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Network neighborhood for query Sequence : RRP44_HUMAN

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RRP44_HUMAN
SwissProt Accessions	Q9Y2L1, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36	Gene names	DIS3, KIAA1008, RRP44
Domain Architecture
Description	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RRP44_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2L1, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36	Gene names	DIS3, KIAA1008, RRP44
Domain Architecture
Description	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog).

PR285_HUMAN
θ value	3.07116e-24 (rank : 2)	NC score	0.362803 (rank : 2)
Query Neighborhood Hits	35	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

REST_MOUSE
θ value	0.00665767 (rank : 3)	NC score	0.048226 (rank : 21)
Query Neighborhood Hits	35	Target Neighborhood Hits	1506	Shared Neighborhood Hits	12
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

REST_HUMAN
θ value	0.279714 (rank : 4)	NC score	0.040793 (rank : 23)
Query Neighborhood Hits	35	Target Neighborhood Hits	1605	Shared Neighborhood Hits	13
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

DMD_HUMAN
θ value	0.62314 (rank : 5)	NC score	0.045077 (rank : 22)
Query Neighborhood Hits	35	Target Neighborhood Hits	1135	Shared Neighborhood Hits	16
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

SPTB2_HUMAN
θ value	0.813845 (rank : 6)	NC score	0.056188 (rank : 12)
Query Neighborhood Hits	35	Target Neighborhood Hits	748	Shared Neighborhood Hits	12
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.055481 (rank : 15)
Query Neighborhood Hits	35	Target Neighborhood Hits	770	Shared Neighborhood Hits	12
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

IPO11_HUMAN
θ value	1.06291 (rank : 8)	NC score	0.066357 (rank : 6)
Query Neighborhood Hits	35	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO11_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.064847 (rank : 7)
Query Neighborhood Hits	35	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

G6PD2_MOUSE
θ value	1.81305 (rank : 10)	NC score	0.033948 (rank : 25)
Query Neighborhood Hits	35	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P97324	Gene names	G6pd2, G6pd-2
Domain Architecture
Description	Glucose-6-phosphate 1-dehydrogenase 2 (EC 1.1.1.49) (G6PD).

SPTN4_HUMAN
θ value	1.81305 (rank : 11)	NC score	0.055342 (rank : 16)
Query Neighborhood Hits	35	Target Neighborhood Hits	570	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

ZN33A_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.003857 (rank : 44)
Query Neighborhood Hits	35	Target Neighborhood Hits	780	Shared Neighborhood Hits	4
SwissProt Accessions	Q06730, Q5VZ86	Gene names	ZNF33A, KIAA0065, KOX31, ZNF33
Domain Architecture
Description	Zinc finger protein 33A (Zinc finger protein KOX31) (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK).

ITPR3_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.027200 (rank : 30)
Query Neighborhood Hits	35	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

SPTB1_HUMAN
θ value	3.0926 (rank : 14)	NC score	0.055012 (rank : 18)
Query Neighborhood Hits	35	Target Neighborhood Hits	541	Shared Neighborhood Hits	11
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB1_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.055311 (rank : 17)
Query Neighborhood Hits	35	Target Neighborhood Hits	543	Shared Neighborhood Hits	11
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

TAIP2_HUMAN
θ value	3.0926 (rank : 16)	NC score	0.036086 (rank : 24)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WYN3	Gene names	TAIP2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

ZN11B_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.003591 (rank : 45)
Query Neighborhood Hits	35	Target Neighborhood Hits	802	Shared Neighborhood Hits	4
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.

BPAEA_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.033936 (rank : 26)
Query Neighborhood Hits	35	Target Neighborhood Hits	1369	Shared Neighborhood Hits	13
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

ITPR3_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.026450 (rank : 31)
Query Neighborhood Hits	35	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

EXO1_HUMAN
θ value	5.27518 (rank : 20)	NC score	0.025017 (rank : 32)
Query Neighborhood Hits	35	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UQ84, O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0	Gene names	EXO1, EXOI, HEX1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (hExo1) (Exonuclease I) (hExoI).

