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Network neighborhood for query Sequence : C163A_HUMAN

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C163A_HUMAN
SwissProt Accessions	Q86VB7, Q07898, Q07899, Q07900, Q07901, Q2VLH7	Gene names	CD163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

C163A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	54	Target Neighborhood Hits	54	Shared Neighborhood Hits	54
SwissProt Accessions	Q86VB7, Q07898, Q07899, Q07900, Q07901, Q2VLH7	Gene names	CD163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)].

C163A_MOUSE
θ value	0 (rank : 2)	NC score	0.997146 (rank : 2)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	36
SwissProt Accessions	Q2VLH6, Q2VLH5, Q99MX8	Gene names	Cd163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) [Contains: Soluble CD163 (sCD163)].

C163B_HUMAN
θ value	0 (rank : 3)	NC score	0.991627 (rank : 3)
Query Neighborhood Hits	54	Target Neighborhood Hits	64	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

DMBT1_HUMAN
θ value	0 (rank : 4)	NC score	0.794876 (rank : 15)
Query Neighborhood Hits	54	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

DMBT1_MOUSE
θ value	0 (rank : 5)	NC score	0.718383 (rank : 16)
Query Neighborhood Hits	54	Target Neighborhood Hits	134	Shared Neighborhood Hits	33
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

NETR_HUMAN
θ value	5.49406e-90 (rank : 6)	NC score	0.458820 (rank : 22)
Query Neighborhood Hits	54	Target Neighborhood Hits	218	Shared Neighborhood Hits	35
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
θ value	9.74306e-71 (rank : 7)	NC score	0.443302 (rank : 23)
Query Neighborhood Hits	54	Target Neighborhood Hits	216	Shared Neighborhood Hits	35
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

CD5L_HUMAN
θ value	2.3998e-69 (rank : 8)	NC score	0.951535 (rank : 4)
Query Neighborhood Hits	54	Target Neighborhood Hits	45	Shared Neighborhood Hits	34
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

CD5L_MOUSE
θ value	2.24614e-67 (rank : 9)	NC score	0.950529 (rank : 5)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

LOXL3_MOUSE
θ value	3.0428e-56 (rank : 10)	NC score	0.824094 (rank : 11)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z175, Q9JJ39	Gene names	Loxl3, Lor2
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3) (Lysyl oxidase-related protein 2).

LOXL2_MOUSE
θ value	1.97229e-55 (rank : 11)	NC score	0.823471 (rank : 12)
Query Neighborhood Hits	54	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

LOXL3_HUMAN
θ value	3.36421e-55 (rank : 12)	NC score	0.822776 (rank : 13)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P58215, Q96RS1	Gene names	LOXL3, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3).

LOXL2_HUMAN
θ value	4.39379e-55 (rank : 13)	NC score	0.822181 (rank : 14)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4K0, Q9BW70, Q9Y5Y8	Gene names	LOXL2
Domain Architecture
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14).

LOXL4_HUMAN
θ value	4.39379e-55 (rank : 14)	NC score	0.824955 (rank : 10)
Query Neighborhood Hits	54	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q96JB6, Q96DY1, Q96PC0, Q9H6T5	Gene names	LOXL4, LOXC
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL4_MOUSE
θ value	5.73848e-55 (rank : 15)	NC score	0.825479 (rank : 9)
Query Neighborhood Hits	54	Target Neighborhood Hits	50	Shared Neighborhood Hits	32
SwissProt Accessions	Q924C6	Gene names	Loxl4, Loxc
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

CD6_HUMAN
θ value	2.25659e-51 (rank : 16)	NC score	0.911338 (rank : 6)
Query Neighborhood Hits	54	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CD6_MOUSE
θ value	5.20228e-48 (rank : 17)	NC score	0.908574 (rank : 7)
Query Neighborhood Hits	54	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q61003, Q60679, Q61004	Gene names	Cd6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor.

LG3BP_HUMAN
θ value	1.52067e-31 (rank : 18)	NC score	0.854556 (rank : 8)
Query Neighborhood Hits	54	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q08380	Gene names	LGALS3BP, M2BP
Domain Architecture
Description	Galectin-3-binding protein precursor (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (Mac-2 BP) (MAC2BP) (Tumor-associated antigen 90K).

MSRE_MOUSE
θ value	1.85889e-29 (rank : 19)	NC score	0.670810 (rank : 17)
Query Neighborhood Hits	54	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P30204, Q923G0, Q9QZ56	Gene names	Msr1, Scvr
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A).

MSRE_HUMAN
θ value	5.97985e-28 (rank : 20)	NC score	0.611276 (rank : 19)
Query Neighborhood Hits	54	Target Neighborhood Hits	298	Shared Neighborhood Hits	31
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

MARCO_HUMAN
θ value	5.23862e-24 (rank : 21)	NC score	0.523383 (rank : 21)
Query Neighborhood Hits	54	Target Neighborhood Hits	199	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UEW3, Q9Y5S3	Gene names	MARCO, SCARA2
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2).

MARCO_MOUSE
θ value	8.93572e-24 (rank : 22)	NC score	0.419095 (rank : 24)
Query Neighborhood Hits	54	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

CD5_HUMAN
θ value	3.52202e-12 (rank : 23)	NC score	0.587835 (rank : 20)
Query Neighborhood Hits	54	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P06127	Gene names	CD5, LEU1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu- 1).

