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Network neighborhood for query Sequence : SORC3_HUMAN

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SORC3_HUMAN
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SORC1_HUMAN
θ value	0 (rank : 1)	NC score	0.992303 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	28	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC1_MOUSE
θ value	0 (rank : 2)	NC score	0.991722 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC2_HUMAN
θ value	0 (rank : 3)	NC score	0.976781 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_MOUSE
θ value	0 (rank : 4)	NC score	0.981484 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC3_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_MOUSE
θ value	0 (rank : 6)	NC score	0.994879 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORL_MOUSE
θ value	2.83479e-70 (rank : 7)	NC score	0.460494 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORL_HUMAN
θ value	4.09345e-69 (rank : 8)	NC score	0.456862 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	440	Shared Neighborhood Hits	12
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORT_MOUSE
θ value	6.13105e-57 (rank : 9)	NC score	0.860466 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

SORT_HUMAN
θ value	1.15626e-55 (rank : 10)	NC score	0.859663 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

DEND_HUMAN
θ value	0.0563607 (rank : 11)	NC score	0.042000 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	O94850	Gene names	DDN, KIAA0749
Domain Architecture	No domain graphic available
Description	Dendrin.

CENPB_MOUSE
θ value	0.163984 (rank : 12)	NC score	0.029774 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	P27790	Gene names	Cenpb, Cenp-b
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

OGFR_HUMAN
θ value	0.163984 (rank : 13)	NC score	0.014169 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	1582	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PHLPP_MOUSE
θ value	0.163984 (rank : 14)	NC score	0.017790 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

AOC3_HUMAN
θ value	0.365318 (rank : 15)	NC score	0.023359 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q16853, Q45F94	Gene names	AOC3, VAP1
Domain Architecture
Description	Membrane copper amine oxidase (EC 1.4.3.6) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) (HPAO).

LTK_MOUSE
θ value	0.365318 (rank : 16)	NC score	0.002433 (rank : 69)
Query Neighborhood Hits	57	Target Neighborhood Hits	770	Shared Neighborhood Hits	3
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

GPR61_HUMAN
θ value	0.47712 (rank : 17)	NC score	0.014861 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	710	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZJ8, Q6NWS0, Q8TDV4, Q96PR4	Gene names	GPR61, BALGR
Domain Architecture
Description	Probable G-protein coupled receptor 61 (Biogenic amine receptor-like G-protein coupled receptor).

HME2_HUMAN
θ value	0.47712 (rank : 18)	NC score	0.007790 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	355	Shared Neighborhood Hits	3
SwissProt Accessions	P19622	Gene names	EN2
Domain Architecture
Description	Homeobox protein engrailed-2 (Hu-En-2).

PAPPA_HUMAN
θ value	0.47712 (rank : 19)	NC score	0.024638 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

PHLPP_HUMAN
θ value	0.47712 (rank : 20)	NC score	0.018746 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	604	Shared Neighborhood Hits	11
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PKD1_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.051064 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	387	Shared Neighborhood Hits	12
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

AVEN_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.030389 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQS1	Gene names	AVEN
Domain Architecture	No domain graphic available
Description	Cell death regulator Aven.

GCH1_HUMAN
θ value	0.62314 (rank : 23)	NC score	0.048175 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

H1X_HUMAN
θ value	0.813845 (rank : 24)	NC score	0.030902 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q92522	Gene names	H1FX
Domain Architecture
Description	Histone H1x.

SRRM2_MOUSE
θ value	0.813845 (rank : 25)	NC score	0.016170 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	1470	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

GPR61_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.012922 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	702	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C010	Gene names	Gpr61
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 61.

HNRPR_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.008275 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	240	Shared Neighborhood Hits	2
SwissProt Accessions	O43390	Gene names	HNRPR
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein R (hnRNP R).

IP3KC_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.014729 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q96DU7, Q9UE25, Q9Y475	Gene names	ITPKC, IP3KC
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase C) (InsP 3-kinase C) (IP3K-C).

