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Network neighborhood for query Sequence : EF2K_MOUSE

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EF2K_MOUSE
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EF2K_HUMAN
θ value	0 (rank : 1)	NC score	0.993659 (rank : 2)
Query Neighborhood Hits	33	Target Neighborhood Hits	32	Shared Neighborhood Hits	17
SwissProt Accessions	O00418	Gene names	EEF2K
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

EF2K_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	33	Target Neighborhood Hits	33	Shared Neighborhood Hits	33
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

TRPM6_HUMAN
θ value	4.59992e-12 (rank : 3)	NC score	0.345804 (rank : 3)
Query Neighborhood Hits	33	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_MOUSE
θ value	4.59992e-12 (rank : 4)	NC score	0.343178 (rank : 4)
Query Neighborhood Hits	33	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM7_HUMAN
θ value	1.47974e-10 (rank : 5)	NC score	0.326661 (rank : 6)
Query Neighborhood Hits	33	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM7_MOUSE
θ value	1.47974e-10 (rank : 6)	NC score	0.330840 (rank : 5)
Query Neighborhood Hits	33	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

SEL1L_HUMAN
θ value	0.000270298 (rank : 7)	NC score	0.186145 (rank : 9)
Query Neighborhood Hits	33	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEL1L_MOUSE
θ value	0.000270298 (rank : 8)	NC score	0.186391 (rank : 8)
Query Neighborhood Hits	33	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

LEO1_MOUSE
θ value	0.0431538 (rank : 9)	NC score	0.050516 (rank : 19)
Query Neighborhood Hits	33	Target Neighborhood Hits	946	Shared Neighborhood Hits	17
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

K0141_MOUSE
θ value	0.365318 (rank : 10)	NC score	0.110635 (rank : 14)
Query Neighborhood Hits	33	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DCV6, Q6A0B8	Gene names	Kiaa0141
Domain Architecture
Description	Protein KIAA0141.

CLK1_HUMAN
θ value	1.06291 (rank : 11)	NC score	0.010924 (rank : 39)
Query Neighborhood Hits	33	Target Neighborhood Hits	756	Shared Neighborhood Hits	4
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

SASH1_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.028212 (rank : 26)
Query Neighborhood Hits	33	Target Neighborhood Hits	263	Shared Neighborhood Hits	5
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

LEO1_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.043668 (rank : 21)
Query Neighborhood Hits	33	Target Neighborhood Hits	958	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

UROL1_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.025950 (rank : 29)
Query Neighborhood Hits	33	Target Neighborhood Hits	213	Shared Neighborhood Hits	2
SwissProt Accessions	Q5DID0, Q5DIC9, Q6LA40, Q6LA41, Q8N216	Gene names	UMODL1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

K0141_HUMAN
θ value	1.81305 (rank : 15)	NC score	0.082329 (rank : 15)
Query Neighborhood Hits	33	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

OSTP_HUMAN
θ value	1.81305 (rank : 16)	NC score	0.044455 (rank : 20)
Query Neighborhood Hits	33	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

IF4B_HUMAN
θ value	2.36792 (rank : 17)	NC score	0.038865 (rank : 23)
Query Neighborhood Hits	33	Target Neighborhood Hits	417	Shared Neighborhood Hits	9
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

IF4B_MOUSE
θ value	2.36792 (rank : 18)	NC score	0.039834 (rank : 22)
Query Neighborhood Hits	33	Target Neighborhood Hits	368	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

RBM10_HUMAN
θ value	3.0926 (rank : 19)	NC score	0.021179 (rank : 32)
Query Neighborhood Hits	33	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	P98175, Q14136	Gene names	RBM10, DXS8237E, KIAA0122
Domain Architecture
Description	RNA-binding protein 10 (RNA-binding motif protein 10).

CLK1_MOUSE
θ value	4.03905 (rank : 20)	NC score	0.006532 (rank : 40)
Query Neighborhood Hits	33	Target Neighborhood Hits	760	Shared Neighborhood Hits	3
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

IF3A_HUMAN
θ value	4.03905 (rank : 21)	NC score	0.013042 (rank : 38)
Query Neighborhood Hits	33	Target Neighborhood Hits	875	Shared Neighborhood Hits	6
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

RU17_HUMAN
θ value	4.03905 (rank : 22)	NC score	0.018917 (rank : 34)
Query Neighborhood Hits	33	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	P08621, P78493, P78494, Q15364, Q15686, Q15687, Q15689, Q99377, Q9UE45, Q9UE46, Q9UE47, Q9UE48, Q9UFQ6	Gene names	SNRP70, RPU1, U1AP1
Domain Architecture
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (snRNP70) (U1-70K).