CD5_MOUSE
θ value	3.52202e-12 (rank : 24)	NC score	0.616875 (rank : 18)
Query Neighborhood Hits	54	Target Neighborhood Hits	33	Shared Neighborhood Hits	25
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

CFAI_MOUSE
θ value	4.1701e-05 (rank : 25)	NC score	0.130204 (rank : 32)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CFAI_HUMAN
θ value	0.00175202 (rank : 26)	NC score	0.132348 (rank : 31)
Query Neighborhood Hits	54	Target Neighborhood Hits	289	Shared Neighborhood Hits	34
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

TMPS3_MOUSE
θ value	0.0113563 (rank : 27)	NC score	0.092918 (rank : 36)
Query Neighborhood Hits	54	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPSD_MOUSE
θ value	0.0252991 (rank : 28)	NC score	0.089763 (rank : 37)
Query Neighborhood Hits	54	Target Neighborhood Hits	334	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPS3_HUMAN
θ value	0.0330416 (rank : 29)	NC score	0.096677 (rank : 35)
Query Neighborhood Hits	54	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

ENTK_HUMAN
θ value	0.0563607 (rank : 30)	NC score	0.110092 (rank : 34)
Query Neighborhood Hits	54	Target Neighborhood Hits	310	Shared Neighborhood Hits	35
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

ENTK_MOUSE
θ value	0.163984 (rank : 31)	NC score	0.123018 (rank : 33)
Query Neighborhood Hits	54	Target Neighborhood Hits	338	Shared Neighborhood Hits	34
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

MEGF9_MOUSE
θ value	0.21417 (rank : 32)	NC score	0.011417 (rank : 131)
Query Neighborhood Hits	54	Target Neighborhood Hits	896	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

CSMD2_HUMAN
θ value	0.365318 (rank : 33)	NC score	0.062276 (rank : 84)
Query Neighborhood Hits	54	Target Neighborhood Hits	188	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

CORIN_MOUSE
θ value	0.62314 (rank : 34)	NC score	0.073177 (rank : 42)
Query Neighborhood Hits	54	Target Neighborhood Hits	451	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

TNR27_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.019113 (rank : 129)
Query Neighborhood Hits	54	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAV5, Q6UWM2, Q8IZA6	Gene names	EDA2R, TNFRSF27, XEDAR
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor).

FHL3_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.005638 (rank : 139)
Query Neighborhood Hits	54	Target Neighborhood Hits	354	Shared Neighborhood Hits	3
SwissProt Accessions	Q13643	Gene names	FHL3, SLIM2
Domain Architecture
Description	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM- protein 2) (SLIM 2).

TMPSD_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.068260 (rank : 53)
Query Neighborhood Hits	54	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ITB2_MOUSE
θ value	1.81305 (rank : 38)	NC score	0.007571 (rank : 135)
Query Neighborhood Hits	54	Target Neighborhood Hits	326	Shared Neighborhood Hits	11
SwissProt Accessions	P11835, Q64482	Gene names	Itgb2
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/P150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).

TMPS5_MOUSE
θ value	1.81305 (rank : 39)	NC score	0.068651 (rank : 50)
Query Neighborhood Hits	54	Target Neighborhood Hits	185	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

ZAN_MOUSE
θ value	1.81305 (rank : 40)	NC score	0.008587 (rank : 134)
Query Neighborhood Hits	54	Target Neighborhood Hits	808	Shared Neighborhood Hits	15
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

CORIN_HUMAN
θ value	2.36792 (rank : 41)	NC score	0.059809 (rank : 88)
Query Neighborhood Hits	54	Target Neighborhood Hits	453	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

UROM_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.042039 (rank : 128)
Query Neighborhood Hits	54	Target Neighborhood Hits	284	Shared Neighborhood Hits	13
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

ANR38_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.002917 (rank : 143)
Query Neighborhood Hits	54	Target Neighborhood Hits	443	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

JAG2_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.003565 (rank : 140)
Query Neighborhood Hits	54	Target Neighborhood Hits	491	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

RSPO4_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.006627 (rank : 137)
Query Neighborhood Hits	54	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

ZADH1_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.009332 (rank : 133)
Query Neighborhood Hits	54	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDQ1, Q8BZA2, Q9D1W8	Gene names	Zadh1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

ACS2L_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.005999 (rank : 138)
Query Neighborhood Hits	54	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q99NB1, Q8K0M6	Gene names	Acss1, Acas2, Acas2l
Domain Architecture
Description	Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1).

LRP1B_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.012642 (rank : 130)
Query Neighborhood Hits	54	Target Neighborhood Hits	606	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

RNT2_HUMAN
θ value	6.88961 (rank : 49)	NC score	0.010707 (rank : 132)
Query Neighborhood Hits	54	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O00584, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47	Gene names	RNASET2, RNASE6PL
Domain Architecture
Description	Ribonuclease T2 precursor (EC 3.1.27.-) (Ribonuclease 6).

DLL1_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.003165 (rank : 142)
Query Neighborhood Hits	54	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

JAG2_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.003316 (rank : 141)
Query Neighborhood Hits	54	Target Neighborhood Hits	504	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

O51I2_HUMAN
θ value	8.99809 (rank : 52)	NC score	-0.003389 (rank : 145)
Query Neighborhood Hits	54	Target Neighborhood Hits	718	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H344, Q6IF81	Gene names	OR51I2
Domain Architecture
Description	Olfactory receptor 51I2 (Odorant receptor HOR5'beta12) (Olfactory receptor OR11-38).

SIG12_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.002184 (rank : 144)
Query Neighborhood Hits	54	Target Neighborhood Hits	225	Shared Neighborhood Hits	2
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

ZN403_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.006779 (rank : 136)
Query Neighborhood Hits	54	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SV77, Q5SV75, Q5SV76, Q5SV78, Q6GVH6, Q6P9J4, Q920N4	Gene names	Znf403, Ggnbp2, Zfp403
Domain Architecture	No domain graphic available
Description	Protein ZNF403 (Gametogenetin-binding protein 2) (Dioxin-inducible factor 3) (DIF-3).

