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Network neighborhood for query Sequence : SORC1_MOUSE

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SORC1_MOUSE
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SORC1_HUMAN
θ value	0 (rank : 1)	NC score	0.997661 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC2_HUMAN
θ value	0 (rank : 3)	NC score	0.979600 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_MOUSE
θ value	0 (rank : 4)	NC score	0.984273 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC3_HUMAN
θ value	0 (rank : 5)	NC score	0.991722 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_MOUSE
θ value	0 (rank : 6)	NC score	0.992814 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORL_MOUSE
θ value	9.43692e-66 (rank : 7)	NC score	0.459974 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORL_HUMAN
θ value	1.6097e-65 (rank : 8)	NC score	0.456388 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORT_MOUSE
θ value	2.32979e-56 (rank : 9)	NC score	0.862706 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

SORT_HUMAN
θ value	8.85319e-56 (rank : 10)	NC score	0.861896 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

PKD1_HUMAN
θ value	0.365318 (rank : 11)	NC score	0.050433 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

USH2A_HUMAN
θ value	0.47712 (rank : 12)	NC score	0.026335 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	600	Shared Neighborhood Hits	8
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

WASL_HUMAN
θ value	0.47712 (rank : 13)	NC score	0.025443 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	312	Shared Neighborhood Hits	6
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ALEX_HUMAN
θ value	1.06291 (rank : 14)	NC score	0.019383 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

EVL_MOUSE
θ value	1.06291 (rank : 15)	NC score	0.015644 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	203	Shared Neighborhood Hits	4
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

PHF3_HUMAN
θ value	1.38821 (rank : 16)	NC score	0.017415 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	419	Shared Neighborhood Hits	4
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

SHAN1_HUMAN
θ value	1.81305 (rank : 17)	NC score	0.006848 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	1041	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

WASL_MOUSE
θ value	1.81305 (rank : 18)	NC score	0.021191 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	339	Shared Neighborhood Hits	6
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

CDCP1_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.016608 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q5U462, Q810J0, Q921M9	Gene names	Cdcp1
Domain Architecture	No domain graphic available
Description	CUB domain-containing protein 1 precursor (Transmembrane and associated with src kinases) (Membrane glycoprotein gp140) (CD318 antigen).

CK042_HUMAN
θ value	2.36792 (rank : 20)	NC score	0.026660 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5U0	Gene names	C11orf42
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf42.

CYLN2_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.004043 (rank : 49)
Query Neighborhood Hits	41	Target Neighborhood Hits	1004	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

PACR_MOUSE
θ value	2.36792 (rank : 22)	NC score	0.005896 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P70205	Gene names	Adcyap1r1
Domain Architecture
Description	Pituitary adenylate cyclase-activating polypeptide type I receptor precursor (PACAP type I receptor) (PACAP-R-1).

CBL_MOUSE
θ value	3.0926 (rank : 23)	NC score	0.008599 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	426	Shared Neighborhood Hits	5
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

CEAM5_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.006141 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	343	Shared Neighborhood Hits	3
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

PDLI7_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.006019 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

HTRA3_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.010450 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

ITB3_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.015593 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	P05106, O15495, Q13413, Q14648, Q16499	Gene names	ITGB3, GP3A
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

PDCD7_MOUSE
θ value	4.03905 (rank : 28)	NC score	0.013696 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

PRIC1_HUMAN
θ value	4.03905 (rank : 29)	NC score	0.006672 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MT3, Q71QF8, Q96N00	Gene names	PRICKLE1, RILP
Domain Architecture	No domain graphic available
Description	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1).

SFR15_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.009863 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SPR2K_MOUSE
θ value	5.27518 (rank : 31)	NC score	0.023210 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	O70562	Gene names	Sprr2k
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2K.

CASC3_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.009263 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	204	Shared Neighborhood Hits	4
SwissProt Accessions	O15234	Gene names	CASC3, MLN51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node protein 51) (Protein MLN 51) (Protein barentsz) (Btz).