SMC4_HUMAN
θ value	5.27518 (rank : 21)	NC score	0.021508 (rank : 35)
Query Neighborhood Hits	35	Target Neighborhood Hits	937	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

SPTN2_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.055773 (rank : 14)
Query Neighborhood Hits	35	Target Neighborhood Hits	535	Shared Neighborhood Hits	12
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

AKAP2_HUMAN
θ value	6.88961 (rank : 23)	NC score	0.022071 (rank : 34)
Query Neighborhood Hits	35	Target Neighborhood Hits	507	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

ERN2_HUMAN
θ value	6.88961 (rank : 24)	NC score	0.004135 (rank : 43)
Query Neighborhood Hits	35	Target Neighborhood Hits	844	Shared Neighborhood Hits	2
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

RGS12_HUMAN
θ value	6.88961 (rank : 25)	NC score	0.012730 (rank : 40)
Query Neighborhood Hits	35	Target Neighborhood Hits	333	Shared Neighborhood Hits	2
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

ROBO4_MOUSE
θ value	6.88961 (rank : 26)	NC score	0.009374 (rank : 42)
Query Neighborhood Hits	35	Target Neighborhood Hits	358	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

SIN1_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.033449 (rank : 27)
Query Neighborhood Hits	35	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BPZ7, Q00426	Gene names	MAPKAP1, SIN1
Domain Architecture
Description	Stress-activated map kinase-interacting protein 1 (SAPK-interacting protein 1) (Putative Ras inhibitor JC310).

TAF1A_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.024914 (rank : 33)
Query Neighborhood Hits	35	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q15573, Q9NWA1	Gene names	TAF1A
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor RNA polymerase I subunit A (TATA box-binding protein-associated factor 1A) (TBP-associated factor RNA polymerase I 48 kDa) (TAFI48) (Transcription factor SL1).

GRPE2_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.019836 (rank : 36)
Query Neighborhood Hits	35	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TAA5	Gene names	GRPEL2
Domain Architecture
Description	GrpE protein homolog 2, mitochondrial precursor (Mt-GrpE#2).

NRX2A_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.010598 (rank : 41)
Query Neighborhood Hits	35	Target Neighborhood Hits	614	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.014949 (rank : 39)
Query Neighborhood Hits	35	Target Neighborhood Hits	481	Shared Neighborhood Hits	3
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PHF3_HUMAN
θ value	8.99809 (rank : 32)	NC score	0.016748 (rank : 38)
Query Neighborhood Hits	35	Target Neighborhood Hits	419	Shared Neighborhood Hits	4
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

TAI12_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.029676 (rank : 28)
Query Neighborhood Hits	35	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H175	Gene names	TAIP12, C12orf22
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

TAI12_MOUSE
θ value	8.99809 (rank : 34)	NC score	0.029612 (rank : 29)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BGQ2, Q3UIH1	Gene names	Taip12
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

ZN541_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.016750 (rank : 37)
Query Neighborhood Hits	35	Target Neighborhood Hits	203	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

HELZ_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.114908 (rank : 3)
Query Neighborhood Hits	35	Target Neighborhood Hits	198	Shared Neighborhood Hits	1
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

M10L1_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.058011 (rank : 9)
Query Neighborhood Hits	35	Target Neighborhood Hits	36	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BXT6, Q5TGD5, Q8NBD4, Q9NXW3, Q9UFB3, Q9UGX9	Gene names	MOV10L1
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1).

