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Network neighborhood for query Sequence : TMG2_MOUSE

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TMG2_MOUSE
SwissProt Accessions	Q8R182, Q9EQI2	Gene names	Prrg2, N4wbp1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2) (NEDD4 WW domain-binding protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TMG2_MOUSE
θ value	3.67668e-94 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R182, Q9EQI2	Gene names	Prrg2, N4wbp1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2) (NEDD4 WW domain-binding protein 1).

TMG2_HUMAN
θ value	2.3998e-69 (rank : 2)	NC score	0.995279 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	O14669	Gene names	PRRG2, PRGP2, TMG2
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2).

TMG4_MOUSE
θ value	1.80466e-16 (rank : 3)	NC score	0.832442 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BGN6, Q8BM25	Gene names	Prrg4, Tmg4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

TMG4_HUMAN
θ value	1.99529e-15 (rank : 4)	NC score	0.806708 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BZD6	Gene names	PRRG4, TMG4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

PROZ_MOUSE
θ value	2.98157e-11 (rank : 5)	NC score	0.449489 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	410	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

TMG1_HUMAN
θ value	5.08577e-11 (rank : 6)	NC score	0.796271 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	O14668	Gene names	PRRG1, PRGP1, TMG1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 1 precursor (Proline- rich Gla protein 1) (Proline-rich gamma-carboxyglutamic acid protein 1).

TMG3_HUMAN
θ value	1.47974e-10 (rank : 7)	NC score	0.766519 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BZD7, Q8N2N6	Gene names	PRRG3, TMG3
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

TMG3_MOUSE
θ value	5.62301e-10 (rank : 8)	NC score	0.753088 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PAQ9	Gene names	Prrg3, Gm368, Tmg3
Domain Architecture	No domain graphic available
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

PROZ_HUMAN
θ value	9.59137e-10 (rank : 9)	NC score	0.433999 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	422	Shared Neighborhood Hits	22
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

FA7_HUMAN
θ value	1.63604e-09 (rank : 10)	NC score	0.293419 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	404	Shared Neighborhood Hits	22
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

FA9_HUMAN
θ value	1.63604e-09 (rank : 11)	NC score	0.280944 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	421	Shared Neighborhood Hits	22
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

FA10_HUMAN
θ value	8.11959e-09 (rank : 12)	NC score	0.305707 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	431	Shared Neighborhood Hits	22
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

THRB_HUMAN
θ value	1.38499e-08 (rank : 13)	NC score	0.260247 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	196	Shared Neighborhood Hits	22
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

THRB_MOUSE
θ value	1.38499e-08 (rank : 14)	NC score	0.257787 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	195	Shared Neighborhood Hits	22
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

FA10_MOUSE
θ value	1.17247e-07 (rank : 15)	NC score	0.301621 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	435	Shared Neighborhood Hits	22
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA7_MOUSE
θ value	1.99992e-07 (rank : 16)	NC score	0.287253 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

PROS_HUMAN
θ value	1.29631e-06 (rank : 17)	NC score	0.321388 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	340	Shared Neighborhood Hits	22
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

PROS_MOUSE
θ value	2.88788e-06 (rank : 18)	NC score	0.321034 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	330	Shared Neighborhood Hits	22
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

GAS6_MOUSE
θ value	8.40245e-06 (rank : 19)	NC score	0.296185 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	343	Shared Neighborhood Hits	22
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

PROC_MOUSE
θ value	1.43324e-05 (rank : 20)	NC score	0.265582 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	426	Shared Neighborhood Hits	22
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

GAS6_HUMAN
θ value	1.87187e-05 (rank : 21)	NC score	0.294891 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	348	Shared Neighborhood Hits	22
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

PROC_HUMAN
θ value	0.00102713 (rank : 22)	NC score	0.247235 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	406	Shared Neighborhood Hits	22
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

LMA1L_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.033346 (rank : 293)
Query Neighborhood Hits	25	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAT1, Q6UWN2	Gene names	LMAN1L, ERGL
Domain Architecture
Description	ERGIC-53-like protein precursor (ERGIC53-like protein) (Lectin, mannose-binding 1-like) (LMAN1-like protein).

MFN2_HUMAN
θ value	2.36792 (rank : 24)	NC score	0.021002 (rank : 294)
Query Neighborhood Hits	25	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	O95140, O95572, Q5JXC3, Q5JXC4, Q9H131, Q9NSX8	Gene names	MFN2, CPRP1, KIAA0214
Domain Architecture
Description	Transmembrane GTPase MFN2 (EC 3.6.5.-) (Mitofusin-2).

NFAC4_HUMAN
θ value	8.99809 (rank : 25)	NC score	0.007978 (rank : 295)
Query Neighborhood Hits	25	Target Neighborhood Hits	165	Shared Neighborhood Hits	2
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

ACRO_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.097863 (rank : 97)
Query Neighborhood Hits	25	Target Neighborhood Hits	291	Shared Neighborhood Hits	11
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

ACRO_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.098559 (rank : 95)
Query Neighborhood Hits	25	Target Neighborhood Hits	185	Shared Neighborhood Hits	11
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

APOA_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.103537 (rank : 60)
Query Neighborhood Hits	25	Target Neighborhood Hits	221	Shared Neighborhood Hits	11
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

BSSP4_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.100113 (rank : 83)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

BSSP4_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.100568 (rank : 81)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

C1QR1_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.076575 (rank : 201)
Query Neighborhood Hits	25	Target Neighborhood Hits	493	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

C1QR1_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.077063 (rank : 199)
Query Neighborhood Hits	25	Target Neighborhood Hits	342	Shared Neighborhood Hits	13
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

C1RA_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.114102 (rank : 33)
Query Neighborhood Hits	25	Target Neighborhood Hits	379	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.112214 (rank : 35)
Query Neighborhood Hits	25	Target Neighborhood Hits	380	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

C1R_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.116004 (rank : 30)
Query Neighborhood Hits	25	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

C1S_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.107187 (rank : 48)
Query Neighborhood Hits	25	Target Neighborhood Hits	359	Shared Neighborhood Hits	15
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

CAP7_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.074831 (rank : 205)
Query Neighborhood Hits	25	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	P20160, P80014, Q52LG4	Gene names	AZU1
Domain Architecture
Description	Azurocidin precursor (Cationic antimicrobial protein CAP37) (Heparin- binding protein) (HBP).

CATG_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.088063 (rank : 150)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P08311	Gene names	CTSG
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (CG).

CATG_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.092986 (rank : 126)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P28293	Gene names	Ctsg
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (Vimentin-specific protease) (VSP).

CD248_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.089096 (rank : 145)
Query Neighborhood Hits	25	Target Neighborhood Hits	679	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD248_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.088917 (rank : 146)
Query Neighborhood Hits	25	Target Neighborhood Hits	578	Shared Neighborhood Hits	13
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD97_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.052729 (rank : 277)
Query Neighborhood Hits	25	Target Neighborhood Hits	353	Shared Neighborhood Hits	13
SwissProt Accessions	P48960, O00718, O76101, Q8NG72, Q8TBQ7	Gene names	CD97
Domain Architecture
Description	CD97 antigen precursor (Leukocyte antigen CD97).

CFAB_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.097825 (rank : 98)
Query Neighborhood Hits	25	Target Neighborhood Hits	251	Shared Neighborhood Hits	11
SwissProt Accessions	P00751, O15006, Q29944, Q96HX6, Q9BTF5, Q9BX92	Gene names	CFB, BF
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Glycine-rich beta glycoprotein) (GBG) (PBF2) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CFAB_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.097787 (rank : 99)
Query Neighborhood Hits	25	Target Neighborhood Hits	262	Shared Neighborhood Hits	11
SwissProt Accessions	P04186	Gene names	Cfb, Bf, H2-Bf
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CFAD_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.085946 (rank : 154)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

CFAD_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.082728 (rank : 171)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	10
SwissProt Accessions	P03953, Q61280	Gene names	Cfd, Adn, Df
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin) (28 kDa adipocyte protein).

CFAI_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.092062 (rank : 130)
Query Neighborhood Hits	25	Target Neighborhood Hits	289	Shared Neighborhood Hits	10
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CFAI_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.090595 (rank : 139)
Query Neighborhood Hits	25	Target Neighborhood Hits	290	Shared Neighborhood Hits	10
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CLCR_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.102981 (rank : 67)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

CO2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.089455 (rank : 144)
Query Neighborhood Hits	25	Target Neighborhood Hits	258	Shared Neighborhood Hits	11
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CO2_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.095961 (rank : 110)
Query Neighborhood Hits	25	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	P21180	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CORIN_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.089829 (rank : 143)
Query Neighborhood Hits	25	Target Neighborhood Hits	453	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

CORIN_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.090549 (rank : 140)
Query Neighborhood Hits	25	Target Neighborhood Hits	451	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

CRUM1_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.074671 (rank : 206)
Query Neighborhood Hits	25	Target Neighborhood Hits	457	Shared Neighborhood Hits	13
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

CRUM1_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.073573 (rank : 211)
Query Neighborhood Hits	25	Target Neighborhood Hits	444	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

CRUM2_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.070687 (rank : 219)
Query Neighborhood Hits	25	Target Neighborhood Hits	453	Shared Neighborhood Hits	13
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

CS1A_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.108246 (rank : 43)
Query Neighborhood Hits	25	Target Neighborhood Hits	360	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

CS1B_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.108482 (rank : 41)
Query Neighborhood Hits	25	Target Neighborhood Hits	361	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CSPG2_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.057793 (rank : 253)
Query Neighborhood Hits	25	Target Neighborhood Hits	681	Shared Neighborhood Hits	13
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

CSPG2_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.058052 (rank : 252)
Query Neighborhood Hits	25	Target Neighborhood Hits	711	Shared Neighborhood Hits	13
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CSPG3_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.059650 (rank : 249)
Query Neighborhood Hits	25	Target Neighborhood Hits	676	Shared Neighborhood Hits	13
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CSPG3_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.063030 (rank : 238)
Query Neighborhood Hits	25	Target Neighborhood Hits	657	Shared Neighborhood Hits	13
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CTRB1_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.107036 (rank : 51)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

CTRL_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.108401 (rank : 42)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

CUBN_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.053103 (rank : 274)
Query Neighborhood Hits	25	Target Neighborhood Hits	482	Shared Neighborhood Hits	13
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

CUBN_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.056250 (rank : 260)
Query Neighborhood Hits	25	Target Neighborhood Hits	477	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

DESC4_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.103290 (rank : 64)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

DLK_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.061841 (rank : 244)
Query Neighborhood Hits	25	Target Neighborhood Hits	401	Shared Neighborhood Hits	13
SwissProt Accessions	P80370, P15803, Q96DW5	Gene names	DLK1, DLK
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (pG2) [Contains: Fetal antigen 1 (FA1)].

DLK_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.068220 (rank : 224)
Query Neighborhood Hits	25	Target Neighborhood Hits	374	Shared Neighborhood Hits	13
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

DLL1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.075649 (rank : 203)
Query Neighborhood Hits	25	Target Neighborhood Hits	455	Shared Neighborhood Hits	13
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

DLL1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.074266 (rank : 207)
Query Neighborhood Hits	25	Target Neighborhood Hits	456	Shared Neighborhood Hits	13
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

DLL3_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.069267 (rank : 222)
Query Neighborhood Hits	25	Target Neighborhood Hits	419	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

DLL3_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.070685 (rank : 220)
Query Neighborhood Hits	25	Target Neighborhood Hits	399	Shared Neighborhood Hits	13
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

DLL4_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.062870 (rank : 239)
Query Neighborhood Hits	25	Target Neighborhood Hits	435	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

DLL4_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.065631 (rank : 229)
Query Neighborhood Hits	25	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

DNER_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.066806 (rank : 226)
Query Neighborhood Hits	25	Target Neighborhood Hits	460	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

DNER_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.069356 (rank : 221)
Query Neighborhood Hits	25	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

EDIL3_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.059869 (rank : 248)
Query Neighborhood Hits	25	Target Neighborhood Hits	292	Shared Neighborhood Hits	13
SwissProt Accessions	O43854, O43855	Gene names	EDIL3, DEL1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

EDIL3_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.061267 (rank : 245)
Query Neighborhood Hits	25	Target Neighborhood Hits	317	Shared Neighborhood Hits	13
SwissProt Accessions	O35474, O35475	Gene names	Edil3, Del1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

EGFB2_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.082230 (rank : 177)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P36368, P00754	Gene names	Egfbp2, Egfbp-2, Klk-13, Klk13
Domain Architecture
Description	Epidermal growth factor-binding protein type B precursor (EC 3.4.21.35) (EGF-BP B) (Glandular kallikrein K13) (Tissue kallikrein 13) (mGK-13) (Prorenin-converting enzyme) (PRECE).

