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Network neighborhood for query Sequence : ECHP_HUMAN

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ECHP_HUMAN
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ECHP_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_MOUSE
θ value	0 (rank : 2)	NC score	0.985805 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHA_HUMAN
θ value	1.50314e-71 (rank : 3)	NC score	0.909260 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

HCDH_HUMAN
θ value	2.86786e-30 (rank : 4)	NC score	0.683574 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_MOUSE
θ value	9.2256e-29 (rank : 5)	NC score	0.678774 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

ECHM_MOUSE
θ value	2.96777e-27 (rank : 6)	NC score	0.727878 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

ECHM_HUMAN
θ value	2.12685e-25 (rank : 7)	NC score	0.718707 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AUHM_MOUSE
θ value	1.02238e-19 (rank : 8)	NC score	0.692925 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

AUMH_HUMAN
θ value	3.88503e-19 (rank : 9)	NC score	0.688348 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

ECH1_MOUSE
θ value	4.44505e-15 (rank : 10)	NC score	0.607875 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECH1_HUMAN
θ value	4.91457e-14 (rank : 11)	NC score	0.629549 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

D3D2_MOUSE
θ value	2.98157e-11 (rank : 12)	NC score	0.566756 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_HUMAN
θ value	4.30538e-10 (rank : 13)	NC score	0.565175 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CRYL1_HUMAN
θ value	5.62301e-10 (rank : 14)	NC score	0.474312 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

CDYL1_HUMAN
θ value	5.26297e-08 (rank : 15)	NC score	0.399154 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y232	Gene names	CDYL, CDYL1
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDYL_MOUSE
θ value	1.99992e-07 (rank : 16)	NC score	0.401605 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDY1_HUMAN
θ value	3.41135e-07 (rank : 17)	NC score	0.397248 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	48	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

CDY2_HUMAN
θ value	7.59969e-07 (rank : 18)	NC score	0.393936 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	49	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

PECI_MOUSE
θ value	7.59969e-07 (rank : 19)	NC score	0.406560 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WUR2	Gene names	Peci
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CRYL1_MOUSE
θ value	1.69304e-06 (rank : 20)	NC score	0.414117 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

ADH7_MOUSE
θ value	0.163984 (rank : 21)	NC score	0.054299 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

ADH6_HUMAN
θ value	0.279714 (rank : 22)	NC score	0.053526 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ADHX_MOUSE
θ value	0.365318 (rank : 23)	NC score	0.052361 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

ADH7_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.051754 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

ADHX_HUMAN
θ value	0.813845 (rank : 25)	NC score	0.050290 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

ASCC2_HUMAN
θ value	3.0926 (rank : 26)	NC score	0.020779 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H1I8, Q4TT54, Q8TAZ0, Q9H711, Q9H9D6	Gene names	ASCC2, ASC1P100
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100).

REST_HUMAN
θ value	6.88961 (rank : 27)	NC score	-0.000322 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	1605	Shared Neighborhood Hits	3
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

JIP2_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.007481 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	288	Shared Neighborhood Hits	2
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

CDYL2_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.359573 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N8U2	Gene names	CDYL2
Domain Architecture
Description	Chromodomain Y-like protein 2 (CDY-like 2).

PECI_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.288294 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	O75521, Q5JYK5, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55	Gene names	PECI, DRS1, HCA88
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (DBI-related protein 1) (DRS-1) (Hepatocellular carcinoma- associated antigen 88) (NY-REN-1 antigen).

Hits sorted by NC score

ECHP_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_MOUSE
NC score	0.985805 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHA_HUMAN
NC score	0.909260 (rank : 3)	θ value	1.50314e-71 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

ECHM_MOUSE
NC score	0.727878 (rank : 4)	θ value	2.96777e-27 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

ECHM_HUMAN
NC score	0.718707 (rank : 5)	θ value	2.12685e-25 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AUHM_MOUSE
NC score	0.692925 (rank : 6)	θ value	1.02238e-19 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

AUMH_HUMAN
NC score	0.688348 (rank : 7)	θ value	3.88503e-19 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

HCDH_HUMAN
NC score	0.683574 (rank : 8)	θ value	2.86786e-30 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_MOUSE
NC score	0.678774 (rank : 9)	θ value	9.2256e-29 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

ECH1_HUMAN
NC score	0.629549 (rank : 10)	θ value	4.91457e-14 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECH1_MOUSE
NC score	0.607875 (rank : 11)	θ value	4.44505e-15 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

D3D2_MOUSE
NC score	0.566756 (rank : 12)	θ value	2.98157e-11 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_HUMAN
NC score	0.565175 (rank : 13)	θ value	4.30538e-10 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CRYL1_HUMAN
NC score	0.474312 (rank : 14)	θ value	5.62301e-10 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

CRYL1_MOUSE
NC score	0.414117 (rank : 15)	θ value	1.69304e-06 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

PECI_MOUSE
NC score	0.406560 (rank : 16)	θ value	7.59969e-07 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WUR2	Gene names	Peci
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CDYL_MOUSE
NC score	0.401605 (rank : 17)	θ value	1.99992e-07 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDYL1_HUMAN
NC score	0.399154 (rank : 18)	θ value	5.26297e-08 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y232	Gene names	CDYL, CDYL1
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDY1_HUMAN
NC score	0.397248 (rank : 19)	θ value	3.41135e-07 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	48	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

CDY2_HUMAN
NC score	0.393936 (rank : 20)	θ value	7.59969e-07 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	49	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

CDYL2_HUMAN
NC score	0.359573 (rank : 21)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N8U2	Gene names	CDYL2
Domain Architecture
Description	Chromodomain Y-like protein 2 (CDY-like 2).

PECI_HUMAN
NC score	0.288294 (rank : 22)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	O75521, Q5JYK5, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55	Gene names	PECI, DRS1, HCA88
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (DBI-related protein 1) (DRS-1) (Hepatocellular carcinoma- associated antigen 88) (NY-REN-1 antigen).

ADH7_MOUSE
NC score	0.054299 (rank : 23)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

ADH6_HUMAN
NC score	0.053526 (rank : 24)	θ value	0.279714 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ADHX_MOUSE
NC score	0.052361 (rank : 25)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

ADH7_HUMAN
NC score	0.051754 (rank : 26)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

ADHX_HUMAN
NC score	0.050290 (rank : 27)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

ASCC2_HUMAN
NC score	0.020779 (rank : 28)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H1I8, Q4TT54, Q8TAZ0, Q9H711, Q9H9D6	Gene names	ASCC2, ASC1P100
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100).

JIP2_HUMAN
NC score	0.007481 (rank : 29)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	288	Shared Neighborhood Hits	2
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

REST_HUMAN
NC score	-0.000322 (rank : 30)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	1605	Shared Neighborhood Hits	3
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).