ACRO_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.052640 (rank : 103)
Query Neighborhood Hits	54	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

ACRO_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.053580 (rank : 97)
Query Neighborhood Hits	54	Target Neighborhood Hits	185	Shared Neighborhood Hits	13
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

BMP1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.065016 (rank : 72)
Query Neighborhood Hits	54	Target Neighborhood Hits	233	Shared Neighborhood Hits	9
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BMP1_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.065180 (rank : 71)
Query Neighborhood Hits	54	Target Neighborhood Hits	236	Shared Neighborhood Hits	9
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

C1RA_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.064634 (rank : 74)
Query Neighborhood Hits	54	Target Neighborhood Hits	379	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.065205 (rank : 70)
Query Neighborhood Hits	54	Target Neighborhood Hits	380	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

C1R_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.065583 (rank : 67)
Query Neighborhood Hits	54	Target Neighborhood Hits	364	Shared Neighborhood Hits	20
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

C1S_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.068750 (rank : 49)
Query Neighborhood Hits	54	Target Neighborhood Hits	359	Shared Neighborhood Hits	20
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

CS1A_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.068349 (rank : 51)
Query Neighborhood Hits	54	Target Neighborhood Hits	360	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

CS1B_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.069171 (rank : 48)
Query Neighborhood Hits	54	Target Neighborhood Hits	361	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CSMD1_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.051539 (rank : 114)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	6
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

CSMD1_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.052547 (rank : 105)
Query Neighborhood Hits	54	Target Neighborhood Hits	193	Shared Neighborhood Hits	7
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

CSMD3_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.053597 (rank : 96)
Query Neighborhood Hits	54	Target Neighborhood Hits	199	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

CUBN_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.053899 (rank : 95)
Query Neighborhood Hits	54	Target Neighborhood Hits	482	Shared Neighborhood Hits	14
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

CUBN_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.052646 (rank : 102)
Query Neighborhood Hits	54	Target Neighborhood Hits	477	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

CUZD1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.133475 (rank : 30)
Query Neighborhood Hits	54	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

CUZD1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.137573 (rank : 29)
Query Neighborhood Hits	54	Target Neighborhood Hits	91	Shared Neighborhood Hits	6
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

DCBD2_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.050585 (rank : 123)
Query Neighborhood Hits	54	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q96PD2, Q8N6M4, Q8TDX2	Gene names	DCBLD2, CLCP1, ESDN
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein) (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1).

DESC4_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.051500 (rank : 115)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

FA11_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.051623 (rank : 112)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

FA11_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.050600 (rank : 122)
Query Neighborhood Hits	54	Target Neighborhood Hits	180	Shared Neighborhood Hits	13
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

GP2_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.059345 (rank : 89)
Query Neighborhood Hits	54	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D733	Gene names	Gp2
Domain Architecture	No domain graphic available
Description	Pancreatic secretory granule membrane major glycoprotein GP2 precursor (Pancreatic zymogen granule membrane protein GP-2).

HEPS_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.053193 (rank : 98)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HEPS_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.052593 (rank : 104)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

KLKB1_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.051043 (rank : 119)
Query Neighborhood Hits	54	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

KREM1_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.054092 (rank : 93)
Query Neighborhood Hits	54	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q96MU8, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1	Gene names	KREMEN1, KREMEN, KRM1
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

KREM1_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.057221 (rank : 92)
Query Neighborhood Hits	54	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

LOXL1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.264120 (rank : 27)
Query Neighborhood Hits	54	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

LOXL1_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.263203 (rank : 28)
Query Neighborhood Hits	54	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

LRP12_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.065491 (rank : 68)
Query Neighborhood Hits	54	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP12_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.065471 (rank : 69)
Query Neighborhood Hits	54	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LYOX_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.277621 (rank : 25)
Query Neighborhood Hits	54	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P28300, Q5FWF0	Gene names	LOX
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase).

LYOX_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.275512 (rank : 26)
Query Neighborhood Hits	54	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P28301	Gene names	Lox, Rrg
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase) (RAS excision protein).

MASP1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.068322 (rank : 52)
Query Neighborhood Hits	54	Target Neighborhood Hits	369	Shared Neighborhood Hits	19
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

MASP1_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.067584 (rank : 57)
Query Neighborhood Hits	54	Target Neighborhood Hits	364	Shared Neighborhood Hits	19
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP2_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.067105 (rank : 61)
Query Neighborhood Hits	54	Target Neighborhood Hits	364	Shared Neighborhood Hits	18
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MASP2_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.063631 (rank : 80)
Query Neighborhood Hits	54	Target Neighborhood Hits	382	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MFRP_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.062966 (rank : 82)
Query Neighborhood Hits	54	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

MFRP_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.064160 (rank : 76)
Query Neighborhood Hits	54	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

NETO1_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.063781 (rank : 78)
Query Neighborhood Hits	54	Target Neighborhood Hits	110	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO1_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.062869 (rank : 83)
Query Neighborhood Hits	54	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO2_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.063623 (rank : 81)
Query Neighborhood Hits	54	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO2_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.063945 (rank : 77)
Query Neighborhood Hits	54	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NRP2_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.050003 (rank : 127)
Query Neighborhood Hits	54	Target Neighborhood Hits	120	Shared Neighborhood Hits	6
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

NRP2_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.050462 (rank : 125)
Query Neighborhood Hits	54	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O35375, O35373, O35374, O35376, O35377, O35378	Gene names	Nrp2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

PCOC1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.066685 (rank : 63)
Query Neighborhood Hits	54	Target Neighborhood Hits	146	Shared Neighborhood Hits	5
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

PCOC1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.068022 (rank : 56)
Query Neighborhood Hits	54	Target Neighborhood Hits	100	Shared Neighborhood Hits	6
SwissProt Accessions	Q61398, O35113	Gene names	Pcolce, Pcpe1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein) (P14).