EGFL7_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.129736 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	325	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

EGFL7_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.091239 (rank : 135)
Query Neighborhood Hits	25	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXT5, Q6XD35, Q9DCP5	Gene names	Egfl7, Megf7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (Zneu1).

EGFL8_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.121285 (rank : 27)
Query Neighborhood Hits	25	Target Neighborhood Hits	270	Shared Neighborhood Hits	13
SwissProt Accessions	Q99944, Q8IV30	Gene names	EGFL8, C6orf8, NG3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8) (Vascular endothelial-statin 2) (VE-statin-2).

EGFL8_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.115091 (rank : 31)
Query Neighborhood Hits	25	Target Neighborhood Hits	266	Shared Neighborhood Hits	13
SwissProt Accessions	Q6GUQ1, O35447	Gene names	Egfl8, Ng3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8).

EGFL9_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.070974 (rank : 218)
Query Neighborhood Hits	25	Target Neighborhood Hits	365	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

EGFL9_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.067918 (rank : 225)
Query Neighborhood Hits	25	Target Neighborhood Hits	379	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

EGF_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.061121 (rank : 246)
Query Neighborhood Hits	25	Target Neighborhood Hits	343	Shared Neighborhood Hits	13
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.061885 (rank : 243)
Query Neighborhood Hits	25	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

ELA1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.091384 (rank : 133)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UNI1, Q5MLF0, Q6DJT0, Q6ISM6	Gene names	ELA1
Domain Architecture
Description	Elastase-1 precursor (EC 3.4.21.36).

ELA2A_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.093051 (rank : 125)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

ELA2A_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.091243 (rank : 134)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

ELA2B_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.092322 (rank : 128)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

ELA3A_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.082697 (rank : 172)
Query Neighborhood Hits	25	Target Neighborhood Hits	173	Shared Neighborhood Hits	10
SwissProt Accessions	P09093, Q9BRW4	Gene names	ELA3A, ELA3
Domain Architecture
Description	Elastase-3A precursor (EC 3.4.21.70) (Elastase IIIA) (Protease E).

ELA3B_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.078930 (rank : 193)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	10
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

ELNE_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.065313 (rank : 232)
Query Neighborhood Hits	25	Target Neighborhood Hits	164	Shared Neighborhood Hits	10
SwissProt Accessions	P08246, P09649, Q6B0D9, Q6LDP5	Gene names	ELA2
Domain Architecture
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase) (PMN elastase) (Bone marrow serine protease) (Medullasin) (Human leukocyte elastase) (HLE).

ELNE_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.060485 (rank : 247)
Query Neighborhood Hits	25	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UP87, Q61515	Gene names	Ela2
Domain Architecture	No domain graphic available
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase).

EMR1_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.050491 (rank : 289)
Query Neighborhood Hits	25	Target Neighborhood Hits	382	Shared Neighborhood Hits	13
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

EMR2_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.054576 (rank : 267)
Query Neighborhood Hits	25	Target Neighborhood Hits	345	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UHX3, Q8NG96, Q9Y4B1	Gene names	EMR2
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 2 precursor (EGF-like module EMR2) (CD312 antigen).

ENTK_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.098005 (rank : 96)
Query Neighborhood Hits	25	Target Neighborhood Hits	310	Shared Neighborhood Hits	11
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

ENTK_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.097280 (rank : 104)
Query Neighborhood Hits	25	Target Neighborhood Hits	338	Shared Neighborhood Hits	11
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

FA11_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.103845 (rank : 58)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

FA11_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.102064 (rank : 70)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

FA12_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.090511 (rank : 141)
Query Neighborhood Hits	25	Target Neighborhood Hits	425	Shared Neighborhood Hits	13
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

FBLN1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.072408 (rank : 215)
Query Neighborhood Hits	25	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

FBLN1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.071454 (rank : 216)
Query Neighborhood Hits	25	Target Neighborhood Hits	329	Shared Neighborhood Hits	13
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

FBLN2_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.075594 (rank : 204)
Query Neighborhood Hits	25	Target Neighborhood Hits	392	Shared Neighborhood Hits	13
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN2_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.073956 (rank : 208)
Query Neighborhood Hits	25	Target Neighborhood Hits	505	Shared Neighborhood Hits	13
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN3_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.071367 (rank : 217)
Query Neighborhood Hits	25	Target Neighborhood Hits	293	Shared Neighborhood Hits	13
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

FBLN3_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.073017 (rank : 212)
Query Neighborhood Hits	25	Target Neighborhood Hits	279	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

FBLN4_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.072822 (rank : 214)
Query Neighborhood Hits	25	Target Neighborhood Hits	278	Shared Neighborhood Hits	13
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

FBLN4_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.072902 (rank : 213)
Query Neighborhood Hits	25	Target Neighborhood Hits	270	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

FBLN5_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.083176 (rank : 169)
Query Neighborhood Hits	25	Target Neighborhood Hits	329	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

FBLN5_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.082344 (rank : 176)
Query Neighborhood Hits	25	Target Neighborhood Hits	317	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

FBN1_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.063556 (rank : 237)
Query Neighborhood Hits	25	Target Neighborhood Hits	557	Shared Neighborhood Hits	13
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.063563 (rank : 236)
Query Neighborhood Hits	25	Target Neighborhood Hits	563	Shared Neighborhood Hits	13
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBN2_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.065200 (rank : 233)
Query Neighborhood Hits	25	Target Neighborhood Hits	560	Shared Neighborhood Hits	13
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.065605 (rank : 230)
Query Neighborhood Hits	25	Target Neighborhood Hits	549	Shared Neighborhood Hits	13
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.064365 (rank : 234)
Query Neighborhood Hits	25	Target Neighborhood Hits	543	Shared Neighborhood Hits	13
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

GRAC_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.080075 (rank : 185)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P08882, Q61389	Gene names	Gzmc, Ctla-5, Ctla5
Domain Architecture
Description	Granzyme C precursor (EC 3.4.21.-) (Cytotoxic cell protease 2) (CCP2) (B10).

GRAD_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.081885 (rank : 179)
Query Neighborhood Hits	25	Target Neighborhood Hits	173	Shared Neighborhood Hits	11
SwissProt Accessions	P11033, P97387	Gene names	Gzmd
Domain Architecture
Description	Granzyme D precursor (EC 3.4.21.-).

GRAE_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.080699 (rank : 183)
Query Neighborhood Hits	25	Target Neighborhood Hits	172	Shared Neighborhood Hits	11
SwissProt Accessions	P08884, P97389	Gene names	Gzme, Ccp3, Ctla-6, Ctla6
Domain Architecture
Description	Granzyme E precursor (EC 3.4.21.-) (Cytotoxic cell protease 3) (CCP3) (CTL serine protease 2) (D12) (Cytotoxic serine protease 2) (MCSP2).

GRAF_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.077538 (rank : 198)
Query Neighborhood Hits	25	Target Neighborhood Hits	172	Shared Neighborhood Hits	11
SwissProt Accessions	P08883	Gene names	Gzmf, Ccp4, Ctla-7, Ctla7
Domain Architecture
Description	Granzyme F precursor (EC 3.4.21.-) (Cytotoxic cell protease 4) (CCP4) (CTL serine protease 3) (C134) (Cytotoxic serine protease 3) (MCSP3).

GRAG_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.079298 (rank : 189)
Query Neighborhood Hits	25	Target Neighborhood Hits	173	Shared Neighborhood Hits	11
SwissProt Accessions	P13366, P97388	Gene names	Gzmg
Domain Architecture
Description	Granzyme G precursor (EC 3.4.21.-) (CTL serine protease 1) (MCSP-1).

GRAH_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.082029 (rank : 178)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P20718	Gene names	GZMH, CGL2, CTSGL2
Domain Architecture
Description	Granzyme H precursor (EC 3.4.21.-) (Cytotoxic T-lymphocyte proteinase) (Cathepsin G-like 2) (CTSGL2) (CCP-X) (Cytotoxic serine protease C) (CSP-C).

GRAK_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.080352 (rank : 184)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	10
SwissProt Accessions	O35205	Gene names	Gzmk
Domain Architecture
Description	Granzyme K precursor (EC 3.4.21.-).

GRAM_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.080771 (rank : 182)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P51124	Gene names	GZMM, MET1
Domain Architecture
Description	Granzyme M precursor (EC 3.4.21.-) (Met-ase) (Natural killer cell granular protease) (HU-Met-1) (Met-1 serine protease).

HABP2_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.108877 (rank : 39)
Query Neighborhood Hits	25	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

HABP2_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.107094 (rank : 50)
Query Neighborhood Hits	25	Target Neighborhood Hits	445	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

HEPS_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.101323 (rank : 75)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HEPS_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.100106 (rank : 84)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HGFA_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.099138 (rank : 93)
Query Neighborhood Hits	25	Target Neighborhood Hits	436	Shared Neighborhood Hits	15
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

HGFA_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.101039 (rank : 77)
Query Neighborhood Hits	25	Target Neighborhood Hits	419	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

HGFL_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.099595 (rank : 89)
Query Neighborhood Hits	25	Target Neighborhood Hits	190	Shared Neighborhood Hits	11
SwissProt Accessions	P26927, Q13350, Q14870	Gene names	MST1, HGFL
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) (Macrophage-stimulating protein) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

HGFL_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.101268 (rank : 76)
Query Neighborhood Hits	25	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P26928	Gene names	Mst1, Hgfl
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

HGF_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.084625 (rank : 160)
Query Neighborhood Hits	25	Target Neighborhood Hits	191	Shared Neighborhood Hits	10
SwissProt Accessions	P14210, Q02935, Q13494, Q14519, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6	Gene names	HGF, HPTA
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

HGF_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.082532 (rank : 173)
Query Neighborhood Hits	25	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	Q08048, Q61662, Q64007, Q6LBE6	Gene names	Hgf
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

HPTR_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.128530 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	166	Shared Neighborhood Hits	11
SwissProt Accessions	P00739, Q7LE20, Q92658, Q92659, Q9ULB0	Gene names	HPR
Domain Architecture
Description	Haptoglobin-related protein precursor.

HPT_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.130313 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	P00738, P00737, Q2PP15, Q3B7J0, Q6LBY9	Gene names	HP
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

HPT_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.123347 (rank : 26)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

JAG1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.066220 (rank : 227)
Query Neighborhood Hits	25	Target Neighborhood Hits	514	Shared Neighborhood Hits	13
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.065826 (rank : 228)
Query Neighborhood Hits	25	Target Neighborhood Hits	518	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG2_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.062307 (rank : 241)
Query Neighborhood Hits	25	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.062666 (rank : 240)
Query Neighborhood Hits	25	Target Neighborhood Hits	504	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

K1B11_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.086157 (rank : 153)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	P15946	Gene names	Klk1b11, Klk-11, Klk11
Domain Architecture
Description	Kallikrein 1-related peptidase b11 precursor (EC 3.4.21.35) (Tissue kallikrein-11) (Glandular kallikrein K11) (mGK-11).

K1B16_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.078997 (rank : 192)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P04071	Gene names	Klk1b16, Klk-16, Klk16
Domain Architecture
Description	Kallikrein 1-related peptidase b16 precursor (EC 3.4.21.54) (Gamma- renin, submandibular gland) (mGK-16).

K1B21_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.083192 (rank : 168)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q61759, Q61760, Q9JM70	Gene names	Klk1b21, Klk-21, Klk21
Domain Architecture
Description	Kallikrein 1-related peptidase b21 precursor (EC 3.4.21.35) (Tissue kallikrein 21) (Glandular kallikrein K21) (mGK-21).

K1B22_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.082460 (rank : 175)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P15948	Gene names	Klk1b22, Klk-22, Klk22
Domain Architecture
Description	Kallikrein 1-related peptidase b22 precursor (EC 3.4.21.35) (Glandular kallikrein K22) (Tissue kallikrein 22) (mGK-22) (Epidermal growth factor-binding protein type A) (EGF-BP A) (Nerve growth factor beta chain endopeptidase) (Beta-NGF-endopeptidase).

K1B24_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.079404 (rank : 188)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	Q61754, Q61755, Q9JM69	Gene names	Klk1b24, Klk-24, Klk24
Domain Architecture
Description	Kallikrein 1-related peptidase b24 precursor (EC 3.4.21.35) (Glandular kallikrein K24) (Tissue kallikrein 24) (mGK-24).

