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Network neighborhood for query Sequence : EF2K_HUMAN

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EF2K_HUMAN
SwissProt Accessions	O00418	Gene names	EEF2K
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EF2K_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	O00418	Gene names	EEF2K
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

EF2K_MOUSE
θ value	0 (rank : 2)	NC score	0.993659 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	33	Shared Neighborhood Hits	17
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

TRPM6_HUMAN
θ value	2.28291e-11 (rank : 3)	NC score	0.337678 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_MOUSE
θ value	5.08577e-11 (rank : 4)	NC score	0.334990 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM7_HUMAN
θ value	9.59137e-10 (rank : 5)	NC score	0.318571 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM7_MOUSE
θ value	9.59137e-10 (rank : 6)	NC score	0.322648 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

SEL1L_HUMAN
θ value	0.000786445 (rank : 7)	NC score	0.176293 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEL1L_MOUSE
θ value	0.000786445 (rank : 8)	NC score	0.176522 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

IWS1_MOUSE
θ value	0.813845 (rank : 9)	NC score	0.026721 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	1258	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SRCH_HUMAN
θ value	0.813845 (rank : 10)	NC score	0.058379 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

OXR1_MOUSE
θ value	1.38821 (rank : 11)	NC score	0.026496 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	516	Shared Neighborhood Hits	8
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

OTX1_MOUSE
θ value	1.81305 (rank : 12)	NC score	0.014045 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	372	Shared Neighborhood Hits	4
SwissProt Accessions	P80205	Gene names	Otx1, Otx-1
Domain Architecture
Description	Homeobox protein OTX1.

SFRS4_MOUSE
θ value	1.81305 (rank : 13)	NC score	0.024946 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

K0141_MOUSE
θ value	2.36792 (rank : 14)	NC score	0.084510 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DCV6, Q6A0B8	Gene names	Kiaa0141
Domain Architecture
Description	Protein KIAA0141.

CLK1_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.007277 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	756	Shared Neighborhood Hits	3
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

SRRM2_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.013846 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	1470	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

BRCA1_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.015712 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	436	Shared Neighborhood Hits	8
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

CC019_HUMAN
θ value	5.27518 (rank : 18)	NC score	0.021384 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PII3, Q96CS5	Gene names	C3orf19
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf19.

HUWE1_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.019086 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	443	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.018996 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

MCL1_HUMAN
θ value	5.27518 (rank : 21)	NC score	0.020249 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q07820, Q9HD91, Q9NRQ3, Q9NRQ4, Q9UHR7, Q9UHR8, Q9UHR9, Q9UNJ1	Gene names	MCL1
Domain Architecture
Description	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2- related protein EAT/mcl1) (mcl1/EAT).

OTX1_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.010753 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	379	Shared Neighborhood Hits	5
SwissProt Accessions	P32242, Q53TG6	Gene names	OTX1
Domain Architecture
Description	Homeobox protein OTX1.

UBP42_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.010330 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	445	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

PTHB1_HUMAN
θ value	6.88961 (rank : 24)	NC score	0.024556 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q3SYG4, P78514, Q7KYS6, Q7KYS7, Q8N570, Q99844, Q99854, Q9Y699, Q9Y6A0	Gene names	PTHB1, BBS9
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein) (Bardet-Biedl syndrome 9 protein).

AN32E_HUMAN
θ value	8.99809 (rank : 25)	NC score	0.009076 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	291	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

CA082_HUMAN
θ value	8.99809 (rank : 26)	NC score	0.020127 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXW5, Q49AS7, Q9H8Y2	Gene names	C1orf82
Domain Architecture	No domain graphic available
Description	UPF0385 protein C1orf82.

CBPB1_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.006664 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	P15086, O60834, Q96BQ8	Gene names	CPB1, CPB, PCPB
Domain Architecture
Description	Carboxypeptidase B precursor (EC 3.4.17.2) (Pancreas-specific protein) (PASP).

DHX34_MOUSE
θ value	8.99809 (rank : 28)	NC score	0.005923 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DSPP_MOUSE
θ value	8.99809 (rank : 29)	NC score	0.022766 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	491	Shared Neighborhood Hits	9
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

GIMA4_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.009360 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUV9	Gene names	GIMAP4, IAN1, IMAP4
Domain Architecture
Description	GTPase, IMAP family member 4 (Immunity-associated protein 4) (Immunity-associated nucleotide 1 protein) (hIAN1).