PCOC2_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.072473 (rank : 43)
Query Neighborhood Hits	54	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKZ9, Q9BRH3	Gene names	PCOLCE2, PCPE2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

PCOC2_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.073343 (rank : 41)
Query Neighborhood Hits	54	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4W6, Q3V1K6, Q9CX06	Gene names	Pcolce2, Pcpe2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

ST14_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.073989 (rank : 40)
Query Neighborhood Hits	54	Target Neighborhood Hits	409	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

ST14_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.076414 (rank : 39)
Query Neighborhood Hits	54	Target Neighborhood Hits	419	Shared Neighborhood Hits	21
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

TECTA_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.050673 (rank : 120)
Query Neighborhood Hits	54	Target Neighborhood Hits	244	Shared Neighborhood Hits	11
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

TECTB_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.067396 (rank : 59)
Query Neighborhood Hits	54	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PL2	Gene names	TECTB
Domain Architecture
Description	Beta-tectorin precursor.

TECTB_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.067436 (rank : 58)
Query Neighborhood Hits	54	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O08524	Gene names	Tectb
Domain Architecture
Description	Beta-tectorin precursor.

TEST_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.052283 (rank : 107)
Query Neighborhood Hits	54	Target Neighborhood Hits	172	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

TGBR3_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.066538 (rank : 64)
Query Neighborhood Hits	54	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q03167, Q5T2T4, Q5U731, Q9UGI2	Gene names	TGFBR3
Domain Architecture
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

TGBR3_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.064862 (rank : 73)
Query Neighborhood Hits	54	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O88393, Q6NS72	Gene names	Tgfbr3
Domain Architecture	No domain graphic available
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

TLL1_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.069377 (rank : 47)
Query Neighborhood Hits	54	Target Neighborhood Hits	236	Shared Neighborhood Hits	10
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

TLL1_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.070305 (rank : 45)
Query Neighborhood Hits	54	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

TLL2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.067363 (rank : 60)
Query Neighborhood Hits	54	Target Neighborhood Hits	241	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TLL2_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.068120 (rank : 55)
Query Neighborhood Hits	54	Target Neighborhood Hits	240	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TM11D_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.051410 (rank : 116)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11D_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.051680 (rank : 111)
Query Neighborhood Hits	54	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11E_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.052422 (rank : 106)
Query Neighborhood Hits	54	Target Neighborhood Hits	181	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TM11E_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.051374 (rank : 117)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TMPS2_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.066824 (rank : 62)
Query Neighborhood Hits	54	Target Neighborhood Hits	252	Shared Neighborhood Hits	25
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS2_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.057817 (rank : 91)
Query Neighborhood Hits	54	Target Neighborhood Hits	243	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS4_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.058673 (rank : 90)
Query Neighborhood Hits	54	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

TMPS4_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.070430 (rank : 44)
Query Neighborhood Hits	54	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

TMPS5_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.061989 (rank : 85)
Query Neighborhood Hits	54	Target Neighborhood Hits	181	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS6_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.052787 (rank : 100)
Query Neighborhood Hits	54	Target Neighborhood Hits	338	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS6_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.051919 (rank : 109)
Query Neighborhood Hits	54	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS7_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.064513 (rank : 75)
Query Neighborhood Hits	54	Target Neighborhood Hits	275	Shared Neighborhood Hits	17
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TMPS7_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.061832 (rank : 86)
Query Neighborhood Hits	54	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TMPS9_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.050606 (rank : 121)
Query Neighborhood Hits	54	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

TMPS9_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.050287 (rank : 126)
Query Neighborhood Hits	54	Target Neighborhood Hits	296	Shared Neighborhood Hits	15
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

TMSP8_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.051545 (rank : 113)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

TPA_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.051849 (rank : 110)
Query Neighborhood Hits	54	Target Neighborhood Hits	324	Shared Neighborhood Hits	17
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TPA_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.053023 (rank : 99)
Query Neighborhood Hits	54	Target Neighborhood Hits	335	Shared Neighborhood Hits	18
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TRYG1_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.050523 (rank : 124)
Query Neighborhood Hits	54	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TRYG1_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.051066 (rank : 118)
Query Neighborhood Hits	54	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TSG6_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.066323 (rank : 65)
Query Neighborhood Hits	54	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	P98066, Q8WWI9	Gene names	TNFAIP6, TSG6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein) (Hyaluronate-binding protein).

TSG6_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.066174 (rank : 66)
Query Neighborhood Hits	54	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	O08859	Gene names	Tnfaip6, Tnfip6, Tsg6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein).

TSP50_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.052675 (rank : 101)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

UROK_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.052139 (rank : 108)
Query Neighborhood Hits	54	Target Neighborhood Hits	272	Shared Neighborhood Hits	17
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

ZP1_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.053912 (rank : 94)
Query Neighborhood Hits	54	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

ZP2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.077204 (rank : 38)
Query Neighborhood Hits	54	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q05996	Gene names	ZP2, ZPA
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

ZP2_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.070131 (rank : 46)
Query Neighborhood Hits	54	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P20239	Gene names	Zp2, Zp-2, Zpa
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

ZP3_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.059956 (rank : 87)
Query Neighborhood Hits	54	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P21754, Q06633	Gene names	ZP3, ZP3A, ZPC
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Zona pellucida protein C) (Sperm receptor) (ZP3A/ZP3B).

ZP3_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.063692 (rank : 79)
Query Neighborhood Hits	54	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P10761	Gene names	Zp3, Zp-3, Zpc
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Sperm receptor) (Zona pellucida protein C).

ZP4_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.068254 (rank : 54)
Query Neighborhood Hits	54	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q12836	Gene names	ZP4, ZPB
Domain Architecture
Description	Zona pellucida sperm-binding protein 4 precursor (Zona pellucida sperm-binding protein B).

Hits sorted by NC score

C163A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	54	Target Neighborhood Hits	54	Shared Neighborhood Hits	54
SwissProt Accessions	Q86VB7, Q07898, Q07899, Q07900, Q07901, Q2VLH7	Gene names	CD163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)].

C163A_MOUSE
NC score	0.997146 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	36
SwissProt Accessions	Q2VLH6, Q2VLH5, Q99MX8	Gene names	Cd163, M130
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) [Contains: Soluble CD163 (sCD163)].

