)].

LOXL1_HUMAN
θ value	1.51013e-55 (rank : 15)	NC score	0.715351 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

LOXL1_MOUSE
θ value	3.36421e-55 (rank : 16)	NC score	0.712985 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	58	Shared Neighborhood Hits	11
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

C163A_HUMAN
θ value	4.39379e-55 (rank : 17)	NC score	0.824955 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	33
SwissProt Accessions	Q86VB7, Q07898, Q07899, Q07900, Q07901, Q2VLH7	Gene names	CD163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)].

CD5L_HUMAN
θ value	2.34062e-40 (rank : 18)	NC score	0.842960 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	33
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

CD5L_MOUSE
θ value	2.86122e-38 (rank : 19)	NC score	0.839507 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

CD6_HUMAN
θ value	8.91499e-32 (rank : 20)	NC score	0.802600 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CD6_MOUSE
θ value	7.80994e-28 (rank : 21)	NC score	0.795742 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q61003, Q60679, Q61004	Gene names	Cd6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor.

MSRE_MOUSE
θ value	2.27234e-27 (rank : 22)	NC score	0.626502 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P30204, Q923G0, Q9QZ56	Gene names	Msr1, Scvr
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A).

MSRE_HUMAN
θ value	2.96777e-27 (rank : 23)	NC score	0.572987 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	298	Shared Neighborhood Hits	31
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

LG3BP_HUMAN
θ value	6.18819e-25 (rank : 24)	NC score	0.786472 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q08380	Gene names	LGALS3BP, M2BP
Domain Architecture
Description	Galectin-3-binding protein precursor (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (Mac-2 BP) (MAC2BP) (Tumor-associated antigen 90K).

MARCO_HUMAN
θ value	3.17815e-21 (rank : 25)	NC score	0.489846 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	199	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UEW3, Q9Y5S3	Gene names	MARCO, SCARA2
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2).

MARCO_MOUSE
θ value	1.2077e-20 (rank : 26)	NC score	0.390588 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

CFAI_MOUSE
θ value	0.00035302 (rank : 27)	NC score	0.119239 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CFAI_HUMAN
θ value	0.00175202 (rank : 28)	NC score	0.118749 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	289	Shared Neighborhood Hits	33
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CD5_MOUSE
θ value	0.0961366 (rank : 29)	NC score	0.415764 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	33	Shared Neighborhood Hits	24
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

K1849_HUMAN
θ value	0.0961366 (rank : 30)	NC score	0.021944 (rank : 55)
Query Neighborhood Hits	43	Target Neighborhood Hits	220	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

TMPS3_MOUSE
θ value	0.0961366 (rank : 31)	NC score	0.082124 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPS5_MOUSE
θ value	0.125558 (rank : 32)	NC score	0.058958 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

CD5_HUMAN
θ value	0.21417 (rank : 33)	NC score	0.389451 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P06127	Gene names	CD5, LEU1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu- 1).

TMPS4_MOUSE
θ value	0.279714 (rank : 34)	NC score	0.065586 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

ENTK_MOUSE
θ value	0.365318 (rank : 35)	NC score	0.101584 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	338	Shared Neighborhood Hits	32
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TMPS3_HUMAN
θ value	0.813845 (rank : 36)	NC score	0.083875 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS4_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.054876 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

TMPSD_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.074314 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	334	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPS5_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.053857 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	181	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

ENTK_HUMAN
θ value	3.0926 (rank : 40)	NC score	0.086280 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	310	Shared Neighborhood Hits	33
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TMPSD_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.057399 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

VGFR1_MOUSE
θ value	6.88961 (rank : 42)	NC score	-0.000874 (rank : 57)
Query Neighborhood Hits	43	Target Neighborhood Hits	1118	Shared Neighborhood Hits	6
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

ATS13_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.000773 (rank : 56)
Query Neighborhood Hits	43	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

C1S_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.051657 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	359	Shared Neighborhood Hits	16
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

CORIN_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.052946 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	451	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

CS1A_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.051460 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	360	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