RNF6_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.010343 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

TOP1_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.011793 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

K0141_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.055368 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

TRPC4_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.050527 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.050347 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPM2_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.140357 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM2_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.140781 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM3_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.208167 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TRPM8_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.128503 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.127071 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

Hits sorted by NC score

EF2K_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	O00418	Gene names	EEF2K
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

EF2K_MOUSE
NC score	0.993659 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	33	Shared Neighborhood Hits	17
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

TRPM6_HUMAN
NC score	0.337678 (rank : 3)	θ value	2.28291e-11 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_MOUSE
NC score	0.334990 (rank : 4)	θ value	5.08577e-11 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM7_MOUSE
NC score	0.322648 (rank : 5)	θ value	9.59137e-10 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPM7_HUMAN
NC score	0.318571 (rank : 6)	θ value	9.59137e-10 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM3_HUMAN
NC score	0.208167 (rank : 7)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

SEL1L_MOUSE
NC score	0.176522 (rank : 8)	θ value	0.000786445 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEL1L_HUMAN
NC score	0.176293 (rank : 9)	θ value	0.000786445 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

TRPM2_MOUSE
NC score	0.140781 (rank : 10)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM2_HUMAN
NC score	0.140357 (rank : 11)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM8_HUMAN
NC score	0.128503 (rank : 12)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
NC score	0.127071 (rank : 13)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

K0141_MOUSE
NC score	0.084510 (rank : 14)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DCV6, Q6A0B8	Gene names	Kiaa0141
Domain Architecture
Description	Protein KIAA0141.

SRCH_HUMAN
NC score	0.058379 (rank : 15)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

K0141_HUMAN
NC score	0.055368 (rank : 16)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

TRPC4_HUMAN
NC score	0.050527 (rank : 17)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.050347 (rank : 18)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

IWS1_MOUSE
NC score	0.026721 (rank : 19)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	1258	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

OXR1_MOUSE
NC score	0.026496 (rank : 20)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	516	Shared Neighborhood Hits	8
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

SFRS4_MOUSE
NC score	0.024946 (rank : 21)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

PTHB1_HUMAN
NC score	0.024556 (rank : 22)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q3SYG4, P78514, Q7KYS6, Q7KYS7, Q8N570, Q99844, Q99854, Q9Y699, Q9Y6A0	Gene names	PTHB1, BBS9
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein) (Bardet-Biedl syndrome 9 protein).

DSPP_MOUSE
NC score	0.022766 (rank : 23)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	491	Shared Neighborhood Hits	9
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

CC019_HUMAN
NC score	0.021384 (rank : 24)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PII3, Q96CS5	Gene names	C3orf19
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf19.

MCL1_HUMAN
NC score	0.020249 (rank : 25)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q07820, Q9HD91, Q9NRQ3, Q9NRQ4, Q9UHR7, Q9UHR8, Q9UHR9, Q9UNJ1	Gene names	MCL1
Domain Architecture
Description	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2- related protein EAT/mcl1) (mcl1/EAT).

CA082_HUMAN
NC score	0.020127 (rank : 26)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXW5, Q49AS7, Q9H8Y2	Gene names	C1orf82
Domain Architecture	No domain graphic available
Description	UPF0385 protein C1orf82.

HUWE1_HUMAN
NC score	0.019086 (rank : 27)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	443	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
NC score	0.018996 (rank : 28)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

BRCA1_MOUSE
NC score	0.015712 (rank : 29)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	436	Shared Neighborhood Hits	8
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

OTX1_MOUSE
NC score	0.014045 (rank : 30)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	372	Shared Neighborhood Hits	4
SwissProt Accessions	P80205	Gene names	Otx1, Otx-1
Domain Architecture
Description	Homeobox protein OTX1.

SRRM2_MOUSE
NC score	0.013846 (rank : 31)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	1470	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TOP1_MOUSE
NC score	0.011793 (rank : 32)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

OTX1_HUMAN
NC score	0.010753 (rank : 33)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	379	Shared Neighborhood Hits	5
SwissProt Accessions	P32242, Q53TG6	Gene names	OTX1
Domain Architecture
Description	Homeobox protein OTX1.

RNF6_HUMAN
NC score	0.010343 (rank : 34)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

UBP42_HUMAN
NC score	0.010330 (rank : 35)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	445	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

GIMA4_HUMAN
NC score	0.009360 (rank : 36)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUV9	Gene names	GIMAP4, IAN1, IMAP4
Domain Architecture
Description	GTPase, IMAP family member 4 (Immunity-associated protein 4) (Immunity-associated nucleotide 1 protein) (hIAN1).

AN32E_HUMAN
NC score	0.009076 (rank : 37)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	291	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

CLK1_HUMAN
NC score	0.007277 (rank : 38)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	756	Shared Neighborhood Hits	3
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CBPB1_HUMAN
NC score	0.006664 (rank : 39)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	P15086, O60834, Q96BQ8	Gene names	CPB1, CPB, PCPB
Domain Architecture
Description	Carboxypeptidase B precursor (EC 3.4.17.2) (Pancreas-specific protein) (PASP).

DHX34_MOUSE
NC score	0.005923 (rank : 40)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).