C163B_HUMAN
NC score	0.991627 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	54	Target Neighborhood Hits	64	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR16, Q6UWC2	Gene names	CD163L1, CD163B, M160
Domain Architecture	No domain graphic available
Description	Scavenger receptor cysteine-rich type 1 protein M160 precursor (CD163 antigen-like 1) (CD163b antigen).

CD5L_HUMAN
NC score	0.951535 (rank : 4)	θ value	2.3998e-69 (rank : 8)
Query Neighborhood Hits	54	Target Neighborhood Hits	45	Shared Neighborhood Hits	34
SwissProt Accessions	O43866, Q6UX63	Gene names	CD5L
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (IgM-associated peptide).

CD5L_MOUSE
NC score	0.950529 (rank : 5)	θ value	2.24614e-67 (rank : 9)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QWK4, O35300, O35301, Q505P6, Q91W05	Gene names	Cd5l, Aim, Api6
Domain Architecture
Description	CD5 antigen-like precursor (SP-alpha) (CT-2) (Apoptosis inhibitory 6) (Apoptosis inhibitor expressed by macrophages).

CD6_HUMAN
NC score	0.911338 (rank : 6)	θ value	2.25659e-51 (rank : 16)
Query Neighborhood Hits	54	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CD6_MOUSE
NC score	0.908574 (rank : 7)	θ value	5.20228e-48 (rank : 17)
Query Neighborhood Hits	54	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q61003, Q60679, Q61004	Gene names	Cd6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor.

LG3BP_HUMAN
NC score	0.854556 (rank : 8)	θ value	1.52067e-31 (rank : 18)
Query Neighborhood Hits	54	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q08380	Gene names	LGALS3BP, M2BP
Domain Architecture
Description	Galectin-3-binding protein precursor (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (Mac-2 BP) (MAC2BP) (Tumor-associated antigen 90K).

LOXL4_MOUSE
NC score	0.825479 (rank : 9)	θ value	5.73848e-55 (rank : 15)
Query Neighborhood Hits	54	Target Neighborhood Hits	50	Shared Neighborhood Hits	32
SwissProt Accessions	Q924C6	Gene names	Loxl4, Loxc
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL4_HUMAN
NC score	0.824955 (rank : 10)	θ value	4.39379e-55 (rank : 14)
Query Neighborhood Hits	54	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q96JB6, Q96DY1, Q96PC0, Q9H6T5	Gene names	LOXL4, LOXC
Domain Architecture
Description	Lysyl oxidase homolog 4 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C).

LOXL3_MOUSE
NC score	0.824094 (rank : 11)	θ value	3.0428e-56 (rank : 10)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z175, Q9JJ39	Gene names	Loxl3, Lor2
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3) (Lysyl oxidase-related protein 2).

LOXL2_MOUSE
NC score	0.823471 (rank : 12)	θ value	1.97229e-55 (rank : 11)
Query Neighborhood Hits	54	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

LOXL3_HUMAN
NC score	0.822776 (rank : 13)	θ value	3.36421e-55 (rank : 12)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P58215, Q96RS1	Gene names	LOXL3, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 3 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 3).

LOXL2_HUMAN
NC score	0.822181 (rank : 14)	θ value	4.39379e-55 (rank : 13)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4K0, Q9BW70, Q9Y5Y8	Gene names	LOXL2
Domain Architecture
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14).

DMBT1_HUMAN
NC score	0.794876 (rank : 15)	θ value	0 (rank : 4)
Query Neighborhood Hits	54	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

DMBT1_MOUSE
NC score	0.718383 (rank : 16)	θ value	0 (rank : 5)
Query Neighborhood Hits	54	Target Neighborhood Hits	134	Shared Neighborhood Hits	33
SwissProt Accessions	Q60997, Q80YC6, Q9JMJ9	Gene names	Dmbt1, Crpd
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (CRP-ductin) (Vomeroglandin).

MSRE_MOUSE
NC score	0.670810 (rank : 17)	θ value	1.85889e-29 (rank : 19)
Query Neighborhood Hits	54	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P30204, Q923G0, Q9QZ56	Gene names	Msr1, Scvr
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A).

CD5_MOUSE
NC score	0.616875 (rank : 18)	θ value	3.52202e-12 (rank : 24)
Query Neighborhood Hits	54	Target Neighborhood Hits	33	Shared Neighborhood Hits	25
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

MSRE_HUMAN
NC score	0.611276 (rank : 19)	θ value	5.97985e-28 (rank : 20)
Query Neighborhood Hits	54	Target Neighborhood Hits	298	Shared Neighborhood Hits	31
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

CD5_HUMAN
NC score	0.587835 (rank : 20)	θ value	3.52202e-12 (rank : 23)
Query Neighborhood Hits	54	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P06127	Gene names	CD5, LEU1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu- 1).

MARCO_HUMAN
NC score	0.523383 (rank : 21)	θ value	5.23862e-24 (rank : 21)
Query Neighborhood Hits	54	Target Neighborhood Hits	199	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UEW3, Q9Y5S3	Gene names	MARCO, SCARA2
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2).

NETR_HUMAN
NC score	0.458820 (rank : 22)	θ value	5.49406e-90 (rank : 6)
Query Neighborhood Hits	54	Target Neighborhood Hits	218	Shared Neighborhood Hits	35
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
NC score	0.443302 (rank : 23)	θ value	9.74306e-71 (rank : 7)
Query Neighborhood Hits	54	Target Neighborhood Hits	216	Shared Neighborhood Hits	35
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

MARCO_MOUSE
NC score	0.419095 (rank : 24)	θ value	8.93572e-24 (rank : 22)
Query Neighborhood Hits	54	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

LYOX_HUMAN
NC score	0.277621 (rank : 25)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	54	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P28300, Q5FWF0	Gene names	LOX
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase).

