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Network neighborhood for query Sequence : NALD2_HUMAN

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NALD2_HUMAN
SwissProt Accessions	Q9Y3Q0	Gene names	NAALAD2
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FOLH1_HUMAN
θ value	0 (rank : 1)	NC score	0.996093 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

FOLH1_MOUSE
θ value	0 (rank : 2)	NC score	0.995960 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

NALD2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y3Q0	Gene names	NAALAD2
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II).

NALD2_MOUSE
θ value	0 (rank : 4)	NC score	0.998872 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CZR2, Q80YF8	Gene names	Naalad2
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II).

NALDL_MOUSE
θ value	8.0776e-142 (rank : 5)	NC score	0.969481 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q7M758	Gene names	Naaladl1, Naaladasel
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L).

NALDL_HUMAN
θ value	1.86219e-138 (rank : 6)	NC score	0.969107 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQQ1, O43176	Gene names	NAALADL1, NAALADASEL, NAALADL
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L) (Ileal dipeptidylpeptidase) (100 kDa ileum brush border membrane protein) (I100).

TFR2_MOUSE
θ value	7.2256e-66 (rank : 7)	NC score	0.887303 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKX3, Q920I6, Q99MQ9, Q9CPT2	Gene names	Tfr2, Trfr2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR2_HUMAN
θ value	9.43692e-66 (rank : 8)	NC score	0.890659 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UP52, O75422, Q9HA99, Q9NX67	Gene names	TFR2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR1_HUMAN
θ value	3.0428e-56 (rank : 9)	NC score	0.875147 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	P02786, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21	Gene names	TFRC
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen) (T9) (p90).

TFR1_MOUSE
θ value	5.19021e-56 (rank : 10)	NC score	0.873996 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

CLH_MOUSE
θ value	0.125558 (rank : 11)	NC score	0.027086 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FD5	Gene names	Cltc
Domain Architecture	No domain graphic available
Description	Clathrin heavy chain.

NCLN_HUMAN
θ value	0.813845 (rank : 12)	NC score	0.086410 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q969V3, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2	Gene names	NCLN
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

FREM2_HUMAN
θ value	1.81305 (rank : 13)	NC score	0.011830 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

YETS2_MOUSE
θ value	1.81305 (rank : 14)	NC score	0.015090 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	278	Shared Neighborhood Hits	2
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

CAD12_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.002301 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	P55289	Gene names	CDH12
Domain Architecture
Description	Cadherin-12 precursor (Brain-cadherin) (BR-cadherin) (N-cadherin 2) (Neural type cadherin 2).

ECH1_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.011563 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

NCLN_MOUSE
θ value	4.03905 (rank : 17)	NC score	0.079187 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCM8, Q8C7Y4, Q9CX81	Gene names	Ncln
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

ATS1_MOUSE
θ value	5.27518 (rank : 18)	NC score	0.002670 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

PAOX_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.007383 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0L6, Q8K254	Gene names	Paox, Pao
Domain Architecture	No domain graphic available
Description	Peroxisomal N1-acetyl-spermine/spermidine oxidase (EC 1.5.3.11) (Polyamine oxidase).

GRLF1_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.003536 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	167	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

ITSN1_HUMAN
θ value	8.99809 (rank : 21)	NC score	-0.001332 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	1757	Shared Neighborhood Hits	2
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MBOA5_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.008670 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P1A2, Q7KZS1, Q92980, Q9BW40	Gene names	MBOAT5, OACT5
Domain Architecture	No domain graphic available
Description	Membrane bound O-acyltransferase domain-containing protein 5 (EC 2.3.-.-) (O-acyltransferase domain-containing protein 5).

XRN1_MOUSE
θ value	8.99809 (rank : 23)	NC score	0.006503 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	P97789, O35651, P97790, Q3TE44, Q3TRE9, Q3UQL5	Gene names	Xrn1, Dhm2, Exo, Sep1
Domain Architecture	No domain graphic available
Description	5'-3' exoribonuclease 1 (EC 3.1.11.-) (mXRN1) (Strand-exchange protein 1 homolog) (Protein Dhm2).

