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Network neighborhood for query Sequence : TFR1_HUMAN

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TFR1_HUMAN
SwissProt Accessions	P02786, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21	Gene names	TFRC
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen) (T9) (p90).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TFR1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P02786, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21	Gene names	TFRC
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen) (T9) (p90).

TFR1_MOUSE
θ value	0 (rank : 2)	NC score	0.998156 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

TFR2_MOUSE
θ value	1.08415e-162 (rank : 3)	NC score	0.975125 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKX3, Q920I6, Q99MQ9, Q9CPT2	Gene names	Tfr2, Trfr2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR2_HUMAN
θ value	2.26059e-160 (rank : 4)	NC score	0.976127 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UP52, O75422, Q9HA99, Q9NX67	Gene names	TFR2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

NALD2_MOUSE
θ value	5.35859e-61 (rank : 5)	NC score	0.878962 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZR2, Q80YF8	Gene names	Naalad2
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II).

FOLH1_HUMAN
θ value	5.0155e-59 (rank : 6)	NC score	0.876939 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

FOLH1_MOUSE
θ value	1.61343e-57 (rank : 7)	NC score	0.876272 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

NALD2_HUMAN
θ value	3.0428e-56 (rank : 8)	NC score	0.875147 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y3Q0	Gene names	NAALAD2
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II).

NALDL_MOUSE
θ value	5.73848e-55 (rank : 9)	NC score	0.885874 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q7M758	Gene names	Naaladl1, Naaladasel
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L).

NALDL_HUMAN
θ value	2.41096e-53 (rank : 10)	NC score	0.881969 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQQ1, O43176	Gene names	NAALADL1, NAALADASEL, NAALADL
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L) (Ileal dipeptidylpeptidase) (100 kDa ileum brush border membrane protein) (I100).

NCLN_HUMAN
θ value	0.0148317 (rank : 11)	NC score	0.156138 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q969V3, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2	Gene names	NCLN
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

NCLN_MOUSE
θ value	0.0193708 (rank : 12)	NC score	0.149078 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCM8, Q8C7Y4, Q9CX81	Gene names	Ncln
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

GOLI_HUMAN
θ value	0.62314 (rank : 13)	NC score	0.044273 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).

GOLI_MOUSE
θ value	0.62314 (rank : 14)	NC score	0.044248 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	134	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

KPYM_MOUSE
θ value	1.81305 (rank : 15)	NC score	0.026748 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	P52480, Q64484, Q91YI8	Gene names	Pkm2, Pk3, Pykm
Domain Architecture
Description	Pyruvate kinase isozyme M2 (EC 2.7.1.40).

ABCA1_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.004765 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	P41233	Gene names	Abca1, Abc1
Domain Architecture
Description	ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ATP-binding cassette 1) (ABC-1).

KPYM_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.025011 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P14618, P14786, Q96E76, Q9BWB5, Q9UPF2	Gene names	PKM2, PK2, PK3, PKM
Domain Architecture
Description	Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) (Pyruvate kinase muscle isozyme) (Pyruvate kinase 2/3) (Cytosolic thyroid hormone-binding protein) (CTHBP) (THBP1).

EDEM3_HUMAN
θ value	5.27518 (rank : 18)	NC score	0.023017 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

CAC1S_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.003465 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CASC5_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.006915 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	376	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

CCAR1_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.005338 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	414	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

MARE1_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.006754 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q15691	Gene names	MAPRE1
Domain Architecture
Description	Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1).

Hits sorted by NC score

TFR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P02786, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21	Gene names	TFRC
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen) (T9) (p90).

TFR1_MOUSE
NC score	0.998156 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

TFR2_HUMAN
NC score	0.976127 (rank : 3)	θ value	2.26059e-160 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UP52, O75422, Q9HA99, Q9NX67	Gene names	TFR2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

TFR2_MOUSE
NC score	0.975125 (rank : 4)	θ value	1.08415e-162 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKX3, Q920I6, Q99MQ9, Q9CPT2	Gene names	Tfr2, Trfr2
Domain Architecture
Description	Transferrin receptor protein 2 (TfR2).

NALDL_MOUSE
NC score	0.885874 (rank : 5)	θ value	5.73848e-55 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q7M758	Gene names	Naaladl1, Naaladasel
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L).

NALDL_HUMAN
NC score	0.881969 (rank : 6)	θ value	2.41096e-53 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQQ1, O43176	Gene names	NAALADL1, NAALADASEL, NAALADL
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase-like protein (EC 3.4.17.21) (NAALADase L) (Ileal dipeptidylpeptidase) (100 kDa ileum brush border membrane protein) (I100).

NALD2_MOUSE
NC score	0.878962 (rank : 7)	θ value	5.35859e-61 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZR2, Q80YF8	Gene names	Naalad2
Domain Architecture	No domain graphic available
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II).

FOLH1_HUMAN
NC score	0.876939 (rank : 8)	θ value	5.0155e-59 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

FOLH1_MOUSE
NC score	0.876272 (rank : 9)	θ value	1.61343e-57 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O35409, Q9DCC2	Gene names	Folh1, Mopsm, Naalad1
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen homolog).

NALD2_HUMAN
NC score	0.875147 (rank : 10)	θ value	3.0428e-56 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y3Q0	Gene names	NAALAD2
Domain Architecture
Description	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (N- acetylated-alpha-linked acidic dipeptidase II) (NAALADase II).

NCLN_HUMAN
NC score	0.156138 (rank : 11)	θ value	0.0148317 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q969V3, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2	Gene names	NCLN
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

NCLN_MOUSE
NC score	0.149078 (rank : 12)	θ value	0.0193708 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCM8, Q8C7Y4, Q9CX81	Gene names	Ncln
Domain Architecture	No domain graphic available
Description	Nicalin precursor (Nicastrin-like protein).

GOLI_HUMAN
NC score	0.044273 (rank : 13)	θ value	0.62314 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).

GOLI_MOUSE
NC score	0.044248 (rank : 14)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	134	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

KPYM_MOUSE
NC score	0.026748 (rank : 15)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	P52480, Q64484, Q91YI8	Gene names	Pkm2, Pk3, Pykm
Domain Architecture
Description	Pyruvate kinase isozyme M2 (EC 2.7.1.40).

KPYM_HUMAN
NC score	0.025011 (rank : 16)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P14618, P14786, Q96E76, Q9BWB5, Q9UPF2	Gene names	PKM2, PK2, PK3, PKM
Domain Architecture
Description	Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) (Pyruvate kinase muscle isozyme) (Pyruvate kinase 2/3) (Cytosolic thyroid hormone-binding protein) (CTHBP) (THBP1).

EDEM3_HUMAN
NC score	0.023017 (rank : 17)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

CASC5_HUMAN
NC score	0.006915 (rank : 18)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	376	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

MARE1_HUMAN
NC score	0.006754 (rank : 19)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q15691	Gene names	MAPRE1
Domain Architecture
Description	Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1).

CCAR1_MOUSE
NC score	0.005338 (rank : 20)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	414	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

ABCA1_MOUSE
NC score	0.004765 (rank : 21)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	P41233	Gene names	Abca1, Abc1
Domain Architecture
Description	ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ATP-binding cassette 1) (ABC-1).

CAC1S_MOUSE
NC score	0.003465 (rank : 22)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).