K1B26_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.083410 (rank : 165)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P36369, P00753, P00754	Gene names	Klk1b26, Klk-26, Klk26
Domain Architecture
Description	Kallikrein 1-related peptidase b26 precursor (EC 3.4.21.35) (Glandular kallikrein K26) (Tissue kallikrein 26) (mGK-26) (Prorenin-converting enzyme 2) (PRECE-2).

K1B27_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.078928 (rank : 194)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JM71	Gene names	Klk1b27, Klk-27, Klk27
Domain Architecture
Description	Kallikrein 1-related peptidase b27 precursor (EC 3.4.21.-) (Tissue kallikrein 27) (Glandular kallikrein K27) (mGK-27) (mKlk27).

K1KB1_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.084820 (rank : 157)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	P00755	Gene names	Klk1b1, Klk-1, Klk1
Domain Architecture
Description	Kallikrein 1-related peptidase b1 precursor (EC 3.4.21.35) (Glandular kallikrein K1) (Tissue kallikrein-1) (mGK-1).

K1KB3_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.084733 (rank : 158)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P00756	Gene names	Klk1b3, Klk-3, Klk3, Ngfg
Domain Architecture
Description	Kallikrein 1-related peptidase b3 precursor (EC 3.4.21.35) (Glandular kallikrein K3) (Tissue kallikrein-3) (mGK-3) (7S nerve growth factor gamma chain) (Gamma-NGF) [Contains: Nerve growth factor gamma chain 1; Nerve growth factor gamma chain 2].

K1KB4_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.083519 (rank : 164)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P00757	Gene names	Klk1b4, Klk-4, Klk4, Ngfa
Domain Architecture
Description	Kallikrein 1-related peptidase-like b4 precursor (7S nerve growth factor alpha chain) (Alpha-NGF).

K1KB5_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.082512 (rank : 174)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P15945, Q52KM1, Q565D7	Gene names	Klk1b5, Klk-5, Klk5
Domain Architecture
Description	Kallikrein 1-related peptidase b5 precursor (EC 3.4.21.35) (Glandular kallikrein K5) (Tissue kallikrein-5) (mGK-5).

K1KB8_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.083320 (rank : 166)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P07628	Gene names	Klk1b8, Klk-8, Klk8
Domain Architecture
Description	Kallikrein 1-related peptidase b8 precursor (EC 3.4.21.35) (Tissue kallikrein-8) (Glandular kallikrein K8) (mGK-8).

K1KB9_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.088656 (rank : 147)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P15949	Gene names	Klk1b9, Egfbp3, Klk-9, Klk9
Domain Architecture
Description	Kallikrein 1-related peptidase b9 precursor (EC 3.4.21.35) (Tissue kallikrein-9) (Glandular kallikrein K9) (mGK-9) (Epidermal growth factor-binding protein type C) (EGF-BP C).

KLK10_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.092178 (rank : 129)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	O43240, Q99920, Q9GZW9	Gene names	KLK10, NES1, PRRSL1
Domain Architecture
Description	Kallikrein-10 precursor (EC 3.4.21.-) (Protease serine-like 1) (Normal epithelial cell-specific 1).

KLK11_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.092045 (rank : 131)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBX7, O75837, Q9NS65	Gene names	KLK11, PRSS20, TLSP
Domain Architecture
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin) (Trypsin-like protease).

KLK11_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.096072 (rank : 109)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYN3, Q9QYN4	Gene names	Klk11, Prss20
Domain Architecture	No domain graphic available
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin).

KLK12_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.097365 (rank : 102)
Query Neighborhood Hits	25	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKR0, Q9UKR1	Gene names	KLK12, KLKL5
Domain Architecture
Description	Kallikrein-12 precursor (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5).

KLK13_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.098635 (rank : 94)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKR3, Q9Y433	Gene names	KLK13, KLKL4
Domain Architecture
Description	Kallikrein-13 precursor (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4).

KLK14_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.100266 (rank : 82)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P0G3	Gene names	KLK14, KLKL6
Domain Architecture
Description	Kallikrein-14 precursor (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6).

KLK15_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.099765 (rank : 88)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2R5, Q15358, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9	Gene names	KLK15
Domain Architecture
Description	Kallikrein-15 precursor (EC 3.4.21.-) (ACO protease).

KLK1_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.076806 (rank : 200)
Query Neighborhood Hits	25	Target Neighborhood Hits	183	Shared Neighborhood Hits	10
SwissProt Accessions	P06870, Q8TCV8, Q9BS53, Q9NQU4, Q9UMJ1	Gene names	KLK1
Domain Architecture
Description	Kallikrein-1 precursor (EC 3.4.21.35) (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein).

KLK1_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.084682 (rank : 159)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P15947, Q61855	Gene names	Klk1, Klk-6, Klk6
Domain Architecture
Description	Glandular kallikrein K1 precursor (EC 3.4.21.35) (Tissue kallikrein-6) (mGK-6) (Renal kallikrein) (KAL-B).

KLK2_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.085196 (rank : 156)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P20151, Q15946, Q9UJZ9	Gene names	KLK2
Domain Architecture
Description	Kallikrein-2 precursor (EC 3.4.21.35) (Tissue kallikrein-2) (Glandular kallikrein-1) (hGK-1).

KLK3_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.090714 (rank : 138)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P07288, Q16272, Q86TG8	Gene names	KLK3, APS
Domain Architecture
Description	Prostate-specific antigen precursor (EC 3.4.21.77) (PSA) (Kallikrein- 3) (Semenogelase) (Gamma-seminoprotein) (Seminin) (P-30 antigen).

KLK4_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.094086 (rank : 119)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y5K2, Q4VB16, Q9GZL6, Q9UBJ6	Gene names	KLK4, EMSP1, PRSS17, PSTS
Domain Architecture
Description	Kallikrein-4 precursor (EC 3.4.21.-) (Prostase) (Kallikrein-like protein 1) (KLK-L1) (Enamel matrix serine proteinase 1).

KLK5_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.093895 (rank : 120)
Query Neighborhood Hits	25	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y337, Q9HBG8	Gene names	KLK5, SCTE
Domain Architecture
Description	Kallikrein-5 precursor (EC 3.4.21.-) (Stratum corneum tryptic enzyme) (Kallikrein-like protein 2) (KLK-L2).

KLK6_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.097319 (rank : 103)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q92876	Gene names	KLK6, PRSS18, PRSS9
Domain Architecture
Description	Kallikrein-6 precursor (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59).

KLK7_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.091687 (rank : 132)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P49862, Q8N5N9, Q8NFV7	Gene names	KLK7, PRSS6, SCCE
Domain Architecture
Description	Kallikrein-7 precursor (EC 3.4.21.-) (hK7) (Stratum corneum chymotryptic enzyme) (hSCCE).

KLK7_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.094800 (rank : 115)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VE3, Q9R048	Gene names	Klk7, Prss6, Scce
Domain Architecture	No domain graphic available
Description	Kallikrein-7 precursor (EC 3.4.21.-) (Stratum corneum chymotryptic enzyme) (Thymopsin).

KLK9_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.087959 (rank : 151)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKQ9	Gene names	KLK9
Domain Architecture
Description	Kallikrein-9 precursor (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK- L3).

KLKB1_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.110051 (rank : 37)
Query Neighborhood Hits	25	Target Neighborhood Hits	183	Shared Neighborhood Hits	11
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

KLKB1_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.107803 (rank : 44)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

LDLR_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.054166 (rank : 269)
Query Neighborhood Hits	25	Target Neighborhood Hits	375	Shared Neighborhood Hits	13
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP1B_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.050863 (rank : 288)
Query Neighborhood Hits	25	Target Neighborhood Hits	602	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.051098 (rank : 287)
Query Neighborhood Hits	25	Target Neighborhood Hits	606	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP2_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.053271 (rank : 273)
Query Neighborhood Hits	25	Target Neighborhood Hits	573	Shared Neighborhood Hits	13
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP4_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.051305 (rank : 285)
Query Neighborhood Hits	25	Target Neighborhood Hits	351	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

LRP8_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.050152 (rank : 292)
Query Neighborhood Hits	25	Target Neighborhood Hits	385	Shared Neighborhood Hits	12
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LTB1L_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.057493 (rank : 255)
Query Neighborhood Hits	25	Target Neighborhood Hits	553	Shared Neighborhood Hits	13
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1L_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.055522 (rank : 264)
Query Neighborhood Hits	25	Target Neighborhood Hits	514	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.057396 (rank : 256)
Query Neighborhood Hits	25	Target Neighborhood Hits	502	Shared Neighborhood Hits	13
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.055799 (rank : 262)
Query Neighborhood Hits	25	Target Neighborhood Hits	479	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTBP2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.056470 (rank : 258)
Query Neighborhood Hits	25	Target Neighborhood Hits	552	Shared Neighborhood Hits	13
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.055305 (rank : 266)
Query Neighborhood Hits	25	Target Neighborhood Hits	617	Shared Neighborhood Hits	13
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP3_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.056462 (rank : 259)
Query Neighborhood Hits	25	Target Neighborhood Hits	502	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP3_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.063792 (rank : 235)
Query Neighborhood Hits	25	Target Neighborhood Hits	475	Shared Neighborhood Hits	13
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP4_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.058674 (rank : 250)
Query Neighborhood Hits	25	Target Neighborhood Hits	607	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

LYAM2_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.052393 (rank : 279)
Query Neighborhood Hits	25	Target Neighborhood Hits	420	Shared Neighborhood Hits	13
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

LYAM3_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.050251 (rank : 291)
Query Neighborhood Hits	25	Target Neighborhood Hits	390	Shared Neighborhood Hits	11
SwissProt Accessions	Q01102	Gene names	Selp, Grmp
Domain Architecture
Description	P-selectin precursor (Granule membrane protein 140) (GMP-140) (PADGEM) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (CD62P antigen).

MASP1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.116182 (rank : 29)
Query Neighborhood Hits	25	Target Neighborhood Hits	369	Shared Neighborhood Hits	15
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

MASP1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.116387 (rank : 28)
Query Neighborhood Hits	25	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP2_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.113388 (rank : 34)
Query Neighborhood Hits	25	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MASP2_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.114133 (rank : 32)
Query Neighborhood Hits	25	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MATN2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.077724 (rank : 195)
Query Neighborhood Hits	25	Target Neighborhood Hits	365	Shared Neighborhood Hits	13
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

MATN2_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.075678 (rank : 202)
Query Neighborhood Hits	25	Target Neighborhood Hits	356	Shared Neighborhood Hits	13
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

MATN3_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.089883 (rank : 142)
Query Neighborhood Hits	25	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	O15232	Gene names	MATN3
Domain Architecture
Description	Matrilin-3 precursor.

MATN3_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.086588 (rank : 152)
Query Neighborhood Hits	25	Target Neighborhood Hits	261	Shared Neighborhood Hits	13
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

MATN4_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.079011 (rank : 191)
Query Neighborhood Hits	25	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

MATN4_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.077619 (rank : 197)
Query Neighborhood Hits	25	Target Neighborhood Hits	277	Shared Neighborhood Hits	13
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

MCPT1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.085264 (rank : 155)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P23946, Q16018	Gene names	CMA1, CYH, CYM
Domain Architecture
Description	Chymase precursor (EC 3.4.21.39) (Mast cell protease I).

MCPT1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.083313 (rank : 167)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P11034	Gene names	Mcpt1
Domain Architecture
Description	Mast cell protease 1 precursor (EC 3.4.21.-) (MMCP-1).

MCPT2_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.079263 (rank : 190)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P15119	Gene names	Mcpt2
Domain Architecture
Description	Mast cell protease 2 precursor (EC 3.4.21.-) (MMCP-2).

MCPT4_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.082901 (rank : 170)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P21812, Q9EPQ9, Q9EQT2	Gene names	Mcpt4
Domain Architecture
Description	Mast cell protease 4 precursor (EC 3.4.21.-) (MMCP-4) (Serosal mast cell protease) (MSMCP) (Myonase).

MCPT5_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.077685 (rank : 196)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P21844, Q9R1F0	Gene names	Mcpt5
Domain Architecture
Description	Mast cell protease 5 precursor (EC 3.4.21.-) (MMCP-5) (Mast cell chymase 1).

MCPT6_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.100001 (rank : 86)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

MCPT8_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.079546 (rank : 187)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P43430, Q9R1F1	Gene names	Mcpt8
Domain Architecture
Description	Mast cell protease 8 precursor (EC 3.4.21.-) (MMCP-8).