CS1B_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.052005 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	361	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CUZD1_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.084061 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

CUZD1_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.086800 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

MASP1_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.051932 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	369	Shared Neighborhood Hits	16
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

MASP1_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.051564 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	364	Shared Neighborhood Hits	16
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP2_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.051360 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	364	Shared Neighborhood Hits	16
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

ST14_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.055559 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

ST14_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.057361 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	419	Shared Neighborhood Hits	16
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

TMPS2_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.054798 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	252	Shared Neighborhood Hits	25
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS7_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.051983 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	275	Shared Neighborhood Hits	16
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TMPS7_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.050054 (rank : 54)
Query Neighborhood Hits	43	Target Neighborhood Hits	275	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

Hits sorted by NC score

LOXL4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JB6, Q96DY1, Q96PC0, Q9H6T5	Gene names	LOXL4, LOXC
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL4_MOUSE
NC score	0.999033 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	50	Shared Neighborhood Hits	40
SwissProt Accessions	Q924C6	Gene names	Loxl4, Loxc
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL2_MOUSE
NC score	0.994620 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	44	Shared Neighborhood Hits	37
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

LOXL2_HUMAN
NC score	0.994586 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y4K0, Q9BW70, Q9Y5Y8	Gene names	LOXL2
Domain Architecture
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14).

LOXL3_HUMAN
NC score	0.994391 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	P58215, Q96RS1	Gene names	LOXL3, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3).

LOXL3_MOUSE
NC score	0.993675 (rank : 6)	θ value	0 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	48	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z175, Q9JJ39	Gene names	Loxl3, Lor2
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3) (Lysyl oxidase-related protein 2).

CD5L_HUMAN
NC score	0.842960 (rank : 7)	θ value	2.34062e-40 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	33
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

CD5L_MOUSE
NC score	0.839507 (rank : 8)	θ value	2.86122e-38 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

C163A_MOUSE
NC score	0.824971 (rank : 9)	θ value	5.19021e-56 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	Q2VLH6, Q2VLH5, Q99MX8	Gene names	Cd163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) [Contains: Soluble CD163 (sCD163)].

C163A_HUMAN
NC score	0.824955 (rank : 10)	θ value	4.39379e-55 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	33
SwissProt Accessions	Q86VB7, Q07898, Q07899, Q07900, Q07901, Q2VLH7	Gene names	CD163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)].

C163B_HUMAN
NC score	0.822786 (rank : 11)	θ value	2.7521e-57 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

CD6_HUMAN
NC score	0.802600 (rank : 12)	θ value	8.91499e-32 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CD6_MOUSE
NC score	0.795742 (rank : 13)	θ value	7.80994e-28 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q61003, Q60679, Q61004	Gene names	Cd6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor.

LG3BP_HUMAN
NC score	0.786472 (rank : 14)	θ value	6.18819e-25 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q08380	Gene names	LGALS3BP, M2BP
Domain Architecture
Description	Galectin-3-binding protein precursor (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (Mac-2 BP) (MAC2BP) (Tumor-associated antigen 90K).

LYOX_HUMAN
NC score	0.733322 (rank : 15)	θ value	1.23536e-57 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P28300, Q5FWF0	Gene names	LOX
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase).

LYOX_MOUSE
NC score	0.730445 (rank : 16)	θ value	7.24236e-58 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	P28301	Gene names	Lox, Rrg
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase) (RAS excision protein).

LOXL1_HUMAN
NC score	0.715351 (rank : 17)	θ value	1.51013e-55 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

LOXL1_MOUSE
NC score	0.712985 (rank : 18)	θ value	3.36421e-55 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	58	Shared Neighborhood Hits	11
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

DMBT1_HUMAN
NC score	0.671503 (rank : 19)	θ value	1.7756e-72 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

MSRE_MOUSE
NC score	0.626502 (rank : 20)	θ value	2.27234e-27 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P30204, Q923G0, Q9QZ56	Gene names	Msr1, Scvr
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A).