M10L1_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.057553 (rank : 10)
Query Neighborhood Hits	35	Target Neighborhood Hits	59	Shared Neighborhood Hits	1
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

MOV10_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.053788 (rank : 20)
Query Neighborhood Hits	35	Target Neighborhood Hits	46	Shared Neighborhood Hits	1
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

MOV10_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.054228 (rank : 19)
Query Neighborhood Hits	35	Target Neighborhood Hits	39	Shared Neighborhood Hits	1
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

RENT1_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.067740 (rank : 4)
Query Neighborhood Hits	35	Target Neighborhood Hits	51	Shared Neighborhood Hits	1
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.067662 (rank : 5)
Query Neighborhood Hits	35	Target Neighborhood Hits	54	Shared Neighborhood Hits	1
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

SETX_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.056015 (rank : 13)
Query Neighborhood Hits	35	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

SMBP2_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.057291 (rank : 11)
Query Neighborhood Hits	35	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

SMBP2_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.061791 (rank : 8)
Query Neighborhood Hits	35	Target Neighborhood Hits	104	Shared Neighborhood Hits	1
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

Hits sorted by NC score

RRP44_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2L1, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36	Gene names	DIS3, KIAA1008, RRP44
Domain Architecture
Description	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog).

PR285_HUMAN
NC score	0.362803 (rank : 2)	θ value	3.07116e-24 (rank : 2)
Query Neighborhood Hits	35	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

HELZ_HUMAN
NC score	0.114908 (rank : 3)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	35	Target Neighborhood Hits	198	Shared Neighborhood Hits	1
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

RENT1_HUMAN
NC score	0.067740 (rank : 4)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	35	Target Neighborhood Hits	51	Shared Neighborhood Hits	1
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
NC score	0.067662 (rank : 5)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	35	Target Neighborhood Hits	54	Shared Neighborhood Hits	1
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

IPO11_HUMAN
NC score	0.066357 (rank : 6)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	35	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO11_MOUSE
NC score	0.064847 (rank : 7)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	35	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

SMBP2_MOUSE
NC score	0.061791 (rank : 8)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	35	Target Neighborhood Hits	104	Shared Neighborhood Hits	1
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

M10L1_HUMAN
NC score	0.058011 (rank : 9)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	35	Target Neighborhood Hits	36	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BXT6, Q5TGD5, Q8NBD4, Q9NXW3, Q9UFB3, Q9UGX9	Gene names	MOV10L1
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1).

M10L1_MOUSE
NC score	0.057553 (rank : 10)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	35	Target Neighborhood Hits	59	Shared Neighborhood Hits	1
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

SMBP2_HUMAN
NC score	0.057291 (rank : 11)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	35	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

SPTB2_HUMAN
NC score	0.056188 (rank : 12)	θ value	0.813845 (rank : 6)
Query Neighborhood Hits	35	Target Neighborhood Hits	748	Shared Neighborhood Hits	12
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SETX_HUMAN
NC score	0.056015 (rank : 13)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	35	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

SPTN2_HUMAN
NC score	0.055773 (rank : 14)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	35	Target Neighborhood Hits	535	Shared Neighborhood Hits	12
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

SPTB2_MOUSE
NC score	0.055481 (rank : 15)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	35	Target Neighborhood Hits	770	Shared Neighborhood Hits	12
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN4_HUMAN
NC score	0.055342 (rank : 16)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	35	Target Neighborhood Hits	570	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPTB1_MOUSE
NC score	0.055311 (rank : 17)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	35	Target Neighborhood Hits	543	Shared Neighborhood Hits	11
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB1_HUMAN
NC score	0.055012 (rank : 18)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	35	Target Neighborhood Hits	541	Shared Neighborhood Hits	11
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

MOV10_MOUSE
NC score	0.054228 (rank : 19)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	35	Target Neighborhood Hits	39	Shared Neighborhood Hits	1
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

MOV10_HUMAN
NC score	0.053788 (rank : 20)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	35	Target Neighborhood Hits	46	Shared Neighborhood Hits	1
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

REST_MOUSE
NC score	0.048226 (rank : 21)	θ value	0.00665767 (rank : 3)
Query Neighborhood Hits	35	Target Neighborhood Hits	1506	Shared Neighborhood Hits	12
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

DMD_HUMAN
NC score	0.045077 (rank : 22)	θ value	0.62314 (rank : 5)
Query Neighborhood Hits	35	Target Neighborhood Hits	1135	Shared Neighborhood Hits	16
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

REST_HUMAN
NC score	0.040793 (rank : 23)	θ value	0.279714 (rank : 4)
Query Neighborhood Hits	35	Target Neighborhood Hits	1605	Shared Neighborhood Hits	13
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

TAIP2_HUMAN
NC score	0.036086 (rank : 24)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WYN3	Gene names	TAIP2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

G6PD2_MOUSE
NC score	0.033948 (rank : 25)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	35	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P97324	Gene names	G6pd2, G6pd-2
Domain Architecture
Description	Glucose-6-phosphate 1-dehydrogenase 2 (EC 1.1.1.49) (G6PD).