SFRS4_MOUSE
θ value	4.03905 (rank : 23)	NC score	0.026316 (rank : 28)
Query Neighborhood Hits	33	Target Neighborhood Hits	406	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

ATOH1_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.014015 (rank : 37)
Query Neighborhood Hits	33	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

DSPP_MOUSE
θ value	5.27518 (rank : 25)	NC score	0.035386 (rank : 24)
Query Neighborhood Hits	33	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

HUWE1_HUMAN
θ value	5.27518 (rank : 26)	NC score	0.021232 (rank : 31)
Query Neighborhood Hits	33	Target Neighborhood Hits	443	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.020985 (rank : 33)
Query Neighborhood Hits	33	Target Neighborhood Hits	406	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

RP1L1_HUMAN
θ value	5.27518 (rank : 28)	NC score	0.014491 (rank : 36)
Query Neighborhood Hits	33	Target Neighborhood Hits	1072	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

PTHB1_HUMAN
θ value	6.88961 (rank : 29)	NC score	0.024345 (rank : 30)
Query Neighborhood Hits	33	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q3SYG4, P78514, Q7KYS6, Q7KYS7, Q8N570, Q99844, Q99854, Q9Y699, Q9Y6A0	Gene names	PTHB1, BBS9
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein) (Bardet-Biedl syndrome 9 protein).

SRCH_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.052685 (rank : 16)
Query Neighborhood Hits	33	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

DSPP_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.026425 (rank : 27)
Query Neighborhood Hits	33	Target Neighborhood Hits	645	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

IWS1_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.028257 (rank : 25)
Query Neighborhood Hits	33	Target Neighborhood Hits	1258	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SFR15_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.015883 (rank : 35)
Query Neighborhood Hits	33	Target Neighborhood Hits	368	Shared Neighborhood Hits	7
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

TRPC4_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.052500 (rank : 17)
Query Neighborhood Hits	33	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.052316 (rank : 18)
Query Neighborhood Hits	33	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPM2_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.145858 (rank : 11)
Query Neighborhood Hits	33	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM2_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.146298 (rank : 10)
Query Neighborhood Hits	33	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM3_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.216092 (rank : 7)
Query Neighborhood Hits	33	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TRPM8_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.133589 (rank : 12)
Query Neighborhood Hits	33	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.131935 (rank : 13)
Query Neighborhood Hits	33	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

Hits sorted by NC score

EF2K_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	33	Target Neighborhood Hits	33	Shared Neighborhood Hits	33
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

EF2K_HUMAN
NC score	0.993659 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	33	Target Neighborhood Hits	32	Shared Neighborhood Hits	17
SwissProt Accessions	O00418	Gene names	EEF2K
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

TRPM6_HUMAN
NC score	0.345804 (rank : 3)	θ value	4.59992e-12 (rank : 3)
Query Neighborhood Hits	33	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_MOUSE
NC score	0.343178 (rank : 4)	θ value	4.59992e-12 (rank : 4)
Query Neighborhood Hits	33	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM7_MOUSE
NC score	0.330840 (rank : 5)	θ value	1.47974e-10 (rank : 6)
Query Neighborhood Hits	33	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPM7_HUMAN
NC score	0.326661 (rank : 6)	θ value	1.47974e-10 (rank : 5)
Query Neighborhood Hits	33	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM3_HUMAN
NC score	0.216092 (rank : 7)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	33	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

SEL1L_MOUSE
NC score	0.186391 (rank : 8)	θ value	0.000270298 (rank : 8)
Query Neighborhood Hits	33	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEL1L_HUMAN
NC score	0.186145 (rank : 9)	θ value	0.000270298 (rank : 7)
Query Neighborhood Hits	33	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

TRPM2_MOUSE
NC score	0.146298 (rank : 10)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	33	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM2_HUMAN
NC score	0.145858 (rank : 11)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	33	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM8_HUMAN
NC score	0.133589 (rank : 12)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	33	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
NC score	0.131935 (rank : 13)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	33	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

K0141_MOUSE
NC score	0.110635 (rank : 14)	θ value	0.365318 (rank : 10)
Query Neighborhood Hits	33	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DCV6, Q6A0B8	Gene names	Kiaa0141
Domain Architecture
Description	Protein KIAA0141.

