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Network neighborhood for query Sequence : DEDD_HUMAN

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DEDD_HUMAN
SwissProt Accessions	O75618, O60737	Gene names	DEDD, DEDPRO1, DEFT
Domain Architecture
Description	Death effector domain-containing protein (Death effector domain- containing testicular molecule) (DEDPro1) (FLDED-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DEDD_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	O75618, O60737	Gene names	DEDD, DEDPRO1, DEFT
Domain Architecture
Description	Death effector domain-containing protein (Death effector domain- containing testicular molecule) (DEDPro1) (FLDED-1).

DEDD_MOUSE
θ value	2.48205e-183 (rank : 2)	NC score	0.994928 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z1L3, Q7TQH8, Q9R227	Gene names	Dedd
Domain Architecture
Description	Death effector domain-containing protein (DEDPro1).

DEDD2_MOUSE
θ value	1.11475e-66 (rank : 3)	NC score	0.948751 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q8QZV0, Q569Y9, Q8JZV1	Gene names	Dedd2, Flame3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

DEDD2_HUMAN
θ value	3.24342e-66 (rank : 4)	NC score	0.948255 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXF8, Q8NBR2, Q8NES1, Q8TAA8, Q96D35	Gene names	DEDD2, FLAME3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

ADRB3_HUMAN
θ value	0.0736092 (rank : 5)	NC score	0.018162 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	900	Shared Neighborhood Hits	3
SwissProt Accessions	P13945, Q4JFT4	Gene names	ADRB3, ADRB3R, B3AR
Domain Architecture
Description	Beta-3 adrenergic receptor (Beta-3 adrenoceptor) (Beta-3 adrenoreceptor).

ZFHX2_HUMAN
θ value	0.21417 (rank : 6)	NC score	0.035125 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	1178	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

CASP8_MOUSE
θ value	0.279714 (rank : 7)	NC score	0.055204 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

BRD4_MOUSE
θ value	0.47712 (rank : 8)	NC score	0.038563 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	845	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

SPR2H_MOUSE
θ value	0.47712 (rank : 9)	NC score	0.060320 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

BRD4_HUMAN
θ value	0.813845 (rank : 10)	NC score	0.037107 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	851	Shared Neighborhood Hits	10
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

MDC1_MOUSE
θ value	1.06291 (rank : 11)	NC score	0.035999 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	998	Shared Neighborhood Hits	20
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PRP2_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.026960 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

ACHA4_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.016159 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	P43681, Q4JGR7	Gene names	CHRNA4, NACRA4
Domain Architecture
Description	Neuronal acetylcholine receptor protein subunit alpha-4 precursor.

ATF5_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.052168 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2D1, Q9BSA1, Q9UNQ3	Gene names	ATF5, ATFX
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-5 (Activating transcription factor 5) (Transcription factor ATFx).

CCDC6_HUMAN
θ value	1.81305 (rank : 15)	NC score	0.024488 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	723	Shared Neighborhood Hits	6
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CD2L5_MOUSE
θ value	1.81305 (rank : 16)	NC score	0.006304 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	1011	Shared Neighborhood Hits	10
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

SRRM2_HUMAN
θ value	1.81305 (rank : 17)	NC score	0.027211 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	1296	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CASP8_HUMAN
θ value	2.36792 (rank : 18)	NC score	0.048133 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

GSCL_HUMAN
θ value	2.36792 (rank : 19)	NC score	0.010574 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	O15499	Gene names	GSCL
Domain Architecture
Description	Homeobox protein goosecoid-like (GSC-2).

HRX_HUMAN
θ value	2.36792 (rank : 20)	NC score	0.023594 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MMP9_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.022354 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

MMP9_MOUSE
θ value	2.36792 (rank : 22)	NC score	0.019580 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	151	Shared Neighborhood Hits	6
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

CD2L5_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.005629 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	987	Shared Neighborhood Hits	8
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

SHAN1_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.009338 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	1041	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SPAG5_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.012753 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	612	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

EP400_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.012465 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	556	Shared Neighborhood Hits	10
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

MLL2_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.015123 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	1788	Shared Neighborhood Hits	13
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NKX28_HUMAN
θ value	4.03905 (rank : 28)	NC score	0.011858 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	352	Shared Neighborhood Hits	5
SwissProt Accessions	O15522	Gene names	NKX2-8, NKX-2.8, NKX2G, NKX2H
Domain Architecture
Description	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H).

CAC1C_MOUSE
θ value	5.27518 (rank : 29)	NC score	0.010210 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

JPH2_MOUSE
θ value	5.27518 (rank : 30)	NC score	0.011897 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	279	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

UBP51_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.008380 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q70EK9, Q8IWJ8	Gene names	USP51
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.1.2.15) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) (Deubiquitinating enzyme 51).

B3GA2_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.025411 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P59270	Gene names	B3gat2, Glcats
Domain Architecture
Description	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (Glucuronosyltransferase-S) (GlcAT-S) (UDP-glucuronosyltransferase-S) (GlcAT-D).

IRAK4_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.002563 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	820	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

K1543_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.023491 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	435	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

SRRM1_MOUSE
θ value	6.88961 (rank : 35)	NC score	0.017222 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	966	Shared Neighborhood Hits	19
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TNK1_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.004060 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	806	Shared Neighborhood Hits	7
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

K1543_MOUSE
θ value	8.99809 (rank : 37)	NC score	0.027155 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	497	Shared Neighborhood Hits	16
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MLL4_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.019062 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	722	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MMP15_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.008415 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

SPR2K_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.022787 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	O70562	Gene names	Sprr2k
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2K.