MCPT9_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.080981 (rank : 180)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	O35164	Gene names	Mcpt9
Domain Architecture
Description	Mast cell protease 9 precursor (EC 3.4.21.-) (MMCP-9).

MCPTX_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.079836 (rank : 186)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q00356	Gene names	Mcptl
Domain Architecture
Description	Mast cell protease-like protein precursor (EC 3.4.21.-).

MEGF6_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.065420 (rank : 231)
Query Neighborhood Hits	25	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

NETR_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.097368 (rank : 101)
Query Neighborhood Hits	25	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.094916 (rank : 114)
Query Neighborhood Hits	25	Target Neighborhood Hits	216	Shared Neighborhood Hits	11
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

NID2_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.057788 (rank : 254)
Query Neighborhood Hits	25	Target Neighborhood Hits	456	Shared Neighborhood Hits	13
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

NID2_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.054136 (rank : 270)
Query Neighborhood Hits	25	Target Neighborhood Hits	338	Shared Neighborhood Hits	13
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NOTC1_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.054541 (rank : 268)
Query Neighborhood Hits	25	Target Neighborhood Hits	906	Shared Neighborhood Hits	13
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.057067 (rank : 257)
Query Neighborhood Hits	25	Target Neighborhood Hits	916	Shared Neighborhood Hits	13
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC2_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.055618 (rank : 263)
Query Neighborhood Hits	25	Target Neighborhood Hits	1113	Shared Neighborhood Hits	13
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.055459 (rank : 265)
Query Neighborhood Hits	25	Target Neighborhood Hits	1069	Shared Neighborhood Hits	13
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC3_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.058237 (rank : 251)
Query Neighborhood Hits	25	Target Neighborhood Hits	1062	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.055913 (rank : 261)
Query Neighborhood Hits	25	Target Neighborhood Hits	975	Shared Neighborhood Hits	13
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC4_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.052935 (rank : 275)
Query Neighborhood Hits	25	Target Neighborhood Hits	905	Shared Neighborhood Hits	13
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC4_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.053880 (rank : 272)
Query Neighborhood Hits	25	Target Neighborhood Hits	872	Shared Neighborhood Hits	13
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

NRPN_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.094478 (rank : 116)
Query Neighborhood Hits	25	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	O60259, Q9HCB3, Q9UIL9, Q9UQ47	Gene names	KLK8, NRPN, PRSS19, TADG14
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein).

NRPN_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.093749 (rank : 123)
Query Neighborhood Hits	25	Target Neighborhood Hits	186	Shared Neighborhood Hits	11
SwissProt Accessions	Q61955	Gene names	Klk8, Nrpn, Prss19
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8).

PHXR5_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.073925 (rank : 210)
Query Neighborhood Hits	25	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	P08399	Gene names	Phxr5, Per
Domain Architecture	No domain graphic available
Description	Per-hexamer repeat protein 5.

PLMN_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.103433 (rank : 63)
Query Neighborhood Hits	25	Target Neighborhood Hits	204	Shared Neighborhood Hits	11
SwissProt Accessions	P00747, Q15146, Q6PA00	Gene names	PLG
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

PLMN_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.102414 (rank : 68)
Query Neighborhood Hits	25	Target Neighborhood Hits	208	Shared Neighborhood Hits	11
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

POLS2_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.095315 (rank : 112)
Query Neighborhood Hits	25	Target Neighborhood Hits	192	Shared Neighborhood Hits	11
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

POLS2_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.096208 (rank : 108)
Query Neighborhood Hits	25	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

PRS27_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.106659 (rank : 52)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

PRS27_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.103877 (rank : 57)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

PRSS8_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.107211 (rank : 47)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

PRSS8_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.106287 (rank : 54)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

PRTN3_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.080824 (rank : 181)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P24158, P15637, P18078, Q6LBM7, Q9UQD8	Gene names	PRTN3, MBN
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Leukocyte proteinase 3) (PR-3) (PR3) (AGP7) (Wegener autoantigen) (P29) (C-ANCA antigen) (Neutrophil proteinase 4) (NP-4).

PRTN3_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.084179 (rank : 162)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q61096, O08809	Gene names	Prtn3
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Proteinase 3) (PR-3).

SCUB3_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.084606 (rank : 161)
Query Neighborhood Hits	25	Target Neighborhood Hits	428	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SCUB3_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.084032 (rank : 163)
Query Neighborhood Hits	25	Target Neighborhood Hits	442	Shared Neighborhood Hits	13
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SHBG_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.111252 (rank : 36)
Query Neighborhood Hits	25	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	P04278, P14689, Q16616	Gene names	SHBG
Domain Architecture
Description	Sex hormone-binding globulin precursor (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estrogen-binding globulin) (Testosterone-estradiol- binding globulin) (TeBG).

SHBG_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.107350 (rank : 46)
Query Neighborhood Hits	25	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	P97497	Gene names	Shbg
Domain Architecture
Description	Sex hormone-binding globulin precursor (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP).

SLIT1_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.052177 (rank : 280)
Query Neighborhood Hits	25	Target Neighborhood Hits	700	Shared Neighborhood Hits	13
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SLIT1_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.051223 (rank : 286)
Query Neighborhood Hits	25	Target Neighborhood Hits	715	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

SLIT2_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.051488 (rank : 283)
Query Neighborhood Hits	25	Target Neighborhood Hits	708	Shared Neighborhood Hits	13
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.052145 (rank : 281)
Query Neighborhood Hits	25	Target Neighborhood Hits	684	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

ST14_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.099196 (rank : 92)
Query Neighborhood Hits	25	Target Neighborhood Hits	409	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

ST14_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.103229 (rank : 65)
Query Neighborhood Hits	25	Target Neighborhood Hits	419	Shared Neighborhood Hits	15
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

STAB2_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.052875 (rank : 276)
Query Neighborhood Hits	25	Target Neighborhood Hits	534	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

STAB2_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.051779 (rank : 282)
Query Neighborhood Hits	25	Target Neighborhood Hits	528	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

SUSD1_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.062202 (rank : 242)
Query Neighborhood Hits	25	Target Neighborhood Hits	285	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UWL2, Q5T8V7, Q6P9G7, Q8WU83, Q9H6V2, Q9NTA7	Gene names	SUSD1
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 1 precursor.

TEST_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.092772 (rank : 127)
Query Neighborhood Hits	25	Target Neighborhood Hits	172	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

TEST_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.093801 (rank : 121)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

TM11D_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.101932 (rank : 72)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11D_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.103589 (rank : 59)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11E_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.107146 (rank : 49)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TM11E_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.103467 (rank : 62)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TMPS2_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.101989 (rank : 71)
Query Neighborhood Hits	25	Target Neighborhood Hits	252	Shared Neighborhood Hits	11
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS2_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.103190 (rank : 66)
Query Neighborhood Hits	25	Target Neighborhood Hits	243	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS3_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.094392 (rank : 117)
Query Neighborhood Hits	25	Target Neighborhood Hits	245	Shared Neighborhood Hits	11
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS3_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.097775 (rank : 100)
Query Neighborhood Hits	25	Target Neighborhood Hits	239	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPS4_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.102317 (rank : 69)
Query Neighborhood Hits	25	Target Neighborhood Hits	203	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

TMPS4_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.100737 (rank : 79)
Query Neighborhood Hits	25	Target Neighborhood Hits	210	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

TMPS5_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.091156 (rank : 136)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS5_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.095492 (rank : 111)
Query Neighborhood Hits	25	Target Neighborhood Hits	185	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS6_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.108761 (rank : 40)
Query Neighborhood Hits	25	Target Neighborhood Hits	338	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS6_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.110008 (rank : 38)
Query Neighborhood Hits	25	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS7_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.093774 (rank : 122)
Query Neighborhood Hits	25	Target Neighborhood Hits	275	Shared Neighborhood Hits	10
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TMPS7_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.093375 (rank : 124)
Query Neighborhood Hits	25	Target Neighborhood Hits	275	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TMPS9_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.105919 (rank : 55)
Query Neighborhood Hits	25	Target Neighborhood Hits	276	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

TMPS9_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.106328 (rank : 53)
Query Neighborhood Hits	25	Target Neighborhood Hits	296	Shared Neighborhood Hits	11
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

TMPSD_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.099289 (rank : 91)
Query Neighborhood Hits	25	Target Neighborhood Hits	333	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPSD_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.100838 (rank : 78)
Query Neighborhood Hits	25	Target Neighborhood Hits	334	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMSP8_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.107743 (rank : 45)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

TPA_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.099955 (rank : 87)
Query Neighborhood Hits	25	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TPA_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.101892 (rank : 73)
Query Neighborhood Hits	25	Target Neighborhood Hits	335	Shared Neighborhood Hits	13
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TRBM_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.073941 (rank : 209)
Query Neighborhood Hits	25	Target Neighborhood Hits	339	Shared Neighborhood Hits	13
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TRBM_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.068251 (rank : 223)
Query Neighborhood Hits	25	Target Neighborhood Hits	361	Shared Neighborhood Hits	13
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TRY1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.099391 (rank : 90)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	P07477, Q92955, Q9HAN4, Q9HAN5, Q9HAN6, Q9HAN7	Gene names	PRSS1, TRP1, TRY1, TRYP1
Domain Architecture
Description	Trypsin-1 precursor (EC 3.4.21.4) (Trypsin I) (Cationic trypsinogen).

TRY2_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.103524 (rank : 61)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	10
SwissProt Accessions	P07478	Gene names	PRSS2, TRY2, TRYP2
Domain Architecture
Description	Trypsin-2 precursor (EC 3.4.21.4) (Trypsin II) (Anionic trypsinogen).

TRY2_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.100713 (rank : 80)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P07146	Gene names	Prss2, Try2
Domain Architecture
Description	Anionic trypsin-2 precursor (EC 3.4.21.4) (Anionic trypsin II) (Pretrypsinogen II).

TRY3_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.104736 (rank : 56)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

TRYA1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.095183 (rank : 113)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

TRYB1_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.096831 (rank : 105)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB1_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.094184 (rank : 118)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

TRYB2_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.096831 (rank : 106)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

TRYD_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.088357 (rank : 148)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

TRYG1_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.100104 (rank : 85)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TRYG1_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.096607 (rank : 107)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TSP50_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.101870 (rank : 74)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

UROK_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.088293 (rank : 149)
Query Neighborhood Hits	25	Target Neighborhood Hits	272	Shared Neighborhood Hits	9
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

UROK_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.091111 (rank : 137)
Query Neighborhood Hits	25	Target Neighborhood Hits	273	Shared Neighborhood Hits	9
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

UROM_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.053938 (rank : 271)
Query Neighborhood Hits	25	Target Neighborhood Hits	284	Shared Neighborhood Hits	12
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

UROM_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.050309 (rank : 290)
Query Neighborhood Hits	25	Target Neighborhood Hits	276	Shared Neighborhood Hits	11
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

VLDLR_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.051455 (rank : 284)
Query Neighborhood Hits	25	Target Neighborhood Hits	383	Shared Neighborhood Hits	13
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.052462 (rank : 278)
Query Neighborhood Hits	25	Target Neighborhood Hits	360	Shared Neighborhood Hits	13
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

Hits sorted by NC score

TMG2_MOUSE
NC score	0.999962 (rank : 1)	θ value	3.67668e-94 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R182, Q9EQI2	Gene names	Prrg2, N4wbp1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2) (NEDD4 WW domain-binding protein 1).

TMG2_HUMAN
NC score	0.995279 (rank : 2)	θ value	2.3998e-69 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	O14669	Gene names	PRRG2, PRGP2, TMG2
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 2 precursor (Proline- rich Gla protein 2) (Proline-rich gamma-carboxyglutamic acid protein 2).

TMG4_MOUSE
NC score	0.832442 (rank : 3)	θ value	1.80466e-16 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BGN6, Q8BM25	Gene names	Prrg4, Tmg4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

TMG4_HUMAN
NC score	0.806708 (rank : 4)	θ value	1.99529e-15 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	31	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BZD6	Gene names	PRRG4, TMG4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

TMG1_HUMAN
NC score	0.796271 (rank : 5)	θ value	5.08577e-11 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	O14668	Gene names	PRRG1, PRGP1, TMG1
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 1 precursor (Proline- rich Gla protein 1) (Proline-rich gamma-carboxyglutamic acid protein 1).

TMG3_HUMAN
NC score	0.766519 (rank : 6)	θ value	1.47974e-10 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BZD7, Q8N2N6	Gene names	PRRG3, TMG3
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

TMG3_MOUSE
NC score	0.753088 (rank : 7)	θ value	5.62301e-10 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PAQ9	Gene names	Prrg3, Gm368, Tmg3
Domain Architecture	No domain graphic available
Description	Transmembrane gamma-carboxyglutamic acid protein 3 precursor (Proline- rich Gla protein 3) (Proline-rich gamma-carboxyglutamic acid protein 3).

