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Network neighborhood for query Sequence : PARP1_HUMAN

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PARP1_HUMAN
SwissProt Accessions	P09874, Q8IUZ9	Gene names	PARP1, ADPRT, PPOL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PARP1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	54	Target Neighborhood Hits	54	Shared Neighborhood Hits	54
SwissProt Accessions	P09874, Q8IUZ9	Gene names	PARP1, ADPRT, PPOL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1).

PARP1_MOUSE
θ value	0 (rank : 2)	NC score	0.987324 (rank : 2)
Query Neighborhood Hits	54	Target Neighborhood Hits	102	Shared Neighborhood Hits	31
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

PARP2_MOUSE
θ value	9.32813e-106 (rank : 3)	NC score	0.917143 (rank : 4)
Query Neighborhood Hits	54	Target Neighborhood Hits	53	Shared Neighborhood Hits	17
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

PARP2_HUMAN
θ value	8.73085e-104 (rank : 4)	NC score	0.920451 (rank : 3)
Query Neighborhood Hits	54	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

PARP3_HUMAN
θ value	6.32992e-62 (rank : 5)	NC score	0.887538 (rank : 5)
Query Neighborhood Hits	54	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

PARP4_HUMAN
θ value	3.07116e-24 (rank : 6)	NC score	0.557600 (rank : 6)
Query Neighborhood Hits	54	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

DNL3_HUMAN
θ value	1.29631e-06 (rank : 7)	NC score	0.203643 (rank : 7)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL3_MOUSE
θ value	1.29631e-06 (rank : 8)	NC score	0.201646 (rank : 8)
Query Neighborhood Hits	54	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

TNKS1_HUMAN
θ value	0.000461057 (rank : 9)	NC score	0.073561 (rank : 15)
Query Neighborhood Hits	54	Target Neighborhood Hits	477	Shared Neighborhood Hits	15
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

TNKS2_HUMAN
θ value	0.00509761 (rank : 10)	NC score	0.069164 (rank : 16)
Query Neighborhood Hits	54	Target Neighborhood Hits	361	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

NEBU_HUMAN
θ value	0.0563607 (rank : 11)	NC score	0.036042 (rank : 27)
Query Neighborhood Hits	54	Target Neighborhood Hits	420	Shared Neighborhood Hits	10
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PARP6_HUMAN
θ value	0.0736092 (rank : 12)	NC score	0.148819 (rank : 9)
Query Neighborhood Hits	54	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4	Gene names	PARP6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP6_MOUSE
θ value	0.0736092 (rank : 13)	NC score	0.148750 (rank : 10)
Query Neighborhood Hits	54	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P6P7, Q8BVW1	Gene names	Parp6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP8_HUMAN
θ value	0.0961366 (rank : 14)	NC score	0.148056 (rank : 11)
Query Neighborhood Hits	54	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARP8_MOUSE
θ value	0.0961366 (rank : 15)	NC score	0.147710 (rank : 12)
Query Neighborhood Hits	54	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

SPC25_HUMAN
θ value	0.163984 (rank : 16)	NC score	0.077911 (rank : 14)
Query Neighborhood Hits	54	Target Neighborhood Hits	273	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

GLE1_HUMAN
θ value	0.365318 (rank : 17)	NC score	0.049053 (rank : 23)
Query Neighborhood Hits	54	Target Neighborhood Hits	445	Shared Neighborhood Hits	14
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

RFC1_MOUSE
θ value	0.47712 (rank : 18)	NC score	0.063761 (rank : 18)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	11
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

KIF2C_HUMAN
θ value	0.62314 (rank : 19)	NC score	0.020461 (rank : 32)
Query Neighborhood Hits	54	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

LETM1_HUMAN
θ value	0.813845 (rank : 20)	NC score	0.029427 (rank : 30)
Query Neighborhood Hits	54	Target Neighborhood Hits	338	Shared Neighborhood Hits	15
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

