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Network neighborhood for query Sequence : ENPP7_HUMAN

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ENPP7_HUMAN
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ENPP7_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

ENPP5_MOUSE
θ value	1.27248e-70 (rank : 2)	NC score	0.955522 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_HUMAN
θ value	2.65329e-68 (rank : 3)	NC score	0.954587 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP6_HUMAN
θ value	7.01481e-53 (rank : 4)	NC score	0.932509 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_MOUSE
θ value	3.04986e-48 (rank : 5)	NC score	0.930286 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP3_HUMAN
θ value	3.37202e-47 (rank : 6)	NC score	0.891783 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	34	Shared Neighborhood Hits	13
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
θ value	7.51208e-47 (rank : 7)	NC score	0.886609 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
θ value	9.81109e-47 (rank : 8)	NC score	0.875613 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
θ value	2.18568e-46 (rank : 9)	NC score	0.886554 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	65	Shared Neighborhood Hits	17
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_HUMAN
θ value	7.03111e-45 (rank : 10)	NC score	0.875918 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	61	Shared Neighborhood Hits	14
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

PIGO_HUMAN
θ value	0.000158464 (rank : 11)	NC score	0.226173 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TEQ8, Q6P154, Q6UX80, Q8TDS8, Q96CS9, Q9BVN9, Q9Y4B0	Gene names	PIGO
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

PIGO_MOUSE
θ value	0.000786445 (rank : 12)	NC score	0.217341 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJI6, Q9CRY2	Gene names	Pigo
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

ARSG_MOUSE
θ value	0.0330416 (rank : 13)	NC score	0.063546 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4	Gene names	Arsg, Kiaa1001
Domain Architecture	No domain graphic available
Description	Arylsulfatase G precursor (EC 3.1.6.-) (ASG).

ARSJ_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.068113 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	27	Shared Neighborhood Hits	11
SwissProt Accessions	Q5FYB0, Q5FWE4, Q6UWT9	Gene names	ARSJ
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

ARSE_HUMAN
θ value	0.62314 (rank : 15)	NC score	0.049609 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	P51690, Q53FT2, Q53FU8	Gene names	ARSE
Domain Architecture
Description	Arylsulfatase E precursor (EC 3.1.6.-) (ASE).

ARSJ_MOUSE
θ value	0.62314 (rank : 16)	NC score	0.065821 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BM89, Q8BKG5, Q8BL46	Gene names	Arsj
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

ARSI_HUMAN
θ value	0.813845 (rank : 17)	NC score	0.063713 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	Q5FYB1	Gene names	ARSI
Domain Architecture	No domain graphic available
Description	Arylsulfatase I precursor (EC 3.1.6.-) (ASI).

PIGN_MOUSE
θ value	0.813845 (rank : 18)	NC score	0.116715 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

SULF1_MOUSE
θ value	1.38821 (rank : 19)	NC score	0.039212 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K007, Q8BLJ0, Q8C1D3	Gene names	Sulf1
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (MSulf-1).

NPHN_HUMAN
θ value	1.81305 (rank : 20)	NC score	0.009679 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	362	Shared Neighborhood Hits	2
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

PIGN_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.101810 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	O95427, Q7L8F8, Q8TC01, Q9NT05	Gene names	PIGN, MCD4
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).

PIGG_HUMAN
θ value	3.0926 (rank : 22)	NC score	0.205927 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

SULF1_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.037096 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWU6, Q86YV8, Q8NCA2, Q9UPS5	Gene names	SULF1, KIAA1077
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (HSulf-1).

ABL2_HUMAN
θ value	5.27518 (rank : 24)	NC score	-0.001188 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	1045	Shared Neighborhood Hits	2
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ARSB_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.058223 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	P15848	Gene names	ARSB
Domain Architecture
Description	Arylsulfatase B precursor (EC 3.1.6.12) (ASB) (N-acetylgalactosamine- 4-sulfatase) (G4S).

IRF5_MOUSE
θ value	6.88961 (rank : 26)	NC score	0.007238 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

STS_MOUSE
θ value	6.88961 (rank : 27)	NC score	0.050659 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

ARSF_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.052134 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

CT055_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.012912 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQ89	Gene names	C20orf55
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55.