ONEC2_MOUSE
θ value	1.81305 (rank : 29)	NC score	0.013883 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q6XBJ3	Gene names	Onecut2, Oc2
Domain Architecture	No domain graphic available
Description	One cut domain family member 2 (Transcription factor ONECUT-2) (OC-2).

SDK1_HUMAN
θ value	1.81305 (rank : 30)	NC score	0.018902 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	511	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CAC1E_MOUSE
θ value	2.36792 (rank : 31)	NC score	0.005602 (rank : 65)
Query Neighborhood Hits	57	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

HCN4_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.007462 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	303	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

MDC1_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.009191 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	1446	Shared Neighborhood Hits	16
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SRRM2_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.014634 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	1296	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SYN3_MOUSE
θ value	2.36792 (rank : 35)	NC score	0.013078 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	200	Shared Neighborhood Hits	7
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

LSR_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.014759 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

PK1L1_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.021699 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	140	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PRKDC_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.011946 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

RP1L1_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.007694 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	1072	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

S12A2_MOUSE
θ value	4.03905 (rank : 40)	NC score	0.006652 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	P55012	Gene names	Slc12a2, Nkcc1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

TTBK1_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.002030 (rank : 70)
Query Neighborhood Hits	57	Target Neighborhood Hits	1058	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

CT012_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.017228 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	205	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

CT012_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.012391 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	229	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

GCNL2_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.008801 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

NCOA6_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.006944 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	1076	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ZN409_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.004418 (rank : 66)
Query Neighborhood Hits	57	Target Neighborhood Hits	842	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

GGA2_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.005899 (rank : 64)
Query Neighborhood Hits	57	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

GPNMB_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.016715 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q14956, Q6UVX1, Q8N1A1	Gene names	GPNMB, HGFIN, NMB
Domain Architecture
Description	Transmembrane glycoprotein NMB precursor (Transmembrane glycoprotein HGFIN).

MKRN3_HUMAN
θ value	6.88961 (rank : 49)	NC score	0.006390 (rank : 63)
Query Neighborhood Hits	57	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

PHLD2_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.012349 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

TBCD3_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.006980 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

LAMA2_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.002813 (rank : 68)
Query Neighborhood Hits	57	Target Neighborhood Hits	1092	Shared Neighborhood Hits	4
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MTCH1_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.006510 (rank : 62)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q791T5, Q3U4W7, Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4	Gene names	Mtch1
Domain Architecture	No domain graphic available
Description	Mitochondrial carrier homolog 1 (Mitochondrial carrier-like protein 1).

PME17_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.015222 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q60696	Gene names	Silv, D10H12S53E, Pmel17, Si
Domain Architecture
Description	Melanocyte protein Pmel 17 precursor (Silver locus protein).

PRP1_HUMAN
θ value	8.99809 (rank : 55)	NC score	0.008305 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	385	Shared Neighborhood Hits	10
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

SI1L3_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.004192 (rank : 67)
Query Neighborhood Hits	57	Target Neighborhood Hits	305	Shared Neighborhood Hits	5
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

VLDLR_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.052722 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

CD320_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.067186 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LDLR_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.051330 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	382	Shared Neighborhood Hits	4
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP12_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.051376 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP1_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.051539 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	617	Shared Neighborhood Hits	6
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP2_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.056016 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	573	Shared Neighborhood Hits	6
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP3_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.052346 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	280	Shared Neighborhood Hits	6
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP5_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.050847 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP5_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.050598 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

LRP6_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.051154 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.051528 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.051614 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	346	Shared Neighborhood Hits	4
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.051931 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	385	Shared Neighborhood Hits	3
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.054234 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

Hits sorted by NC score

SORC3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_MOUSE
NC score	0.994879 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC1_HUMAN
NC score	0.992303 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	28	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC1_MOUSE
NC score	0.991722 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC2_MOUSE
NC score	0.981484 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_HUMAN
NC score	0.976781 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORT_MOUSE
NC score	0.860466 (rank : 7)	θ value	6.13105e-57 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