PROZ_MOUSE
NC score	0.449489 (rank : 8)	θ value	2.98157e-11 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	410	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PROZ_HUMAN
NC score	0.433999 (rank : 9)	θ value	9.59137e-10 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	422	Shared Neighborhood Hits	22
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PROS_HUMAN
NC score	0.321388 (rank : 10)	θ value	1.29631e-06 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	340	Shared Neighborhood Hits	22
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

PROS_MOUSE
NC score	0.321034 (rank : 11)	θ value	2.88788e-06 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	330	Shared Neighborhood Hits	22
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

FA10_HUMAN
NC score	0.305707 (rank : 12)	θ value	8.11959e-09 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	431	Shared Neighborhood Hits	22
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA10_MOUSE
NC score	0.301621 (rank : 13)	θ value	1.17247e-07 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	435	Shared Neighborhood Hits	22
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

GAS6_MOUSE
NC score	0.296185 (rank : 14)	θ value	8.40245e-06 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	343	Shared Neighborhood Hits	22
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

GAS6_HUMAN
NC score	0.294891 (rank : 15)	θ value	1.87187e-05 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	348	Shared Neighborhood Hits	22
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

FA7_HUMAN
NC score	0.293419 (rank : 16)	θ value	1.63604e-09 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	404	Shared Neighborhood Hits	22
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

FA7_MOUSE
NC score	0.287253 (rank : 17)	θ value	1.99992e-07 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

FA9_HUMAN
NC score	0.280944 (rank : 18)	θ value	1.63604e-09 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	421	Shared Neighborhood Hits	22
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

PROC_MOUSE
NC score	0.265582 (rank : 19)	θ value	1.43324e-05 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	426	Shared Neighborhood Hits	22
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

THRB_HUMAN
NC score	0.260247 (rank : 20)	θ value	1.38499e-08 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	196	Shared Neighborhood Hits	22
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

THRB_MOUSE
NC score	0.257787 (rank : 21)	θ value	1.38499e-08 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	195	Shared Neighborhood Hits	22
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

PROC_HUMAN
NC score	0.247235 (rank : 22)	θ value	0.00102713 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	406	Shared Neighborhood Hits	22
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

HPT_HUMAN
NC score	0.130313 (rank : 23)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	25	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	P00738, P00737, Q2PP15, Q3B7J0, Q6LBY9	Gene names	HP
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

EGFL7_HUMAN
NC score	0.129736 (rank : 24)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	25	Target Neighborhood Hits	325	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

HPTR_HUMAN
NC score	0.128530 (rank : 25)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	25	Target Neighborhood Hits	166	Shared Neighborhood Hits	11
SwissProt Accessions	P00739, Q7LE20, Q92658, Q92659, Q9ULB0	Gene names	HPR
Domain Architecture
Description	Haptoglobin-related protein precursor.

HPT_MOUSE
NC score	0.123347 (rank : 26)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

EGFL8_HUMAN
NC score	0.121285 (rank : 27)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	25	Target Neighborhood Hits	270	Shared Neighborhood Hits	13
SwissProt Accessions	Q99944, Q8IV30	Gene names	EGFL8, C6orf8, NG3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8) (Vascular endothelial-statin 2) (VE-statin-2).

MASP1_MOUSE
NC score	0.116387 (rank : 28)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	25	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP1_HUMAN
NC score	0.116182 (rank : 29)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	25	Target Neighborhood Hits	369	Shared Neighborhood Hits	15
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

C1R_HUMAN
NC score	0.116004 (rank : 30)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	25	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

EGFL8_MOUSE
NC score	0.115091 (rank : 31)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	25	Target Neighborhood Hits	266	Shared Neighborhood Hits	13
SwissProt Accessions	Q6GUQ1, O35447	Gene names	Egfl8, Ng3
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 8 precursor (Epidermal growth factor-like protein 8) (Multiple EGF-like domain protein 8).

MASP2_MOUSE
NC score	0.114133 (rank : 32)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	25	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

C1RA_MOUSE
NC score	0.114102 (rank : 33)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	25	Target Neighborhood Hits	379	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

MASP2_HUMAN
NC score	0.113388 (rank : 34)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	25	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

C1RB_MOUSE
NC score	0.112214 (rank : 35)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	25	Target Neighborhood Hits	380	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

SHBG_HUMAN
NC score	0.111252 (rank : 36)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	25	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	P04278, P14689, Q16616	Gene names	SHBG
Domain Architecture
Description	Sex hormone-binding globulin precursor (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estrogen-binding globulin) (Testosterone-estradiol- binding globulin) (TeBG).

KLKB1_HUMAN
NC score	0.110051 (rank : 37)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	25	Target Neighborhood Hits	183	Shared Neighborhood Hits	11
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

TMPS6_MOUSE
NC score	0.110008 (rank : 38)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	25	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

HABP2_HUMAN
NC score	0.108877 (rank : 39)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	25	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

TMPS6_HUMAN
NC score	0.108761 (rank : 40)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	25	Target Neighborhood Hits	338	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

CS1B_MOUSE
NC score	0.108482 (rank : 41)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	25	Target Neighborhood Hits	361	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CTRL_HUMAN
NC score	0.108401 (rank : 42)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

CS1A_MOUSE
NC score	0.108246 (rank : 43)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	25	Target Neighborhood Hits	360	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

KLKB1_MOUSE
NC score	0.107803 (rank : 44)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

TMSP8_MOUSE
NC score	0.107743 (rank : 45)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

SHBG_MOUSE
NC score	0.107350 (rank : 46)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	25	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	P97497	Gene names	Shbg
Domain Architecture
Description	Sex hormone-binding globulin precursor (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP).

PRSS8_HUMAN
NC score	0.107211 (rank : 47)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

C1S_HUMAN
NC score	0.107187 (rank : 48)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	25	Target Neighborhood Hits	359	Shared Neighborhood Hits	15
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

TM11E_HUMAN
NC score	0.107146 (rank : 49)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

HABP2_MOUSE
NC score	0.107094 (rank : 50)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	25	Target Neighborhood Hits	445	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

CTRB1_HUMAN
NC score	0.107036 (rank : 51)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

PRS27_HUMAN
NC score	0.106659 (rank : 52)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

TMPS9_MOUSE
NC score	0.106328 (rank : 53)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	25	Target Neighborhood Hits	296	Shared Neighborhood Hits	11
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

PRSS8_MOUSE
NC score	0.106287 (rank : 54)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

TMPS9_HUMAN
NC score	0.105919 (rank : 55)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	25	Target Neighborhood Hits	276	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

TRY3_HUMAN
NC score	0.104736 (rank : 56)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

PRS27_MOUSE
NC score	0.103877 (rank : 57)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

FA11_HUMAN
NC score	0.103845 (rank : 58)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TM11D_MOUSE
NC score	0.103589 (rank : 59)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

APOA_HUMAN
NC score	0.103537 (rank : 60)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	25	Target Neighborhood Hits	221	Shared Neighborhood Hits	11
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

TRY2_HUMAN
NC score	0.103524 (rank : 61)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	10
SwissProt Accessions	P07478	Gene names	PRSS2, TRY2, TRYP2
Domain Architecture
Description	Trypsin-2 precursor (EC 3.4.21.4) (Trypsin II) (Anionic trypsinogen).

TM11E_MOUSE
NC score	0.103467 (rank : 62)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

PLMN_HUMAN
NC score	0.103433 (rank : 63)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	25	Target Neighborhood Hits	204	Shared Neighborhood Hits	11
SwissProt Accessions	P00747, Q15146, Q6PA00	Gene names	PLG
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

DESC4_MOUSE
NC score	0.103290 (rank : 64)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

ST14_MOUSE
NC score	0.103229 (rank : 65)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	25	Target Neighborhood Hits	419	Shared Neighborhood Hits	15
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

TMPS2_MOUSE
NC score	0.103190 (rank : 66)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	25	Target Neighborhood Hits	243	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

CLCR_HUMAN
NC score	0.102981 (rank : 67)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

PLMN_MOUSE
NC score	0.102414 (rank : 68)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	25	Target Neighborhood Hits	208	Shared Neighborhood Hits	11
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

TMPS4_HUMAN
NC score	0.102317 (rank : 69)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	25	Target Neighborhood Hits	203	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

FA11_MOUSE
NC score	0.102064 (rank : 70)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

TMPS2_HUMAN
NC score	0.101989 (rank : 71)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	25	Target Neighborhood Hits	252	Shared Neighborhood Hits	11
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TM11D_HUMAN
NC score	0.101932 (rank : 72)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TPA_MOUSE
NC score	0.101892 (rank : 73)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	25	Target Neighborhood Hits	335	Shared Neighborhood Hits	13
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TSP50_HUMAN
NC score	0.101870 (rank : 74)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

HEPS_HUMAN
NC score	0.101323 (rank : 75)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HGFL_MOUSE
NC score	0.101268 (rank : 76)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	25	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P26928	Gene names	Mst1, Hgfl
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

HGFA_MOUSE
NC score	0.101039 (rank : 77)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	25	Target Neighborhood Hits	419	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

TMPSD_MOUSE
NC score	0.100838 (rank : 78)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	25	Target Neighborhood Hits	334	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPS4_MOUSE
NC score	0.100737 (rank : 79)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	25	Target Neighborhood Hits	210	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

TRY2_MOUSE
NC score	0.100713 (rank : 80)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P07146	Gene names	Prss2, Try2
Domain Architecture
Description	Anionic trypsin-2 precursor (EC 3.4.21.4) (Anionic trypsin II) (Pretrypsinogen II).

BSSP4_MOUSE
NC score	0.100568 (rank : 81)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

KLK14_HUMAN
NC score	0.100266 (rank : 82)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P0G3	Gene names	KLK14, KLKL6
Domain Architecture
Description	Kallikrein-14 precursor (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6).

BSSP4_HUMAN
NC score	0.100113 (rank : 83)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

HEPS_MOUSE
NC score	0.100106 (rank : 84)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

TRYG1_HUMAN
NC score	0.100104 (rank : 85)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

MCPT6_MOUSE
NC score	0.100001 (rank : 86)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

TPA_HUMAN
NC score	0.099955 (rank : 87)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	25	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

KLK15_HUMAN
NC score	0.099765 (rank : 88)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2R5, Q15358, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9	Gene names	KLK15
Domain Architecture
Description	Kallikrein-15 precursor (EC 3.4.21.-) (ACO protease).

HGFL_HUMAN
NC score	0.099595 (rank : 89)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	25	Target Neighborhood Hits	190	Shared Neighborhood Hits	11
SwissProt Accessions	P26927, Q13350, Q14870	Gene names	MST1, HGFL
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) (Macrophage-stimulating protein) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

TRY1_HUMAN
NC score	0.099391 (rank : 90)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	P07477, Q92955, Q9HAN4, Q9HAN5, Q9HAN6, Q9HAN7	Gene names	PRSS1, TRP1, TRY1, TRYP1
Domain Architecture
Description	Trypsin-1 precursor (EC 3.4.21.4) (Trypsin I) (Cationic trypsinogen).

TMPSD_HUMAN
NC score	0.099289 (rank : 91)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	25	Target Neighborhood Hits	333	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ST14_HUMAN
NC score	0.099196 (rank : 92)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	25	Target Neighborhood Hits	409	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

HGFA_HUMAN
NC score	0.099138 (rank : 93)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	25	Target Neighborhood Hits	436	Shared Neighborhood Hits	15
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

KLK13_HUMAN
NC score	0.098635 (rank : 94)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKR3, Q9Y433	Gene names	KLK13, KLKL4
Domain Architecture
Description	Kallikrein-13 precursor (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4).