K0141_HUMAN
NC score	0.082329 (rank : 15)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	33	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

SRCH_HUMAN
NC score	0.052685 (rank : 16)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	33	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

TRPC4_HUMAN
NC score	0.052500 (rank : 17)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	33	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.052316 (rank : 18)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	33	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

LEO1_MOUSE
NC score	0.050516 (rank : 19)	θ value	0.0431538 (rank : 9)
Query Neighborhood Hits	33	Target Neighborhood Hits	946	Shared Neighborhood Hits	17
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

OSTP_HUMAN
NC score	0.044455 (rank : 20)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	33	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

LEO1_HUMAN
NC score	0.043668 (rank : 21)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	33	Target Neighborhood Hits	958	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

IF4B_MOUSE
NC score	0.039834 (rank : 22)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	33	Target Neighborhood Hits	368	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

IF4B_HUMAN
NC score	0.038865 (rank : 23)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	33	Target Neighborhood Hits	417	Shared Neighborhood Hits	9
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

DSPP_MOUSE
NC score	0.035386 (rank : 24)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	33	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

IWS1_MOUSE
NC score	0.028257 (rank : 25)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	33	Target Neighborhood Hits	1258	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SASH1_MOUSE
NC score	0.028212 (rank : 26)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	33	Target Neighborhood Hits	263	Shared Neighborhood Hits	5
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

DSPP_HUMAN
NC score	0.026425 (rank : 27)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	33	Target Neighborhood Hits	645	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

SFRS4_MOUSE
NC score	0.026316 (rank : 28)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	33	Target Neighborhood Hits	406	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

UROL1_HUMAN
NC score	0.025950 (rank : 29)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	33	Target Neighborhood Hits	213	Shared Neighborhood Hits	2
SwissProt Accessions	Q5DID0, Q5DIC9, Q6LA40, Q6LA41, Q8N216	Gene names	UMODL1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

PTHB1_HUMAN
NC score	0.024345 (rank : 30)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	33	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q3SYG4, P78514, Q7KYS6, Q7KYS7, Q8N570, Q99844, Q99854, Q9Y699, Q9Y6A0	Gene names	PTHB1, BBS9
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein) (Bardet-Biedl syndrome 9 protein).

HUWE1_HUMAN
NC score	0.021232 (rank : 31)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	33	Target Neighborhood Hits	443	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

RBM10_HUMAN
NC score	0.021179 (rank : 32)	θ value	3.0926 (rank : 19)
Query Neighborhood Hits	33	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	P98175, Q14136	Gene names	RBM10, DXS8237E, KIAA0122
Domain Architecture
Description	RNA-binding protein 10 (RNA-binding motif protein 10).

HUWE1_MOUSE
NC score	0.020985 (rank : 33)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	33	Target Neighborhood Hits	406	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

RU17_HUMAN
NC score	0.018917 (rank : 34)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	33	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	P08621, P78493, P78494, Q15364, Q15686, Q15687, Q15689, Q99377, Q9UE45, Q9UE46, Q9UE47, Q9UE48, Q9UFQ6	Gene names	SNRP70, RPU1, U1AP1
Domain Architecture
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (snRNP70) (U1-70K).

SFR15_HUMAN
NC score	0.015883 (rank : 35)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	33	Target Neighborhood Hits	368	Shared Neighborhood Hits	7
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

RP1L1_HUMAN
NC score	0.014491 (rank : 36)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	33	Target Neighborhood Hits	1072	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

ATOH1_MOUSE
NC score	0.014015 (rank : 37)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	33	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

IF3A_HUMAN
NC score	0.013042 (rank : 38)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	33	Target Neighborhood Hits	875	Shared Neighborhood Hits	6
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

CLK1_HUMAN
NC score	0.010924 (rank : 39)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	33	Target Neighborhood Hits	756	Shared Neighborhood Hits	4
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK1_MOUSE
NC score	0.006532 (rank : 40)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	33	Target Neighborhood Hits	760	Shared Neighborhood Hits	3
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).