LYOX_MOUSE
NC score	0.275512 (rank : 26)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	54	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P28301	Gene names	Lox, Rrg
Domain Architecture
Description	Protein-lysine 6-oxidase precursor (EC 1.4.3.13) (Lysyl oxidase) (RAS excision protein).

LOXL1_HUMAN
NC score	0.264120 (rank : 27)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	54	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

LOXL1_MOUSE
NC score	0.263203 (rank : 28)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	54	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

CUZD1_MOUSE
NC score	0.137573 (rank : 29)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	54	Target Neighborhood Hits	91	Shared Neighborhood Hits	6
SwissProt Accessions	P70412, Q9CTZ7	Gene names	Cuzd1, Itmap1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Integral membrane-associated protein 1).

CUZD1_HUMAN
NC score	0.133475 (rank : 30)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	54	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q86UP6, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7	Gene names	CUZD1
Domain Architecture	No domain graphic available
Description	CUB and zona pellucida-like domain-containing protein 1 precursor (Transmembrane protein UO-44).

CFAI_HUMAN
NC score	0.132348 (rank : 31)	θ value	0.00175202 (rank : 26)
Query Neighborhood Hits	54	Target Neighborhood Hits	289	Shared Neighborhood Hits	34
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CFAI_MOUSE
NC score	0.130204 (rank : 32)	θ value	4.1701e-05 (rank : 25)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

ENTK_MOUSE
NC score	0.123018 (rank : 33)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	54	Target Neighborhood Hits	338	Shared Neighborhood Hits	34
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

ENTK_HUMAN
NC score	0.110092 (rank : 34)	θ value	0.0563607 (rank : 30)
Query Neighborhood Hits	54	Target Neighborhood Hits	310	Shared Neighborhood Hits	35
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TMPS3_HUMAN
NC score	0.096677 (rank : 35)	θ value	0.0330416 (rank : 29)
Query Neighborhood Hits	54	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS3_MOUSE
NC score	0.092918 (rank : 36)	θ value	0.0113563 (rank : 27)
Query Neighborhood Hits	54	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPSD_MOUSE
NC score	0.089763 (rank : 37)	θ value	0.0252991 (rank : 28)
Query Neighborhood Hits	54	Target Neighborhood Hits	334	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ZP2_HUMAN
NC score	0.077204 (rank : 38)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	54	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q05996	Gene names	ZP2, ZPA
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

ST14_MOUSE
NC score	0.076414 (rank : 39)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	54	Target Neighborhood Hits	419	Shared Neighborhood Hits	21
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

ST14_HUMAN
NC score	0.073989 (rank : 40)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	54	Target Neighborhood Hits	409	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

PCOC2_MOUSE
NC score	0.073343 (rank : 41)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	54	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4W6, Q3V1K6, Q9CX06	Gene names	Pcolce2, Pcpe2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

CORIN_MOUSE
NC score	0.073177 (rank : 42)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	54	Target Neighborhood Hits	451	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

PCOC2_HUMAN
NC score	0.072473 (rank : 43)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	54	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKZ9, Q9BRH3	Gene names	PCOLCE2, PCPE2
Domain Architecture	No domain graphic available
Description	Procollagen C-endopeptidase enhancer 2 precursor (Procollagen COOH- terminal proteinase enhancer 2) (Procollagen C-proteinase enhancer 2) (PCPE-2).

TMPS4_MOUSE
NC score	0.070430 (rank : 44)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	54	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

TLL1_MOUSE
NC score	0.070305 (rank : 45)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	54	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

ZP2_MOUSE
NC score	0.070131 (rank : 46)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	54	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P20239	Gene names	Zp2, Zp-2, Zpa
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

TLL1_HUMAN
NC score	0.069377 (rank : 47)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	54	Target Neighborhood Hits	236	Shared Neighborhood Hits	10
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

CS1B_MOUSE
NC score	0.069171 (rank : 48)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	54	Target Neighborhood Hits	361	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

C1S_HUMAN
NC score	0.068750 (rank : 49)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	54	Target Neighborhood Hits	359	Shared Neighborhood Hits	20
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

TMPS5_MOUSE
NC score	0.068651 (rank : 50)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	54	Target Neighborhood Hits	185	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

CS1A_MOUSE
NC score	0.068349 (rank : 51)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	54	Target Neighborhood Hits	360	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

MASP1_HUMAN
NC score	0.068322 (rank : 52)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	54	Target Neighborhood Hits	369	Shared Neighborhood Hits	19
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

TMPSD_HUMAN
NC score	0.068260 (rank : 53)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	54	Target Neighborhood Hits	333	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ZP4_HUMAN
NC score	0.068254 (rank : 54)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	54	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q12836	Gene names	ZP4, ZPB
Domain Architecture
Description	Zona pellucida sperm-binding protein 4 precursor (Zona pellucida sperm-binding protein B).

TLL2_MOUSE
NC score	0.068120 (rank : 55)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	54	Target Neighborhood Hits	240	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

PCOC1_MOUSE
NC score	0.068022 (rank : 56)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	54	Target Neighborhood Hits	100	Shared Neighborhood Hits	6
SwissProt Accessions	Q61398, O35113	Gene names	Pcolce, Pcpe1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein) (P14).

MASP1_MOUSE
NC score	0.067584 (rank : 57)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	54	Target Neighborhood Hits	364	Shared Neighborhood Hits	19
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

TECTB_MOUSE
NC score	0.067436 (rank : 58)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	54	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O08524	Gene names	Tectb
Domain Architecture
Description	Beta-tectorin precursor.

TECTB_HUMAN
NC score	0.067396 (rank : 59)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	54	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PL2	Gene names	TECTB
Domain Architecture
Description	Beta-tectorin precursor.