BPAEA_HUMAN
NC score	0.033936 (rank : 26)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	35	Target Neighborhood Hits	1369	Shared Neighborhood Hits	13
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SIN1_HUMAN
NC score	0.033449 (rank : 27)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	35	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BPZ7, Q00426	Gene names	MAPKAP1, SIN1
Domain Architecture
Description	Stress-activated map kinase-interacting protein 1 (SAPK-interacting protein 1) (Putative Ras inhibitor JC310).

TAI12_HUMAN
NC score	0.029676 (rank : 28)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	35	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H175	Gene names	TAIP12, C12orf22
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

TAI12_MOUSE
NC score	0.029612 (rank : 29)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BGQ2, Q3UIH1	Gene names	Taip12
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

ITPR3_HUMAN
NC score	0.027200 (rank : 30)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	35	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

ITPR3_MOUSE
NC score	0.026450 (rank : 31)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	35	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

EXO1_HUMAN
NC score	0.025017 (rank : 32)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	35	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UQ84, O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0	Gene names	EXO1, EXOI, HEX1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (hExo1) (Exonuclease I) (hExoI).

TAF1A_HUMAN
NC score	0.024914 (rank : 33)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	35	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q15573, Q9NWA1	Gene names	TAF1A
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor RNA polymerase I subunit A (TATA box-binding protein-associated factor 1A) (TBP-associated factor RNA polymerase I 48 kDa) (TAFI48) (Transcription factor SL1).

AKAP2_HUMAN
NC score	0.022071 (rank : 34)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	35	Target Neighborhood Hits	507	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

SMC4_HUMAN
NC score	0.021508 (rank : 35)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	35	Target Neighborhood Hits	937	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

GRPE2_HUMAN
NC score	0.019836 (rank : 36)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	35	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TAA5	Gene names	GRPEL2
Domain Architecture
Description	GrpE protein homolog 2, mitochondrial precursor (Mt-GrpE#2).

ZN541_HUMAN
NC score	0.016750 (rank : 37)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	35	Target Neighborhood Hits	203	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

PHF3_HUMAN
NC score	0.016748 (rank : 38)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	35	Target Neighborhood Hits	419	Shared Neighborhood Hits	4
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

NRX2B_HUMAN
NC score	0.014949 (rank : 39)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	35	Target Neighborhood Hits	481	Shared Neighborhood Hits	3
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

RGS12_HUMAN
NC score	0.012730 (rank : 40)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	35	Target Neighborhood Hits	333	Shared Neighborhood Hits	2
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

NRX2A_HUMAN
NC score	0.010598 (rank : 41)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	35	Target Neighborhood Hits	614	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

ROBO4_MOUSE
NC score	0.009374 (rank : 42)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	35	Target Neighborhood Hits	358	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

ERN2_HUMAN
NC score	0.004135 (rank : 43)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	35	Target Neighborhood Hits	844	Shared Neighborhood Hits	2
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ZN33A_HUMAN
NC score	0.003857 (rank : 44)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	35	Target Neighborhood Hits	780	Shared Neighborhood Hits	4
SwissProt Accessions	Q06730, Q5VZ86	Gene names	ZNF33A, KIAA0065, KOX31, ZNF33
Domain Architecture
Description	Zinc finger protein 33A (Zinc finger protein KOX31) (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK).

ZN11B_HUMAN
NC score	0.003591 (rank : 45)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	35	Target Neighborhood Hits	802	Shared Neighborhood Hits	4
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.