PAR14_MOUSE
θ value	0.813845 (rank : 21)	NC score	0.053518 (rank : 20)
Query Neighborhood Hits	54	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

TR150_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.037706 (rank : 26)
Query Neighborhood Hits	54	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

TR150_MOUSE
θ value	1.06291 (rank : 23)	NC score	0.032655 (rank : 28)
Query Neighborhood Hits	54	Target Neighborhood Hits	468	Shared Neighborhood Hits	9
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

TRAK1_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.019192 (rank : 35)
Query Neighborhood Hits	54	Target Neighborhood Hits	660	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

CT2NL_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.017328 (rank : 36)
Query Neighborhood Hits	54	Target Neighborhood Hits	1059	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

PARPT_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.067636 (rank : 17)
Query Neighborhood Hits	54	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z3E1, Q68CY9, Q86VP4, Q9Y4P7	Gene names	TIPARP, PARP7
Domain Architecture	No domain graphic available
Description	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7).

PARPT_MOUSE
θ value	1.38821 (rank : 27)	NC score	0.081556 (rank : 13)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C1B2, Q3UD50, Q8C032	Gene names	Tiparp
Domain Architecture	No domain graphic available
Description	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30).

SPTB2_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.015018 (rank : 42)
Query Neighborhood Hits	54	Target Neighborhood Hits	748	Shared Neighborhood Hits	16
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.015192 (rank : 41)
Query Neighborhood Hits	54	Target Neighborhood Hits	770	Shared Neighborhood Hits	17
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TOPB1_HUMAN
θ value	1.38821 (rank : 30)	NC score	0.039959 (rank : 25)
Query Neighborhood Hits	54	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q92547, Q7LGC1, Q9UEB9	Gene names	TOPBP1, KIAA0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-binding protein 1) (DNA topoisomerase IIbeta-binding protein 1) (TopBP1).

JHD2C_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.021250 (rank : 31)
Query Neighborhood Hits	54	Target Neighborhood Hits	297	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9	Gene names	Jmjd1c, Jhdm2c, Kiaa1380
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C).

RFC1_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.053322 (rank : 22)
Query Neighborhood Hits	54	Target Neighborhood Hits	352	Shared Neighborhood Hits	12
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

THAP2_MOUSE
θ value	1.81305 (rank : 33)	NC score	0.040540 (rank : 24)
Query Neighborhood Hits	54	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D305	Gene names	Thap2
Domain Architecture
Description	THAP domain-containing protein 2.

ROCK1_MOUSE
θ value	2.36792 (rank : 34)	NC score	0.004538 (rank : 52)
Query Neighborhood Hits	54	Target Neighborhood Hits	2126	Shared Neighborhood Hits	26
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ROCK1_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.004464 (rank : 53)
Query Neighborhood Hits	54	Target Neighborhood Hits	2000	Shared Neighborhood Hits	24
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

XL3A_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.031503 (rank : 29)
Query Neighborhood Hits	54	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	Q60595	Gene names	Xlr3a
Domain Architecture
Description	X-linked lymphocyte-regulated protein 3A.

CKAP4_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.013956 (rank : 44)
Query Neighborhood Hits	54	Target Neighborhood Hits	596	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

MYPT1_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.015347 (rank : 40)
Query Neighborhood Hits	54	Target Neighborhood Hits	539	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

OFD1_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.019680 (rank : 33)
Query Neighborhood Hits	54	Target Neighborhood Hits	753	Shared Neighborhood Hits	19
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

TRAIP_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.019243 (rank : 34)
Query Neighborhood Hits	54	Target Neighborhood Hits	780	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

ABCG4_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.006017 (rank : 50)
Query Neighborhood Hits	54	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H172	Gene names	ABCG4, WHITE2
Domain Architecture
Description	ATP-binding cassette sub-family G member 4.