Hits sorted by NC score

NALD2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y3Q0	Gene names	NAALAD2
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II).

NALD2_MOUSE
NC score	0.998872 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CZR2, Q80YF8	Gene names	Naalad2
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II).

FOLH1_HUMAN
NC score	0.996093 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

FOLH1_MOUSE
NC score	0.995960 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

NALDL_MOUSE
NC score	0.969481 (rank : 5)	θ value	8.0776e-142 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q7M758	Gene names	Naaladl1, Naaladasel
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L).

NALDL_HUMAN
NC score	0.969107 (rank : 6)	θ value	1.86219e-138 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQQ1, O43176	Gene names	NAALADL1, NAALADASEL, NAALADL
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L) (Ileal dipeptidylpeptidase) (100 kDa ileum brush border membrane protein) (I100).

TFR2_HUMAN
NC score	0.890659 (rank : 7)	θ value	9.43692e-66 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UP52, O75422, Q9HA99, Q9NX67	Gene names	TFR2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR2_MOUSE
NC score	0.887303 (rank : 8)	θ value	7.2256e-66 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKX3, Q920I6, Q99MQ9, Q9CPT2	Gene names	Tfr2, Trfr2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR1_HUMAN
NC score	0.875147 (rank : 9)	θ value	3.0428e-56 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	P02786, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21	Gene names	TFRC
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen) (T9) (p90).

TFR1_MOUSE
NC score	0.873996 (rank : 10)	θ value	5.19021e-56 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

NCLN_HUMAN
NC score	0.086410 (rank : 11)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q969V3, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2	Gene names	NCLN
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

NCLN_MOUSE
NC score	0.079187 (rank : 12)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCM8, Q8C7Y4, Q9CX81	Gene names	Ncln
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

CLH_MOUSE
NC score	0.027086 (rank : 13)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FD5	Gene names	Cltc
Domain Architecture	No domain graphic available
Description	Clathrin heavy chain.

YETS2_MOUSE
NC score	0.015090 (rank : 14)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	278	Shared Neighborhood Hits	2
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

FREM2_HUMAN
NC score	0.011830 (rank : 15)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

ECH1_MOUSE
NC score	0.011563 (rank : 16)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

MBOA5_HUMAN
NC score	0.008670 (rank : 17)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P1A2, Q7KZS1, Q92980, Q9BW40	Gene names	MBOAT5, OACT5
Domain Architecture	No domain graphic available
Description	Membrane bound O-acyltransferase domain-containing protein 5 (EC 2.3.-.-) (O-acyltransferase domain-containing protein 5).

PAOX_MOUSE
NC score	0.007383 (rank : 18)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0L6, Q8K254	Gene names	Paox, Pao
Domain Architecture	No domain graphic available
Description	Peroxisomal N1-acetyl-spermine/spermidine oxidase (EC 1.5.3.11) (Polyamine oxidase).

XRN1_MOUSE
NC score	0.006503 (rank : 19)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	P97789, O35651, P97790, Q3TE44, Q3TRE9, Q3UQL5	Gene names	Xrn1, Dhm2, Exo, Sep1
Domain Architecture	No domain graphic available
Description	5'-3' exoribonuclease 1 (EC 3.1.11.-) (mXRN1) (Strand-exchange protein 1 homolog) (Protein Dhm2).

GRLF1_HUMAN
NC score	0.003536 (rank : 20)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	167	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

ATS1_MOUSE
NC score	0.002670 (rank : 21)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

CAD12_HUMAN
NC score	0.002301 (rank : 22)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	P55289	Gene names	CDH12
Domain Architecture
Description	Cadherin-12 precursor (Brain-cadherin) (BR-cadherin) (N-cadherin 2) (Neural type cadherin 2).

ITSN1_HUMAN
NC score	-0.001332 (rank : 23)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	1757	Shared Neighborhood Hits	2
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).