TLL2_HUMAN
NC score	0.067363 (rank : 60)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	54	Target Neighborhood Hits	241	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

MASP2_HUMAN
NC score	0.067105 (rank : 61)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	54	Target Neighborhood Hits	364	Shared Neighborhood Hits	18
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

TMPS2_HUMAN
NC score	0.066824 (rank : 62)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	54	Target Neighborhood Hits	252	Shared Neighborhood Hits	25
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

PCOC1_HUMAN
NC score	0.066685 (rank : 63)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	54	Target Neighborhood Hits	146	Shared Neighborhood Hits	5
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

TGBR3_HUMAN
NC score	0.066538 (rank : 64)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	54	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q03167, Q5T2T4, Q5U731, Q9UGI2	Gene names	TGFBR3
Domain Architecture
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

TSG6_HUMAN
NC score	0.066323 (rank : 65)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	54	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	P98066, Q8WWI9	Gene names	TNFAIP6, TSG6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein) (Hyaluronate-binding protein).

TSG6_MOUSE
NC score	0.066174 (rank : 66)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	54	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	O08859	Gene names	Tnfaip6, Tnfip6, Tsg6
Domain Architecture
Description	Tumor necrosis factor-inducible protein TSG-6 precursor (TNF- stimulated gene 6 protein).

C1R_HUMAN
NC score	0.065583 (rank : 67)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	54	Target Neighborhood Hits	364	Shared Neighborhood Hits	20
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

LRP12_HUMAN
NC score	0.065491 (rank : 68)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	54	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP12_MOUSE
NC score	0.065471 (rank : 69)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	54	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

C1RB_MOUSE
NC score	0.065205 (rank : 70)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	54	Target Neighborhood Hits	380	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

BMP1_MOUSE
NC score	0.065180 (rank : 71)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	54	Target Neighborhood Hits	236	Shared Neighborhood Hits	9
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BMP1_HUMAN
NC score	0.065016 (rank : 72)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	54	Target Neighborhood Hits	233	Shared Neighborhood Hits	9
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

TGBR3_MOUSE
NC score	0.064862 (rank : 73)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	54	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O88393, Q6NS72	Gene names	Tgfbr3
Domain Architecture	No domain graphic available
Description	TGF-beta receptor type III precursor (TGFR-3) (Transforming growth factor beta receptor III) (Betaglycan).

C1RA_MOUSE
NC score	0.064634 (rank : 74)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	54	Target Neighborhood Hits	379	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

TMPS7_HUMAN
NC score	0.064513 (rank : 75)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	54	Target Neighborhood Hits	275	Shared Neighborhood Hits	17
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

MFRP_MOUSE
NC score	0.064160 (rank : 76)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	54	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

NETO2_MOUSE
NC score	0.063945 (rank : 77)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	54	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO1_HUMAN
NC score	0.063781 (rank : 78)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	54	Target Neighborhood Hits	110	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

ZP3_MOUSE
NC score	0.063692 (rank : 79)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	54	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P10761	Gene names	Zp3, Zp-3, Zpc
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Sperm receptor) (Zona pellucida protein C).

MASP2_MOUSE
NC score	0.063631 (rank : 80)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	54	Target Neighborhood Hits	382	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

NETO2_HUMAN
NC score	0.063623 (rank : 81)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	54	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

MFRP_HUMAN
NC score	0.062966 (rank : 82)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	54	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

NETO1_MOUSE
NC score	0.062869 (rank : 83)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	54	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

CSMD2_HUMAN
NC score	0.062276 (rank : 84)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	54	Target Neighborhood Hits	188	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

TMPS5_HUMAN
NC score	0.061989 (rank : 85)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	54	Target Neighborhood Hits	181	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS7_MOUSE
NC score	0.061832 (rank : 86)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	54	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

ZP3_HUMAN
NC score	0.059956 (rank : 87)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	54	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P21754, Q06633	Gene names	ZP3, ZP3A, ZPC
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Zona pellucida protein C) (Sperm receptor) (ZP3A/ZP3B).

CORIN_HUMAN
NC score	0.059809 (rank : 88)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	54	Target Neighborhood Hits	453	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

GP2_MOUSE
NC score	0.059345 (rank : 89)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	54	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D733	Gene names	Gp2
Domain Architecture	No domain graphic available
Description	Pancreatic secretory granule membrane major glycoprotein GP2 precursor (Pancreatic zymogen granule membrane protein GP-2).

TMPS4_HUMAN
NC score	0.058673 (rank : 90)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	54	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

TMPS2_MOUSE
NC score	0.057817 (rank : 91)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	54	Target Neighborhood Hits	243	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

KREM1_MOUSE
NC score	0.057221 (rank : 92)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	54	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N43	Gene names	Kremen1, Kremen
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

KREM1_HUMAN
NC score	0.054092 (rank : 93)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	54	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q96MU8, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1	Gene names	KREMEN1, KREMEN, KRM1
Domain Architecture
Description	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor).

ZP1_MOUSE
NC score	0.053912 (rank : 94)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	54	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

CUBN_HUMAN
NC score	0.053899 (rank : 95)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	54	Target Neighborhood Hits	482	Shared Neighborhood Hits	14
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

CSMD3_HUMAN
NC score	0.053597 (rank : 96)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	54	Target Neighborhood Hits	199	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

ACRO_MOUSE
NC score	0.053580 (rank : 97)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	54	Target Neighborhood Hits	185	Shared Neighborhood Hits	13
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

HEPS_HUMAN
NC score	0.053193 (rank : 98)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

TPA_MOUSE
NC score	0.053023 (rank : 99)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	54	Target Neighborhood Hits	335	Shared Neighborhood Hits	18
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TMPS6_HUMAN
NC score	0.052787 (rank : 100)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	54	Target Neighborhood Hits	338	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TSP50_HUMAN
NC score	0.052675 (rank : 101)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

CUBN_MOUSE
NC score	0.052646 (rank : 102)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	54	Target Neighborhood Hits	477	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

ACRO_HUMAN
NC score	0.052640 (rank : 103)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	54	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

HEPS_MOUSE
NC score	0.052593 (rank : 104)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

CSMD1_MOUSE
NC score	0.052547 (rank : 105)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	54	Target Neighborhood Hits	193	Shared Neighborhood Hits	7
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