Hits sorted by NC score

DEDD_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	O75618, O60737	Gene names	DEDD, DEDPRO1, DEFT
Domain Architecture
Description	Death effector domain-containing protein (Death effector domain- containing testicular molecule) (DEDPro1) (FLDED-1).

DEDD_MOUSE
NC score	0.994928 (rank : 2)	θ value	2.48205e-183 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z1L3, Q7TQH8, Q9R227	Gene names	Dedd
Domain Architecture
Description	Death effector domain-containing protein (DEDPro1).

DEDD2_MOUSE
NC score	0.948751 (rank : 3)	θ value	1.11475e-66 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q8QZV0, Q569Y9, Q8JZV1	Gene names	Dedd2, Flame3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

DEDD2_HUMAN
NC score	0.948255 (rank : 4)	θ value	3.24342e-66 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXF8, Q8NBR2, Q8NES1, Q8TAA8, Q96D35	Gene names	DEDD2, FLAME3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

SPR2H_MOUSE
NC score	0.060320 (rank : 5)	θ value	0.47712 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

CASP8_MOUSE
NC score	0.055204 (rank : 6)	θ value	0.279714 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	O89110, O35669	Gene names	Casp8
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

ATF5_HUMAN
NC score	0.052168 (rank : 7)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2D1, Q9BSA1, Q9UNQ3	Gene names	ATF5, ATFX
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-5 (Activating transcription factor 5) (Transcription factor ATFx).

CASP8_HUMAN
NC score	0.048133 (rank : 8)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

BRD4_MOUSE
NC score	0.038563 (rank : 9)	θ value	0.47712 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	845	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

BRD4_HUMAN
NC score	0.037107 (rank : 10)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	851	Shared Neighborhood Hits	10
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

MDC1_MOUSE
NC score	0.035999 (rank : 11)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	998	Shared Neighborhood Hits	20
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

ZFHX2_HUMAN
NC score	0.035125 (rank : 12)	θ value	0.21417 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	1178	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

SRRM2_HUMAN
NC score	0.027211 (rank : 13)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	1296	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

K1543_MOUSE
NC score	0.027155 (rank : 14)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	497	Shared Neighborhood Hits	16
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

PRP2_MOUSE
NC score	0.026960 (rank : 15)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

B3GA2_MOUSE
NC score	0.025411 (rank : 16)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P59270	Gene names	B3gat2, Glcats
Domain Architecture
Description	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (Glucuronosyltransferase-S) (GlcAT-S) (UDP-glucuronosyltransferase-S) (GlcAT-D).

CCDC6_HUMAN
NC score	0.024488 (rank : 17)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	723	Shared Neighborhood Hits	6
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

HRX_HUMAN
NC score	0.023594 (rank : 18)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

K1543_HUMAN
NC score	0.023491 (rank : 19)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	435	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

SPR2K_MOUSE
NC score	0.022787 (rank : 20)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	O70562	Gene names	Sprr2k
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2K.

MMP9_HUMAN
NC score	0.022354 (rank : 21)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

MMP9_MOUSE
NC score	0.019580 (rank : 22)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	151	Shared Neighborhood Hits	6
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

MLL4_HUMAN
NC score	0.019062 (rank : 23)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	722	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

ADRB3_HUMAN
NC score	0.018162 (rank : 24)	θ value	0.0736092 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	900	Shared Neighborhood Hits	3
SwissProt Accessions	P13945, Q4JFT4	Gene names	ADRB3, ADRB3R, B3AR
Domain Architecture
Description	Beta-3 adrenergic receptor (Beta-3 adrenoceptor) (Beta-3 adrenoreceptor).

SRRM1_MOUSE
NC score	0.017222 (rank : 25)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	966	Shared Neighborhood Hits	19
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ACHA4_HUMAN
NC score	0.016159 (rank : 26)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	P43681, Q4JGR7	Gene names	CHRNA4, NACRA4
Domain Architecture
Description	Neuronal acetylcholine receptor protein subunit alpha-4 precursor.

MLL2_HUMAN
NC score	0.015123 (rank : 27)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	1788	Shared Neighborhood Hits	13
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SPAG5_MOUSE
NC score	0.012753 (rank : 28)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	612	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

EP400_HUMAN
NC score	0.012465 (rank : 29)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	556	Shared Neighborhood Hits	10
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

JPH2_MOUSE
NC score	0.011897 (rank : 30)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	279	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

NKX28_HUMAN
NC score	0.011858 (rank : 31)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	352	Shared Neighborhood Hits	5
SwissProt Accessions	O15522	Gene names	NKX2-8, NKX-2.8, NKX2G, NKX2H
Domain Architecture
Description	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H).

GSCL_HUMAN
NC score	0.010574 (rank : 32)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	O15499	Gene names	GSCL
Domain Architecture
Description	Homeobox protein goosecoid-like (GSC-2).

CAC1C_MOUSE
NC score	0.010210 (rank : 33)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

SHAN1_HUMAN
NC score	0.009338 (rank : 34)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	1041	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

MMP15_HUMAN
NC score	0.008415 (rank : 35)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

UBP51_HUMAN
NC score	0.008380 (rank : 36)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q70EK9, Q8IWJ8	Gene names	USP51
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.1.2.15) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) (Deubiquitinating enzyme 51).

CD2L5_MOUSE
NC score	0.006304 (rank : 37)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	1011	Shared Neighborhood Hits	10
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L5_HUMAN
NC score	0.005629 (rank : 38)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	987	Shared Neighborhood Hits	8
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

TNK1_MOUSE
NC score	0.004060 (rank : 39)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	806	Shared Neighborhood Hits	7
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

IRAK4_MOUSE
NC score	0.002563 (rank : 40)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	820	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).