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Network neighborhood for query Sequence : NALDL_HUMAN

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NALDL_HUMAN
SwissProt Accessions	Q9UQQ1, O43176	Gene names	NAALADL1, NAALADASEL, NAALADL
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L) (Ileal dipeptidylpeptidase) (100 kDa ileum brush border membrane protein) (I100).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NALDL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UQQ1, O43176	Gene names	NAALADL1, NAALADASEL, NAALADL
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L) (Ileal dipeptidylpeptidase) (100 kDa ileum brush border membrane protein) (I100).

NALDL_MOUSE
θ value	0 (rank : 2)	NC score	0.997305 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	Q7M758	Gene names	Naaladl1, Naaladasel
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L).

NALD2_HUMAN
θ value	1.86219e-138 (rank : 3)	NC score	0.969107 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y3Q0	Gene names	NAALAD2
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II).

FOLH1_HUMAN
θ value	2.4321e-138 (rank : 4)	NC score	0.968706 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

NALD2_MOUSE
θ value	3.88293e-136 (rank : 5)	NC score	0.969733 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZR2, Q80YF8	Gene names	Naalad2
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II).

FOLH1_MOUSE
θ value	8.65023e-136 (rank : 6)	NC score	0.968177 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

TFR2_HUMAN
θ value	1.11475e-66 (rank : 7)	NC score	0.900198 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UP52, O75422, Q9HA99, Q9NX67	Gene names	TFR2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR2_MOUSE
θ value	2.10232e-65 (rank : 8)	NC score	0.898158 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JKX3, Q920I6, Q99MQ9, Q9CPT2	Gene names	Tfr2, Trfr2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR1_HUMAN
θ value	2.41096e-53 (rank : 9)	NC score	0.881969 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	P02786, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21	Gene names	TFRC
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen) (T9) (p90).

TFR1_MOUSE
θ value	1.788e-48 (rank : 10)	NC score	0.879831 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

SYBU_HUMAN
θ value	0.0431538 (rank : 11)	NC score	0.040043 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NX95, Q5R1T1, Q5R1T2, Q5R1T3, Q5Y2M6, Q8ND49, Q8TCR6, Q9P256	Gene names	SYBU, GOLSYN, KIAA1472
Domain Architecture	No domain graphic available
Description	Syntabulin (Syntaxin-1-binding protein) (Golgi-localized syntaphilin- related protein).

MYO15_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.010003 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	467	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

RYR3_HUMAN
θ value	1.06291 (rank : 13)	NC score	0.019365 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

IQEC3_HUMAN
θ value	2.36792 (rank : 14)	NC score	0.017173 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

KCP2_HUMAN
θ value	2.36792 (rank : 15)	NC score	0.035424 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6L1, Q6PG45, Q86XW2, Q8IWS4	Gene names	KRTCAP2, KCP2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated protein 2 (KCP-2).

ETV5_HUMAN
θ value	3.0926 (rank : 16)	NC score	0.011421 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	P41161	Gene names	ETV5, ERM
Domain Architecture
Description	ETS translocation variant 5 (Ets-related protein ERM).

KIF17_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.009418 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	365	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).

TCFL5_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.022089 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

IQEC3_MOUSE
θ value	5.27518 (rank : 19)	NC score	0.010795 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

HAOX1_MOUSE
θ value	6.88961 (rank : 20)	NC score	0.009537 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WU19	Gene names	Hao1, Gox1, Hao-1
Domain Architecture
Description	Hydroxyacid oxidase 1 (EC 1.1.3.15) (HAOX1) (Glycolate oxidase) (GOX).

NCLN_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.067479 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q969V3, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2	Gene names	NCLN
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

NCLN_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.061789 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCM8, Q8C7Y4, Q9CX81	Gene names	Ncln
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

Hits sorted by NC score

NALDL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UQQ1, O43176	Gene names	NAALADL1, NAALADASEL, NAALADL
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L) (Ileal dipeptidylpeptidase) (100 kDa ileum brush border membrane protein) (I100).

NALDL_MOUSE
NC score	0.997305 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	Q7M758	Gene names	Naaladl1, Naaladasel
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L).

NALD2_MOUSE
NC score	0.969733 (rank : 3)	θ value	3.88293e-136 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZR2, Q80YF8	Gene names	Naalad2
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II).

NALD2_HUMAN
NC score	0.969107 (rank : 4)	θ value	1.86219e-138 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y3Q0	Gene names	NAALAD2
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II).

FOLH1_HUMAN
NC score	0.968706 (rank : 5)	θ value	2.4321e-138 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

FOLH1_MOUSE
NC score	0.968177 (rank : 6)	θ value	8.65023e-136 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

TFR2_HUMAN
NC score	0.900198 (rank : 7)	θ value	1.11475e-66 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UP52, O75422, Q9HA99, Q9NX67	Gene names	TFR2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR2_MOUSE
NC score	0.898158 (rank : 8)	θ value	2.10232e-65 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JKX3, Q920I6, Q99MQ9, Q9CPT2	Gene names	Tfr2, Trfr2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR1_HUMAN
NC score	0.881969 (rank : 9)	θ value	2.41096e-53 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	P02786, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21	Gene names	TFRC
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen) (T9) (p90).

TFR1_MOUSE
NC score	0.879831 (rank : 10)	θ value	1.788e-48 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

NCLN_HUMAN
NC score	0.067479 (rank : 11)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q969V3, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2	Gene names	NCLN
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

NCLN_MOUSE
NC score	0.061789 (rank : 12)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCM8, Q8C7Y4, Q9CX81	Gene names	Ncln
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

SYBU_HUMAN
NC score	0.040043 (rank : 13)	θ value	0.0431538 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NX95, Q5R1T1, Q5R1T2, Q5R1T3, Q5Y2M6, Q8ND49, Q8TCR6, Q9P256	Gene names	SYBU, GOLSYN, KIAA1472
Domain Architecture	No domain graphic available
Description	Syntabulin (Syntaxin-1-binding protein) (Golgi-localized syntaphilin- related protein).

KCP2_HUMAN
NC score	0.035424 (rank : 14)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6L1, Q6PG45, Q86XW2, Q8IWS4	Gene names	KRTCAP2, KCP2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated protein 2 (KCP-2).

TCFL5_HUMAN
NC score	0.022089 (rank : 15)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

RYR3_HUMAN
NC score	0.019365 (rank : 16)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

IQEC3_HUMAN
NC score	0.017173 (rank : 17)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

ETV5_HUMAN
NC score	0.011421 (rank : 18)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	P41161	Gene names	ETV5, ERM
Domain Architecture
Description	ETS translocation variant 5 (Ets-related protein ERM).

IQEC3_MOUSE
NC score	0.010795 (rank : 19)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

MYO15_MOUSE
NC score	0.010003 (rank : 20)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	467	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

HAOX1_MOUSE
NC score	0.009537 (rank : 21)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WU19	Gene names	Hao1, Gox1, Hao-1
Domain Architecture
Description	Hydroxyacid oxidase 1 (EC 1.1.3.15) (HAOX1) (Glycolate oxidase) (GOX).

KIF17_HUMAN
NC score	0.009418 (rank : 22)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	365	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).