DMBT1_MOUSE
NC score	0.612329 (rank : 21)	θ value	2.74572e-65 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

MSRE_HUMAN
NC score	0.572987 (rank : 22)	θ value	2.96777e-27 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	298	Shared Neighborhood Hits	31
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

MARCO_HUMAN
NC score	0.489846 (rank : 23)	θ value	3.17815e-21 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	199	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UEW3, Q9Y5S3	Gene names	MARCO, SCARA2
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2).

CD5_MOUSE
NC score	0.415764 (rank : 24)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	33	Shared Neighborhood Hits	24
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

NETR_HUMAN
NC score	0.414126 (rank : 25)	θ value	1.01059e-59 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	218	Shared Neighborhood Hits	36
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
NC score	0.406020 (rank : 26)	θ value	5.54529e-58 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	36
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

MARCO_MOUSE
NC score	0.390588 (rank : 27)	θ value	1.2077e-20 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

CD5_HUMAN
NC score	0.389451 (rank : 28)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P06127	Gene names	CD5, LEU1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu- 1).

CFAI_MOUSE
NC score	0.119239 (rank : 29)	θ value	0.00035302 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CFAI_HUMAN
NC score	0.118749 (rank : 30)	θ value	0.00175202 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	289	Shared Neighborhood Hits	33
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

ENTK_MOUSE
NC score	0.101584 (rank : 31)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	338	Shared Neighborhood Hits	32
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

CUZD1_MOUSE
NC score	0.086800 (rank : 32)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

ENTK_HUMAN
NC score	0.086280 (rank : 33)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	310	Shared Neighborhood Hits	33
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

CUZD1_HUMAN
NC score	0.084061 (rank : 34)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

TMPS3_HUMAN
NC score	0.083875 (rank : 35)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS3_MOUSE
NC score	0.082124 (rank : 36)	θ value	0.0961366 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPSD_MOUSE
NC score	0.074314 (rank : 37)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	334	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPS4_MOUSE
NC score	0.065586 (rank : 38)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

TMPS5_MOUSE
NC score	0.058958 (rank : 39)	θ value	0.125558 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPSD_HUMAN
NC score	0.057399 (rank : 40)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ST14_MOUSE
NC score	0.057361 (rank : 41)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	43	Target Neighborhood Hits	419	Shared Neighborhood Hits	16
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

ST14_HUMAN
NC score	0.055559 (rank : 42)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

TMPS4_HUMAN
NC score	0.054876 (rank : 43)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

TMPS2_HUMAN
NC score	0.054798 (rank : 44)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	43	Target Neighborhood Hits	252	Shared Neighborhood Hits	25
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS5_HUMAN
NC score	0.053857 (rank : 45)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	181	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

CORIN_MOUSE
NC score	0.052946 (rank : 46)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	451	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

CS1B_MOUSE
NC score	0.052005 (rank : 47)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	361	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

TMPS7_HUMAN
NC score	0.051983 (rank : 48)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	43	Target Neighborhood Hits	275	Shared Neighborhood Hits	16
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

MASP1_HUMAN
NC score	0.051932 (rank : 49)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	369	Shared Neighborhood Hits	16
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

C1S_HUMAN
NC score	0.051657 (rank : 50)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	359	Shared Neighborhood Hits	16
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

MASP1_MOUSE
NC score	0.051564 (rank : 51)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	364	Shared Neighborhood Hits	16
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

CS1A_MOUSE
NC score	0.051460 (rank : 52)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	360	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

MASP2_HUMAN
NC score	0.051360 (rank : 53)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	364	Shared Neighborhood Hits	16
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

TMPS7_MOUSE
NC score	0.050054 (rank : 54)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	43	Target Neighborhood Hits	275	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

K1849_HUMAN
NC score	0.021944 (rank : 55)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	220	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ATS13_HUMAN
NC score	0.000773 (rank : 56)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

VGFR1_MOUSE
NC score	-0.000874 (rank : 57)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	1118	Shared Neighborhood Hits	6
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).