CYLN2_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.002957 (rank : 51)
Query Neighborhood Hits	41	Target Neighborhood Hits	1002	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

MLL3_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.004108 (rank : 48)
Query Neighborhood Hits	41	Target Neighborhood Hits	1399	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PABP2_MOUSE
θ value	6.88961 (rank : 35)	NC score	0.006397 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCS6, O35935	Gene names	Pabpn1, Pab2, Pabp2
Domain Architecture
Description	Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (Poly(A)- binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Nuclear poly(A)-binding protein 1).

TGON2_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.002473 (rank : 52)
Query Neighborhood Hits	41	Target Neighborhood Hits	1037	Shared Neighborhood Hits	5
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CAD15_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.003457 (rank : 50)
Query Neighborhood Hits	41	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).

HD_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.006406 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P42859	Gene names	Hd, Hdh
Domain Architecture
Description	Huntingtin (Huntington disease protein homolog) (HD protein).

LTB1L_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.014950 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	553	Shared Neighborhood Hits	7
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

MCSP_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.009114 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

STAC_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.006273 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CD320_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.065230 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LDLR_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.050301 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	382	Shared Neighborhood Hits	5
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP12_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.050546 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.050872 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	617	Shared Neighborhood Hits	7
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP2_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.055001 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	573	Shared Neighborhood Hits	5
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP3_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.050578 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	280	Shared Neighborhood Hits	4
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP6_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.050225 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.050265 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	346	Shared Neighborhood Hits	4
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.051260 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	385	Shared Neighborhood Hits	6
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.051138 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.053099 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	360	Shared Neighborhood Hits	6
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

Hits sorted by NC score

SORC1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC1_HUMAN
NC score	0.997661 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC3_MOUSE
NC score	0.992814 (rank : 3)	θ value	0 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_HUMAN
NC score	0.991722 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC2_MOUSE
NC score	0.984273 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_HUMAN
NC score	0.979600 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORT_MOUSE
NC score	0.862706 (rank : 7)	θ value	2.32979e-56 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

SORT_HUMAN
NC score	0.861896 (rank : 8)	θ value	8.85319e-56 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

SORL_MOUSE
NC score	0.459974 (rank : 9)	θ value	9.43692e-66 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORL_HUMAN
NC score	0.456388 (rank : 10)	θ value	1.6097e-65 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

CD320_HUMAN
NC score	0.065230 (rank : 11)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LRP2_HUMAN
NC score	0.055001 (rank : 12)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	573	Shared Neighborhood Hits	5
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

VLDLR_MOUSE
NC score	0.053099 (rank : 13)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	41	Target Neighborhood Hits	360	Shared Neighborhood Hits	6
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP8_MOUSE
NC score	0.051260 (rank : 14)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	41	Target Neighborhood Hits	385	Shared Neighborhood Hits	6
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_HUMAN
NC score	0.051138 (rank : 15)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	41	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP1_HUMAN
NC score	0.050872 (rank : 16)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	617	Shared Neighborhood Hits	7
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP3_HUMAN
NC score	0.050578 (rank : 17)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	280	Shared Neighborhood Hits	4
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP12_MOUSE
NC score	0.050546 (rank : 18)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

PKD1_HUMAN
NC score	0.050433 (rank : 19)	θ value	0.365318 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

LDLR_MOUSE
NC score	0.050301 (rank : 20)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	382	Shared Neighborhood Hits	5
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP8_HUMAN
NC score	0.050265 (rank : 21)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	41	Target Neighborhood Hits	346	Shared Neighborhood Hits	4
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP6_MOUSE
NC score	0.050225 (rank : 22)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	41	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

CK042_HUMAN
NC score	0.026660 (rank : 23)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5U0	Gene names	C11orf42
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf42.