ACRO_MOUSE
NC score	0.098559 (rank : 95)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	25	Target Neighborhood Hits	185	Shared Neighborhood Hits	11
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

ENTK_HUMAN
NC score	0.098005 (rank : 96)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	25	Target Neighborhood Hits	310	Shared Neighborhood Hits	11
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

ACRO_HUMAN
NC score	0.097863 (rank : 97)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	25	Target Neighborhood Hits	291	Shared Neighborhood Hits	11
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

CFAB_HUMAN
NC score	0.097825 (rank : 98)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	25	Target Neighborhood Hits	251	Shared Neighborhood Hits	11
SwissProt Accessions	P00751, O15006, Q29944, Q96HX6, Q9BTF5, Q9BX92	Gene names	CFB, BF
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Glycine-rich beta glycoprotein) (GBG) (PBF2) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CFAB_MOUSE
NC score	0.097787 (rank : 99)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	25	Target Neighborhood Hits	262	Shared Neighborhood Hits	11
SwissProt Accessions	P04186	Gene names	Cfb, Bf, H2-Bf
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

TMPS3_MOUSE
NC score	0.097775 (rank : 100)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	25	Target Neighborhood Hits	239	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

NETR_HUMAN
NC score	0.097368 (rank : 101)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	25	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

KLK12_HUMAN
NC score	0.097365 (rank : 102)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	25	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKR0, Q9UKR1	Gene names	KLK12, KLKL5
Domain Architecture
Description	Kallikrein-12 precursor (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5).

KLK6_HUMAN
NC score	0.097319 (rank : 103)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q92876	Gene names	KLK6, PRSS18, PRSS9
Domain Architecture
Description	Kallikrein-6 precursor (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59).

ENTK_MOUSE
NC score	0.097280 (rank : 104)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	25	Target Neighborhood Hits	338	Shared Neighborhood Hits	11
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TRYB1_HUMAN
NC score	0.096831 (rank : 105)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB2_HUMAN
NC score	0.096831 (rank : 106)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

TRYG1_MOUSE
NC score	0.096607 (rank : 107)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

POLS2_MOUSE
NC score	0.096208 (rank : 108)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	25	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

KLK11_MOUSE
NC score	0.096072 (rank : 109)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYN3, Q9QYN4	Gene names	Klk11, Prss20
Domain Architecture	No domain graphic available
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin).

CO2_MOUSE
NC score	0.095961 (rank : 110)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	25	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	P21180	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

TMPS5_MOUSE
NC score	0.095492 (rank : 111)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	25	Target Neighborhood Hits	185	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

POLS2_HUMAN
NC score	0.095315 (rank : 112)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	25	Target Neighborhood Hits	192	Shared Neighborhood Hits	11
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

TRYA1_HUMAN
NC score	0.095183 (rank : 113)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

NETR_MOUSE
NC score	0.094916 (rank : 114)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	25	Target Neighborhood Hits	216	Shared Neighborhood Hits	11
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

KLK7_MOUSE
NC score	0.094800 (rank : 115)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VE3, Q9R048	Gene names	Klk7, Prss6, Scce
Domain Architecture	No domain graphic available
Description	Kallikrein-7 precursor (EC 3.4.21.-) (Stratum corneum chymotryptic enzyme) (Thymopsin).

NRPN_HUMAN
NC score	0.094478 (rank : 116)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	25	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	O60259, Q9HCB3, Q9UIL9, Q9UQ47	Gene names	KLK8, NRPN, PRSS19, TADG14
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein).

TMPS3_HUMAN
NC score	0.094392 (rank : 117)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	25	Target Neighborhood Hits	245	Shared Neighborhood Hits	11
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TRYB1_MOUSE
NC score	0.094184 (rank : 118)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

KLK4_HUMAN
NC score	0.094086 (rank : 119)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y5K2, Q4VB16, Q9GZL6, Q9UBJ6	Gene names	KLK4, EMSP1, PRSS17, PSTS
Domain Architecture
Description	Kallikrein-4 precursor (EC 3.4.21.-) (Prostase) (Kallikrein-like protein 1) (KLK-L1) (Enamel matrix serine proteinase 1).

KLK5_HUMAN
NC score	0.093895 (rank : 120)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	25	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y337, Q9HBG8	Gene names	KLK5, SCTE
Domain Architecture
Description	Kallikrein-5 precursor (EC 3.4.21.-) (Stratum corneum tryptic enzyme) (Kallikrein-like protein 2) (KLK-L2).

TEST_MOUSE
NC score	0.093801 (rank : 121)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

TMPS7_HUMAN
NC score	0.093774 (rank : 122)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	25	Target Neighborhood Hits	275	Shared Neighborhood Hits	10
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

NRPN_MOUSE
NC score	0.093749 (rank : 123)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	25	Target Neighborhood Hits	186	Shared Neighborhood Hits	11
SwissProt Accessions	Q61955	Gene names	Klk8, Nrpn, Prss19
Domain Architecture
Description	Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8).

TMPS7_MOUSE
NC score	0.093375 (rank : 124)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	25	Target Neighborhood Hits	275	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

ELA2A_HUMAN
NC score	0.093051 (rank : 125)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

CATG_MOUSE
NC score	0.092986 (rank : 126)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P28293	Gene names	Ctsg
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (Vimentin-specific protease) (VSP).

TEST_HUMAN
NC score	0.092772 (rank : 127)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	25	Target Neighborhood Hits	172	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

ELA2B_HUMAN
NC score	0.092322 (rank : 128)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

KLK10_HUMAN
NC score	0.092178 (rank : 129)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	O43240, Q99920, Q9GZW9	Gene names	KLK10, NES1, PRRSL1
Domain Architecture
Description	Kallikrein-10 precursor (EC 3.4.21.-) (Protease serine-like 1) (Normal epithelial cell-specific 1).

CFAI_HUMAN
NC score	0.092062 (rank : 130)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	25	Target Neighborhood Hits	289	Shared Neighborhood Hits	10
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

KLK11_HUMAN
NC score	0.092045 (rank : 131)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBX7, O75837, Q9NS65	Gene names	KLK11, PRSS20, TLSP
Domain Architecture
Description	Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin) (Trypsin-like protease).

KLK7_HUMAN
NC score	0.091687 (rank : 132)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P49862, Q8N5N9, Q8NFV7	Gene names	KLK7, PRSS6, SCCE
Domain Architecture
Description	Kallikrein-7 precursor (EC 3.4.21.-) (hK7) (Stratum corneum chymotryptic enzyme) (hSCCE).

ELA1_HUMAN
NC score	0.091384 (rank : 133)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UNI1, Q5MLF0, Q6DJT0, Q6ISM6	Gene names	ELA1
Domain Architecture
Description	Elastase-1 precursor (EC 3.4.21.36).

ELA2A_MOUSE
NC score	0.091243 (rank : 134)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

EGFL7_MOUSE
NC score	0.091239 (rank : 135)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	25	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXT5, Q6XD35, Q9DCP5	Gene names	Egfl7, Megf7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (Zneu1).

TMPS5_HUMAN
NC score	0.091156 (rank : 136)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	25	Target Neighborhood Hits	181	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

UROK_MOUSE
NC score	0.091111 (rank : 137)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	25	Target Neighborhood Hits	273	Shared Neighborhood Hits	9
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

KLK3_HUMAN
NC score	0.090714 (rank : 138)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P07288, Q16272, Q86TG8	Gene names	KLK3, APS
Domain Architecture
Description	Prostate-specific antigen precursor (EC 3.4.21.77) (PSA) (Kallikrein- 3) (Semenogelase) (Gamma-seminoprotein) (Seminin) (P-30 antigen).

CFAI_MOUSE
NC score	0.090595 (rank : 139)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	25	Target Neighborhood Hits	290	Shared Neighborhood Hits	10
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CORIN_MOUSE
NC score	0.090549 (rank : 140)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	25	Target Neighborhood Hits	451	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

FA12_HUMAN
NC score	0.090511 (rank : 141)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	25	Target Neighborhood Hits	425	Shared Neighborhood Hits	13
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

MATN3_HUMAN
NC score	0.089883 (rank : 142)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	25	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	O15232	Gene names	MATN3
Domain Architecture
Description	Matrilin-3 precursor.

CORIN_HUMAN
NC score	0.089829 (rank : 143)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	25	Target Neighborhood Hits	453	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

CO2_HUMAN
NC score	0.089455 (rank : 144)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	25	Target Neighborhood Hits	258	Shared Neighborhood Hits	11
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CD248_HUMAN
NC score	0.089096 (rank : 145)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	25	Target Neighborhood Hits	679	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD248_MOUSE
NC score	0.088917 (rank : 146)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	25	Target Neighborhood Hits	578	Shared Neighborhood Hits	13
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

K1KB9_MOUSE
NC score	0.088656 (rank : 147)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P15949	Gene names	Klk1b9, Egfbp3, Klk-9, Klk9
Domain Architecture
Description	Kallikrein 1-related peptidase b9 precursor (EC 3.4.21.35) (Tissue kallikrein-9) (Glandular kallikrein K9) (mGK-9) (Epidermal growth factor-binding protein type C) (EGF-BP C).

TRYD_HUMAN
NC score	0.088357 (rank : 148)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

UROK_HUMAN
NC score	0.088293 (rank : 149)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	25	Target Neighborhood Hits	272	Shared Neighborhood Hits	9
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

CATG_HUMAN
NC score	0.088063 (rank : 150)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P08311	Gene names	CTSG
Domain Architecture
Description	Cathepsin G precursor (EC 3.4.21.20) (CG).

KLK9_HUMAN
NC score	0.087959 (rank : 151)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKQ9	Gene names	KLK9
Domain Architecture
Description	Kallikrein-9 precursor (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK- L3).

MATN3_MOUSE
NC score	0.086588 (rank : 152)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	25	Target Neighborhood Hits	261	Shared Neighborhood Hits	13
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

K1B11_MOUSE
NC score	0.086157 (rank : 153)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	P15946	Gene names	Klk1b11, Klk-11, Klk11
Domain Architecture
Description	Kallikrein 1-related peptidase b11 precursor (EC 3.4.21.35) (Tissue kallikrein-11) (Glandular kallikrein K11) (mGK-11).

CFAD_HUMAN
NC score	0.085946 (rank : 154)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	P00746	Gene names	CFD, DF
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).

MCPT1_HUMAN
NC score	0.085264 (rank : 155)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P23946, Q16018	Gene names	CMA1, CYH, CYM
Domain Architecture
Description	Chymase precursor (EC 3.4.21.39) (Mast cell protease I).

KLK2_HUMAN
NC score	0.085196 (rank : 156)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P20151, Q15946, Q9UJZ9	Gene names	KLK2
Domain Architecture
Description	Kallikrein-2 precursor (EC 3.4.21.35) (Tissue kallikrein-2) (Glandular kallikrein-1) (hGK-1).

K1KB1_MOUSE
NC score	0.084820 (rank : 157)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	P00755	Gene names	Klk1b1, Klk-1, Klk1
Domain Architecture
Description	Kallikrein 1-related peptidase b1 precursor (EC 3.4.21.35) (Glandular kallikrein K1) (Tissue kallikrein-1) (mGK-1).

K1KB3_MOUSE
NC score	0.084733 (rank : 158)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P00756	Gene names	Klk1b3, Klk-3, Klk3, Ngfg
Domain Architecture
Description	Kallikrein 1-related peptidase b3 precursor (EC 3.4.21.35) (Glandular kallikrein K3) (Tissue kallikrein-3) (mGK-3) (7S nerve growth factor gamma chain) (Gamma-NGF) [Contains: Nerve growth factor gamma chain 1; Nerve growth factor gamma chain 2].

KLK1_MOUSE
NC score	0.084682 (rank : 159)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P15947, Q61855	Gene names	Klk1, Klk-6, Klk6
Domain Architecture
Description	Glandular kallikrein K1 precursor (EC 3.4.21.35) (Tissue kallikrein-6) (mGK-6) (Renal kallikrein) (KAL-B).

HGF_HUMAN
NC score	0.084625 (rank : 160)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	25	Target Neighborhood Hits	191	Shared Neighborhood Hits	10
SwissProt Accessions	P14210, Q02935, Q13494, Q14519, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6	Gene names	HGF, HPTA
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

SCUB3_HUMAN
NC score	0.084606 (rank : 161)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	25	Target Neighborhood Hits	428	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

PRTN3_MOUSE
NC score	0.084179 (rank : 162)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q61096, O08809	Gene names	Prtn3
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Proteinase 3) (PR-3).

SCUB3_MOUSE
NC score	0.084032 (rank : 163)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	25	Target Neighborhood Hits	442	Shared Neighborhood Hits	13
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

K1KB4_MOUSE
NC score	0.083519 (rank : 164)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P00757	Gene names	Klk1b4, Klk-4, Klk4, Ngfa
Domain Architecture
Description	Kallikrein 1-related peptidase-like b4 precursor (7S nerve growth factor alpha chain) (Alpha-NGF).

K1B26_MOUSE
NC score	0.083410 (rank : 165)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P36369, P00753, P00754	Gene names	Klk1b26, Klk-26, Klk26
Domain Architecture
Description	Kallikrein 1-related peptidase b26 precursor (EC 3.4.21.35) (Glandular kallikrein K26) (Tissue kallikrein 26) (mGK-26) (Prorenin-converting enzyme 2) (PRECE-2).