SORT_HUMAN
NC score	0.859663 (rank : 8)	θ value	1.15626e-55 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

SORL_MOUSE
NC score	0.460494 (rank : 9)	θ value	2.83479e-70 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORL_HUMAN
NC score	0.456862 (rank : 10)	θ value	4.09345e-69 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	440	Shared Neighborhood Hits	12
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

CD320_HUMAN
NC score	0.067186 (rank : 11)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LRP2_HUMAN
NC score	0.056016 (rank : 12)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	57	Target Neighborhood Hits	573	Shared Neighborhood Hits	6
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

VLDLR_MOUSE
NC score	0.054234 (rank : 13)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	57	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_HUMAN
NC score	0.052722 (rank : 14)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP3_HUMAN
NC score	0.052346 (rank : 15)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	57	Target Neighborhood Hits	280	Shared Neighborhood Hits	6
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP8_MOUSE
NC score	0.051931 (rank : 16)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	57	Target Neighborhood Hits	385	Shared Neighborhood Hits	3
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_HUMAN
NC score	0.051614 (rank : 17)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	57	Target Neighborhood Hits	346	Shared Neighborhood Hits	4
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP1_HUMAN
NC score	0.051539 (rank : 18)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	617	Shared Neighborhood Hits	6
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP6_MOUSE
NC score	0.051528 (rank : 19)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	57	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP12_MOUSE
NC score	0.051376 (rank : 20)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LDLR_MOUSE
NC score	0.051330 (rank : 21)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	382	Shared Neighborhood Hits	4
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP6_HUMAN
NC score	0.051154 (rank : 22)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	57	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

PKD1_HUMAN
NC score	0.051064 (rank : 23)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	387	Shared Neighborhood Hits	12
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

LRP5_HUMAN
NC score	0.050847 (rank : 24)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	57	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP5_MOUSE
NC score	0.050598 (rank : 25)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	57	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

GCH1_HUMAN
NC score	0.048175 (rank : 26)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

DEND_HUMAN
NC score	0.042000 (rank : 27)	θ value	0.0563607 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	O94850	Gene names	DDN, KIAA0749
Domain Architecture	No domain graphic available
Description	Dendrin.

H1X_HUMAN
NC score	0.030902 (rank : 28)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q92522	Gene names	H1FX
Domain Architecture
Description	Histone H1x.

AVEN_HUMAN
NC score	0.030389 (rank : 29)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQS1	Gene names	AVEN
Domain Architecture	No domain graphic available
Description	Cell death regulator Aven.

CENPB_MOUSE
NC score	0.029774 (rank : 30)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	P27790	Gene names	Cenpb, Cenp-b
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

PAPPA_HUMAN
NC score	0.024638 (rank : 31)	θ value	0.47712 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

AOC3_HUMAN
NC score	0.023359 (rank : 32)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q16853, Q45F94	Gene names	AOC3, VAP1
Domain Architecture
Description	Membrane copper amine oxidase (EC 1.4.3.6) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) (HPAO).

PK1L1_HUMAN
NC score	0.021699 (rank : 33)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	140	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

SDK1_HUMAN
NC score	0.018902 (rank : 34)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	511	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

PHLPP_HUMAN
NC score	0.018746 (rank : 35)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	604	Shared Neighborhood Hits	11
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PHLPP_MOUSE
NC score	0.017790 (rank : 36)	θ value	0.163984 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

CT012_HUMAN
NC score	0.017228 (rank : 37)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	205	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

GPNMB_HUMAN
NC score	0.016715 (rank : 38)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q14956, Q6UVX1, Q8N1A1	Gene names	GPNMB, HGFIN, NMB
Domain Architecture
Description	Transmembrane glycoprotein NMB precursor (Transmembrane glycoprotein HGFIN).

SRRM2_MOUSE
NC score	0.016170 (rank : 39)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	1470	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PME17_MOUSE
NC score	0.015222 (rank : 40)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q60696	Gene names	Silv, D10H12S53E, Pmel17, Si
Domain Architecture
Description	Melanocyte protein Pmel 17 precursor (Silver locus protein).