TM11E_HUMAN
NC score	0.052422 (rank : 106)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	54	Target Neighborhood Hits	181	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TEST_HUMAN
NC score	0.052283 (rank : 107)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	54	Target Neighborhood Hits	172	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

UROK_HUMAN
NC score	0.052139 (rank : 108)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	54	Target Neighborhood Hits	272	Shared Neighborhood Hits	17
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

TMPS6_MOUSE
NC score	0.051919 (rank : 109)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	54	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TPA_HUMAN
NC score	0.051849 (rank : 110)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	54	Target Neighborhood Hits	324	Shared Neighborhood Hits	17
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TM11D_MOUSE
NC score	0.051680 (rank : 111)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	54	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

FA11_HUMAN
NC score	0.051623 (rank : 112)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	54	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TMSP8_MOUSE
NC score	0.051545 (rank : 113)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

CSMD1_HUMAN
NC score	0.051539 (rank : 114)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	6
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

DESC4_MOUSE
NC score	0.051500 (rank : 115)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

TM11D_HUMAN
NC score	0.051410 (rank : 116)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11E_MOUSE
NC score	0.051374 (rank : 117)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	54	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TRYG1_MOUSE
NC score	0.051066 (rank : 118)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	54	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

KLKB1_MOUSE
NC score	0.051043 (rank : 119)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	54	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

TECTA_MOUSE
NC score	0.050673 (rank : 120)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	54	Target Neighborhood Hits	244	Shared Neighborhood Hits	11
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

TMPS9_HUMAN
NC score	0.050606 (rank : 121)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	54	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

FA11_MOUSE
NC score	0.050600 (rank : 122)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	54	Target Neighborhood Hits	180	Shared Neighborhood Hits	13
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

DCBD2_HUMAN
NC score	0.050585 (rank : 123)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	54	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q96PD2, Q8N6M4, Q8TDX2	Gene names	DCBLD2, CLCP1, ESDN
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein) (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1).

TRYG1_HUMAN
NC score	0.050523 (rank : 124)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	54	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

NRP2_MOUSE
NC score	0.050462 (rank : 125)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	54	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O35375, O35373, O35374, O35376, O35377, O35378	Gene names	Nrp2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

TMPS9_MOUSE
NC score	0.050287 (rank : 126)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	54	Target Neighborhood Hits	296	Shared Neighborhood Hits	15
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

NRP2_HUMAN
NC score	0.050003 (rank : 127)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	54	Target Neighborhood Hits	120	Shared Neighborhood Hits	6
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

UROM_HUMAN
NC score	0.042039 (rank : 128)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	54	Target Neighborhood Hits	284	Shared Neighborhood Hits	13
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

TNR27_HUMAN
NC score	0.019113 (rank : 129)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	54	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAV5, Q6UWM2, Q8IZA6	Gene names	EDA2R, TNFRSF27, XEDAR
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor).

LRP1B_MOUSE
NC score	0.012642 (rank : 130)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	54	Target Neighborhood Hits	606	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

MEGF9_MOUSE
NC score	0.011417 (rank : 131)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	54	Target Neighborhood Hits	896	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

RNT2_HUMAN
NC score	0.010707 (rank : 132)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	54	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O00584, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47	Gene names	RNASET2, RNASE6PL
Domain Architecture
Description	Ribonuclease T2 precursor (EC 3.1.27.-) (Ribonuclease 6).

ZADH1_MOUSE
NC score	0.009332 (rank : 133)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	54	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDQ1, Q8BZA2, Q9D1W8	Gene names	Zadh1
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 1 (EC 1.-.-.-).

ZAN_MOUSE
NC score	0.008587 (rank : 134)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	54	Target Neighborhood Hits	808	Shared Neighborhood Hits	15
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ITB2_MOUSE
NC score	0.007571 (rank : 135)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	54	Target Neighborhood Hits	326	Shared Neighborhood Hits	11
SwissProt Accessions	P11835, Q64482	Gene names	Itgb2
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/P150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).

ZN403_MOUSE
NC score	0.006779 (rank : 136)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	54	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SV77, Q5SV75, Q5SV76, Q5SV78, Q6GVH6, Q6P9J4, Q920N4	Gene names	Znf403, Ggnbp2, Zfp403
Domain Architecture	No domain graphic available
Description	Protein ZNF403 (Gametogenetin-binding protein 2) (Dioxin-inducible factor 3) (DIF-3).

RSPO4_MOUSE
NC score	0.006627 (rank : 137)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	54	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

ACS2L_MOUSE
NC score	0.005999 (rank : 138)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	54	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q99NB1, Q8K0M6	Gene names	Acss1, Acas2, Acas2l
Domain Architecture
Description	Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1).

FHL3_HUMAN
NC score	0.005638 (rank : 139)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	54	Target Neighborhood Hits	354	Shared Neighborhood Hits	3
SwissProt Accessions	Q13643	Gene names	FHL3, SLIM2
Domain Architecture
Description	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM- protein 2) (SLIM 2).

JAG2_HUMAN
NC score	0.003565 (rank : 140)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	54	Target Neighborhood Hits	491	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
NC score	0.003316 (rank : 141)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	54	Target Neighborhood Hits	504	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

DLL1_HUMAN
NC score	0.003165 (rank : 142)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	54	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

ANR38_HUMAN
NC score	0.002917 (rank : 143)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	54	Target Neighborhood Hits	443	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

SIG12_MOUSE
NC score	0.002184 (rank : 144)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	54	Target Neighborhood Hits	225	Shared Neighborhood Hits	2
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

O51I2_HUMAN
NC score	-0.003389 (rank : 145)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	54	Target Neighborhood Hits	718	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H344, Q6IF81	Gene names	OR51I2
Domain Architecture
Description	Olfactory receptor 51I2 (Odorant receptor HOR5'beta12) (Olfactory receptor OR11-38).