ANS4B_MOUSE
θ value	6.88961 (rank : 42)	NC score	0.014339 (rank : 43)
Query Neighborhood Hits	54	Target Neighborhood Hits	294	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

CENPF_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.008995 (rank : 47)
Query Neighborhood Hits	54	Target Neighborhood Hits	1932	Shared Neighborhood Hits	23
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

IWS1_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.006501 (rank : 49)
Query Neighborhood Hits	54	Target Neighborhood Hits	1241	Shared Neighborhood Hits	15
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

WRN_MOUSE
θ value	6.88961 (rank : 45)	NC score	0.008555 (rank : 48)
Query Neighborhood Hits	54	Target Neighborhood Hits	295	Shared Neighborhood Hits	7
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

CT2NL_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.015706 (rank : 37)
Query Neighborhood Hits	54	Target Neighborhood Hits	902	Shared Neighborhood Hits	20
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

GCC2_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.015622 (rank : 38)
Query Neighborhood Hits	54	Target Neighborhood Hits	1558	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

IF2M_MOUSE
θ value	8.99809 (rank : 48)	NC score	0.009171 (rank : 46)
Query Neighborhood Hits	54	Target Neighborhood Hits	183	Shared Neighborhood Hits	5
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

LIMK1_HUMAN
θ value	8.99809 (rank : 49)	NC score	-0.000505 (rank : 56)
Query Neighborhood Hits	54	Target Neighborhood Hits	1005	Shared Neighborhood Hits	5
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MYH10_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.005848 (rank : 51)
Query Neighborhood Hits	54	Target Neighborhood Hits	1620	Shared Neighborhood Hits	23
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NTRK1_HUMAN
θ value	8.99809 (rank : 51)	NC score	-0.000356 (rank : 55)
Query Neighborhood Hits	54	Target Neighborhood Hits	1023	Shared Neighborhood Hits	5
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

PCLO_MOUSE
θ value	8.99809 (rank : 52)	NC score	0.002902 (rank : 54)
Query Neighborhood Hits	54	Target Neighborhood Hits	2275	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RBM25_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.011086 (rank : 45)
Query Neighborhood Hits	54	Target Neighborhood Hits	682	Shared Neighborhood Hits	20
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

RBP24_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.015617 (rank : 39)
Query Neighborhood Hits	54	Target Neighborhood Hits	1559	Shared Neighborhood Hits	24
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

LHR2A_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.053460 (rank : 21)
Query Neighborhood Hits	54	Target Neighborhood Hits	16	Shared Neighborhood Hits	1
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

LHR2A_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.056897 (rank : 19)
Query Neighborhood Hits	54	Target Neighborhood Hits	16	Shared Neighborhood Hits	1
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

Hits sorted by NC score

PARP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	54	Target Neighborhood Hits	54	Shared Neighborhood Hits	54
SwissProt Accessions	P09874, Q8IUZ9	Gene names	PARP1, ADPRT, PPOL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1).

PARP1_MOUSE
NC score	0.987324 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	54	Target Neighborhood Hits	102	Shared Neighborhood Hits	31
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

PARP2_HUMAN
NC score	0.920451 (rank : 3)	θ value	8.73085e-104 (rank : 4)
Query Neighborhood Hits	54	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

PARP2_MOUSE
NC score	0.917143 (rank : 4)	θ value	9.32813e-106 (rank : 3)
Query Neighborhood Hits	54	Target Neighborhood Hits	53	Shared Neighborhood Hits	17
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

PARP3_HUMAN
NC score	0.887538 (rank : 5)	θ value	6.32992e-62 (rank : 5)
Query Neighborhood Hits	54	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

PARP4_HUMAN
NC score	0.557600 (rank : 6)	θ value	3.07116e-24 (rank : 6)
Query Neighborhood Hits	54	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

DNL3_HUMAN
NC score	0.203643 (rank : 7)	θ value	1.29631e-06 (rank : 7)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL3_MOUSE
NC score	0.201646 (rank : 8)	θ value	1.29631e-06 (rank : 8)
Query Neighborhood Hits	54	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