GON4L_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.006428 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	555	Shared Neighborhood Hits	2
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

ARSA_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.058395 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

ARSA_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.052060 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

PP11_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.156721 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

PRG4_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.082435 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	764	Shared Neighborhood Hits	6
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.095903 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	624	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

VTNC_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.055691 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

VTNC_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.063317 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

Hits sorted by NC score

ENPP7_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

ENPP5_MOUSE
NC score	0.955522 (rank : 2)	θ value	1.27248e-70 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_HUMAN
NC score	0.954587 (rank : 3)	θ value	2.65329e-68 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP6_HUMAN
NC score	0.932509 (rank : 4)	θ value	7.01481e-53 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_MOUSE
NC score	0.930286 (rank : 5)	θ value	3.04986e-48 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP3_HUMAN
NC score	0.891783 (rank : 6)	θ value	3.37202e-47 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	34	Shared Neighborhood Hits	13
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
NC score	0.886609 (rank : 7)	θ value	7.51208e-47 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
NC score	0.886554 (rank : 8)	θ value	2.18568e-46 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	65	Shared Neighborhood Hits	17
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_HUMAN
NC score	0.875918 (rank : 9)	θ value	7.03111e-45 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	61	Shared Neighborhood Hits	14
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
NC score	0.875613 (rank : 10)	θ value	9.81109e-47 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

PIGO_HUMAN
NC score	0.226173 (rank : 11)	θ value	0.000158464 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TEQ8, Q6P154, Q6UX80, Q8TDS8, Q96CS9, Q9BVN9, Q9Y4B0	Gene names	PIGO
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

PIGO_MOUSE
NC score	0.217341 (rank : 12)	θ value	0.000786445 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJI6, Q9CRY2	Gene names	Pigo
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

PIGG_HUMAN
NC score	0.205927 (rank : 13)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

PP11_HUMAN
NC score	0.156721 (rank : 14)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

PIGN_MOUSE
NC score	0.116715 (rank : 15)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

PIGN_HUMAN
NC score	0.101810 (rank : 16)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	O95427, Q7L8F8, Q8TC01, Q9NT05	Gene names	PIGN, MCD4
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).

PRG4_MOUSE
NC score	0.095903 (rank : 17)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	624	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
NC score	0.082435 (rank : 18)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	764	Shared Neighborhood Hits	6
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ARSJ_HUMAN
NC score	0.068113 (rank : 19)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	27	Shared Neighborhood Hits	11
SwissProt Accessions	Q5FYB0, Q5FWE4, Q6UWT9	Gene names	ARSJ
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

ARSJ_MOUSE
NC score	0.065821 (rank : 20)	θ value	0.62314 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BM89, Q8BKG5, Q8BL46	Gene names	Arsj
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

ARSI_HUMAN
NC score	0.063713 (rank : 21)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	Q5FYB1	Gene names	ARSI
Domain Architecture	No domain graphic available
Description	Arylsulfatase I precursor (EC 3.1.6.-) (ASI).

ARSG_MOUSE
NC score	0.063546 (rank : 22)	θ value	0.0330416 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4	Gene names	Arsg, Kiaa1001
Domain Architecture	No domain graphic available
Description	Arylsulfatase G precursor (EC 3.1.6.-) (ASG).

VTNC_MOUSE
NC score	0.063317 (rank : 23)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

ARSA_HUMAN
NC score	0.058395 (rank : 24)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

ARSB_HUMAN
NC score	0.058223 (rank : 25)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	P15848	Gene names	ARSB
Domain Architecture
Description	Arylsulfatase B precursor (EC 3.1.6.12) (ASB) (N-acetylgalactosamine- 4-sulfatase) (G4S).

VTNC_HUMAN
NC score	0.055691 (rank : 26)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

ARSF_HUMAN
NC score	0.052134 (rank : 27)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

ARSA_MOUSE
NC score	0.052060 (rank : 28)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

STS_MOUSE
NC score	0.050659 (rank : 29)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

ARSE_HUMAN
NC score	0.049609 (rank : 30)	θ value	0.62314 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	P51690, Q53FT2, Q53FU8	Gene names	ARSE
Domain Architecture
Description	Arylsulfatase E precursor (EC 3.1.6.-) (ASE).

SULF1_MOUSE
NC score	0.039212 (rank : 31)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K007, Q8BLJ0, Q8C1D3	Gene names	Sulf1
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (MSulf-1).

SULF1_HUMAN
NC score	0.037096 (rank : 32)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWU6, Q86YV8, Q8NCA2, Q9UPS5	Gene names	SULF1, KIAA1077
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (HSulf-1).

CT055_HUMAN
NC score	0.012912 (rank : 33)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQ89	Gene names	C20orf55
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55.

NPHN_HUMAN
NC score	0.009679 (rank : 34)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	362	Shared Neighborhood Hits	2
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

IRF5_MOUSE
NC score	0.007238 (rank : 35)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

GON4L_HUMAN
NC score	0.006428 (rank : 36)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	555	Shared Neighborhood Hits	2
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

ABL2_HUMAN
NC score	-0.001188 (rank : 37)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	1045	Shared Neighborhood Hits	2
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).