K1KB8_MOUSE
NC score	0.083320 (rank : 166)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P07628	Gene names	Klk1b8, Klk-8, Klk8
Domain Architecture
Description	Kallikrein 1-related peptidase b8 precursor (EC 3.4.21.35) (Tissue kallikrein-8) (Glandular kallikrein K8) (mGK-8).

MCPT1_MOUSE
NC score	0.083313 (rank : 167)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P11034	Gene names	Mcpt1
Domain Architecture
Description	Mast cell protease 1 precursor (EC 3.4.21.-) (MMCP-1).

K1B21_MOUSE
NC score	0.083192 (rank : 168)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	25	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	Q61759, Q61760, Q9JM70	Gene names	Klk1b21, Klk-21, Klk21
Domain Architecture
Description	Kallikrein 1-related peptidase b21 precursor (EC 3.4.21.35) (Tissue kallikrein 21) (Glandular kallikrein K21) (mGK-21).

FBLN5_HUMAN
NC score	0.083176 (rank : 169)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	25	Target Neighborhood Hits	329	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

MCPT4_MOUSE
NC score	0.082901 (rank : 170)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P21812, Q9EPQ9, Q9EQT2	Gene names	Mcpt4
Domain Architecture
Description	Mast cell protease 4 precursor (EC 3.4.21.-) (MMCP-4) (Serosal mast cell protease) (MSMCP) (Myonase).

CFAD_MOUSE
NC score	0.082728 (rank : 171)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	10
SwissProt Accessions	P03953, Q61280	Gene names	Cfd, Adn, Df
Domain Architecture
Description	Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin) (28 kDa adipocyte protein).

ELA3A_HUMAN
NC score	0.082697 (rank : 172)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	25	Target Neighborhood Hits	173	Shared Neighborhood Hits	10
SwissProt Accessions	P09093, Q9BRW4	Gene names	ELA3A, ELA3
Domain Architecture
Description	Elastase-3A precursor (EC 3.4.21.70) (Elastase IIIA) (Protease E).

HGF_MOUSE
NC score	0.082532 (rank : 173)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	25	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	Q08048, Q61662, Q64007, Q6LBE6	Gene names	Hgf
Domain Architecture
Description	Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain].

K1KB5_MOUSE
NC score	0.082512 (rank : 174)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P15945, Q52KM1, Q565D7	Gene names	Klk1b5, Klk-5, Klk5
Domain Architecture
Description	Kallikrein 1-related peptidase b5 precursor (EC 3.4.21.35) (Glandular kallikrein K5) (Tissue kallikrein-5) (mGK-5).

K1B22_MOUSE
NC score	0.082460 (rank : 175)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P15948	Gene names	Klk1b22, Klk-22, Klk22
Domain Architecture
Description	Kallikrein 1-related peptidase b22 precursor (EC 3.4.21.35) (Glandular kallikrein K22) (Tissue kallikrein 22) (mGK-22) (Epidermal growth factor-binding protein type A) (EGF-BP A) (Nerve growth factor beta chain endopeptidase) (Beta-NGF-endopeptidase).

FBLN5_MOUSE
NC score	0.082344 (rank : 176)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	25	Target Neighborhood Hits	317	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

EGFB2_MOUSE
NC score	0.082230 (rank : 177)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	P36368, P00754	Gene names	Egfbp2, Egfbp-2, Klk-13, Klk13
Domain Architecture
Description	Epidermal growth factor-binding protein type B precursor (EC 3.4.21.35) (EGF-BP B) (Glandular kallikrein K13) (Tissue kallikrein 13) (mGK-13) (Prorenin-converting enzyme) (PRECE).

GRAH_HUMAN
NC score	0.082029 (rank : 178)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P20718	Gene names	GZMH, CGL2, CTSGL2
Domain Architecture
Description	Granzyme H precursor (EC 3.4.21.-) (Cytotoxic T-lymphocyte proteinase) (Cathepsin G-like 2) (CTSGL2) (CCP-X) (Cytotoxic serine protease C) (CSP-C).

GRAD_MOUSE
NC score	0.081885 (rank : 179)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	25	Target Neighborhood Hits	173	Shared Neighborhood Hits	11
SwissProt Accessions	P11033, P97387	Gene names	Gzmd
Domain Architecture
Description	Granzyme D precursor (EC 3.4.21.-).

MCPT9_MOUSE
NC score	0.080981 (rank : 180)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	O35164	Gene names	Mcpt9
Domain Architecture
Description	Mast cell protease 9 precursor (EC 3.4.21.-) (MMCP-9).

PRTN3_HUMAN
NC score	0.080824 (rank : 181)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P24158, P15637, P18078, Q6LBM7, Q9UQD8	Gene names	PRTN3, MBN
Domain Architecture
Description	Myeloblastin precursor (EC 3.4.21.76) (Leukocyte proteinase 3) (PR-3) (PR3) (AGP7) (Wegener autoantigen) (P29) (C-ANCA antigen) (Neutrophil proteinase 4) (NP-4).

GRAM_HUMAN
NC score	0.080771 (rank : 182)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	P51124	Gene names	GZMM, MET1
Domain Architecture
Description	Granzyme M precursor (EC 3.4.21.-) (Met-ase) (Natural killer cell granular protease) (HU-Met-1) (Met-1 serine protease).

GRAE_MOUSE
NC score	0.080699 (rank : 183)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	25	Target Neighborhood Hits	172	Shared Neighborhood Hits	11
SwissProt Accessions	P08884, P97389	Gene names	Gzme, Ccp3, Ctla-6, Ctla6
Domain Architecture
Description	Granzyme E precursor (EC 3.4.21.-) (Cytotoxic cell protease 3) (CCP3) (CTL serine protease 2) (D12) (Cytotoxic serine protease 2) (MCSP2).

GRAK_MOUSE
NC score	0.080352 (rank : 184)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	10
SwissProt Accessions	O35205	Gene names	Gzmk
Domain Architecture
Description	Granzyme K precursor (EC 3.4.21.-).

GRAC_MOUSE
NC score	0.080075 (rank : 185)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	25	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	P08882, Q61389	Gene names	Gzmc, Ctla-5, Ctla5
Domain Architecture
Description	Granzyme C precursor (EC 3.4.21.-) (Cytotoxic cell protease 2) (CCP2) (B10).

MCPTX_MOUSE
NC score	0.079836 (rank : 186)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	25	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q00356	Gene names	Mcptl
Domain Architecture
Description	Mast cell protease-like protein precursor (EC 3.4.21.-).

MCPT8_MOUSE
NC score	0.079546 (rank : 187)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P43430, Q9R1F1	Gene names	Mcpt8
Domain Architecture
Description	Mast cell protease 8 precursor (EC 3.4.21.-) (MMCP-8).

K1B24_MOUSE
NC score	0.079404 (rank : 188)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	25	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	Q61754, Q61755, Q9JM69	Gene names	Klk1b24, Klk-24, Klk24
Domain Architecture
Description	Kallikrein 1-related peptidase b24 precursor (EC 3.4.21.35) (Glandular kallikrein K24) (Tissue kallikrein 24) (mGK-24).

GRAG_MOUSE
NC score	0.079298 (rank : 189)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	25	Target Neighborhood Hits	173	Shared Neighborhood Hits	11
SwissProt Accessions	P13366, P97388	Gene names	Gzmg
Domain Architecture
Description	Granzyme G precursor (EC 3.4.21.-) (CTL serine protease 1) (MCSP-1).

MCPT2_MOUSE
NC score	0.079263 (rank : 190)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P15119	Gene names	Mcpt2
Domain Architecture
Description	Mast cell protease 2 precursor (EC 3.4.21.-) (MMCP-2).

MATN4_HUMAN
NC score	0.079011 (rank : 191)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	25	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

K1B16_MOUSE
NC score	0.078997 (rank : 192)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	25	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P04071	Gene names	Klk1b16, Klk-16, Klk16
Domain Architecture
Description	Kallikrein 1-related peptidase b16 precursor (EC 3.4.21.54) (Gamma- renin, submandibular gland) (mGK-16).

ELA3B_HUMAN
NC score	0.078930 (rank : 193)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	10
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

K1B27_MOUSE
NC score	0.078928 (rank : 194)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	25	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JM71	Gene names	Klk1b27, Klk-27, Klk27
Domain Architecture
Description	Kallikrein 1-related peptidase b27 precursor (EC 3.4.21.-) (Tissue kallikrein 27) (Glandular kallikrein K27) (mGK-27) (mKlk27).

MATN2_HUMAN
NC score	0.077724 (rank : 195)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	25	Target Neighborhood Hits	365	Shared Neighborhood Hits	13
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

MCPT5_MOUSE
NC score	0.077685 (rank : 196)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	25	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	P21844, Q9R1F0	Gene names	Mcpt5
Domain Architecture
Description	Mast cell protease 5 precursor (EC 3.4.21.-) (MMCP-5) (Mast cell chymase 1).

MATN4_MOUSE
NC score	0.077619 (rank : 197)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	25	Target Neighborhood Hits	277	Shared Neighborhood Hits	13
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

GRAF_MOUSE
NC score	0.077538 (rank : 198)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	25	Target Neighborhood Hits	172	Shared Neighborhood Hits	11
SwissProt Accessions	P08883	Gene names	Gzmf, Ccp4, Ctla-7, Ctla7
Domain Architecture
Description	Granzyme F precursor (EC 3.4.21.-) (Cytotoxic cell protease 4) (CCP4) (CTL serine protease 3) (C134) (Cytotoxic serine protease 3) (MCSP3).

C1QR1_MOUSE
NC score	0.077063 (rank : 199)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	25	Target Neighborhood Hits	342	Shared Neighborhood Hits	13
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

KLK1_HUMAN
NC score	0.076806 (rank : 200)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	25	Target Neighborhood Hits	183	Shared Neighborhood Hits	10
SwissProt Accessions	P06870, Q8TCV8, Q9BS53, Q9NQU4, Q9UMJ1	Gene names	KLK1
Domain Architecture
Description	Kallikrein-1 precursor (EC 3.4.21.35) (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein).

C1QR1_HUMAN
NC score	0.076575 (rank : 201)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	25	Target Neighborhood Hits	493	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

MATN2_MOUSE
NC score	0.075678 (rank : 202)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	25	Target Neighborhood Hits	356	Shared Neighborhood Hits	13
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

DLL1_HUMAN
NC score	0.075649 (rank : 203)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	25	Target Neighborhood Hits	455	Shared Neighborhood Hits	13
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

FBLN2_HUMAN
NC score	0.075594 (rank : 204)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	25	Target Neighborhood Hits	392	Shared Neighborhood Hits	13
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

CAP7_HUMAN
NC score	0.074831 (rank : 205)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	25	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	P20160, P80014, Q52LG4	Gene names	AZU1
Domain Architecture
Description	Azurocidin precursor (Cationic antimicrobial protein CAP37) (Heparin- binding protein) (HBP).

CRUM1_HUMAN
NC score	0.074671 (rank : 206)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	25	Target Neighborhood Hits	457	Shared Neighborhood Hits	13
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

DLL1_MOUSE
NC score	0.074266 (rank : 207)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	25	Target Neighborhood Hits	456	Shared Neighborhood Hits	13
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

FBLN2_MOUSE
NC score	0.073956 (rank : 208)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	25	Target Neighborhood Hits	505	Shared Neighborhood Hits	13
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

TRBM_HUMAN
NC score	0.073941 (rank : 209)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	25	Target Neighborhood Hits	339	Shared Neighborhood Hits	13
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

PHXR5_MOUSE
NC score	0.073925 (rank : 210)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	25	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	P08399	Gene names	Phxr5, Per
Domain Architecture	No domain graphic available
Description	Per-hexamer repeat protein 5.