PARP6_HUMAN
NC score	0.148819 (rank : 9)	θ value	0.0736092 (rank : 12)
Query Neighborhood Hits	54	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4	Gene names	PARP6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP6_MOUSE
NC score	0.148750 (rank : 10)	θ value	0.0736092 (rank : 13)
Query Neighborhood Hits	54	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P6P7, Q8BVW1	Gene names	Parp6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP8_HUMAN
NC score	0.148056 (rank : 11)	θ value	0.0961366 (rank : 14)
Query Neighborhood Hits	54	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARP8_MOUSE
NC score	0.147710 (rank : 12)	θ value	0.0961366 (rank : 15)
Query Neighborhood Hits	54	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARPT_MOUSE
NC score	0.081556 (rank : 13)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C1B2, Q3UD50, Q8C032	Gene names	Tiparp
Domain Architecture	No domain graphic available
Description	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30).

SPC25_HUMAN
NC score	0.077911 (rank : 14)	θ value	0.163984 (rank : 16)
Query Neighborhood Hits	54	Target Neighborhood Hits	273	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

TNKS1_HUMAN
NC score	0.073561 (rank : 15)	θ value	0.000461057 (rank : 9)
Query Neighborhood Hits	54	Target Neighborhood Hits	477	Shared Neighborhood Hits	15
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

TNKS2_HUMAN
NC score	0.069164 (rank : 16)	θ value	0.00509761 (rank : 10)
Query Neighborhood Hits	54	Target Neighborhood Hits	361	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

PARPT_HUMAN
NC score	0.067636 (rank : 17)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	54	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z3E1, Q68CY9, Q86VP4, Q9Y4P7	Gene names	TIPARP, PARP7
Domain Architecture	No domain graphic available
Description	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7).

RFC1_MOUSE
NC score	0.063761 (rank : 18)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	11
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

LHR2A_MOUSE
NC score	0.056897 (rank : 19)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	54	Target Neighborhood Hits	16	Shared Neighborhood Hits	1
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

PAR14_MOUSE
NC score	0.053518 (rank : 20)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	54	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

LHR2A_HUMAN
NC score	0.053460 (rank : 21)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	54	Target Neighborhood Hits	16	Shared Neighborhood Hits	1
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

RFC1_HUMAN
NC score	0.053322 (rank : 22)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	54	Target Neighborhood Hits	352	Shared Neighborhood Hits	12
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

GLE1_HUMAN
NC score	0.049053 (rank : 23)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	54	Target Neighborhood Hits	445	Shared Neighborhood Hits	14
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

THAP2_MOUSE
NC score	0.040540 (rank : 24)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	54	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D305	Gene names	Thap2
Domain Architecture
Description	THAP domain-containing protein 2.

TOPB1_HUMAN
NC score	0.039959 (rank : 25)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	54	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q92547, Q7LGC1, Q9UEB9	Gene names	TOPBP1, KIAA0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-binding protein 1) (DNA topoisomerase IIbeta-binding protein 1) (TopBP1).

TR150_HUMAN
NC score	0.037706 (rank : 26)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	54	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

NEBU_HUMAN
NC score	0.036042 (rank : 27)	θ value	0.0563607 (rank : 11)
Query Neighborhood Hits	54	Target Neighborhood Hits	420	Shared Neighborhood Hits	10
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

TR150_MOUSE
NC score	0.032655 (rank : 28)	θ value	1.06291 (rank : 23)
Query Neighborhood Hits	54	Target Neighborhood Hits	468	Shared Neighborhood Hits	9
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

XL3A_MOUSE
NC score	0.031503 (rank : 29)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	54	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	Q60595	Gene names	Xlr3a
Domain Architecture
Description	X-linked lymphocyte-regulated protein 3A.