USH2A_HUMAN
NC score	0.026335 (rank : 24)	θ value	0.47712 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	600	Shared Neighborhood Hits	8
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

WASL_HUMAN
NC score	0.025443 (rank : 25)	θ value	0.47712 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	312	Shared Neighborhood Hits	6
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

SPR2K_MOUSE
NC score	0.023210 (rank : 26)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	O70562	Gene names	Sprr2k
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2K.

WASL_MOUSE
NC score	0.021191 (rank : 27)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	339	Shared Neighborhood Hits	6
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ALEX_HUMAN
NC score	0.019383 (rank : 28)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

PHF3_HUMAN
NC score	0.017415 (rank : 29)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	419	Shared Neighborhood Hits	4
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

CDCP1_MOUSE
NC score	0.016608 (rank : 30)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q5U462, Q810J0, Q921M9	Gene names	Cdcp1
Domain Architecture	No domain graphic available
Description	CUB domain-containing protein 1 precursor (Transmembrane and associated with src kinases) (Membrane glycoprotein gp140) (CD318 antigen).

EVL_MOUSE
NC score	0.015644 (rank : 31)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	203	Shared Neighborhood Hits	4
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

ITB3_HUMAN
NC score	0.015593 (rank : 32)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	P05106, O15495, Q13413, Q14648, Q16499	Gene names	ITGB3, GP3A
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

LTB1L_HUMAN
NC score	0.014950 (rank : 33)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	553	Shared Neighborhood Hits	7
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

PDCD7_MOUSE
NC score	0.013696 (rank : 34)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

HTRA3_HUMAN
NC score	0.010450 (rank : 35)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

SFR15_HUMAN
NC score	0.009863 (rank : 36)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

CASC3_HUMAN
NC score	0.009263 (rank : 37)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	204	Shared Neighborhood Hits	4
SwissProt Accessions	O15234	Gene names	CASC3, MLN51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node protein 51) (Protein MLN 51) (Protein barentsz) (Btz).

MCSP_MOUSE
NC score	0.009114 (rank : 38)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

CBL_MOUSE
NC score	0.008599 (rank : 39)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	426	Shared Neighborhood Hits	5
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

SHAN1_HUMAN
NC score	0.006848 (rank : 40)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	1041	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PRIC1_HUMAN
NC score	0.006672 (rank : 41)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MT3, Q71QF8, Q96N00	Gene names	PRICKLE1, RILP
Domain Architecture	No domain graphic available
Description	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1).

HD_MOUSE
NC score	0.006406 (rank : 42)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P42859	Gene names	Hd, Hdh
Domain Architecture
Description	Huntingtin (Huntington disease protein homolog) (HD protein).

PABP2_MOUSE
NC score	0.006397 (rank : 43)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCS6, O35935	Gene names	Pabpn1, Pab2, Pabp2
Domain Architecture
Description	Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (Poly(A)- binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Nuclear poly(A)-binding protein 1).

STAC_HUMAN
NC score	0.006273 (rank : 44)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CEAM5_HUMAN
NC score	0.006141 (rank : 45)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	343	Shared Neighborhood Hits	3
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

PDLI7_MOUSE
NC score	0.006019 (rank : 46)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PACR_MOUSE
NC score	0.005896 (rank : 47)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P70205	Gene names	Adcyap1r1
Domain Architecture
Description	Pituitary adenylate cyclase-activating polypeptide type I receptor precursor (PACAP type I receptor) (PACAP-R-1).

MLL3_MOUSE
NC score	0.004108 (rank : 48)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	1399	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CYLN2_HUMAN
NC score	0.004043 (rank : 49)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	1004	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CAD15_HUMAN
NC score	0.003457 (rank : 50)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).

CYLN2_MOUSE
NC score	0.002957 (rank : 51)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	1002	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

TGON2_HUMAN
NC score	0.002473 (rank : 52)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	1037	Shared Neighborhood Hits	5
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).