CRUM1_MOUSE
NC score	0.073573 (rank : 211)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	25	Target Neighborhood Hits	444	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

FBLN3_MOUSE
NC score	0.073017 (rank : 212)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	25	Target Neighborhood Hits	279	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

FBLN4_MOUSE
NC score	0.072902 (rank : 213)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	25	Target Neighborhood Hits	270	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

FBLN4_HUMAN
NC score	0.072822 (rank : 214)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	25	Target Neighborhood Hits	278	Shared Neighborhood Hits	13
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

FBLN1_HUMAN
NC score	0.072408 (rank : 215)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	25	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

FBLN1_MOUSE
NC score	0.071454 (rank : 216)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	25	Target Neighborhood Hits	329	Shared Neighborhood Hits	13
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

FBLN3_HUMAN
NC score	0.071367 (rank : 217)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	25	Target Neighborhood Hits	293	Shared Neighborhood Hits	13
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

EGFL9_HUMAN
NC score	0.070974 (rank : 218)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	25	Target Neighborhood Hits	365	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

CRUM2_HUMAN
NC score	0.070687 (rank : 219)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	25	Target Neighborhood Hits	453	Shared Neighborhood Hits	13
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

DLL3_MOUSE
NC score	0.070685 (rank : 220)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	25	Target Neighborhood Hits	399	Shared Neighborhood Hits	13
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

DNER_MOUSE
NC score	0.069356 (rank : 221)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	25	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

DLL3_HUMAN
NC score	0.069267 (rank : 222)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	25	Target Neighborhood Hits	419	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

TRBM_MOUSE
NC score	0.068251 (rank : 223)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	25	Target Neighborhood Hits	361	Shared Neighborhood Hits	13
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

DLK_MOUSE
NC score	0.068220 (rank : 224)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	25	Target Neighborhood Hits	374	Shared Neighborhood Hits	13
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

EGFL9_MOUSE
NC score	0.067918 (rank : 225)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	25	Target Neighborhood Hits	379	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

DNER_HUMAN
NC score	0.066806 (rank : 226)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	25	Target Neighborhood Hits	460	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

JAG1_HUMAN
NC score	0.066220 (rank : 227)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	25	Target Neighborhood Hits	514	Shared Neighborhood Hits	13
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
NC score	0.065826 (rank : 228)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	25	Target Neighborhood Hits	518	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

DLL4_MOUSE
NC score	0.065631 (rank : 229)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	25	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

FBN2_MOUSE
NC score	0.065605 (rank : 230)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	25	Target Neighborhood Hits	549	Shared Neighborhood Hits	13
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

MEGF6_HUMAN
NC score	0.065420 (rank : 231)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	25	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

ELNE_HUMAN
NC score	0.065313 (rank : 232)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	25	Target Neighborhood Hits	164	Shared Neighborhood Hits	10
SwissProt Accessions	P08246, P09649, Q6B0D9, Q6LDP5	Gene names	ELA2
Domain Architecture
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase) (PMN elastase) (Bone marrow serine protease) (Medullasin) (Human leukocyte elastase) (HLE).

FBN2_HUMAN
NC score	0.065200 (rank : 233)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	25	Target Neighborhood Hits	560	Shared Neighborhood Hits	13
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
NC score	0.064365 (rank : 234)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	25	Target Neighborhood Hits	543	Shared Neighborhood Hits	13
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

LTBP3_MOUSE
NC score	0.063792 (rank : 235)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	25	Target Neighborhood Hits	475	Shared Neighborhood Hits	13
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

FBN1_MOUSE
NC score	0.063563 (rank : 236)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	25	Target Neighborhood Hits	563	Shared Neighborhood Hits	13
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_HUMAN
NC score	0.063556 (rank : 237)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	25	Target Neighborhood Hits	557	Shared Neighborhood Hits	13
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

CSPG3_MOUSE
NC score	0.063030 (rank : 238)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	25	Target Neighborhood Hits	657	Shared Neighborhood Hits	13
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

DLL4_HUMAN
NC score	0.062870 (rank : 239)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	25	Target Neighborhood Hits	435	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

JAG2_MOUSE
NC score	0.062666 (rank : 240)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	25	Target Neighborhood Hits	504	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

JAG2_HUMAN
NC score	0.062307 (rank : 241)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	25	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

SUSD1_HUMAN
NC score	0.062202 (rank : 242)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	25	Target Neighborhood Hits	285	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UWL2, Q5T8V7, Q6P9G7, Q8WU83, Q9H6V2, Q9NTA7	Gene names	SUSD1
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 1 precursor.

EGF_MOUSE
NC score	0.061885 (rank : 243)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	25	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

DLK_HUMAN
NC score	0.061841 (rank : 244)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	25	Target Neighborhood Hits	401	Shared Neighborhood Hits	13
SwissProt Accessions	P80370, P15803, Q96DW5	Gene names	DLK1, DLK
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (pG2) [Contains: Fetal antigen 1 (FA1)].

EDIL3_MOUSE
NC score	0.061267 (rank : 245)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	25	Target Neighborhood Hits	317	Shared Neighborhood Hits	13
SwissProt Accessions	O35474, O35475	Gene names	Edil3, Del1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

EGF_HUMAN
NC score	0.061121 (rank : 246)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	25	Target Neighborhood Hits	343	Shared Neighborhood Hits	13
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

ELNE_MOUSE
NC score	0.060485 (rank : 247)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	25	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UP87, Q61515	Gene names	Ela2
Domain Architecture	No domain graphic available
Description	Leukocyte elastase precursor (EC 3.4.21.37) (Elastase-2) (Neutrophil elastase).

EDIL3_HUMAN
NC score	0.059869 (rank : 248)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	25	Target Neighborhood Hits	292	Shared Neighborhood Hits	13
SwissProt Accessions	O43854, O43855	Gene names	EDIL3, DEL1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

CSPG3_HUMAN
NC score	0.059650 (rank : 249)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	25	Target Neighborhood Hits	676	Shared Neighborhood Hits	13
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

LTBP4_MOUSE
NC score	0.058674 (rank : 250)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	25	Target Neighborhood Hits	607	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

NOTC3_HUMAN
NC score	0.058237 (rank : 251)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	25	Target Neighborhood Hits	1062	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

CSPG2_MOUSE
NC score	0.058052 (rank : 252)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	25	Target Neighborhood Hits	711	Shared Neighborhood Hits	13
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CSPG2_HUMAN
NC score	0.057793 (rank : 253)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	25	Target Neighborhood Hits	681	Shared Neighborhood Hits	13
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

NID2_HUMAN
NC score	0.057788 (rank : 254)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	25	Target Neighborhood Hits	456	Shared Neighborhood Hits	13
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

LTB1L_HUMAN
NC score	0.057493 (rank : 255)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	25	Target Neighborhood Hits	553	Shared Neighborhood Hits	13
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
NC score	0.057396 (rank : 256)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	25	Target Neighborhood Hits	502	Shared Neighborhood Hits	13
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

NOTC1_MOUSE
NC score	0.057067 (rank : 257)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	25	Target Neighborhood Hits	916	Shared Neighborhood Hits	13
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

LTBP2_HUMAN
NC score	0.056470 (rank : 258)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	25	Target Neighborhood Hits	552	Shared Neighborhood Hits	13
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP3_HUMAN
NC score	0.056462 (rank : 259)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	25	Target Neighborhood Hits	502	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

CUBN_MOUSE
NC score	0.056250 (rank : 260)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	25	Target Neighborhood Hits	477	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

NOTC3_MOUSE
NC score	0.055913 (rank : 261)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	25	Target Neighborhood Hits	975	Shared Neighborhood Hits	13
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

LTB1S_MOUSE
NC score	0.055799 (rank : 262)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	25	Target Neighborhood Hits	479	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

NOTC2_HUMAN
NC score	0.055618 (rank : 263)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	25	Target Neighborhood Hits	1113	Shared Neighborhood Hits	13
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

LTB1L_MOUSE
NC score	0.055522 (rank : 264)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	25	Target Neighborhood Hits	514	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

NOTC2_MOUSE
NC score	0.055459 (rank : 265)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	25	Target Neighborhood Hits	1069	Shared Neighborhood Hits	13
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

LTBP2_MOUSE
NC score	0.055305 (rank : 266)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	25	Target Neighborhood Hits	617	Shared Neighborhood Hits	13
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

EMR2_HUMAN
NC score	0.054576 (rank : 267)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	25	Target Neighborhood Hits	345	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UHX3, Q8NG96, Q9Y4B1	Gene names	EMR2
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 2 precursor (EGF-like module EMR2) (CD312 antigen).

NOTC1_HUMAN
NC score	0.054541 (rank : 268)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	25	Target Neighborhood Hits	906	Shared Neighborhood Hits	13
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

LDLR_HUMAN
NC score	0.054166 (rank : 269)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	25	Target Neighborhood Hits	375	Shared Neighborhood Hits	13
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

NID2_MOUSE
NC score	0.054136 (rank : 270)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	25	Target Neighborhood Hits	338	Shared Neighborhood Hits	13
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

UROM_HUMAN
NC score	0.053938 (rank : 271)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	25	Target Neighborhood Hits	284	Shared Neighborhood Hits	12
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

NOTC4_MOUSE
NC score	0.053880 (rank : 272)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	25	Target Neighborhood Hits	872	Shared Neighborhood Hits	13
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

LRP2_HUMAN
NC score	0.053271 (rank : 273)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	25	Target Neighborhood Hits	573	Shared Neighborhood Hits	13
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

CUBN_HUMAN
NC score	0.053103 (rank : 274)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	25	Target Neighborhood Hits	482	Shared Neighborhood Hits	13
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

NOTC4_HUMAN
NC score	0.052935 (rank : 275)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	25	Target Neighborhood Hits	905	Shared Neighborhood Hits	13
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

STAB2_HUMAN
NC score	0.052875 (rank : 276)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	25	Target Neighborhood Hits	534	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

CD97_HUMAN
NC score	0.052729 (rank : 277)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	25	Target Neighborhood Hits	353	Shared Neighborhood Hits	13
SwissProt Accessions	P48960, O00718, O76101, Q8NG72, Q8TBQ7	Gene names	CD97
Domain Architecture
Description	CD97 antigen precursor (Leukocyte antigen CD97).

VLDLR_MOUSE
NC score	0.052462 (rank : 278)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	25	Target Neighborhood Hits	360	Shared Neighborhood Hits	13
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LYAM2_MOUSE
NC score	0.052393 (rank : 279)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	25	Target Neighborhood Hits	420	Shared Neighborhood Hits	13
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

SLIT1_HUMAN
NC score	0.052177 (rank : 280)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	25	Target Neighborhood Hits	700	Shared Neighborhood Hits	13
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SLIT2_MOUSE
NC score	0.052145 (rank : 281)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	25	Target Neighborhood Hits	684	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

STAB2_MOUSE
NC score	0.051779 (rank : 282)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	25	Target Neighborhood Hits	528	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

SLIT2_HUMAN
NC score	0.051488 (rank : 283)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	25	Target Neighborhood Hits	708	Shared Neighborhood Hits	13
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

VLDLR_HUMAN
NC score	0.051455 (rank : 284)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	25	Target Neighborhood Hits	383	Shared Neighborhood Hits	13
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP4_MOUSE
NC score	0.051305 (rank : 285)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	25	Target Neighborhood Hits	351	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

SLIT1_MOUSE
NC score	0.051223 (rank : 286)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	25	Target Neighborhood Hits	715	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

LRP1B_MOUSE
NC score	0.051098 (rank : 287)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	25	Target Neighborhood Hits	606	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_HUMAN
NC score	0.050863 (rank : 288)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	25	Target Neighborhood Hits	602	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

EMR1_HUMAN
NC score	0.050491 (rank : 289)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	25	Target Neighborhood Hits	382	Shared Neighborhood Hits	13
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

UROM_MOUSE
NC score	0.050309 (rank : 290)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	25	Target Neighborhood Hits	276	Shared Neighborhood Hits	11
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

LYAM3_MOUSE
NC score	0.050251 (rank : 291)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	25	Target Neighborhood Hits	390	Shared Neighborhood Hits	11
SwissProt Accessions	Q01102	Gene names	Selp, Grmp
Domain Architecture
Description	P-selectin precursor (Granule membrane protein 140) (GMP-140) (PADGEM) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (CD62P antigen).

LRP8_MOUSE
NC score	0.050152 (rank : 292)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	25	Target Neighborhood Hits	385	Shared Neighborhood Hits	12
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LMA1L_HUMAN
NC score	0.033346 (rank : 293)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAT1, Q6UWN2	Gene names	LMAN1L, ERGL
Domain Architecture
Description	ERGIC-53-like protein precursor (ERGIC53-like protein) (Lectin, mannose-binding 1-like) (LMAN1-like protein).

MFN2_HUMAN
NC score	0.021002 (rank : 294)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	O95140, O95572, Q5JXC3, Q5JXC4, Q9H131, Q9NSX8	Gene names	MFN2, CPRP1, KIAA0214
Domain Architecture
Description	Transmembrane GTPase MFN2 (EC 3.6.5.-) (Mitofusin-2).

NFAC4_HUMAN
NC score	0.007978 (rank : 295)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	165	Shared Neighborhood Hits	2
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).