LETM1_HUMAN
NC score	0.029427 (rank : 30)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	54	Target Neighborhood Hits	338	Shared Neighborhood Hits	15
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

JHD2C_MOUSE
NC score	0.021250 (rank : 31)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	54	Target Neighborhood Hits	297	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9	Gene names	Jmjd1c, Jhdm2c, Kiaa1380
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C).

KIF2C_HUMAN
NC score	0.020461 (rank : 32)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	54	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

OFD1_HUMAN
NC score	0.019680 (rank : 33)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	54	Target Neighborhood Hits	753	Shared Neighborhood Hits	19
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

TRAIP_HUMAN
NC score	0.019243 (rank : 34)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	54	Target Neighborhood Hits	780	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

TRAK1_HUMAN
NC score	0.019192 (rank : 35)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	54	Target Neighborhood Hits	660	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

CT2NL_HUMAN
NC score	0.017328 (rank : 36)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	54	Target Neighborhood Hits	1059	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CT2NL_MOUSE
NC score	0.015706 (rank : 37)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	54	Target Neighborhood Hits	902	Shared Neighborhood Hits	20
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

GCC2_HUMAN
NC score	0.015622 (rank : 38)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	54	Target Neighborhood Hits	1558	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.015617 (rank : 39)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	54	Target Neighborhood Hits	1559	Shared Neighborhood Hits	24
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

MYPT1_MOUSE
NC score	0.015347 (rank : 40)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	54	Target Neighborhood Hits	539	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

SPTB2_MOUSE
NC score	0.015192 (rank : 41)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	54	Target Neighborhood Hits	770	Shared Neighborhood Hits	17
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_HUMAN
NC score	0.015018 (rank : 42)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	54	Target Neighborhood Hits	748	Shared Neighborhood Hits	16
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ANS4B_MOUSE
NC score	0.014339 (rank : 43)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	54	Target Neighborhood Hits	294	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

CKAP4_MOUSE
NC score	0.013956 (rank : 44)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	54	Target Neighborhood Hits	596	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

RBM25_HUMAN
NC score	0.011086 (rank : 45)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	54	Target Neighborhood Hits	682	Shared Neighborhood Hits	20
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

IF2M_MOUSE
NC score	0.009171 (rank : 46)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	54	Target Neighborhood Hits	183	Shared Neighborhood Hits	5
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

CENPF_HUMAN
NC score	0.008995 (rank : 47)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	54	Target Neighborhood Hits	1932	Shared Neighborhood Hits	23
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

WRN_MOUSE
NC score	0.008555 (rank : 48)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	54	Target Neighborhood Hits	295	Shared Neighborhood Hits	7
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

IWS1_HUMAN
NC score	0.006501 (rank : 49)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	54	Target Neighborhood Hits	1241	Shared Neighborhood Hits	15
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ABCG4_HUMAN
NC score	0.006017 (rank : 50)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	54	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H172	Gene names	ABCG4, WHITE2
Domain Architecture
Description	ATP-binding cassette sub-family G member 4.

MYH10_HUMAN
NC score	0.005848 (rank : 51)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	54	Target Neighborhood Hits	1620	Shared Neighborhood Hits	23
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

ROCK1_MOUSE
NC score	0.004538 (rank : 52)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	54	Target Neighborhood Hits	2126	Shared Neighborhood Hits	26
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ROCK1_HUMAN
NC score	0.004464 (rank : 53)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	54	Target Neighborhood Hits	2000	Shared Neighborhood Hits	24
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

PCLO_MOUSE
NC score	0.002902 (rank : 54)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	54	Target Neighborhood Hits	2275	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

NTRK1_HUMAN
NC score	-0.000356 (rank : 55)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	54	Target Neighborhood Hits	1023	Shared Neighborhood Hits	5
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

LIMK1_HUMAN
NC score	-0.000505 (rank : 56)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	54	Target Neighborhood Hits	1005	Shared Neighborhood Hits	5
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).