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Network neighborhood for query Sequence : CRYL1_HUMAN

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CRYL1_HUMAN
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CRYL1_HUMAN
θ value	9.78303e-172 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

CRYL1_MOUSE
θ value	5.77539e-148 (rank : 2)	NC score	0.985402 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

HCDH_MOUSE
θ value	3.28887e-18 (rank : 3)	NC score	0.710876 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_HUMAN
θ value	5.60996e-18 (rank : 4)	NC score	0.709095 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

ECHP_MOUSE
θ value	7.58209e-15 (rank : 5)	NC score	0.526757 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_HUMAN
θ value	5.62301e-10 (rank : 6)	NC score	0.474312 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHA_HUMAN
θ value	8.97725e-08 (rank : 7)	NC score	0.403564 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

SYCP1_HUMAN
θ value	1.06291 (rank : 8)	NC score	0.012075 (rank : 19)
Query Neighborhood Hits	12	Target Neighborhood Hits	1313	Shared Neighborhood Hits	3
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

REST_HUMAN
θ value	3.0926 (rank : 9)	NC score	0.007103 (rank : 20)
Query Neighborhood Hits	12	Target Neighborhood Hits	1605	Shared Neighborhood Hits	4
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SMBP2_HUMAN
θ value	3.0926 (rank : 10)	NC score	0.020669 (rank : 16)
Query Neighborhood Hits	12	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

NSDHL_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.016794 (rank : 18)
Query Neighborhood Hits	12	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q15738, O00344	Gene names	NSDHL, H105E3
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (H105e3 protein).

NSDHL_MOUSE
θ value	8.99809 (rank : 12)	NC score	0.016833 (rank : 17)
Query Neighborhood Hits	12	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1J0, O55109	Gene names	Nsdhl
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170).

AUHM_MOUSE
θ value	θ > 10 (rank : 13)	NC score	0.103604 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

AUMH_HUMAN
θ value	θ > 10 (rank : 14)	NC score	0.102253 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

D3D2_HUMAN
θ value	θ > 10 (rank : 15)	NC score	0.096954 (rank : 13)
Query Neighborhood Hits	12	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_MOUSE
θ value	θ > 10 (rank : 16)	NC score	0.103641 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

ECH1_HUMAN
θ value	θ > 10 (rank : 17)	NC score	0.089033 (rank : 14)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECH1_MOUSE
θ value	θ > 10 (rank : 18)	NC score	0.083051 (rank : 15)
Query Neighborhood Hits	12	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECHM_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.111512 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

ECHM_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.114610 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

Hits sorted by NC score

CRYL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	9.78303e-172 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

CRYL1_MOUSE
NC score	0.985402 (rank : 2)	θ value	5.77539e-148 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

HCDH_MOUSE
NC score	0.710876 (rank : 3)	θ value	3.28887e-18 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_HUMAN
NC score	0.709095 (rank : 4)	θ value	5.60996e-18 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	7
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

ECHP_MOUSE
NC score	0.526757 (rank : 5)	θ value	7.58209e-15 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_HUMAN
NC score	0.474312 (rank : 6)	θ value	5.62301e-10 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHA_HUMAN
NC score	0.403564 (rank : 7)	θ value	8.97725e-08 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

ECHM_MOUSE
NC score	0.114610 (rank : 8)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

ECHM_HUMAN
NC score	0.111512 (rank : 9)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	12	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

D3D2_MOUSE
NC score	0.103641 (rank : 10)	θ value	θ > 10 (rank : 16)
Query Neighborhood Hits	12	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

AUHM_MOUSE
NC score	0.103604 (rank : 11)	θ value	θ > 10 (rank : 13)
Query Neighborhood Hits	12	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

AUMH_HUMAN
NC score	0.102253 (rank : 12)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	12	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

D3D2_HUMAN
NC score	0.096954 (rank : 13)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	12	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

ECH1_HUMAN
NC score	0.089033 (rank : 14)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECH1_MOUSE
NC score	0.083051 (rank : 15)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	12	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

SMBP2_HUMAN
NC score	0.020669 (rank : 16)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

NSDHL_MOUSE
NC score	0.016833 (rank : 17)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1J0, O55109	Gene names	Nsdhl
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170).

NSDHL_HUMAN
NC score	0.016794 (rank : 18)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q15738, O00344	Gene names	NSDHL, H105E3
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (H105e3 protein).

SYCP1_HUMAN
NC score	0.012075 (rank : 19)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	1313	Shared Neighborhood Hits	3
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

REST_HUMAN
NC score	0.007103 (rank : 20)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	1605	Shared Neighborhood Hits	4
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).