GPR61_HUMAN
NC score	0.014861 (rank : 41)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	710	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZJ8, Q6NWS0, Q8TDV4, Q96PR4	Gene names	GPR61, BALGR
Domain Architecture
Description	Probable G-protein coupled receptor 61 (Biogenic amine receptor-like G-protein coupled receptor).

LSR_HUMAN
NC score	0.014759 (rank : 42)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

IP3KC_HUMAN
NC score	0.014729 (rank : 43)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q96DU7, Q9UE25, Q9Y475	Gene names	ITPKC, IP3KC
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase C) (InsP 3-kinase C) (IP3K-C).

SRRM2_HUMAN
NC score	0.014634 (rank : 44)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	1296	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

OGFR_HUMAN
NC score	0.014169 (rank : 45)	θ value	0.163984 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	1582	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ONEC2_MOUSE
NC score	0.013883 (rank : 46)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q6XBJ3	Gene names	Onecut2, Oc2
Domain Architecture	No domain graphic available
Description	One cut domain family member 2 (Transcription factor ONECUT-2) (OC-2).

SYN3_MOUSE
NC score	0.013078 (rank : 47)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	200	Shared Neighborhood Hits	7
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

GPR61_MOUSE
NC score	0.012922 (rank : 48)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	702	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C010	Gene names	Gpr61
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 61.

CT012_MOUSE
NC score	0.012391 (rank : 49)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	229	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

PHLD2_HUMAN
NC score	0.012349 (rank : 50)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

PRKDC_MOUSE
NC score	0.011946 (rank : 51)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

MDC1_HUMAN
NC score	0.009191 (rank : 52)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	1446	Shared Neighborhood Hits	16
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

GCNL2_MOUSE
NC score	0.008801 (rank : 53)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

PRP1_HUMAN
NC score	0.008305 (rank : 54)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	385	Shared Neighborhood Hits	10
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

HNRPR_HUMAN
NC score	0.008275 (rank : 55)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	240	Shared Neighborhood Hits	2
SwissProt Accessions	O43390	Gene names	HNRPR
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein R (hnRNP R).

HME2_HUMAN
NC score	0.007790 (rank : 56)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	355	Shared Neighborhood Hits	3
SwissProt Accessions	P19622	Gene names	EN2
Domain Architecture
Description	Homeobox protein engrailed-2 (Hu-En-2).

RP1L1_HUMAN
NC score	0.007694 (rank : 57)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	1072	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

HCN4_HUMAN
NC score	0.007462 (rank : 58)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	303	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

TBCD3_HUMAN
NC score	0.006980 (rank : 59)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

NCOA6_MOUSE
NC score	0.006944 (rank : 60)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	1076	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

S12A2_MOUSE
NC score	0.006652 (rank : 61)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	P55012	Gene names	Slc12a2, Nkcc1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

MTCH1_MOUSE
NC score	0.006510 (rank : 62)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q791T5, Q3U4W7, Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4	Gene names	Mtch1
Domain Architecture	No domain graphic available
Description	Mitochondrial carrier homolog 1 (Mitochondrial carrier-like protein 1).

MKRN3_HUMAN
NC score	0.006390 (rank : 63)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

GGA2_MOUSE
NC score	0.005899 (rank : 64)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5E6, Q3U374, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15	Gene names	Gga2, Kiaa1080
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2).

CAC1E_MOUSE
NC score	0.005602 (rank : 65)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

ZN409_HUMAN
NC score	0.004418 (rank : 66)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	842	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

SI1L3_HUMAN
NC score	0.004192 (rank : 67)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	305	Shared Neighborhood Hits	5
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

LAMA2_HUMAN
NC score	0.002813 (rank : 68)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	1092	Shared Neighborhood Hits	4
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LTK_MOUSE
NC score	0.002433 (rank : 69)	θ value	0.365318 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	770	Shared Neighborhood Hits	3
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

TTBK1_HUMAN
NC score	0.002030 (rank : 70)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	1058	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).